Switching from Tirz to Reta

[McPriimate]

Anyone who was using tirzepatide switch to Reta? If so, how’d you do it (titrate tirz down then Reta up, cut over from a maint dose of tirz to starter of Reta, etc.)? How’d it go?


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[J.S.]

First, I’ve never used Tirz just Reta and Sema. If I was going to do this, I’d let the Triz clear my system first, then start Reta. At the very least I would start at a very low dose of Reta if I was going to just jump in. Hopefully others that have actually done this will jump in.

 

[dcdogz]

Tirz half life 4 days. Just pin reta 5th start a little low to assess tolerance.

 

[Astro95]

I simply switched from whatever dose of Tirz to starting dose of Reta once my next Tirz shot was due and had no issues.

 

[WED]

Just make the jump. Titration is really only there to assess sides and access response.

Be aware your appetite suppression will be much lower on Reta

 

[RandomLifter]

Don’t want to hijack the thread but would love additional experiences on pros/cons etc of switching from Sema to Reta and Tirz to Reta.

 

[McPriimate]

Don’t want to hijack the thread but would love additional experiences on pros/cons etc of switching from Sema to Reta and Tirz to Reta.

Not a hijack at all afaic as I’m always interested to hear people’s experiences.

I’m cutting over in a couple weeks but have only used tirzepatide to date.


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[McPriimate]

Just make the jump. Titration is really only there to assess sides and access response.

Be aware your appetite suppression will be much lower on Reta

I’m in a gain phase atm so wouldn’t mind that part, but not sure how I’ll feel about it on a cut lol

I’m at 2mg/wk tirzepatide and can out eat that, but just. From 2mg I’ll likely do as you suggest and just cut over.

Never thought i had much food noise, but coming down to 2mg as ive been increasing calories, I now have sugar cravings that I haven’t had in a long time and kinda forgot about.

I wonder how Reta is generally with the craving part, more so than straight hunger.

Super interesting stuff.


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[J.S.]

I’m in a gain phase atm so wouldn’t mind that part, but not sure how I’ll feel about it on a cut lol

I’m at 2mg/wk tirzepatide and can out eat that, but just. From 2mg I’ll likely do as you suggest and just cut over.

Never thought i had much food noise, but coming down to 2mg as ive been increasing calories, I now have sugar cravings that I haven’t had in a long time and kinda forgot about.

I wonder how Reta is generally with the craving part, more so than straight hunger.

Super interesting stuff.


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As far as Reta goes, for me at least, I don’t get any real hunger suppression, not like I did with Sema, that hammered me hard. Reta is more subtle, I got up to 6mg , which isn’t the top end ,but never got that suppression. What does happen, when I go off of it, which I do around 3 months, I’ll start noticing a jump in hunger and food noise after about ten days, then I’ll say, yep, it was doing something. To me it’s a tool in the tool box, I’m constantly doing an intermittent fasting, have been since I tried it for 12 weeks, so I can go without GLP if I chose, but sometimes I’m lazy, and that’s when the GLP comes out,lol.

 

[dcdogz]

I’m in a gain phase atm so wouldn’t mind that part, but not sure how I’ll feel about it on a cut lol

I’m at 2mg/wk tirzepatide and can out eat that, but just. From 2mg I’ll likely do as you suggest and just cut over.

Never thought i had much food noise, but coming down to 2mg as ive been increasing calories, I now have sugar cravings that I haven’t had in a long time and kinda forgot about.

I wonder how Reta is generally with the craving part, more so than straight hunger.

Super interesting stuff.


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Tirz is way better with cravings and it's not close.

Ultimate shutdown to everything is sema

 

[McPriimate]

Tirz is way better with cravings and it's not close.

Ultimate shutdown to everything is sema

It'll be interesting to see which way this goes for me over time. Had been thinking Reta in a cut, as the glucagon agonism turns up the furnace a bit. But I'm wondering if it'll turn out to be better for a gain phase (keeps lipids and BG in good range, but you can eat more easily) and if Tirz will be better in a cut to just have less hunger to overcome (and still good non-appetite benefits).

Citizen scientist and n of 1 here, but I do love me some physiology...

 

[dcdogz]

It'll be interesting to see which way this goes for me over time. Had been thinking Reta in a cut, as the glucagon agonism turns up the furnace a bit. But I'm wondering if it'll turn out to be better for a gain phase (keeps lipids and BG in good range, but you can eat more easily) and if Tirz will be better in a cut to just have less hunger to overcome (and still good non-appetite benefits).

Citizen scientist and n of 1 here, but I do love me some physiology...

My personal cutting fav stack was
Triz Sunday small sema dose Thursday.

Helped keep hunger in check over the weekend and keep overall dosages low.

Very easy on the wallet as well.

 

[J.S.]

My personal cutting fav stack was
Triz Sunday small sema dose Thursday.

Helped keep hunger in check over the weekend and keep overall dosages low.

Very easy on the wallet as well.

I did a Sema, Reta combo. To start Sema .25 mg and 2mg Reta, after a month I bumped to .5 and 4 mg. Worked good for the short time I was on it.

 

[Big_Jimmy434]

I simply switched from whatever dose of Tirz to starting dose of Reta once my next Tirz shot was due and had no issues.

I did the same. No issues other than after about 4 weeks the Reta didn't work well for me so I switched back.

 

[WED]

As far as Reta goes, for me at least, I don’t get any real hunger suppression, not like I did with Sema, that hammered me hard. Reta is more subtle, I got up to 6mg , which isn’t the top end ,but never got that suppression. What does happen, when I go off of it, which I do around 3 months, I’ll start noticing a jump in hunger and food noise after about ten days, then I’ll say, yep, it was doing something. To me it’s a tool in the tool box, I’m constantly doing an intermittent fasting, have been since I tried it for 12 weeks, so I can go without GLP if I chose, but sometimes I’m lazy, and that’s when the GLP comes out,lol.

I was the same, but feel like Reta give me the ability to control my eating/lessens the noise vs just obliterates my hunger and immediately makes me full like Sema does

I could put eat it, but I couldn't put eat Sema. But give control...just a little different

 

[McPriimate]

I was thinking of trying low dose cagri with the Reta when I cut. Same idea to keep overall doses low but add a bit of appetite suppression while keeping the glucagon agonism in.

Will have to see how I do on Reta, as I might not need it (or might end up switching back to Tirz as some have done).

Great to have so many options to work out something that fits each individual. We're living in the future lol

 

[WED]

I was thinking of trying low dose cagri with the Reta when I cut. Same idea to keep overall doses low but add a bit of appetite suppression while keeping the glucagon agonism in.

Will have to see how I do on Reta, as I might not need it (or might end up switching back to Tirz as some have done).

Great to have so many options to work out something that fits each individual. We're living in the future lol

I'm taking 1.33mg and 6mg of Cargi/Reta right now and in 3 weeks on a very aggressive deficit I'm doing fine. Been surprised a bit

 

[J.S.]

I'm taking 1.33mg and 6mg of Cargi/Reta right now and in 3 weeks on a very aggressive deficit I'm doing fine. Been surprised a bit

Interesting! I was going to try a Cargi/ Sema combo, keep me updated if you would.

 

[McPriimate]

I'm taking 1.33mg and 6mg of Cargi/Reta right now and in 3 weeks on a very aggressive deficit I'm doing fine. Been surprised a bit

Curious where you get the cagri from (my usual sponsors either don’t carry or have in stock atm) and I’m thinking of loading some in for future

 

[Wally954]

You probably won’t feel the Reta switching from tirz or semi.you can try and see, but you’ll probably have to start off at a higher dose than normal, depending on how long you were using the other GLP‘s, I have a friend who was on to tirz and semiglutide for a while and came off for like six months and started Reta and could not feel it at all even at 10 mg a week,he went back to semiglutide, once you get used to the traditional GLP’s, it’s going to be hard for you to feel the appetite suppression of Reta. It doesn’t mean that the Reta isn’t working, but the appetite suppression will be very weak. You can probably take a low dose of tirz while on Reta just to help with the appetite suppression

 

[WED]

Curious where you get the cagri from (my usual sponsors either don’t carry or have in stock atm) and I’m thinking of loading some in for future

Pretty sure I've seen some here carrying it, but I get my Peptides and HGH from China gray market companies

 

[Astro95]

I did the same. No issues other than after about 4 weeks the Reta didn't work well for me so I switched back.

I was using Reta mainly for glucose management which worked incredibly well, but as far as appetite it wasn’t even close in my experience.

 

[Big_Jimmy434]

I was using Reta mainly for glucose management which worked incredibly well, but as far as appetite it wasn’t even close in my experience.

Thats the same experience I had. Zero appetite suppression. At times, I think i was more hungry. Reta really seems to behave very different depending on the person. I know some people on here take 1mg and can't eat for a week. I kept running it up higher and higher and got no suppression at all. It seems like many people agree that the suppression with Triz is far better than both Reta.

 

[J.S.]

Curious where you get the cagri from (my usual sponsors either don’t carry or have in stock atm) and I’m thinking of loading some in for future

AA Solutions has it I’m pretty sure, I believe they have a Cargi/Sema blend to. You won’t see it on their website, DM a Rep and ask.

 

[nm156]

I'm hearing now that people are stacking Tirz with Reta and having good results.

 

[McPriimate]

I'm hearing now that people are stacking Tirz with Reta and having good results.

This is what I’ve ended up doing. 4mg Reta, 2mg tirz. Working great thus far - good suppression but without the bloaty/stuffed feeling


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[WED]

I'm hearing now that people are stacking Tirz with Reta and having good results.

Do you just want the appetite suppression from Tirz? If so Cargilintide might be another option

 

[McPriimate]

Do you just want the appetite suppression from Tirz? If so Cargilintide might be another option

Cagri does add more suppression, at least for me when I ran it alongside tirz (was trying to keep the tirz dose lower).

I’d also thought about cagri with the Reta for exactly that, but we have a bunch of tirz floating around the house as it’s popular here lol. Was too easy for me to go from 2mg tirz back up after a gain phase by just adding Reta a mg at a time

But totally agree, cagri might be all you need in combo with it, if additional appetite suppression the goal


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[J.S.]

Cagri does add more suppression, at least for me when I ran it alongside tirz (was trying to keep the tirz dose lower).

I’d also thought about cagri with the Reta for exactly that, but we have a bunch of tirz floating around the house as it’s popular here lol. Was too easy for me to go from 2mg tirz back up after a gain phase by just adding Reta a mg at a time

But totally agree, cagri might be all you need in combo with it, if additional appetite suppression the goal


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I read where a study was being done with Sema/Carg combo, started out low dose .25 Sema and I can’t remember the Carg, but it was close to that. I think the Sema topped out at 2 mg and the combo was pretty effective.

 

[WED]

I read where a study was being done with Sema/Carg combo, started out low dose .25 Sema and I can’t remember the Carg, but it was close to that. I think the Sema topped out at 2 mg and the combo was pretty effective.

I'm taking 1mg with 6mg or Reta and it's a great combo