Post injection cough "The exact reasons why is right here"
This is known as POME this will happen with just about all and any injections, depending on the individual, sensitivities and precisely where the injection was made.
It happens... Solvents are mostly responsible for this reaction.
Post injection cough "The exact reasons why is right here" FYI - This can happen with any OIL/tren/test...
POME, "Pulmonary Oil Microbolism".. Also - Trenbolone increases the rise of prostaglandin production..
Trenbolone or even any Injection cough can very well be explained.
The 1st portion of this topic is just IMO interpretation & detailed explanation on why some users may experience coughing upon injection of any oils.
Time and time again we see threads and topics containing questions & concerns about Tren cough or Post injection cough, but what exactly is it?
For some it seems to be a phenomenon in the world of PED use and some people could not come up with a definitive answer or reasonable explanation other than “You must have entered the blood stream with your oil“, or other times we see people posting ideas and theories all the while failing to provide any conclusive evidence.
Right here today we are going to review what exactly is taking place inside your body & respiratory system post injection.
Let's keep in mind that some people may very well be misinformed about this cough, at the same times others having a keen understanding of its mechanisms of action. So let's treat this as a refresher for all.
For myself I've experienced “coughing and struggling to breath” numerous times and not just from Trenbolone , furthermore I’ve experienced this with Testosterone with a IM "intramuscular Injections" injection..
Ok, now why does this take place and what is the causes and can this be avoided at all?
So, there’s a few variables that could be happening here in regards to the symptoms that someone may feel almost immediately post injection.. Some ranging from difficulties breathing, to mild or violent coughing fits, eyes watering, mild to extreme flush feeling and red of the face, feeling dizzy/faint, pressure in the chest, so on and so on.
Here's the scary part - this can actually last anywhere from 1-5 minutes and at times 5-10 mins in some cases.. In very rares instances there has been reports of it lasting up to 24-48 hrs with random coughing bouts.
I often hear people advocate that it’s the acetate ester only and others say it's mostly with potent trenbolone and that bunk trenbolone won't do this..
This is very far from the truth, however there's some traits here that bind this to such theories and understandably so.
However, this very well can happen with just about any compound regardless of the ester or parenting hormone..
What is the real initial cause of this?
Prior I stated that there’s many factors in which you could experience this. I’ll begin with the most common one and this is known as POME..
What's POME?
Pulmonary oil microembolism. It’s simply a case of acute respiratory distress/hypoxemia,
following the accidental intravenous injection of an oil steroid solution (Info about this is attached to one of the studies below in blue)..
The oily solution is carried through the blood stream tracking its way to the lungs in which the reaction of coughing is simply your bodies way of clearing it out.. This can be quite violent and very discomforting..
I had it happen with Test. It can happen with any injection. With regards to "solution", Benzyl Benzoate/Benzyl alcohol is found present in MOST products especially UGL's
This is actually an other agent that is known for causing respiratory distress in many users..
This is a temporary acute onset of “Anaphylaxis” (Read study about this)..
Ok, can I avoid this at all?
Yes to a degree, however injection sites will vary with immune response, some areas have a heavy mapping system with veins and vessels....
Ranging from Pulmonary. pulmonary vessels are arteries that transport oxygen-poor blood from the heart’s right ventricle to the lungs. These Pulmonary veins will transport oxygen-rich blood back to the heart.
Systemic. The systemic vessels are arteries that carry oxygen-rich blood from the heart’s left ventricle to the tissues in all parts of the body. These then return oxygen-poor blood through the veins back to the heart.
#1)
Why does this seem to happen most with Trenbolone?
This is what everyone want's to know.. Hmmmm - Trenbolone increases the rise of prostaglandin production which can have great influence over bronchial constriction. Stay with me here..
What are prostaglandins?
There group of hormone like lipid compounds cells that are derived enzymatically from fatty acids that're precursors of Cyclooxygenase and Lipoxygenase.
Lipoxygenase has some dictation through pathways which is expressed through branches of bronchi, in the entire respiratory system..When the Cox-2 lipo levels increase it tends to have restriction or expulsion in the respiratory region..Thus,this is what dicates the Tren cough.
This tends to happen more with the Ace ester as it cause a faster metabolization and a faster rise with the prostaglandin levels!
Below are some studies that may help explain in better detail for those that wish to geek-out, enjoy
What are the symptoms of pulmonary oil microembolism?
Serious pulmonary oil microembolism (POME) reactions, involving cough, urge to cough, dyspnea, hyperhidrosis, throat tightening, chest pain, dizziness, and syncope, have been reported to occur during or immediately after the injection of intramuscular testosterone undecanoate 1000 mg (4 mL) in post-approval use outside ...
Why does my testosterone shot make me cough?
Testosterone esters are administered in oil vehicle via the intramuscular route. Rarely, dry cough together with faintness, diaphoresis, anxiety and syncope caused by pulmonary oil microembolism(POME) may occur. POME events are generally self-limited and last a few minutes. Very rarely they need oxygen therapy.
How long does pulmonary oil Microembolism last?
The reports received indicate that POME is an event that most often spontaneously resolves within 30 minutes of symptom onset. Most dissipate in seconds..
Vision
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Bonus material about other oils and solvents.
Studies below:
Pulmonary Oil Microembolism (POME) and Anaphylaxis in Controlled Clinical Studies
Medical Editor: John P. Cunha, DO, FACOEP
Adverse events attributable to pulmonary oil microembolism and anaphylaxiswere reported in a small number of patients in controlled clinical trials. In the 84-week clinical trial of Aveed, 1 patient experienced a mild coughing fit lasting 10 minutes after his third injection, which was retrospectively attributed to POME. In another clinical trial of intramuscular testosterone undecanoate (1000 mg), a hypogonadal male patient experienced the urge to cough and respiratory distress at 1 minute after his tenth injection, which was also retrospectively attributed to POME.
During a review that involved adjudication of all cases meeting specific criteria, 9 POME events in 8 patients and 2 events of anaphylaxis among 3,556 patients treated with intramuscular testosterone undecanoate in 18 clinical trials were judged to have occurred.
Postmarketing Experience
The following adverse reactions have been identified during post-approval use of Aveed. Because the reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Pulmonary Oil Microembolism (POME) and Anaphylaxis
Serious pulmonary oil microembolism (POME) reactions, involving cough, urge to cough, dyspnea, hyperhidrosis, throat tightening, chest pain, dizziness, andsyncope, have been reported to occur during or immediately after the injection of intramuscular testosterone undecanoate 1000 mg (4 mL) in post-approval use outside the United States. The majority of these events lasted a few minutes and resolved with supportive measures; however, some lasted up to several hours and some required emergency care and/or hospitalization.
In addition to serious POME reactions, episodes of anaphylaxis, including life-threatening reactions, have also been reported to occur following the injection of intramuscular testosterone undecanoate in post-approval use outside of the United States.
Both serious POME reactions and anaphylaxis have been reported to occur after any injection of testosterone undecanoate during the course of therapy, including after the first dose.
