GLP1s - to split dose or not?

[Andy88]

TLdr:/ A "doc" online claims split dosing GLP1s robs the user from "receptor recovery" that happens towards the end of the week and one ends up needing more and more drug long term while dingle dose results with smaller doses needed.

Now a bit more context

I can't find the video, if people really want to watch it I'll search more, but the crux was that receptors get "used up" and need to be recycled and if there is lots of stimulation they get recycled less. That's how tolerance works.

There is lots of anectodal info about benefits of split dosing GLP1s and I've experienced much smoother action when I split my 4mg reta weekly dose into two.

However, this "doc" online (in quotes, because anyone can be an MD in a YouTube vid) is very much against split dosing. Saying his patients needed a lot smaller doses long term if they didn't split.

Again my experience kinda supports this. After 3 months on Reta (about 8 wks on 4mg, ramp up before) and loosing 14% of my body mass, as I'm still few percent away from my target I switched to splitting because I felt the signs "it doesn't work that well" on some specific days of the week (I dosed Sunday evening and by Friday/Saturday I felt hunger up to 2h before I should.

So I started doing Sunday and Wednesday, but just after 2 weeks I noticed overall lower effects. So I bumped to 5mg. I had to bump to feel the same. 3wks later I'm, still on 5mg

This may very well simply be a factor of no longer having large amount of fat or the "doc" may be onto something.

Remember, drug companies don't have a huge incentive to lower the doses if they aren't unsafe. So we need to rely on the public/medical field to find the protocols that need the least of the drug. Lowest dose that still works is always the best, right?

 

[19NorFan]

Yeah, so that is medical quackery, whether said by a legitimate doctor or not…

The halflife of reta is 6 days. If I inject 4mg today, by next Tuesday I will still have more than 2mg in circulation. By the end of the 6th week, I’ll have 7-8mg in circulation. So reducing injection frequency really does not to give receptors a “break.” You need to come off of it completely, usually for 3-4+ months to regain sensitivity. After a 3 month break from GLPs, I can go back to my starter dose of 2-3mg/week and get the same appetite suppression every time.

As far as my preferred dosing schedule, I like to do every other day. If I do it weekly, I have strong, sometimes too strong suppression for
the first 2-3 days and then by day 7 my appetite is coming back.

I’d rather just keep it shut quiet the entire week and not experience fluctuations, so I microdose. It’s just smoother that way.

 

[Meetketchup]

Stop listening to online "Doc's" or influencers number one. There is a ton of random human control trials and meta-analysis on this topic from dosage to frequency. Skip the bullshit and go to the data.

Dosing is entirely dependent on the individual with current bodyfat, appetite, affinity to sides, etc.

I find most obese people which is really who should be using these inject infrequently with no issue due to high dosages and bodyfat. The half-life works for them. Lean people who train tend to do better with frequent low dosages to keep spiking minimal, thus less sides.

Do what works for you.

 

[Unclemoneybags]

Yep, horseshit. The only reason to split dosages is to mitigate sides with higher weekly dosages.