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MOTS-c: a promising PED

01dragonslayer

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MOTS-c (Mitochondrial Open reading frame of the Twelve S rRNA-c) is a 16-amino-acid, mitochondrial analogue peptide that has recently garnered some attention in bodybuilding circles thanks to its seemingly miraculous properties.

The role of MOTS-c is to regulate metabolic functions for the production of energy. It’s mechanism of action is incredibly complicated and not very well-understood, but we can get a good idea of its effects by reading the preclinical trials it has gone through and the anecdotal information shared by users who have experimented with it.

Benefits of MOTS-c

The benefits of this peptide are many, but chances are it has other properties that have not been studied yet.

In a nutshell, we could say that MOTS-c’s main function is to promote metabolic homeostasis. Therefore, it’s main benefits are:

  • A reduction of blood sugar levels and insulin resistance.
  • Improved metabolism, which translates to easier fat loss.
  • Fatty acid metabolism.
  • Greater energy levels.
  • Improved glucose disposal.
  • Prevents osteoporosis.
  • Improves cardiovascular endurance.
  • May help with muscle growth.
In other words, this peptide optimizes some of the primary metabolic pathways involved in fat loss, physical performance and muscle growth.

Side-effects of MOTS-c

MOTS-c appears to have no side-effects when used properly, but it would be safe to assume that it can cause hypoglycemia if abused or combined with compounds like Metformin, Insulin or even Berberine.

More scientific and anecdotal data is necessary to be able to determine other possible side-effects.

How to use it

Inject anywhere from 1 to 3mg subcutaneously every day. There is not set or agreed upon cycle length, but keep it to an effective minimum to prevent unexpected issues.


In conclusion, MOTS-C is a promising PED that could be extremely beneficial to any bodybuilder regardless of what their short-term and long-term goals are.
 
The majority of the research is based on elderly populations on mice. As we age as humans we drop MOT-C levels so I can see a use case for that, but otherwise we need studies on humans, especially age related.

Aside from, "I feel it" it's hard to see any significant markers to see if this makes any significant changes. Haven't seen much over the last 2 years to be honest.

Not saying it doesn't work, but everyone and their mother is on this shizzzz and probably don't need to be.
 
1 to 3mg subcutaneously every day? I ran 10mg a day for 10 days, then dropped to 5mg a day before my last cycle.
 
My understanding is if your younger (say under 45-40) MOT-C is a waste of money. Those of us over 40 on the other hand can recognize greater benefits. Currently running 2 mg daily.
 
My understanding is if your younger (say under 45-40) MOT-C is a waste of money. Those of us over 40 on the other hand can recognize greater benefits. Currently running 2 mg daily.
It’s because your natural motsc levels decline in your late 30’s. Gotta wait till you’re 40 and confuse the body, right babe?
 
The majority of the research is based on elderly populations on mice. As we age as humans we drop MOT-C levels so I can see a use case for that, but otherwise we need studies on humans, especially age related.

Aside from, "I feel it" it's hard to see any significant markers to see if this makes any significant changes. Haven't seen much over the last 2 years to be honest.

Not saying it doesn't work, but everyone and their mother is on this shizzzz and probably don't need to be.
Where did you go? You only spam threads until someone questions you?
 
It’s because your natural motsc levels decline in your late 30’s. Gotta wait till you’re 40 and confuse the body, right babe?
Rich Piana Bodybuilding GIF
 

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