elit3keraed
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Been listening to a few podcasts discussing HGH recently to just refresh my knowledge on it.
Now idk if it’s just a case of being older and more intentional with my thoughts or if things have changed in the last 10 years since I last used GH but some talking point I came across made me question a few things.
So we know GH increases FFA release to increase glucose production in the liver. The massive release of FFA blocks the insulin pathways from storing glucose (unless I misunderstood it). Then the massive increase in glucose from the liver breaking down the FFA to glucose just keeps BG up.
Now obviously this is bad for you in terms of insulin sensitivity and turning yourself type 2. It’s good for fat loss but with GLPs out there like tirz and Reta it seems like GH is the inferior fat burner now. Or at least with a GLP you would get a massive increase in results and maintain your BG levels (although I feel like Reta’s glucagon agonist with HGH would create an even bigger breakdown of FFA and possibly a higher BG level).
So taking multiple shots per day of GH would keep you in a constant fat burning but also constant high BG state. Not good.
Now if we want muscle gain we want IGF. High IGF will help with size. It will start to elevate quickly and after a while it will stay elevated for anywhere from a week to 1+ months before lowering after you stop GH. IGF, if I understood right, can bind to receptors in the fat cells not to increase burning but to decrease fat storage (blocking the insulin receptor). So high IGF would act as a nutrient partitioner by encouraging glucose going into muscle vs fat. Which is good.
So would it not make sense both from a cost and a health side to do EOD dosing of GH in one big dose? Instead of 5 units everyday spread out you do say 7 units before bed (since you’re not going to be eating and raising BG via food intake at night). You get higher IGF levels overall, less time spent in a state where insulin resistance can develop and the elevated IGF means less fat storage and more muscle storage. Since it will remain elevated for a while without further GH administration then you could stretch your kits to last longer, get higher IGF and give yourself less of a risk of becoming type 2?
Obviously adding something like Reta or tirz can/should help curb the unwanted blood sugar impact (I’m assuming it acts as an override during fat loss to keep BG lower?)
But is there any merit to this thought process? I think there was someone who said they ran it EOD but I can’t remember who (Yates or priest maybe?) and yes I know the whole “trying to reinvent the wheel” concept but I’m just genuinely curious if it’s something that was once “a thing” that died out or if anyone has ever heard/tried this.
Now idk if it’s just a case of being older and more intentional with my thoughts or if things have changed in the last 10 years since I last used GH but some talking point I came across made me question a few things.
So we know GH increases FFA release to increase glucose production in the liver. The massive release of FFA blocks the insulin pathways from storing glucose (unless I misunderstood it). Then the massive increase in glucose from the liver breaking down the FFA to glucose just keeps BG up.
Now obviously this is bad for you in terms of insulin sensitivity and turning yourself type 2. It’s good for fat loss but with GLPs out there like tirz and Reta it seems like GH is the inferior fat burner now. Or at least with a GLP you would get a massive increase in results and maintain your BG levels (although I feel like Reta’s glucagon agonist with HGH would create an even bigger breakdown of FFA and possibly a higher BG level).
So taking multiple shots per day of GH would keep you in a constant fat burning but also constant high BG state. Not good.
Now if we want muscle gain we want IGF. High IGF will help with size. It will start to elevate quickly and after a while it will stay elevated for anywhere from a week to 1+ months before lowering after you stop GH. IGF, if I understood right, can bind to receptors in the fat cells not to increase burning but to decrease fat storage (blocking the insulin receptor). So high IGF would act as a nutrient partitioner by encouraging glucose going into muscle vs fat. Which is good.
So would it not make sense both from a cost and a health side to do EOD dosing of GH in one big dose? Instead of 5 units everyday spread out you do say 7 units before bed (since you’re not going to be eating and raising BG via food intake at night). You get higher IGF levels overall, less time spent in a state where insulin resistance can develop and the elevated IGF means less fat storage and more muscle storage. Since it will remain elevated for a while without further GH administration then you could stretch your kits to last longer, get higher IGF and give yourself less of a risk of becoming type 2?
Obviously adding something like Reta or tirz can/should help curb the unwanted blood sugar impact (I’m assuming it acts as an override during fat loss to keep BG lower?)
But is there any merit to this thought process? I think there was someone who said they ran it EOD but I can’t remember who (Yates or priest maybe?) and yes I know the whole “trying to reinvent the wheel” concept but I’m just genuinely curious if it’s something that was once “a thing” that died out or if anyone has ever heard/tried this.
