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Trevogrumab

Bolan

Bolan

Sunrise Pharma sponsored athlete
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Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice - PMC

Loss of skeletal muscle mass and function in humans is associated with significant morbidity and mortality. The role of myostatin as a key negative regulator of skeletal muscle mass and function has supported the concept that inactivation of ...
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice - PMC

Loss of skeletal muscle mass and function in humans is associated with significant morbidity and mortality. The role of myostatin as a key negative regulator of skeletal muscle mass and function has supported the concept that inactivation of ...
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Trevogrumab (REGN1033) is a fully human monoclonal antibody, not a peptide, developed by Regeneron to treat muscle wasting conditions like sarcopenia by blocking myostatin (GDF8), a protein that limits muscle growth, thereby promoting muscle growth and preservation, often studied alongside semaglutide for better weight loss quality.
What it is:
  • A type of therapeutic protein (monoclonal antibody) that mimics natural antibodies.
  • It's an IgG4 kappa isotype, designed to be a selective inhibitor of myostatin (GDF8).
How it works:

  • Myostatin normally tells muscles to stop growing.
  • Trevogrumab binds to and neutralizes myostatin, lifting this "brake" on muscle growth.
What it's used for (Research/Clinical Trials):
  • Muscle atrophy & Sarcopenia: Muscle loss due to aging, chronic diseases, or disuse (like after a cast).
  • Obesity: Combined with semaglutide (a GLP-1 agonist) to improve weight loss by preserving lean muscle mass while reducing fat mass, making weight loss healthier.
Key Points:
  • Not a Peptide: It's a large antibody protein, not a short peptide sequence.
  • Research & Clinical Use: Used in clinical trials (like the COURAGE trial) for muscle-related conditions and obesity.
 
I bought REGN stock when early in trials, then sold after seeing the side effects. Maybe they tweaked since then as I haven't been following.
 
IV admin has been the standard for this class of drugs (monoclonals). I wonder if there's much being done from a formulation standpoint to make sub-q admin more effective (I think one of the trials has a sub-q arm but would have to dig to find if that's accurate). I sure hope so, as if these turn out to be as promising as the early results suggest, I juuuust might want to get me some to try out - and I'm not doing IV admin at home lol

Just checked before posting and looks like there are sc arms to the current trials. It's a trend in MAB therapy, as it's easier for patients than going to the clinic. Hopefully it doesn't need any special formulation to be effective.

(waits for the next IL BOGO)
 
Meetketchup said:
I bought REGN stock when early in trials, then sold after seeing the side effects. Maybe they tweaked since then as I haven't been following.
Click to expand...
All I know is this... I fuckin hurt for at least 2 weeks straight.
DEEP pain... Was told it was skeleton muscle growing "pains"

Now its LFG!
 
Wait - is this already available??

Haven’t seen it anywhere but I suppose it there’s no reason it wouldn’t be… Unless peptide shops aren’t set up for MAB production? Could they get hands on a clone?


Sent from my iPhone using Tapatalk
 
I really need to grab one of these vials. My Bad Case of Bigorexia NEEDS to be fulfilled!
 
McPriimate said:
IV admin has been the standard for this class of drugs (monoclonals). I wonder if there's much being done from a formulation standpoint to make sub-q admin more effective (I think one of the trials has a sub-q arm but would have to dig to find if that's accurate). I sure hope so, as if these turn out to be as promising as the early results suggest, I juuuust might want to get me some to try out - and I'm not doing IV admin at home lol

Just checked before posting and looks like there are sc arms to the current trials. It's a trend in MAB therapy, as it's easier for patients than going to the clinic. Hopefully it doesn't need any special formulation to be effective.

(waits for the next IL BOGO)
Click to expand...
Im 100% sure IL does not carry this.... its 7 grand for 5 weeks of use.
(then continues blocking Myostatin for up to 3 months after last injection)
Sub-q injection.
Afraid of IV? 99% of the pros Ive coached or know use their pharm grade HGH IV. Its no secret, but they wont say it publicly. Just like pros saying they only ran 1g testosterone 1 g Primo, 18ius of HGH to turn Pro.
but say NOTHING about Slin..... and @ 18ius, you can take all the GDA's
Metformin ETC... and fasted BG will still be CRANKED!
 
I’m definitely grabbing some haha. I’ve seen a lotta people talk about it and results and read studies etc. I don’t see how it could be a bad thing at all. Well
Let me rephrase that it could but I prefer the rewards over the risk in this case.
 
Bolan said:
Bigorexia is a thing!
Click to expand...
Shit who you telling. I enjoy cutting as well until I feel like I look like a cancer patient and feel like a fucking field mouse. Even now I had a bunch of people the other day tellll me I just look completely unnatural and freaky and I tell em glad you think so I think I look like a little bitch 🤣
 
Bigjape34 said:
Shit who you telling. I enjoy cutting as well until I feel like I look like a cancer patient and feel like a fucking field mouse. Even now I had a bunch of people the other day tellll me I just look completely unnatural and freaky and I tell em glad you think so I think I look like a little bitch 🤣
Click to expand...
For me, a cut is taking out 4 cups of Rice and 1 Meal.
I don't have to do cardio for hours I don't need to starve...
I can get to 9% BF literally without trying, its just food.
But for me going under 9% I don't like it because Im hungry
and grumpy all the time.
 
Bolan said:
For me, a cut is taking out 4 cups of Rice and 1 Meal.
I don't have to do cardio for hours I don't need to starve...
I can get to 9% BF literally without trying, its just food.
But for me going under 9% I don't like it because Im hungry
and grumpy all the time.
Click to expand...
Me personally I started off in a not ideak
Place laet
Time so it was a lot
More difficult now with the way the body’s responding and growing I think it’ll be a breeze I don’t mind suffering or doing whatever it takes for the goal it’s part of what we do but being in a. Better lap or to achieve the goals will definitely help
 
Bolan said:
Im 100% sure IL does not carry this.... its 7 grand for 5 weeks of use.
(then continues blocking Myostatin for up to 3 months after last injection)
Sub-q injection.
Afraid of IV? 99% of the pros Ive coached or know use their pharm grade HGH IV. Its no secret, but they wont say it publicly. Just like pros saying they only ran 1g testosterone 1 g Primo, 18ius of HGH to turn Pro.
but say NOTHING about Slin..... and @ 18ius, you can take all the GDA's
Metformin ETC... and fasted BG will still be CRANKED!
Click to expand...

lol not afraid of IV - procedures don’t phase me. Was thinking more of what would make it fairly available to most of us here.

I think: it’s gotta be sub-q or it won’t be popular with gen-pop. Even fairly dedicated gym bros/girlies will likely shy away from IV admin, and gen pop definitely won’t like that (they took years to get used to sub-q glp’s - although that they eventually did. But getting big isn’t as important to gen pop as getting small). If it’s not popular with gen pop, then it’s not a big enough market for widespread availability.

Also needs to be easy to rip off and manufacture or it won’t make it to ugl’s. If the only way to make it is by getting regeneron’s actual clone and the only way to get it is through a script and going to an infusion center, and for 7k, it won’t make it to the rest of us any time soon.

So, glad it’s already sub-q and hoping it’s easy to pirate, as I need more bigness!!!


Sent from my iPhone using Tapatalk
 
McPriimate said:
lol not afraid of IV - procedures don’t phase me. Was thinking more of what would make it fairly available to most of us here.

I think: it’s gotta be sub-q or it won’t be popular with gen-pop. Even fairly dedicated gym bros/girlies will likely shy away from IV admin, and gen pop definitely won’t like that (they took years to get used to sub-q glp’s - although that they eventually did. But getting big isn’t as important to gen pop as getting small). If it’s not popular with gen pop, then it’s not a big enough market for widespread availability.

Also needs to be easy to rip off and manufacture or it won’t make it to ugl’s. If the only way to make it is by getting regeneron’s actual clone and the only way to get it is through a script and going to an infusion center, and for 7k, it won’t make it to the rest of us any time soon.

So, glad it’s already sub-q and hoping it’s easy to pirate, as I need more bigness!!!


Sent from my iPhone using Tapatalk
Click to expand...
If I knew how to give myself this shot through an IV I’d be all fucjing in haha
 
Bigjape34 said:
Need to find me a sexy ass nurse 🤣🤣
Click to expand...
That's who I had teach me. I traded her GLP's for her to come and teach me. Even when I worked in the med field I did not learn IV.

The girl I had, had absolute bombs. F cups. And a hot red head. She mentioned like 3 times she was married. I was like yeah right. As I have dated dozens of nurses, I know they are all available. Even the married ones. Nurses put out. LOL
 
GYMnTONIC said:
That's who I had teach me. I traded her GLP's for her to come and teach me. Even when I worked in the med field I did not learn IV.

The girl I had, had absolute bombs. F cups. And a hot red head. She mentioned like 3 times she was married. I was like yeah right. As I have dated dozens of nurses, I know they are all available. Even the married ones. Nurses put out. LOL
Click to expand...
Now your giving me hope Wes red heads are my weakness 🤣🤣
 

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