TRT sub Q

hoyle21 said:
I somewhat agree with that, which why I’ve said it really needs to be a case by case basis. My point is this treatment can be better optimized for people experiencing negative side effects.


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I'm with you on that 💯
 
As high RBC, iron , ferritin levels even high normal are associated with shorter life spans. Daily injects could be more optimal for many. Only 1 way to find out.
 
hoyle21 said:
Test C. It’s American prescription


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Last time I ran subq was like 2014. Been back to it since reading this thread. 20 mg TC daily.

My hematocrit is nowhere near yours but it is always high. Ill get labs in a week or two and see if it drops
 
heavyiron said:
Last time I ran subq was like 2014. Been back to it since reading this thread. 20 mg TC daily.

My hematocrit is nowhere near yours but it is always high. Ill get labs in a week or two and see if it drops
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I hope if works for you as well as it’s working for me so far.


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hoyle21 said:
According to the research it absorbs slower and creates a steady state testosterone level. IM injections cause peaks and troughs, even when the esters. The peaks are what causes the spike in hematocrit.


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Your peaks and trough issue you say you were having were more than likely solved by daily injections and not so much by subq injections. Also why would you pin every 10 days? If you were using test cyp, the half life is 6 days so you’ll experience some lows with a protocol like that. I’ve been on prescribed TRT for 13 years and have tried IM and subq. To be honest I couldn’t tell a difference between the two, but I always pinned three times a week. If it’s working for you keep on with it but I’m still on the thought that frequent injections fixed the majority of your issues and not necessarily subq.
 
hoyle21 said:
I was taking 200mg every 10 days, now I’m taking 10 units every day. It’s the exact same amount by week, just taken every day.


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I’d say majority of your change is the frequency not switching between subq and IM,
You went from the shittiest frequency to the most optimal frequency so I doubt IM would make a difference if you’re honest to god tired of the lumps in your fat


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Was running subq for several months and switched to IM VG approx 1 month ago. Was having lumps/irritation. Easy fix.

*Frequency of pinning from 3x to 4x/week. Hematocrit had been consistently higher at 51.

Bloodwork Saturday. Hematocrit in at 49.

We’ll see how it goes. Right now I feel great.
 
Tried sub Q with my T and Mast today. I’m running out of ass for IM. :ROFLMAO:

Warmed up the oil for several minutes after reading a few posts here. Straight in the abdomen. (29g 1/2”). Very nice. No lumps, irritation, nada.

I was having a lot of that when I was pinning subq previously.
 
Been doing 75mg TC IM twice weekly for a long time. Hematocrit jumped way up. 56.8

Donated yesterday and going to lower dose for a bit. Probably do Subq again.
 
heavyiron said:
Been doing 75mg TC IM twice weekly for a long time. Hematocrit jumped way up. 56.8

Donated yesterday and going to lower dose for a bit. Probably do Subq again.
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Were you good and hydrated before your labs? I try to add extra water the day before and at least a quart before my labs. Hopefully your blood donation will lower it.
 
SamPedd18 said:
Were you good and hydrated before your labs? I try to add extra water the day before and at least a quart before my labs. Hopefully your blood donation will lower it.
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Yes, very hydrated, I take electrolytes and drink a lot of fluids daily. About 90 minutes before the draw a tall glass of water.

I do live at high altitude but this is likely from spikes in T levels. Plus I'm old....

Interestingly my fasting BG was the lowest in years at 87. Tirzepatide appears to be controlling my BG to some degree. Last labs BG was 114.
 
hoyle21 said:
According to the research it absorbs slower and creates a steady state testosterone level. IM injections cause peaks and troughs, even when the esters. The peaks are what causes the spike in hematocrit.


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That makes no sense. 1500ng/dl is 1500ng/dl no matter how long it takes to get there and besides, it's the ester that dictates release not absorption.
 
dirtdevil84 said:
That makes no sense. 1500ng/dl is 1500ng/dl no matter how long it takes to get there and besides, it's the ester that dictates release not absorption.
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Could it be it absorbs “slower”’in Fat than if injected into Muscle?
 
pcf said:
Could it be it absorbs “slower”’in Fat than if injected into Muscle?
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Doesn't matter if it takes a month, after 7-9 days the half life of the ester has expired and it's released
Let's not forget oil based testosterone IS designed for deep muscular injection. Medical science has not changed on that.
If you feel daily injections prevent spikes great, just stick it in a muscle.
 
Nah, I’m good. I did .35 ml twice a week and stopped in March. Been cutting since then. Didn’t notice the lumps until I got leaner. They look worse in the morning, but I notice them all the time now.
a3721d8aece061e2493db1b7bf48c15a.jpg



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Sh195580 said:
Nah, I’m good. I did .35 ml twice a week and stopped in March. Been cutting since then. Didn’t notice the lumps until I got leaner. They look worse in the morning, but I notice them all the time now.
a3721d8aece061e2493db1b7bf48c15a.jpg



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Oof, what carrier oils was that? Im going into the meat in the hips and sides. I did daily to keep volume minimal.
 
Yeah, I started out TRT doing daily subq injections because I was scared of IM. It worked okay for volumes less than 1ml a week, but I’d still get bruises about 40%-50% of the time. Once I titrated up from there subq was an absolute nightmare. Bruising, welts, and lumps for days. And it gets worse the leaner you get. Ended up switching to daily IM injections and I wish I had done this from the start. It’s actually less painful than subq at the end of the day and how the compound was designed to be used. Do yourself a favor and come to terms with doing IM injections. It just flat out works better. Oils IM water based peptides subq like they were designed.
 
dirtdevil84 said:
Doesn't matter if it takes a month, after 7-9 days the half life of the ester has expired and it's released
Let's not forget oil based testosterone IS designed for deep muscular injection. Medical science has not changed on that.
If you feel daily injections prevent spikes great, just stick it in a muscle.
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You’re mixing up absorption, ester release, and elimination. A 7 to 9 day half-life means the drug level declines by roughly 50% during that interval. It does not mean the ester “expires” after 7 to 9 days and then suddenly releases.

Subcutaneous testosterone isn’t theoretical. A 2017 study found that all 63 patients using subcutaneous testosterone cypionate achieved testosterone levels within the normal male range, with effectiveness maintained for up to 42 months. Other pharmacokinetic studies have found stable levels and comparable overall exposure to IM injections.

Generic cypionate being labeled for IM use means subcutaneous administration is off-label. It does not mean it isn’t absorbed or effective. There is even an FDA-approved oil-based subcutaneous testosterone product.

Study: https://pubmed.ncbi.nlm.nih.gov/28379417/


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Its been a minute and we are due for an update. As stated before this is TRT Pharma grade being managed by physicians, and different than what a lot of people are attempting to accomplish here, but there are some TRT guys and if this helps anyone, great.

I have been seeing a hematologist monthly for blood work during this journey, and my hematocrit was high enough today to warrant a phlebotomy. So it seems the problem is less severe but my body is still over reacting to the testosterone. The horrible part is my total test isn’t even super high. Mid 500’s, however, the urologist didn’t check my free test or SHBG during my last visit. My SHBG in the past has been very very low, so there is a chance my free testosterone is sky high, even though my total testosterone is mid range.

I’ll make sure to update once I have those values.


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hoyle21 said:
Its been a minute and we are due for an update. As stated before this is TRT Pharma grade being managed by physicians, and different than what a lot of people are attempting to accomplish here, but there are some TRT guys and if this helps anyone, great.

I have been seeing a hematologist monthly for blood work during this journey, and my hematocrit was high enough today to warrant a phlebotomy. So it seems the problem is less severe but my body is still over reacting to the testosterone. The horrible part is my total test isn’t even super high. Mid 500’s, however, the urologist didn’t check my free test or SHBG during my last visit. My SHBG in the past has been very very low, so there is a chance my free testosterone is sky high, even though my total testosterone is mid range.

I’ll make sure to update once I have those values.


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I’ve been subqing 16 mg of test c for weeks, I was hoping it might help with HCT and Hemoglobin. I recently had BW done through Rythm for the first time, where I’m living right now, I really didn’t have a choice but Rythm, this is what came back. Only thing it might be helping is with E2, unfortunately no USE2 but I’m thinking the regular E2 test is prone to coming back higher then what it really is, I’ll know when I get back to FL. And go to Quest.
IMG_0096.jpegIMG_0097.jpegIMG_0098.jpegIMG_0099.jpeg
 
hoyle21 said:
You’re mixing up absorption, ester release, and elimination. A 7 to 9 day half-life means the drug level declines by roughly 50% during that interval. It does not mean the ester “expires” after 7 to 9 days and then suddenly releases.

Subcutaneous testosterone isn’t theoretical. A 2017 study found that all 63 patients using subcutaneous testosterone cypionate achieved testosterone levels within the normal male range, with effectiveness maintained for up to 42 months. Other pharmacokinetic studies have found stable levels and comparable overall exposure to IM injections.

Generic cypionate being labeled for IM use means subcutaneous administration is off-label. It does not mean it isn’t absorbed or effective. There is even an FDA-approved oil-based subcutaneous testosterone product.

Study: https://pubmed.ncbi.nlm.nih.gov/28379417/


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You do you.
 

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