MOTS-c: a promising PED

[Meetketchup]

What I meant was, swallow it. It’s amazing in the oral version. I use the 20-40mg and get amazing results.

Anyway, Jano, who is a chemist, has said that the oral version is the best way to use it. I can say he’s right based on my experience and others who have ran the high dose SLU. 250-500mcg does nothing, which is how most sources have been selling it.

I'm sure Jano knows the analysis of compounds extremey well, but he's not a chemist by trade and even if he was the interaction between Slu and the body is biochemistry.

All I'm saying is that Slu is a Rev-Erb agonist and needs to be intact to reach the tissue. That doesn't happen after first pass due to gastric acid and such breaking up the compound.

As a result, the bioavailability is very low. This is confirmed by the literature we have on the compound via studies. This has been confirmed with from what I've seen from dozens of guys running it albeit that is personal anecdote.

I am not a biochemist lol so happy to be proven wrong.

 

[WED]

What I meant was, swallow it. It’s amazing in the oral version. I use the 20-40mg and get amazing results.

Anyway, Jano, who is a chemist, has said that the oral version is the best way to use it. I can say he’s right based on my experience and others who have ran the high dose SLU. 250-500mcg does nothing, which is how most sources have been selling it.

Right. I've got 50mg/ml in oil. Oral has ~40% bio availability at best. Some suggestion it is even lower. Most orals are awful vs injections

Unless he's run studies, I'd question his recommendations. Now it can't live in Water, he's right that is 100% pointless.

 

[nm156]

I'm sure Jano knows the analysis of compounds extremey well, but he's not a chemist by trade and even if he was the interaction between Slu and the body is biochemistry.

All I'm saying is that Slu is a Rev-Erb agonist and needs to be intact to reach the tissue. That doesn't happen after first pass due to gastric acid and such breaking up the compound.

As a result, the bioavailability is very low. This is confirmed by the literature we have on the compound via studies. This has been confirmed with from what I've seen from dozens of guys running it albeit that is personal anecdote.

I am not a biochemist lol so happy to be proven wrong.

I hear what you are saying and acknowledge it. Which is likely why the higher dosed SLU from 20-100mg ranges actually gives responses. Also, might be why the low dose versions are pointless. If a percentage is being taken by the liver, then more of it in a one dose will actually get through and do its magic.

You can say it’s anecdotal but might be why it’s amazing for me at 20-40mg and why others report the same.

Who does an oil version? I’m game to try and compare it versus high dosed oral.

 

[WED]

Who does an oil version? I’m game to try and compare it versus high dosed oral.

MA Research

 

[Meetketchup]

I hear what you are saying and acknowledge it. Which is likely why the higher dosed SLU from 20-100mg ranges actually gives responses. Also, might be why the low dose versions are pointless. If a percentage is being taken by the liver, then more of it in a one dose will actually get through and do its magic.

You can say it’s anecdotal but might be why it’s amazing for me at 20-40mg and why others report the same.

Who does an oil version? I’m game to try and compare it versus high dosed oral.

The issue we have is there are no human studies and the research is in its infancy, so we really don't have any idea of even a ballpark bioavailability, but biochemically the mechanism of breakdown as mentioned is in play. As you mentioned people are left with personal anecdote, including myself which is subject to placebo as all compounds. Nobody is except from placebo, so these personal accounts I take with a grain of salt especially when we talk about "feeling" a mitochondrial compound working at a low level. We're not talking about DNP or something full on decoupler. This is a mild peptide acting on ERR's that would most likely not indicate a noticeable boost on a conscious level.

I have had guys tell me things like Turkesterone, HMB, Natural test Boosters and dozens of other things make the "feel" a certain way. I don't think they are lying, but in reality, they essentially do f all. Not to say Slu isn't or won't turn out to be effective, but you get my point.

I'm sure there will be studies on making this compound or future versions more bioavailable via some mutations. THAT is what I will be waiting for along with any controlled human studies that gives us some idea regarding dosing, effect and sides. Until then, I haven't seen anything to make me want to use again or prescribe and to take a risk mega dosing without knowing future sides is a risk not worth taking IMO. That's just me. Everyone has their own risk tolerance.

 

[nm156]

I remember when Bill Phillips introduced HMB, he was marketing it as the next creatine breakthrough. EAS or muscle media, I don’t remember who it was, but they ran a special by six bottles. Get results, if you’re not satisfied, you can return the unused bottles and used bottles for a full refund guaranteed. So I tried it and used all five bottles and nothing. Sent them back and they returned my money. I know it did nothing because all I used back, then was creatine and protein powder.. This was the only thing I added to my diet and saw no results. And now I’m seeing a comeback of HMB in a bunch of supplements.

 

[nm156]

In the studies done by U of FL, in mice prefacing my comments, SLU has shown to increase aerobic activity, shown to increase insulin sensitivity, and reduced fat accumulation. I think due to memetic of exercise.

I keep my diet pretty clean and on no cardarine. After slu 1 month use, I definitely notice increased aerobic ability.

I am an avid mountain biker and am privileged to live at 7,000 ft and climbing up above 10-12,000 ft mountains, I can definitely see ability where my cardio is amazing. I’m not breathing as hard as I usually would that high. Thats all with 40
Mg dose of SLU. I want to try it with cardarine and see how much it helps. My blood pressure is also much lower too.

Thats while using test 275mg and injectable YK11, 10mg morning and 5mg evening. It’s been very noticeable. Again, anecdotal evidence.

Exercise-mimicking drug sheds weight, boosts muscle activity in mice

Exercise in a pill might be a little closer to reality with new research.

news.ufl.edu

A Synthetic ERR Agonist Alleviates Metabolic Syndrome - PMC

Physical exercise induces physiologic adaptations and is effective at reducing the risk of premature death from all causes. Pharmacological exercise mimetics may be effective in the treatment of a range of diseases including obesity and metabolic ...

pmc.ncbi.nlm.nih.gov

New hopes on "SLU-PP-332" as an effective agent for weight loss with indirect kidney protection efficacy; a nephrology point of view

SLU-PP-332 activates estrogen receptor-related orphan receptors, increasing energy expenditure, fatty acid oxidation, and decreasing fat mass accumulation. The drug enhances mitochondrial function and cellular respiration in skeletal muscle cell lines, increases the expression of an estrogen...

jrenendo.com

 

[Meetketchup]

I remember when Bill Phillips introduced HMB, he was marketing it as the next creatine breakthrough. EAS or muscle media, .

Oh, dude, I was in high school and my whole team went out and bought the big tubs of HMB from the local Vitamin shop and thought we were gonna get jacked like it was some sort of steroid. I remember lifting a couple of weeks after thinking I was so much stronger and my workouts were better. Placebo got my ass. Lol.

Regarding the link you posted. Yeah man, it looks good in mice, but as you know that often does not correlate to the human body. So that’s what we’re waiting for. Once we get some human randomized trials with some dosages seeing the results, then we can really assess what the hell is going on.

If you are getting something out of it then hell yeah, keep at it.

Unfortunately, didn’t do anything for me, but I look forward to the future research and data that will certainly come in the future.

 

[nm156]

In the meantime, as usual, bodybuilders are the real case study lab rats trying all this stuff out.