Weekly Topic - GH

[Glycomann]

So, I’m going to face the chance of ridicule here and ask everyone’s opinion on a few things that I chased down a rabbit hole. But I think it’s worth some discussion, or at the very least, furthering MY knowledge on the topic.

Fat-Loss vs. Hyperplasia/hyperteophy

• is there a significant difference between administering the GH sub-q (systemic IGF-1 release from liver), and administering the GH I.M., targeted at specific muscles where localized IGF-1 expression takes place?
• Or might the difference between local/systemic be negated by taking 6iu’s at night, which then by 8am, the max amount of benefit (1.5ius) would be present anyway (based on half-life)?

-Now, I don’t run anywhere near that dosage, as I hold water at 4iu’s, but if I am aiming for muscle growth instead of fat-loss or anti-aging as my primary result, does mode of administration make that big of a difference?

There is much more I could add and/or ask regarding this rabbit hole (estrogen beta receptor function, E2 levels commensurate with GH conversion, etc), but I honestly don’t know enough about it to properly articulate the questions and will most likely sound worse than I already do.

Thanks fellas

The difference is no more than what the lint between your toes make to your response.

 

[TomJ]

I definitely notice a considerable difference when running 8- 10 IUs compared to 3-4.

going from 4iu to just 6iu was a drastic difference for me.

 

[Vision]

going from 4iu to just 6iu was a drastic difference for me.

I did this right out The gate once... Was on 3ius and simply doubled it up to six.. No joke literally within one week, with no exaggeration I wouldn't be surprised if it was between 8: and 12 lb that I gained..
My face look terrible. Some of these very good generic brands that are available need to be respected, and I was handling it like it was supposed to be slightly under and not equivalent to pharmaceutical.

 

[Theotherone55]

Currently running 6iu about 1/4 into my off-season growth phase. That will probably peak out at 8iu or so and will all be dosed pre bed.

Clinical trials as high as 18iu/day in sick children dosed 1x/per were similar in effects to multiple times/day. Even huge doses every other day were seen to be comparable. I have seen this over the years with my clients and on myself. Whether you inject 1x, 2x, 3x per day or ED, EOD is pretty much insignificant across the board. It's one of those things that until more data is available, it's better to just get it in. It's effect on glucose levels may vary on frequency, but 100% user dependent.

This is the most accurately explained response ever.
Every prominent coach, every uber successful bodybuilder will tell you the same thing. Just get it in, it doesnt matter. Focusing on splitting hairs doesnt make a lick of difference. If it did, we would allllreaddy be doing it.

And this goes to @Colbymac 's question too. You're too in the weeds. There is no 'spot injection for a difference in systemic vs local IGF' trick that you're going to discover that suddenly open's pandora's box and elicits some magic growth everyone else is missing out on. Just get it in in a time or way that best fits your schedule, that's all.

 

[Colbymac]

This is the most accurately explained response ever.
Every prominent coach, every uber successful bodybuilder will tell you the same thing. Just get it in, it doesnt matter. Focusing on splitting hairs doesnt make a lick of difference. If it did, we would allllreaddy be doing it.

And this goes to @Colbymac 's question too. You're too in the weeds. There is no 'spot injection for a difference in systemic vs local IGF' trick that you're going to discover that suddenly open's pandora's box and elicits some magic growth everyone else is missing out on. Just get it in in a time or way that best fits your schedule, that's all.

Thanks, my man. I appreciate the feedback. I definitely didn’t/wouldn’t see it as a trick or some hidden science - just trying to be as efficient as possible and to deepen my overall understanding of the processes. Over analyzing is an obvious flaw of mine…

 

[Theotherone55]

Thanks, my man. I appreciate the feedback. I definitely didn’t/wouldn’t see it as a trick or some hidden science - just trying to be as efficient as possible and to deepen my overall understanding of the processes. Over analyzing is an obvious flaw of mine…

Bro, we allll do it lol not just you. Kinda part of the journey with this stuff. Spend some time analyzing the best way to get that 1%...then suddenly you realize that if you just do the 90% super consistent over time, the 1% doesnt really matter.

There's also self experimentation. My first years running GH i did everything. Pre, post, both, 3x a day, one bolus dose, middle of the night, EOD, etc. The only rule I saw that was clearrrllly evident was....more = better lol. Personally, i couldnt realllly see a difference in subq vs IM, or bolus vs pre+post, etc...but i ALWAYS saw a difference when I did more GH.

 

[Syntha Claus]

I think the biggest thing I could tell anyone about all of this is, don't bother trying find some trick or magic. None of this is voodoo or some mystic thing. As they say, it is simple, but not easy.
Just eat properly, train with intention and live a healthy lifestyle. All the progress will come. It just comes at different levels for some. If you try to speed the process too much, you just won't be around long. I have seen this over and over in my nearly 40 years in the gym. This forum has a graveyard of go hard fellas that just disappeared. Not faded away. Disappeared.

Don't try to do what "Dickhead McCelebrity" bodybuilders does. That's him, you are you. I see so much name dropping and hero worship in this game.
Look at all info that is available and choose that which makes sense to you. Not the info that promises fast gains, guaranteed pro card and any of that other nonsense. Building lasting, healthy tissue takes time.

I just wish people would stop looking for shortcuts.

 

[Killionb12]

I think the biggest thing I could tell anyone about all of this is, don't bother trying find some trick or magic. None of this is voodoo or some mystic thing. As they say, it is simple, but not easy.
Just eat properly, train with intention and live a healthy lifestyle. All the progress will come. It just comes at different levels for some. If you try to speed the process too much, you just won't be around long. I have seen this over and over in my nearly 40 years in the gym. This forum has a graveyard of go hard fellas that just disappeared. Not faded away. Disappeared.

Don't try to do what "Dickhead McCelebrity" bodybuilders does. That's him, you are you. I see so much name dropping and hero worship in this game.
Look at all info that is available and choose that which makes sense to you. Not the info that promises fast gains, guaranteed pro card and any of that other nonsense. Building lasting, healthy tissue takes time.

I just wish people would stop looking for shortcuts.

Amen brother! This is spot on!


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