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Various news stories you don't hear on MSM. Feel free to add news.

heavyiron said:
We use fiber daily for our entire marriage. I'm pro fiber but it had zero effect on her gut issues. Probiotics were a complete reversal in days.
Click to expand...

I’ve worked with a cardiology group that immediately puts all diabetic patients on 5 grams of psyllium daily for heart health, but it actually slows the absorption of sugar, which helps the arteries.


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hoyle21 said:
I’ve worked with a cardiology group that immediately puts all diabetic patients on 5 grams of psyllium daily for heart health, but it actually slows the absorption of sugar, which helps the arteries.


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Click to expand...
does that help GERD
 
heckler7 said:
does that help GERD
Click to expand...

Depends on the cause. I can tell you for GERD try to avoid PPI’s, observational studies show an increase in all cause mortality after 2 weeks of use. Stay with H2 blockers.

Observational studies aren’t the best clinical evidence, but most people can control it with H2 blockers, so why take the chance?


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Tampon Tim and the kid-grooming Libs are still at it. Disgusting kid-perving creatures...

www.foxnews.com

Transgender dolls to be available for Minnesota schoolchildren as young as 4 under Walz-backed program: report

Taxpayer-funded transgender dolls with swappable genitalia target children ages 4-10 through a University of Minnesota research program tied to Tim Walz.
www.foxnews.com www.foxnews.com

Transgender dolls to be available for Minnesota schoolchildren as young as 4 under Walz-backed program​


The party of kid-molesters and groomers...

They come with interchangeable accessories and removable and swappable genitalia to help children "realize all the different options that exist for who they can be — regardless of their body parts," University of Minnesota postdoctoral fellow Ben Parchem said in a now-deleted article in the University of Minnesota Foundation's magazine.
 
Rot-Iron66 said:
Tampon Tim and the kid-grooming Libs are still at it. Disgusting kid-perving creatures...

www.foxnews.com

Transgender dolls to be available for Minnesota schoolchildren as young as 4 under Walz-backed program: report

Taxpayer-funded transgender dolls with swappable genitalia target children ages 4-10 through a University of Minnesota research program tied to Tim Walz.
www.foxnews.com www.foxnews.com

Transgender dolls to be available for Minnesota schoolchildren as young as 4 under Walz-backed program​


The party of kid-molesters and groomers...

They come with interchangeable accessories and removable and swappable genitalia to help children "realize all the different options that exist for who they can be — regardless of their body parts," University of Minnesota postdoctoral fellow Ben Parchem said in a now-deleted article in the University of Minnesota Foundation's magazine.
Click to expand...
I don’t think the libs are intentionally trying to turn kids into transgenders, at least not most of them.

More likely, they are so enamored with „supporting” transgender kids that they are inadvertently putting the idea into their heads.

This is a case in point.

Say some little boy thinks it’s funny to put on his sister’s dress as a joke or for Halloween, or some little girl only wants to wear pants and likes playing in the dirt.

The liberal parents start worrying about how to avoid „imposing gender roles” onto their kid, so they start asking all kinds of questions like „do you feel like a boy — or do you think you’re actually a girl?” That gets further reinforced with toys like this and books.

Probably without realizing it, the parents are putting these ideas into the kid’s head, and probably sending signals that they would approve of it claiming to be the opposite sex.

It’s called suggestion, and it’s basically a form of hypnosis.

You can’t tell me that if you give a 4-year-old this type of genital-exchange doll, the kid won’t start thinking about these things in a different way than it would have normally.

The parents THINK they are just being open-minded and giving the kid options, but they’re actually subconsciously feeding suggestions into its mind…
 
oldbull said:
I don’t think the libs are intentionally trying to turn kids into transgenders, at least not most of them.

More likely, they are so enamored with „supporting” transgender kids that they are inadvertently putting the idea into their heads.

This is a case in point.

Say some little boy thinks it’s funny to put on his sister’s dress as a joke or for Halloween, or some little girl only wants to wear pants and likes playing in the dirt.

The liberal parents start worrying about how to avoid „imposing gender roles” onto their kid, so they start asking all kinds of questions like „do you feel like a boy — or do you think you’re actually a girl?” That gets further reinforced with toys like this and books.

Probably without realizing it, the parents are putting these ideas into the kid’s head, and probably sending signals that they would approve of it claiming to be the opposite sex.

It’s called suggestion, and it’s basically a form of hypnosis.

You can’t tell me that if you give a 4-year-old this type of genital-exchange doll, the kid won’t start thinking about these things in a different way than it would have normally.

The parents THINK they are just being open-minded and giving the kid options, but they’re actually subconsciously feeding suggestions into its mind…
Click to expand...

This is reasonable and more than likely has some truth behind it, but I also think these situations get weeded out during the medical evaluation process. The “regret” percentage for medically transitions is between 1-2%. A CABG procedure is around 4-5%. In perspective 4-5% of the CABG patients saying they would have rather died, the 1-2% looks pretty damn good. There is obviously room for improvement, but medical professionals are doing a fairly good job with the process.


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hoyle21 said:
This is reasonable and more than likely has some truth behind it, but I also think these situations get weeded out during the medical evaluation process. The “regret” percentage for medically transitions is between 1-2%. A CABG procedure is around 4-5%. In perspective 4-5% of the CABG patients saying they would have rather died, the 1-2% looks pretty damn good. There is obviously room for improvement, but medical professionals are doing a fairly good job with the process.


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Click to expand...
I’m guessing the statistics you are citing are based on adult transgenders who got sex changes.

I anticipate it will be a whole different story when this generation of kids who were exposed to this stuff from a tender age grows up.

Though I think a big part of this is a fad, I have no doubt that there are „real” transgenders out there.

It doesn’t make a lot of internal logic to me, though, because if gender is a social construct, then how can it be so fundamentally innate that it supersedes their chromosomes?

That said, if someone wants to cut off his cock and balls, far be it for me to get in their way.

As for the kids, I’ve long accepted that urban people on the left have a very different perspective that I will never understand or change.

Aborting them is fine but god forbid you spank them on the butt if they misbehave.

The transgender thing is an extension of the urban left-wing approach to parenting, I think.

None of my business, though. I’ll see how the experiment turns out at a safe distance from my place in the boondocks.
 
oldbull said:
I’m guessing the statistics you are citing are based on adult transgenders who got sex changes.

I anticipate it will be a whole different story when this generation of kids who were exposed to this stuff from a tender age grows up.

Though I think a big part of this is a fad, I have no doubt that there are „real” transgenders out there.

It doesn’t make a lot of internal logic to me, though, because if gender is a social construct, then how can it be so fundamentally innate that it supersedes their chromosomes?

That said, if someone wants to cut off his cock and balls, far be it for me to get in their way.

As for the kids, I’ve long accepted that urban people on the left have a very different perspective that I will never understand or change.

Aborting them is fine but god forbid you spank them on the butt if they misbehave.

The transgender thing is an extension of the urban left-wing approach to parenting, I think.

None of my business, though. I’ll see how the experiment turns out at a safe distance from my place in the boondocks.
Click to expand...

I appreciate that you said “I think,” because that acknowledges this is your opinion rather than an established conclusion. That makes these conversations much easier to have honestly.

Here’s a study to look over



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hoyle21 said:
I appreciate that you said “I think,” because that acknowledges this is your opinion rather than an established conclusion. That makes these conversations much easier to have honestly.

Here’s a study to look over



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Click to expand...
The study says it measures their reactions 3-5 years after puberty blockers and hormones. That’s not very long and using hormones arguably isn’t permanent.

I’ll be interested to see what the study says 15-20 years after they cut off their cocks and balls.

My broader point, though, is arguably aligned with yours: I don’t see this is as quite as big a deal as a lot of folks do. It’s just another quirky trend among the urban elites.

The number of kids that will be experimented upon is likely to remain miniscule, even though it’s become more fashionable.

It does make the left wing urban elites look ridiculous to the rest of us in the country, but I don’t think it’s some grand conspiracy to mutilate children.

It will be damaging to many, and probably will be seen as an example of mass hysteria sort of like „satanic panic” back in the 80s, or the demands to defund the police in 2020.

By definition, „progressives” are eager to jump on the newest bandwagon, because that’s progress. Sometimes that proves to be the moral path, as with abolishing slavery. At other times, it is misguided. I think this is an example of the latter but we’ll see.

There’s a lot of rhetoric about the Dems being the party of groomers and pervs and such, but if you look at the evidence, neither party has a monopoly on that behavior. Remember Dennis Hastert?

Furthermore, I’d argue that most regular Dems are not totally on board with all this transgender stuff either, just like they were not on board with defunding the police or abolishing prisons.

I know many reasonable Dems and conservatives. The problem isn’t that either side is actually extreme — the problem is they’re cowed by the extreme elements in both parties.

Anyone who’s prominent within GOP who speaks out against Trump is risking death threats. Anyone who’s prominent among Dems who speaks out against sacred cows like transgenderism for children is risking becoming a social pariah and getting shunned by the tribe.

So, they let the loudest, most obnoxious members seem like they are setting the agenda. And that makes it easier for members of each party to demonize and ridicule the other.

Now I have made this diagnosis before, but I have no idea what to do about it. Changing the primary system? Good luck with that when it serves the extreme elements of both parties.
 
oldbull said:
The study says it measures their reactions 3-5 years after puberty blockers and hormones. That’s not very long and using hormones arguably isn’t permanent.

I’ll be interested to see what the study says 15-20 years after they cut off their cocks and balls.

My broader point, though, is arguably aligned with yours: I don’t see this is as quite as big a deal as a lot of folks do. It’s just another quirky trend among the urban elites.

The number of kids that will be experimented upon is likely to remain miniscule, even though it’s become more fashionable.

It does make the left wing urban elites look ridiculous to the rest of us in the country, but I don’t think it’s some grand conspiracy to mutilate children.

It will be damaging to many, and probably will be seen as an example of mass hysteria sort of like „satanic panic” back in the 80s, or the demands to defund the police in 2020.

By definition, „progressives” are eager to jump on the newest bandwagon, because that’s progress. Sometimes that proves to be the moral path, as with abolishing slavery. At other times, it is misguided. I think this is an example of the latter but we’ll see.

There’s a lot of rhetoric about the Dems being the party of groomers and pervs and such, but if you look at the evidence, neither party has a monopoly on that behavior. Remember Dennis Hastert?

Furthermore, I’d argue that most regular Dems are not totally on board with all this transgender stuff either, just like they were not on board with defunding the police or abolishing prisons.

I know many reasonable Dems and conservatives. The problem isn’t that either side is actually extreme — the problem is they’re cowed by the extreme elements in both parties.

Anyone who’s prominent within GOP who speaks out against Trump is risking death threats. Anyone who’s prominent among Dems who speaks out against sacred cows like transgenderism for children is risking becoming a social pariah and getting shunned by the tribe.

So, they let the loudest, most obnoxious members seem like they are setting the agenda. And that makes it easier for members of each party to demonize and ridicule the other.

Now I have made this diagnosis before, but I have no idea what to do about it. Changing the primary system? Good luck with that when it serves the extreme elements of both parties.
Click to expand...

This seems very reasonable, and I agree with a lot of it. I do believe that being transgender is real. What I question is how prevalent it actually is and whether every young person questioning gender today would continue feeling that way without social reinforcement or medical intervention.

I also do not think the research on athletic advantage is definitive enough to settle the issue. Until we have better long term, sport specific data, I think transgender women should remain out of women’s competitive sports. The female category exists for a reason, and inclusion should not come at the expense of fairness to female athletes.

What really annoys the shit out of me about the left, though, is its language. “Latinx” is a term almost nobody it supposedly represents actually uses. “Cisgender” may have an academic definition, but it is still an unnecessary label that most people never chose for themselves.

“White privilege” is another example. I understand the concept they are trying to describe. It does not mean that every white person has had an easy or privileged life. It means that being white was probably not one of the specific things making that person’s life harder. But “white privilege” is a terrible way to communicate that idea.

There are millions of poor white people barely surviving. They may have grown up in poverty, worked their asses off, struggled with addiction in their families, lacked access to education, or wondered how they were going to pay the electric bill. When someone tells them they have “white privilege,” they naturally hear, “Your life has been easy.” Then the left acts shocked when those people feel insulted and reject the entire argument.

If you need to give someone a sociology lecture before they understand that your terminology was not meant as an accusation, then the terminology is the problem. The left often takes an idea containing some legitimate truth, gives it the most artificial or inflammatory name possible, and then treats objections to the language as proof that the person rejects the underlying issue. That is terrible communication, and politically it drives ordinary people away.


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hoyle21 said:
This seems very reasonable, and I agree with a lot of it. I do believe that being transgender is real. What I question is how prevalent it actually is and whether every young person questioning gender today would continue feeling that way without social reinforcement or medical intervention.

I also do not think the research on athletic advantage is definitive enough to settle the issue. Until we have better long term, sport specific data, I think transgender women should remain out of women’s competitive sports. The female category exists for a reason, and inclusion should not come at the expense of fairness to female athletes.

What really annoys the shit out of me about the left, though, is its language. “Latinx” is a term almost nobody it supposedly represents actually uses. “Cisgender” may have an academic definition, but it is still an unnecessary label that most people never chose for themselves.

“White privilege” is another example. I understand the concept they are trying to describe. It does not mean that every white person has had an easy or privileged life. It means that being white was probably not one of the specific things making that person’s life harder. But “white privilege” is a terrible way to communicate that idea.

There are millions of poor white people barely surviving. They may have grown up in poverty, worked their asses off, struggled with addiction in their families, lacked access to education, or wondered how they were going to pay the electric bill. When someone tells them they have “white privilege,” they naturally hear, “Your life has been easy.” Then the left acts shocked when those people feel insulted and reject the entire argument.

If you need to give someone a sociology lecture before they understand that your terminology was not meant as an accusation, then the terminology is the problem. The left often takes an idea containing some legitimate truth, gives it the most artificial or inflammatory name possible, and then treats objections to the language as proof that the person rejects the underlying issue. That is terrible communication, and politically it drives ordinary people away.


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Click to expand...
The DSA or “woke” elements of the left aren’t really trying to build a “big tent” — they prefer to be “exclusive” as far as their political beliefs, which makes them feel like the sophisticated, enlightened few. Like certain elements of the right, they want to be in permanent rebellion instead of arriving at imperfect but workable solutions that a larger subset of people can agree upon.

What drives a lot of people’s interest in politics is the desire to feel anger and righteous indignation. I suppose that is a somewhat understandable human tendency — we all engage in it from time to time — but it doesn’t make for a governing philosophy…
 
oldbull said:
The DSA or “woke” elements of the left aren’t really trying to build a “big tent” — they prefer to be “exclusive” as far as their political beliefs, which makes them feel like the sophisticated, enlightened few. Like certain elements of the right, they want to be in permanent rebellion instead of arriving at imperfect but workable solutions that a larger subset of people can agree upon.

What drives a lot of people’s interest in politics is the desire to feel anger and righteous indignation. I suppose that is a somewhat understandable human tendency — we all engage in it from time to time — but it doesn’t make for a governing philosophy…
Click to expand...

I think a lot of people in politics do not actually want the opportunity to solve these problems. They want the problems to remain unresolved because anger is profitable. It generates donations, attention, television appearances, and social media engagement. Reaching a workable compromise would take away the very issue they use to keep their supporters furious and fundraising.

I am currently in more of an FDR state of mind. I am not a socialist by any means, and I believe capitalism is still the best economic system we have. But this version of capitalism is not working for ordinary people. When someone can work full time and still struggle to afford housing, healthcare, groceries, and retirement, something is fundamentally out of balance.

A healthy capitalist system needs a strong middle class. It cannot remain stable when nearly all the gains flow upward while working people are told to accept less security, more debt, and a lower standard of living than their parents had. FDR did not abolish capitalism. He recognized that capitalism had to be restrained and reformed in order to save it from its own excesses.

If we do not make meaningful changes that give working and middle class people a genuine stake in the system, eventually they will stop believing the system deserves to survive. That is when we are going to be in real trouble.


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BackShot said:
For starters, they all know their gender. soooooo thats a pretty big plus.
Click to expand...
Gender recognition is the criteria for your response?

What I see is a celeb doc hanging out with two herion users and a celeb doc nestled up to Oprah.
Soooooo that's a pretty big minus
 
dirtdevil84 said:
Gender recognition is the criteria for your response?

What I see is a celeb doc hanging out with two herion users and a celeb doc nestled up to Oprah.
Soooooo that's a pretty big minus
Click to expand...
Um yes...
Stand Up What GIF by 800 Pound Gorilla Media
 
hoyle21 said:
I think a lot of people in politics do not actually want the opportunity to solve these problems. They want the problems to remain unresolved because anger is profitable. It generates donations, attention, television appearances, and social media engagement. Reaching a workable compromise would take away the very issue they use to keep their supporters furious and fundraising.

I am currently in more of an FDR state of mind. I am not a socialist by any means, and I believe capitalism is still the best economic system we have. But this version of capitalism is not working for ordinary people. When someone can work full time and still struggle to afford housing, healthcare, groceries, and retirement, something is fundamentally out of balance.

A healthy capitalist system needs a strong middle class. It cannot remain stable when nearly all the gains flow upward while working people are told to accept less security, more debt, and a lower standard of living than their parents had. FDR did not abolish capitalism. He recognized that capitalism had to be restrained and reformed in order to save it from its own excesses.

If we do not make meaningful changes that give working and middle class people a genuine stake in the system, eventually they will stop believing the system deserves to survive. That is when we are going to be in real trouble.


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Click to expand...
I’m more of a Theodore Roosevelt guy myself, but either way, such leaders seem in short supply.

Then again, we’ll soon have this magnificent ballroom and triumphal arch, which future generations will appreciate far more than trust busting or the new deal…
 
1/2 my work is on bombardier aircraft, they use the same engines as gulfstream, major difference is bombardier makes an awesome mid size jet, the challenger which is my favorite jet to work on and gulfstream didnt have a mid size so they bought isreali jet and renamed it gulfstream 200 and its a huge piece of shit, one of the worst planes ever mad, I basing this purely on my experience maintaining jets no flying them but its an overall consensus in the field

www.cbsnews.com

Canadian tariffs on U.S. milk, perfume, golf clubs and other goods take effect as trade war grinds on

Canada's steep retaliatory tariffs on $20 billion in U.S. goods took effect just after midnight ET on Tuesday, deepening the trade war between the two countries.
www.cbsnews.com www.cbsnews.com
 
heckler7 said:
1/2 my work is on bombardier aircraft, they use the same engines as gulfstream, major difference is bombardier makes an awesome mid size jet, the challenger which is my favorite jet to work on and gulfstream didnt have a mid size so they bought isreali jet and renamed it gulfstream 200 and its a huge piece of shit, one of the worst planes ever mad, I basing this purely on my experience maintaining jets no flying them but its an overall consensus in the field

www.cbsnews.com

Canadian tariffs on U.S. milk, perfume, golf clubs and other goods take effect as trade war grinds on

Canada's steep retaliatory tariffs on $20 billion in U.S. goods took effect just after midnight ET on Tuesday, deepening the trade war between the two countries.
www.cbsnews.com www.cbsnews.com
Click to expand...

Dumb question and I supposed I could just look it up, but is the airplane company the same as the recreational vehicle company?


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dirtdevil84 said:
This is where you fail pathetically every time. I'm not arguing anything. I'm telling you, no response necessary. Do you go through life reacting to everything anybody says? If so you're the dipshit.
Click to expand...
And here you are hypocritically telling me i don't have to react to everything anybody says, while you're doing so.
 
Based on large-scale, human clinical trial programs (most notably the SURPASS, SURMOUNT, and recent cardiovascular outcomes trials), tirzepatide has proven, quantifiable health benefits that span multiple major organ systems. [1, 2, 3, 4]
Because it targets two gut hormone receptors (GLP-1 and GIP) rather than just one, real human data shows it possesses multifaceted metabolic advantages: [1, 2]

1. Profound Weight Loss
In the SURMOUNT obesity trials, tirzepatide proved to be one of the most potent anti-obesity medications available. [1]
  • The Data: Adults taking the highest dose (15 mg) lost an average of 20% of their total body weight over 72 weeks (compared to roughly 12–13% for patients who have type 2 diabetes). [1]

2. Blood Sugar Control & Diabetes Reversal
Through the SURPASS clinical trial program, tirzepatide was heavily studied against existing type 2 diabetes treatments. [1]
  • The Data: It significantly outperforms standard treatments (like insulin or standard GLP-1 mono-agonists) at lowering HbA1c levels, with up to 92% of trial participants achieving clinical blood sugar goals. It works primarily by rapidly improving systemic insulin sensitivity and dropping fasting insulin levels. [1, 2, 3]

3. Clear Cardiovascular Protection
Data published in the New England Journal of Medicine from the SURPASS-CVOT trial (which followed high-risk cardiovascular patients with type 2 diabetes for up to 54 months) proved major heart health advantages: [1, 2]
  • MACE Reduction: Tirzepatide significantly lowered the risk of Major Adverse Cardiovascular Events (MACE)—which include heart attacks, strokes, and cardiovascular death. [1]
  • All-Cause Mortality: The trial data revealed a statistically significant reduction in all-cause mortality (death from any cause), alongside a 16% lower risk of general cardiorenal adverse outcomes. [1, 2]
  • Heart Failure & Blood Pressure: It consistently lowers systolic blood pressure and reduces ectopic fat buildup around the heart. [1, 2]

4. Resolution of Obstructive Sleep Apnea (OSA)
Tirzepatide is FDA-approved specifically to treat moderate-to-severe sleep apnea in adults with obesity, supported directly by the SURMOUNT-OSA phase 3 trials. [1, 2, 3]
  • The Data: Tirzepatide reduced breathing interruptions (the Apnea-Hypopnea Index, or AHI) by an average of 25 to 30 events per hour. [1, 2]
  • Curing the Need for CPAP: Astonishingly, about 50% of the trial patients achieved complete disease alleviation, meaning their breathing tracking improved so much they no longer clinically required a CPAP machine. [1]
  • Hypoxic Burden: It reduced sleep-specific oxygen deprivation (hypoxic burden) by 95% to 100%, sharply reducing a major driver of nighttime heart strain. [1]

5. Kidney Preservation
Secondary analyses of the SURPASS trials indicate direct and indirect protection for the kidneys. [1, 2]
  • The Data: It drives a 25% to 40% reduction in albuminuria (urinary albumin-to-creatinine ratio), which is the primary early marker of kidney stress and failure. It also dramatically slows down the long-term decline of standard kidney filtration function. [1, 2]

6. Reduction in Systemic Inflammation
Chronic full-body inflammation is the foundation of many age-related diseases. Across multiple clinical trial cohorts, blood panels show that tirzepatide sharply lowers high-sensitivity C-reactive protein (hs-CRP) and other pro-inflammatory cytokines. This anti-inflammatory profile occurs partly from weight loss, but also from the drug directly modulating immune cell signaling pathways. [1, 2, 3]
 
Tirzepatide has shown some of its most powerful clinical results when treating fatty liver disease—specifically its advanced, inflammatory form known as MASH (Metabolic Dysfunction-Associated Steatohepatitis, formerly called NASH). [1]
Data from the landmark SYNERGY-NASH Phase 2 trial published in the New England Journal of Medicine outlines exactly how the drug heals the liver: [1, 2]

1. Complete Clearing of Liver Inflammation (MASH Resolution)
The study looked at 190 adults with biopsy-confirmed MASH and moderate-to-severe liver scarring (fibrosis stages F2 or F3). After 52 weeks of once-weekly injections, tirzepatide successfully eliminated the active liver inflammation and cellular ballooning: [1, 2]
  • Placebo: Only 10% of patients saw disease resolution.
  • 5 mg dose: 44% of patients achieved MASH resolution.
  • 10 mg dose: 56% of patients achieved MASH resolution.
  • 15 mg dose: 62% of patients achieved MASH resolution. [1, 2]

2. Reversing Existing Liver Scarring (Fibrosis)
Once fatty liver disease progresses to fibrosis, the liver develops permanent scars that can lead to cirrhosis or liver failure. Tirzepatide didn't just stop new scars from forming; it actually helped heal existing scars. More than 50% of patients taking the 10 mg and 15 mg doses experienced an improvement of at least one full stage of fibrosis with zero worsening of their liver disease. [1, 2, 3, 4]

3. Drastic Reductions in Liver Fat Content
In an imaging sub-study called SURPASS-3 MRI, researchers used advanced MRI scans to look directly at the percentage of fat inside the liver. Patients taking tirzepatide experienced a relative liver fat reduction of roughly 40% to 50%, effectively normalizing their liver fat levels. [1, 2]

Why Tirzepatide is So Effective on the Liver
While severe weight loss naturally helps pull fat out of organs, researchers found that tirzepatide works through direct metabolic pathways: [1, 2]
  • The GIP Hormone Advantage: The added GIP component helps body fat store energy safely in normal fat tissues, preventing excess lipids from "spilling over" and packing into organs like the liver. [1]
  • Downregulating Lipogenic Genes: Cellular data shows the drug actively downregulates specific genes involved in cellular lipid uptake and fat creation, effectively shutting down the liver's ability to turn excess carbohydrates into triglycerides. [1, 2]
 
heavyiron said:
Tirzepatide has shown some of its most powerful clinical results when treating fatty liver disease—specifically its advanced, inflammatory form known as MASH (Metabolic Dysfunction-Associated Steatohepatitis, formerly called NASH). [1]
Data from the landmark SYNERGY-NASH Phase 2 trial published in the New England Journal of Medicine outlines exactly how the drug heals the liver: [1, 2]

1. Complete Clearing of Liver Inflammation (MASH Resolution)
The study looked at 190 adults with biopsy-confirmed MASH and moderate-to-severe liver scarring (fibrosis stages F2 or F3). After 52 weeks of once-weekly injections, tirzepatide successfully eliminated the active liver inflammation and cellular ballooning: [1, 2]
  • Placebo: Only 10% of patients saw disease resolution.
  • 5 mg dose: 44% of patients achieved MASH resolution.
  • 10 mg dose: 56% of patients achieved MASH resolution.
  • 15 mg dose: 62% of patients achieved MASH resolution. [1, 2]

2. Reversing Existing Liver Scarring (Fibrosis)
Once fatty liver disease progresses to fibrosis, the liver develops permanent scars that can lead to cirrhosis or liver failure. Tirzepatide didn't just stop new scars from forming; it actually helped heal existing scars. More than 50% of patients taking the 10 mg and 15 mg doses experienced an improvement of at least one full stage of fibrosis with zero worsening of their liver disease. [1, 2, 3, 4]

3. Drastic Reductions in Liver Fat Content
In an imaging sub-study called SURPASS-3 MRI, researchers used advanced MRI scans to look directly at the percentage of fat inside the liver. Patients taking tirzepatide experienced a relative liver fat reduction of roughly 40% to 50%, effectively normalizing their liver fat levels. [1, 2]

Why Tirzepatide is So Effective on the Liver
While severe weight loss naturally helps pull fat out of organs, researchers found that tirzepatide works through direct metabolic pathways: [1, 2]
  • The GIP Hormone Advantage: The added GIP component helps body fat store energy safely in normal fat tissues, preventing excess lipids from "spilling over" and packing into organs like the liver. [1]
  • Downregulating Lipogenic Genes: Cellular data shows the drug actively downregulates specific genes involved in cellular lipid uptake and fat creation, effectively shutting down the liver's ability to turn excess carbohydrates into triglycerides. [1, 2]
Click to expand...

Look back at the threads, I’ve been saying it’s really a miracle drug for a while. Tons of benefits, some we are still just starting to see.


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heavyiron said:
Tirzepatide has shown some of its most powerful clinical results when treating fatty liver disease—specifically its advanced, inflammatory form known as MASH (Metabolic Dysfunction-Associated Steatohepatitis, formerly called NASH). [1]
Data from the landmark SYNERGY-NASH Phase 2 trial published in the New England Journal of Medicine outlines exactly how the drug heals the liver: [1, 2]

1. Complete Clearing of Liver Inflammation (MASH Resolution)
The study looked at 190 adults with biopsy-confirmed MASH and moderate-to-severe liver scarring (fibrosis stages F2 or F3). After 52 weeks of once-weekly injections, tirzepatide successfully eliminated the active liver inflammation and cellular ballooning: [1, 2]
  • Placebo: Only 10% of patients saw disease resolution.
  • 5 mg dose: 44% of patients achieved MASH resolution.
  • 10 mg dose: 56% of patients achieved MASH resolution.
  • 15 mg dose: 62% of patients achieved MASH resolution. [1, 2]

2. Reversing Existing Liver Scarring (Fibrosis)
Once fatty liver disease progresses to fibrosis, the liver develops permanent scars that can lead to cirrhosis or liver failure. Tirzepatide didn't just stop new scars from forming; it actually helped heal existing scars. More than 50% of patients taking the 10 mg and 15 mg doses experienced an improvement of at least one full stage of fibrosis with zero worsening of their liver disease. [1, 2, 3, 4]

3. Drastic Reductions in Liver Fat Content
In an imaging sub-study called SURPASS-3 MRI, researchers used advanced MRI scans to look directly at the percentage of fat inside the liver. Patients taking tirzepatide experienced a relative liver fat reduction of roughly 40% to 50%, effectively normalizing their liver fat levels. [1, 2]

Why Tirzepatide is So Effective on the Liver
While severe weight loss naturally helps pull fat out of organs, researchers found that tirzepatide works through direct metabolic pathways: [1, 2]
  • The GIP Hormone Advantage: The added GIP component helps body fat store energy safely in normal fat tissues, preventing excess lipids from "spilling over" and packing into organs like the liver. [1]
  • Downregulating Lipogenic Genes: Cellular data shows the drug actively downregulates specific genes involved in cellular lipid uptake and fat creation, effectively shutting down the liver's ability to turn excess carbohydrates into triglycerides. [1, 2]
Click to expand...

Look back at the threads, I’ve been saying it’s really a miracle drug for a while. Tons of benefits, some we are still just starting to see.


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