Sorry fellows, but the suggestion that you both stated about needing aromasin ED to control estro is not entirely accurate..Just because it has a half-life of 8-12 hrs doesn't mean it needs to be administered daily.. Aromasin is known as an extreme suicide aromatase inhibitor for great reason..
There's plenty of clinical studies to support that aromasin acts relativity fast and enters the bloodstream fairly quick, deploying it's abilities aggressively, so aggressively that up to 80-90% of aromatase enzymes or destroyed at the same time having a pronounced effect with considerable diminution in E1/E2 levels for up to 48-78+ hrs..
It's not a weak AI and can actually crush estro levels relativity fast, yielding lethargy, lack of sex drive,appetite suppression, and so on, all simply after a single dose of 25mgs lasting up to 78 hrs in some individuals..
Below is an
example pic/diagram of "aromasin" displaying estro levels well under baseline for almost 78hrs...At the 78hr mark, it's close to 25% reduction compared to baseline, but slowly climbing...At about 150hrs you'll return to almost norm..So, you see, with it's expressive properties the "roller coaster ride" proves to be nil as there's no rebound.. Be careful with this compound, it's not weak and can wreak havok creating an imbalance within the system..The idea is to treat and manage, no obliterate and annihilate, because there will be consequences..The therapeutic treat in some case and study is far different to what we're attempting in this lifestyle, however the expression of aromasin remains the same!
In the first pic you begin to see that levels "CONTINUE" to drop long after it's "claimed half-life"..
In the next pic you can see that it takes up to 120 hrs to reach baseline levels.
Not to toot on my horn I won't make a suggestion if I can't support it , now can anyone support their method and reasoning behind that suggested administration other than "do this, or I do that,or usually its this"..Show us why? SPECIFICS!
(SO THERE FOR STOP SUGGESTING THE DAILY DOSE WITH THE ONLY SUPPORT OTHER THAN "IT NEEDS TO BE" PLEASE PROVIDE DATA AND NOT SOME REGURGITATED NONSENSE)
There's a reason behind it as "pharmacodydynamics" recognizes its effects and machanism course of actions has been evaluated and documented; Plasma estrogen (estradiol, estrone, and estrone sulfate) suppression was seen starting at a
5-mg daily dose of exemestane, with a maximum suppression of at least 85%,andto 95% achieved at a 25-mg dose.
Exemestane 25 mg daily reduced whole body aromatization (as measured by injecting radiolabeled androstenedione) by 98%..
After a single dose of exemestane 25 mg, the maximal
suppression of circulating estrogens occurred 2 to 3 days after dosing and persisted for 4 to 5 days.
So you see here, taking it daily or even twice daily not only shows some sort of bro-science regurgitation that's been spouting on some panel somewhere, it also has no value, and absolutely no benefit or advantage...Just because a particular medicine has a said half-life, that doesn't always mean we should time our dosages accordingly on the said half-life, because there's specific mechanism of actions taking place in cellular groups that may have a continued expression and influence..Far as pharmacology sees it, there is NO medical suggestions of administration needing to be taken once or twice a daily, SOME medical recommendations/prescriptions may suggest 1 daily dose, depending on the situation and diagnosis with treating early and advanced breast cancer in women who have gone through menopause, as these are extreme detrimental conditions, which hardly fit the protocol and principals/reasons here..
My intention is NOT to sound bold here, but rather bring clarification..
I'm just a little nervous now cause that feeling sucked. I have on deck 20mg Aromsian EP.
