Metformin inhibits muscle gain?

[Sem]

Read this today.

2.2. Metformin inhibits PRT‐induced gains in total lean mass and thigh muscle mass; metformin trends toward inhibiting strength gains​

Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double‐blind, placebo‐controlled, multicenter trial: The MASTERS trial

Progressive resistance exercise training (PRT) is the most effective known intervention for combating aging skeletal muscle atrophy. However, the hypertrophic response to PRT is variable, and this may be due to muscle inflammation susceptibility. Metformin ...

www.ncbi.nlm.nih.gov

The article is making me reconsider using Metformin. Ahh shucks and I just bought 180 tabs....

 

[Bolan]

It lowers IGF-1, so yea I dropped the stuff yrs ago once I heard that.
Bodybuilder cringe at the thought of lowering IGF-1.
I had posted a thread in here somewhere where I told peeps not to run Metformin
Now for anti ageing purposes, it does have its place.

 

[ruffus]

Of course anyone taking HGH will probably have no problems over coming the small amount of IGF-1 that is lowered. And i believe that study uses natural people and not enhanced athletes, which would make a huge difference i would think. Most guys i have talked to that have been in the game for years think the benifits far out weight the little growth then may not be achieved. But that is all a personal decision we all make.

 

[Sem]

I have been stuck in a plateau awhile. Going to keep other PEDs/routine constant just removing the Metformin. That might help me decide long term.