How one "ester" effects user differently (This has been recently asked)

[Vision]

Recently I've noticed the topic about the usage of 1 particular ester yielding different results in users..
Or, others claiming one ester to be Superior to the next..This is all individual based on ones static system of checks/loops,no two individuals are the same..
This is why people argue that cypionate is much more potent than enanthate,
as this is a fragile argument at best and makes little sense,
as your muscles/receptors are only recognizing free bihormone no matter what the ester that was utilized to deploy the parenting hormone!

These are great questions & a worthwhile topic, as there's some real truth behind this;

Let's begin with the expression of a single hormones yielding an opposite effect - rather than a positive "smooth" response to the hormone as some individuals claim/experience..
An appropriate example to begin with would be that of an alcoholic...

Why? Because of Genetics, I'll explain!

Everyone posses different gene expression,with enzymes,protein bonds,and so on..
(Enzymes are known to catalyze more then 5k biochemical types)..
Yet our bodies posses inhibitors and activator molecules that can greatly effect the activity,
by increasing or decreasing hormonal actives..
Now, that of an acholohic,it's a genetic predisposition (same applies for particular endocrines with sensitive users concerning AAS) in which one posses a group of particular enzymes that metabolize alcohol much differently compared to other individuals,
thus the effects will be much greater, and more detrimental in some individuals over the next..(Different metabolization)

Now, let's compare this to the hormones!

(Example) Testosterone can have 3 roles
1) Being testosterone as it's primary function..
2) Converting into DHT (dihydrotestosterone: a more potent metabolite/androgen)..
3)Converting into estrogen

Here you see this effect differs greatly by individual instances, as genetics, age or even ethnicity (in some cases),
or even sex may be a factor, whether one has a greater presence of aromatase enzymes, or even a deficiency..
Hormones/esters have various biosynthetic pathways occurring in the endorcrine,
some either or before reaching their target tissue(to control plasma levels or active compounds),
or at times after termination of their actions (inactivation and elimination)..
However many of hormones and esters are metabolized within their target tissue,
in which a complex interplay between activation and inactivation mechanisms serve to regulate the specificity and the amplitude of the hormonal response..

This is why "singular ester" hormone treatment is NOT designed as a one size fits all therapy...
Just an FYI: There's two main types of enzymes that act in the cleaving process of the ester in which activate the hormone...
These 2 particular "Enzymes" are esterases & hydrolysate.. These come along and cleave pieces of the ester off the hormone,
thereby releasing the active chemical (parenting steroid hormone) and allowing it to do its job (ultimately muscle building/tissue via protein synthesis, positive nitrogen balance and so on )...
Now in the bloodstream which testosterone and blood born nutrients and substances circulate is recognized as the "medium".
These enzymes circulate in the medium and directly affect the release of "active" hormone in the bloodstream by ester cleavage, thus exerting different expression per individuals, trigger a chute of cellular interaction at receptor sites that will differ from one to the next..

People need to remember that hormones are "chemical messengers" that rely messages to cells that display specific receptors for each hormone and respond to the signaling..Depending on the ester and the individuals metabolization ratio the hormone can/may make changes directly to a cell, by changing the genes that are activated, or by making changes indirectly to a cell by stimulating other signaling pathways inside a specific cell group that is effected and effect other processes, thus this can "initiate" an intracellular cascade of events..

This is why the "same/singular hormone ester" effects people differently, because there's numerous ways a hormone can yield different effects..So, depending on which transcription factors are present different genes will be transcribed in response...Thereby the reason some individuals tend to bloat and others do NOT, as some can run 250mgs of Test and begin to see signs of fluid retention or edema exert in the circular system, or particular regions of the body..Yet, there's individuals that can utilize 1000mgs of Test and remain dry..Of course diet permitting.. (but this article's about biosynthesis, and not diet)

Regards,
Vision

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~ bonus info ~

Here's a basic read on how one ester can have MORE sides ( i.e. Acne) compared to an other!
(This also applies to other side effects as well, but that's a different topic)

Acne can be induced through many courses of actions, however this is simply covering the on-set by way of esters for different reasons (not estrogen, Testosterone, 19-nors, DHT etc etc).
Some uses/subjects make all sorts of claims and to a degree everyone has a valid point on or possible explanation that pertains to their particular instance, but the truth is everyone SERIOUSLY responds differently , not everyone's endocrine system will respond the same when it concerns exogenous or endogenous hormones, some people may possess more or less of "targeting cells" of "enzymes" in which these cells bear receptors, and these sites can/may be more hypersensitive or actual desensitized by way of "genetics" or other transcelluar chemical messengers..
These effects can greatly influence a slew of side effects, i.e. the topic at hand "acne by different esters"..
Esters can effect differnt mechinisms over the next, like stated above by way of activation through different transcellular groups, increasing different hormonal out-puts, sections and so on..

Take home note: Please read!
For myself, Nandrolone Phenypropionate doesn't suggest a greater aggressive display or influenced onset of acne compared to it's counter part "Decanoate"...(Decanoate triggers a stronger andmore aggressive state of acne for myself, and many others, compared to NPP, same applies for other hormones with different esterfication!
Why is that? believe it or not besides the hormone , the ester alone plays a pivotal role as esters all possess a different molecular weight, with this said the presence of fatty acids may vary, and this alone has a unique influence on sebaceous lipids which is directly associated specific accumulation of squalene and the presence of fatty acids and lipids yielding a manifestations in increase of sebum..
So, can one particular hormone be more responsible for sebum production verse an other? This will be individually based..
How about the ester, does this matter although it's still the same hormone? Yes, the ester can have direct and indirect effects on different people, depending on the amount of presence enzymes, sensitivity, receptors and so on.. Ester effects are truly miltifactorial by way of activating, deactivating of different cellular groups, especially - lipids as some may be reduced in some subjects such as free fatty acids or in contrast, there could be a greater influx with triglycerides and wax/cholesterol esters could be increased inducing acne, especially in those who are already sensitive and prone/predisposed..

Aside from antiestrogens, acne medication, antibiotics, and other acne treatment protocols, it may be wise for some people to use more liver support,
take antioxidant supplements, or even consider use Tad-600.. Just some food for thought.
​

 

[Lokthan]

Hmm I do always get really bad acne on short esthers, npp in particular gave me the worst acne ever.

Is there a way to increase the enzymes that strip the Esther?


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[chicagosterone]

Great read..... vision did you write this? Or you copy and pasting this shit lol


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[Vision]

Great read..... vision did you write this? Or you copy and pasting this shit lol


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no...it's mine, but the information is just what I've gathered over the years and when I've learned, I'm just passing on what I've learned, what I have heard explained, and what is more accurate and on-point..

 

[chicagosterone]

no...it's mine, but the information is just what I've gathered over the years and when I've learned, I'm just passing on what I've learned, what I have heard explained, and what is more accurate and on-point..

It makes more sense to me than most shit I've read.... this was just an exemplary break down of esters! I'll be screen shotting for further evaluation and absorption. I already have a good understanding of esters and they're effect on hormone release times and all the basics but this adds to my knowledge for sure, thanks for sharing.


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[Vision]

It makes more sense to me than most shit I've read.... this was just an exemplary break down of esters! I'll be screen shotting for further evaluation and absorption. I already have a good understanding of esters and they're effect on hormone release times and all the basics but this adds to my knowledge for sure, thanks for sharing.


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Exactly bro you got what I'm saying here, I mean I could cut copy and paste some really Stellar information but for most of us it's like reading hieroglyphics.. and definitely save it man, because I also have to go back to personal notes now and then just to keep myself refreshed and in the now!

 

[chicagosterone]

Exactly bro you got what I'm saying here, I mean I could cut copy and paste some really Stellar information but for most of us it's like reading hieroglyphics.. and definitely save it man, because I also have to go back to personal notes now and then just to keep myself refreshed and in the now!

Yeah heiroglyphics indeed, studies, statistics, it's all connect the dots if you dig deep enough. I wouldn't say you put it in laments terms, but definately more understandable.... should be a sticky. I've read some other shit you posted a while back some pretty good reads every time, that's what it's all about man ..... sharing that wealth of knowledge some of you guys have. I'm always reading man trying to absorb I figure if I'm gonna change my bodies chemistry there's a lot more to it than drug types, injection frequency,diet training...the real interesting shit is what's happening on a cellular level.


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[Ronin543]

Great info Vision. Thanks for the knowledge

 

[Vision]

Great info Vision. Thanks for the knowledge

Don't thank me man, thank the motherfuckers that make it their Capital intense endeavor to continuously press forward with clinical research, and those biologist that make all this possible for us..

 

[Vision]

Yeah heiroglyphics indeed, studies, statistics, it's all connect the dots if you dig deep enough. I wouldn't say you put it in laments terms, but definately more understandable.... should be a sticky. I've read some other shit you posted a while back some pretty good reads every time, that's what it's all about man ..... sharing that wealth of knowledge some of you guys have. I'm always reading man trying to absorb I figure if I'm gonna change my bodies chemistry there's a lot more to it than drug types, injection frequency,diet training...the real interesting shit is what's happening on a cellular level.


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Right on brother, I remember back in the early 90s all I wanted to do was run a cycle, here I am almost 24 years later continuously digging to see how deep the rabbit hole goes.. it gets frustrating when you find data that can fully support itself only to turn around and read an entirely different finding that contradicts the original one, those are the moments when I'm having a sleepless night and I just research the research that I researching, only to turn around and do research on that research... I'm never satisfied until I know "how & why"..

I asked an old mechanic once how he ever got involved in what he does.. he simply told me "it all began when he wanted to know what made the motor do what it does, and it was a wrap after that"...

 

[chicagosterone]

Right on brother, I remember back in the early 90s all I wanted to do was run a cycle, here I am almost 24 years later continuously digging to see how deep the rabbit hole goes.. it gets frustrating when you find data that can fully support itself only to turn around and read an entirely different finding that contradicts the original one, those are the moments when I'm having a sleepless night and I just research the research that I researching, only to turn around and do research on that research... I'm never satisfied until I know "how & why"..

I asked an old mechanic once how he ever got involved in what he does.. he simply told me "it all began when he wanted to know what made the motor do what it does, and it was a wrap after that"...

It's all subjective, people are always going to determine data based off there personal interests, I think once you get on gear, we like to think it prolongs life and search fir answers to support that. In the back of our minds we're still wondering could injecting all this shit come with lifespan shortening consequences. So we read and read and read hoping to find answers.... I dunno about life expansion, But I do know quality of life is improved through "responsible" aas usage. It's like live a shorter higher quality lifestyle or a longer milder laid back ole simple simpleton lifestyle, the choice is ours. I'm praying in my lifetime they find the holy grail of genetic expression and how to prevent cell oxidization within the body, more or less a true aging cure. Other than cloning like the movie the island, I think stem cells have some real potential.


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[Vision]

Testosterone Esters - a whopping 1 billion percent will be absorbed, as long as your trusty carrier delivers the goods. If you're dealing with something like testosterone undec, it's typically mixed with castor oil, resulting in a heavy half-life and slow release. For many pharmacological reasons, there is different applications, and different half-lives with different oils that are at different weight ratios. That also have different carbon fingerprints, yes carrier oils have different carbons.

On the other hand, if the hormone is in an aqueous base, it's easily absorbed through the capillaries or surrounding tissue.

Long-acting parenteral esters of testosterone will take their sweet time absorbing, with a longer cleaving process, especially if they're administered intramuscularly or subcutaneously.

Whether you're using transdermal applications, gels, patches, tablets, or even air blasting (which is so last season), the release will still be slow and steady. But hey, at least it'll reach the medium eventually.