TRT & Reta? Reta dosing?

[James12166]

Started at 2mg, First day I could not eat anything even after smoking cannabis.

I started at 0.5 for 4 weeks didnt notice anything until week 2 week 3 Ish once I went up to 1mg It's been fine works great 1.5 worked even better had to finish meals some times

 

[MoreTestHairyChest]

From my experience it took about 2 weeks to.feel the appetite suppression

What were your doses first 2-3 weeks

 

[James12166]

What were your doses first 2-3 weeks

First 4 weeks 0.5mg. second 4 weeks 1mg third 4 weeks 1.5mg and I've been on 1.5mg for 14 weeks now working great

 

[Slyosniper]

Did .5 first week and now just wrapping up a week at 1mg. Haven’t felt anything in the slightest.

Going to pin 2mg next

You could be insulin resistant most people that don't notice effects are

 

[James12166]

You could be insulin resistant most people that don't notice effects are

I'll look into that thanks bro

 

[MoreTestHairyChest]

You could be insulin resistant most people that don't notice effects are

I don’t think so, daughters a t1d so I periodically check blood sugars. Always lower on the blood sugar scale even after eating high carbs.

Just pinned the 2mg this morning, was starving all day lol. I’ll see how it is over the next couple of days.

I got my pickup from SB Labs and they have a good rep here

 

[Captain_Furious]

I have to say that since starting retatrutide, I've noticed a slow, but alarming increase in inflammatory markers (ferritin overload, increase in ALT, AST and GGT, decrease in eGFR, increase in C-rp, etc...) over time. It's gotten to the point that my doctor thinks the issue, ironically, is fatty liver, so he's ordered me an ultrasound along with a plyability test. I've been racking my brain trying to figure out what it was and hadn't made the reta connection until this video popped up in my YouTube feed. At first, I didn't want to believe it... but ALL of the concerning health markers he references line up 100% with what I've been experiencing. I was following the dosage increases laid out in the trial groups, bumping all the way up to 12mg p/wk, which is when I think things really went off the rails. If you're using reta, I strongly suggest you watch this video. I'm already dropping my dosages (works anyway since my coach is reversing me out of a very long-term cut, so it was time no matter what since the food is going to ramp up) and implementing his suggested healing protocols.

Retatrutide and Liver Damage: The Missing Dosage Protocol

The irony is that retatrutide really is a MIRACLE drug. But it appears to be being misused and overdosed, and we're going to see the results of those potentially misguided (from perhaps well-intentioned influencers and TRT clinic docs... perhaps not well-intentioned) dosage recommendations rear its ugly head not too far down the line. Watch it. Believe it. Don't believe it. But at least watch it and form your own conclusion and decision. Based on my personal experience, I'm quickly titrarting off. When my blood work normalizes and my body heals, I'll go back to a low 1-2mg dose per week b/c of all of the benefits that come with it. But the days of leaning on it to drop a bunch of BF and cut out the food noise are behind me now.

Hope this post helps at least one person on this form who might be silently struggling with the same issues I've been grappling with since November of last year.

 

[BFulforth]

I worked my way up to 6mg after many months. When I tried going to 7, I felt like complete dog shit. I’m back to 4 per week and feel much better. I’m staying low and slow.


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[Andy88]

I started with 0.25mg on a Friday to see if I'm not alergic or something. After feeling fine I had another 0.75 on Sunday so first week was on 1mg.

I definitely felt this first dose. Hunger diminished. Less desire to snack. No difference to HR (I wear a HR monitoring watch)

Second week was also 1mg, I continued to feel some effects, then I upped to 2mg, next 3mg. I take my dose on Sunday. After 3mg I definitely felt the strongest effects around Mon-Wed, on Thursday-Friday it started diminishing. So I upped to 4mg the week prior and I had another 4mg last Sunday. It seems to be the sweet spot.

I do 20 min of daily cardio (HR at 140-150) eliptical, and weights twice a week. My normal calorie consumption was 3500 (110kg, 185cm, 35% BF). When I dropped to 2500 for almost 2 months I lost only 2kg of water weight (due to dropping all sugars too).

Now I don't count calories on the reta, but I think I eat somewhere in the region of 1600-2000, I just make sure to cram enough protein in. In those 3wks + rampup I already lost 6kg (probably half water), but even 3kg of fat in a bit over a month is an amazing result for me.

I'm actually overweight and my doc offered ozempic, but I decioded to experiment with reta instead as my main problem is not so much control over eating, but keeping my metabolism from going into hibernation mode when I eat a lot less.

 

[WhiteApe]

I have to say that since starting retatrutide, I've noticed a slow, but alarming increase in inflammatory markers (ferritin overload, increase in ALT, AST and GGT, decrease in eGFR, increase in C-rp, etc...) over time. It's gotten to the point that my doctor thinks the issue, ironically, is fatty liver, so he's ordered me an ultrasound along with a plyability test. I've been racking my brain trying to figure out what it was and hadn't made the reta connection until this video popped up in my YouTube feed. At first, I didn't want to believe it... but ALL of the concerning health markers he references line up 100% with what I've been experiencing. I was following the dosage increases laid out in the trial groups, bumping all the way up to 12mg p/wk, which is when I think things really went off the rails. If you're using reta, I strongly suggest you watch this video. I'm already dropping my dosages (works anyway since my coach is reversing me out of a very long-term cut, so it was time no matter what since the food is going to ramp up) and implementing his suggested healing protocols.

Retatrutide and Liver Damage: The Missing Dosage Protocol

The irony is that retatrutide really is a MIRACLE drug. But it appears to be being misused and overdosed, and we're going to see the results of those potentially misguided (from perhaps well-intentioned influencers and TRT clinic docs... perhaps not well-intentioned) dosage recommendations rear its ugly head not too far down the line. Watch it. Believe it. Don't believe it. But at least watch it and form your own conclusion and decision. Based on my personal experience, I'm quickly titrarting off. When my blood work normalizes and my body heals, I'll go back to a low 1-2mg dose per week b/c of all of the benefits that come with it. But the days of leaning on it to drop a bunch of BF and cut out the food noise are behind me now.

Hope this post helps at least one person on this form who might be silently struggling with the same issues I've been grappling with since November of last year.

My ferritin went sky high on 3mg/week and iron went low. Still trying to recover months later. I believe it lowered my T3 as well. I won't touch the stuff again.

 

[MoreTestHairyChest]

I started with 0.25mg on a Friday to see if I'm not alergic or something. After feeling fine I had another 0.75 on Sunday so first week was on 1mg.

I definitely felt this first dose. Hunger diminished. Less desire to snack. No difference to HR (I wear a HR monitoring watch)

Second week was also 1mg, I continued to feel some effects, then I upped to 2mg, next 3mg. I take my dose on Sunday. After 3mg I definitely felt the strongest effects around Mon-Wed, on Thursday-Friday it started diminishing. So I upped to 4mg the week prior and I had another 4mg last Sunday. It seems to be the sweet spot.

I do 20 min of daily cardio (HR at 140-150) eliptical, and weights twice a week. My normal calorie consumption was 3500 (110kg, 185cm, 35% BF). When I dropped to 2500 for almost 2 months I lost only 2kg of water weight (due to dropping all sugars too).

Now I don't count calories on the reta, but I think I eat somewhere in the region of 1600-2000, I just make sure to cram enough protein in. In those 3wks + rampup I already lost 6kg (probably half water), but even 3kg of fat in a bit over a month is an amazing result for me.

I'm actually overweight and my doc offered ozempic, but I decioded to experiment with reta instead as my main problem is not so much control over eating, but keeping my metabolism from going into hibernation mode when I eat a lot less.

Damn, I’m on my 3rd shot, moved to 2mg and I don’t feel a thing

 

[Andy88]

Damn, I’m on my 3rd shot, moved to 2mg and I don’t feel a thing

People react differently.

Some people go to as much as 12mg a week. I can't imagine going that high. Maybe I react stronger to it. Or you react less?

My ferritin went sky high on 3mg/week and iron went low. Still trying to recover months later. I believe it lowered my T3 as well. I won't touch the stuff again.

I few days I'll be doing my first blood test since starting. Thanks for the tip.

 

[Andy88]

Guys, did anyone have their hematocrit go up a month after starting reta?

4 months ago (before reta) mine was slowly creeping up to 50.8, I started dringing more water(added 1 to 1.5L a day) it dropped to 50.4 next month. Then a month has passed, I started reta and another month. Now I test and the hematocrit is 51.2. It is not that bad, but it keeps going in the wrong direction.

Maybe I wasn't drinking as much as I should, but it was far more than before when I had 50.8 (all on static dose of TRT).

So I'm thinking. Reta does make me forget about drinking sometimes, but it is not a big effect. I dropped 8kg of "something". Probably half of that is water...

Why I think that? Because Reta stimulates depletion of glycogen reserves and 1 gram of glycogen holds 3-4g of water.

Anyone else is seeing hematocrit increase on reta?

I noticed no difference to my ferritin and iron.

Edit: I also tested TSH - no difference there too.

 

[calf10]

Guys, did anyone have their hematocrit go up a month after starting reta?

4 months ago (before reta) mine was slowly creeping up to 50.8, I started dringing more water(added 1 to 1.5L a day) it dropped to 50.4 next month. Then a month has passed, I started reta and another month. Now I test and the hematocrit is 51.2. It is not that bad, but it keeps going in the wrong direction.

Maybe I wasn't drinking as much as I should, but it was far more than before when I had 50.8 (all on static dose of TRT).

So I'm thinking. Reta does make me forget about drinking sometimes, but it is not a big effect. I dropped 8kg of "something". Probably half of that is water...

Why I think that? Because Reta stimulates depletion of glycogen reserves and 1 gram of glycogen holds 3-4g of water.

Anyone else is seeing hematocrit increase on reta?

I noticed no difference to my ferritin and iron.

Edit: I also tested TSH - no difference there too.

Started reta 1 month after I started TRT in 2025, reta did not effect hematocrit levels. Splitting TRT into twice a week reduced hematocrit from 52 to 46, splitting weekly TRT dose helps some.

 

[GoBirds1212]

I was on Tirz when I went on TRT last summer and it was great. Then switched to Reta and I don't feel the same on it. I stopped it all for a few months to see if I needed a break. Bought some more Reta, started a 2mg and I just don't think I will ever have the appetite suppression on Reta that I had on Tirz. I like Reta for the other health benefits though but I have a pretty big cut coming up so am thinking about switching back. Or maybe I need a new supplier for GLP's??

 

[MoreTestHairyChest]

I was on Tirz when I went on TRT last summer and it was great. Then switched to Reta and I don't feel the same on it. I stopped it all for a few months to see if I needed a break. Bought some more Reta, started a 2mg and I just don't think I will ever have the appetite suppression on Reta that I had on Tirz. I like Reta for the other health benefits though but I have a pretty big cut coming up so am thinking about switching back. Or maybe I need a new supplier for GLP's??

Yea I hopped up every week and I feel nothing from Reta. At 3mg and no difference. I think the source is bad.

Ordered it from a new source (way cheaper too compared to where I got it in here) that someone at my gym used successfully

 

[MoreTestHairyChest]

—-

 

[GoBirds1212]

Yea I hopped up every week and I feel nothing from Reta. At 3mg and no difference. I think the source is bad.

Ordered it from a new source (way cheaper too compared to where I got it in here) that someone at my gym used successfully

Interesting. I might not to change. I'm only at 2mg right now, but this would be the second vendor I have used for it. Had luck with other stuff.

 

[calf10]

Yea I hopped up every week and I feel nothing from Reta. At 3mg and no difference. I think the source is bad.

Ordered it from a new source (way cheaper too compared to where I got it in here) that someone at my gym used successfully

Out of curiosity I tried Cagrilintide along with low dose reta and Cagri is definetely stronger for only appetite suppression.

 

[GoBirds1212]

Out of curiosity I tried Cagrilintide along with low dose reta and Cagri is definetely stronger for only appetite suppression.

May need to try that!

 

[Andy88]

Started reta 1 month after I started TRT in 2025, reta did not effect hematocrit levels. Splitting TRT into twice a week reduced hematocrit from 52 to 46, splitting weekly TRT dose helps some.

Thanks for answering.

I'm already on every other day (shallow IM).

Wow, 46... Before I started TRT I was at 47.

 

[MoreTestHairyChest]

So got a separate Reta source, went down from 3mg to 2mg, it hits hard. No appetite whatsoever, stomach a little uneasy.

Looks like the original SBL sourced Reta was a bust. Didn’t feel a hint of anything at all, now I went lower in dose with my new one and it’s a world of difference