Reta plateau?!?

[Mo123]

Been on Reta for a while now wanna say since July so 6 months lost over 80 lbs, been on 1500 cals and doing 30 mins cardio everyday. I look pretty lean wanna say like sub 10-12% BF, how do I drop into the single digis without dropping my cals to 1000, at this point 10mg of Reta is still making me feel hungry I don’t gain any weight but I end up messing up on some days and not taking it as serious as I was on a lower dose 5mg where I was eating the same thing and locked in for 8-10 weeks straight. Do I switch to tirz? I’ve heard it’s better for appetite suppression. Pretty much just wanna get shredded and be able to maintain so need you guys advice/help.

 

[rawbuilt]

you build a tolerance to reta overtime and you will need to keep increasing the dosage to get its affects..

thats why it shouldn't be used for long periods of time and needs to be cycled off

and you probably need to go on a diet break if you been cutting for 6 months straight your thyroid is probably low

 

[Joseph booth]

Been on Reta for a while now wanna say since July so 6 months lost over 80 lbs, been on 1500 cals and doing 30 mins cardio everyday. I look pretty lean wanna say like sub 10-12% BF, how do I drop into the single digis without dropping my cals to 1000, at this point 10mg of Reta is still making me feel hungry I don’t gain any weight but I end up messing up on some days and not taking it as serious as I was on a lower dose 5mg where I was eating the same thing and locked in for 8-10 weeks straight. Do I switch to tirz? I’ve heard it’s better for appetite suppression. Pretty much just wanna get shredded and be able to maintain so need you guys advice/help.

Awesome job on the 80-lb loss. To hit single-digit body fat, you don’t need 1,000 cals just tighten up your routine and stay consistent. If Reta isn’t suppressing appetite like before, trying tirz could help, but the real key is staying dialed in.

 

[HGHboy]

thats why it shouldn't be used for long periods of time and needs to be cycled off

and you probably need to go on a diet break if you been cutting for 6 months straight your thyroid is probably low

No that’s completely wrong.

You don’t “build a tolerance” lol.

GLPs at a certain dose lower you body’s set weight. You get appetite suppression until you reach that point. If you regain weight, while on the same dose, appetite suppression will return until you reach the set weight again.

To lose more you increase the dose.

That’s how they work.

That’s why OP didn’t gain weight, just doesn’t notice appetite suppression. Exactly how it’s supposed to work.

On pharma once goal weight is reached you go on a maintenance dose, and the 4 year trials prove weight stays the same while on the same dose.

These are hormones, like insulin for diabetics or testosterone for TRT, not diet pills you build a tolerance to. They’re supposed to be used continuously.

12mg is the max official Reta dose, many go higher, up to 24mg. At a certain point receptors saturate and there’s not more effect beyond that point.

 

[JG1]

No that’s completely wrong.

You don’t “build a tolerance” lol.

GLPs at a certain dose lower you body’s set weight. You get appetite suppression until you reach that point. If you regain weight, while on the same dose, appetite suppression will return until you reach the set weight again.

To lose more you increase the dose.

That’s how they work.

That’s why OP didn’t gain weight, just doesn’t notice appetite suppression. Exactly how it’s supposed to work.

On pharma once goal weight is reached you go on a maintenance dose, and the 4 year trials prove weight stays the same while on the same dose.

These are hormones, like insulin for diabetics or testosterone for TRT, not diet pills you build a tolerance to. They’re supposed to be used continuously.

12mg is the max official Reta dose, many go higher, up to 24mg. At a certain point receptors saturate and there’s not more effect beyond that point.

And what would that maintenance dose be?

 

[HGHboy]

And what would that maintenance dose be?

Response varies greatly by individual. It’s genetic, based on how much endogenous GLP-1 you produce, and your density of GLP-1 receptors.

That’s why some have a strong, even crippling response at starter doses like 2.5mg Tirz, others don’t feel shit until 10mg.

So pharma Sema, Tirz, and Reta all follow the same protocol. 4 weeks at each dose, starting at the lowest, or until that dose becomes tolerable if side effects are too much, then titrate up to the next dose. You either keep going until you’ve reach goal weight, or hit the max dose.

Where you stop is the maintainance dose going forward. Sometimes it’s backed off one level to prevent unwanted continuing loss.

At a stable “maintenance” dose, you don’t feel anything. No appetite suppression, no sides, no delayed gastric emptying. Just normal, with an appetite roughly matched to your caloric requirements. IE, a properly functioning appetite. You still get all the direct health benefits of GLP/GIP/Glucagon agonism, and there are a lot, better insulin sensitivity, anti-inflammation, lower BP, lower cholesterol(all beyond what weight loss is responsible for), less brain fog etc, but unless you “eat beyond your appetite” and regain weight, appetite suppression and side effects won’t return.

You’re essentially using hormones to correct a malfunctioning appetite, like insulin corrects for a malfunction pancreas or TRT for malfunctioning balls.

 

[rollin-tumblin]

so you don't "build a tolerance", but you stay at a dose until in your words it "becomes tolerable"? Is there a difference between those two things?

 

[HGHboy]

so you don't "build a tolerance", but you stay at a dose until in your words it "becomes tolerable"? Is there a difference between those two things?

Yes. Once weight drops to (or gets close to) whatever “set point” that dose of incretin hormones puts you at, sides dimish and stop. In plain English, more time (than 4 weeks) is needed to drop more weight to match what that level of hormones is setting you to. These hormones change the homeostasis weight your body wants to maintain. People who produce excessive GLP naturally have a hard time eating enough to maintain weight, their weight “setting” is very low, and if they try to force more food in, get physically sick. You know the type. Usually scrawny, needing an appetite stim to get some muscle on.

The further you are above the new, lower set weight whatever the dose is establishes, the worse sides will be. The side effects are just supraphysiologically strong versions of the same mechanisms your body uses to get you to stop eating when you’ve had too much.

If “tolerance” were a thing, long term users, using the same maintainance dose 1, 2, 3 years + after weight loss plateaued, would regain weight as tolerance increased.

15,000+ subjects in the trials prove that doesn’t happen.

It’s just Reddit peptide mommies and knuckle draggers who don’t know what the fuck they’re doing, or taken ten seconds to see how these drugs are used successfully 95% of the time, using the pharma protocol.

There is evidence stopping and restarting after a break may weaken response each time. It’s been seen in diabetics no longer getting as good glucose control as those who don’t interrupt treatment. That’s a kind of “tolerance”, and is probably because an effect known with protein drugs where the the immune system gets used to the continuous presence of a protein drug molecule, and leaves it alone, but if it’s stopped, and brought back later, is seen as an invading pathogen, attacked and removed. Essentially building an immunity to the drug, getting worse every time there’s a break, potentially making it completely ineffective eventually. Not something well studied yet, because that’s not how they’re used in legit medicine, and no one is going to spend money on trying to protect illicit users from possibly destroying their ability to ever use GLP compounds effectively in the future.

 

[Bando]

Yes. Once weight drops to (or gets close to) whatever “set point” that dose of incretin hormones puts you at, sides dimish and stop. In plain English, more time (than 4 weeks) is needed to drop more weight to match what that level of hormones is setting you to. These hormones change the homeostasis weight your body wants to maintain. People who produce excessive GLP naturally have a hard time eating enough to maintain weight, their weight “setting” is very low, and if they try to force more food in, get physically sick. You know the type. Usually scrawny, needing an appetite stim to get some muscle on.

The further you are above the new, lower set weight whatever the dose is establishes, the worse sides will be. The side effects are just supraphysiologically strong versions of the same mechanisms your body uses to get you to stop eating when you’ve had too much.

If “tolerance” were a thing, long term users, using the same maintainance dose 1, 2, 3 years + after weight loss plateaued, would regain weight as tolerance increased.

15,000+ subjects in the trials prove that doesn’t happen.

It’s just Reddit peptide mommies and knuckle draggers who don’t know what the fuck they’re doing, or taken ten seconds to see how these drugs are used successfully 95% of the time, using the pharma protocol.

There is evidence stopping and restarting after a break may weaken response each time. It’s been seen in diabetics no longer getting as good glucose control as those who don’t interrupt treatment. That’s a kind of “tolerance”, and is probably because an effect known with protein drugs where the the immune system gets used to the continuous presence of a protein drug molecule, and leaves it alone, but if it’s stopped, and brought back later, is seen as an invading pathogen, attacked and removed. Essentially building an immunity to the drug, getting worse every time there’s a break, potentially making it completely ineffective eventually. Not something well studied yet, because that’s not how they’re used in legit medicine, and no one is going to spend money on trying to protect illicit users from possibly destroying their ability to ever use GLP compounds effectively in the future.

I’m glad someone finally set it straight. I been reading glp misinformation on here forever. Just people regurgitating what they read somewhere.mi can’t rag em too bad. I have done it on other topics lol

 

[Bando]

Yes. Once weight drops to (or gets close to) whatever “set point” that dose of incretin hormones puts you at, sides dimish and stop. In plain English, more time (than 4 weeks) is needed to drop more weight to match what that level of hormones is setting you to. These hormones change the homeostasis weight your body wants to maintain. People who produce excessive GLP naturally have a hard time eating enough to maintain weight, their weight “setting” is very low, and if they try to force more food in, get physically sick. You know the type. Usually scrawny, needing an appetite stim to get some muscle on.

The further you are above the new, lower set weight whatever the dose is establishes, the worse sides will be. The side effects are just supraphysiologically strong versions of the same mechanisms your body uses to get you to stop eating when you’ve had too much.

If “tolerance” were a thing, long term users, using the same maintainance dose 1, 2, 3 years + after weight loss plateaued, would regain weight as tolerance increased.

15,000+ subjects in the trials prove that doesn’t happen.

It’s just Reddit peptide mommies and knuckle draggers who don’t know what the fuck they’re doing, or taken ten seconds to see how these drugs are used successfully 95% of the time, using the pharma protocol.

There is evidence stopping and restarting after a break may weaken response each time. It’s been seen in diabetics no longer getting as good glucose control as those who don’t interrupt treatment. That’s a kind of “tolerance”, and is probably because an effect known with protein drugs where the the immune system gets used to the continuous presence of a protein drug molecule, and leaves it alone, but if it’s stopped, and brought back later, is seen as an invading pathogen, attacked and removed. Essentially building an immunity to the drug, getting worse every time there’s a break, potentially making it completely ineffective eventually. Not something well studied yet, because that’s not how they’re used in legit medicine, and no one is going to spend money on trying to protect illicit users from possibly destroying their ability to ever use GLP compounds effectively in the future.

I’m glad someone finally set it straight. I been reading glp misinformation on here forever. Just people regurgitating what they read somewhere.mi can’t rag em too bad. I have done it on other topics lol

 

[Bando]

Yes. Once weight drops to (or gets close to) whatever “set point” that dose of incretin hormones puts you at, sides dimish and stop. In plain English, more time (than 4 weeks) is needed to drop more weight to match what that level of hormones is setting you to. These hormones change the homeostasis weight your body wants to maintain. People who produce excessive GLP naturally have a hard time eating enough to maintain weight, their weight “setting” is very low, and if they try to force more food in, get physically sick. You know the type. Usually scrawny, needing an appetite stim to get some muscle on.

The further you are above the new, lower set weight whatever the dose is establishes, the worse sides will be. The side effects are just supraphysiologically strong versions of the same mechanisms your body uses to get you to stop eating when you’ve had too much.

If “tolerance” were a thing, long term users, using the same maintainance dose 1, 2, 3 years + after weight loss plateaued, would regain weight as tolerance increased.

15,000+ subjects in the trials prove that doesn’t happen.

It’s just Reddit peptide mommies and knuckle draggers who don’t know what the fuck they’re doing, or taken ten seconds to see how these drugs are used successfully 95% of the time, using the pharma protocol.

There is evidence stopping and restarting after a break may weaken response each time. It’s been seen in diabetics no longer getting as good glucose control as those who don’t interrupt treatment. That’s a kind of “tolerance”, and is probably because an effect known with protein drugs where the the immune system gets used to the continuous presence of a protein drug molecule, and leaves it alone, but if it’s stopped, and brought back later, is seen as an invading pathogen, attacked and removed. Essentially building an immunity to the drug, getting worse every time there’s a break, potentially making it completely ineffective eventually. Not something well studied yet, because that’s not how they’re used in legit medicine, and no one is going to spend money on trying to protect illicit users from possibly destroying their ability to ever use GLP compounds effectively in the future.

I’m glad someone finally set it straight. I been reading glp misinformation on here forever. Just people regurgitating what they read somewhere. I can’t rag em too bad. I have done it on other topics lol

 

[rawbuilt]

No that’s completely wrong.

You don’t “build a tolerance” lol.

GLPs at a certain dose lower you body’s set weight. You get appetite suppression until you reach that point. If you regain weight, while on the same dose, appetite suppression will return until you reach the set weight again.

To lose more you increase the dose.

That’s how they work.

That’s why OP didn’t gain weight, just doesn’t notice appetite suppression. Exactly how it’s supposed to work.

On pharma once goal weight is reached you go on a maintenance dose, and the 4 year trials prove weight stays the same while on the same dose.

These are hormones, like insulin for diabetics or testosterone for TRT, not diet pills you build a tolerance to. They’re supposed to be used continuously.

12mg is the max official Reta dose, many go higher, up to 24mg. At a certain point receptors saturate and there’s not more effect beyond that point.

you have to keep increasing the dose overtime to keep making progress if your gonna be on it for long periods of time... i just said tolerance cause its easier for people to understand but either way you will plateau eventually if you don't increase it

 

[JG1]

Response varies greatly by individual. It’s genetic, based on how much endogenous GLP-1 you produce, and your density of GLP-1 receptors.

That’s why some have a strong, even crippling response at starter doses like 2.5mg Tirz, others don’t feel shit until 10mg.

So pharma Sema, Tirz, and Reta all follow the same protocol. 4 weeks at each dose, starting at the lowest, or until that dose becomes tolerable if side effects are too much, then titrate up to the next dose. You either keep going until you’ve reach goal weight, or hit the max dose.

Where you stop is the maintainance dose going forward. Sometimes it’s backed off one level to prevent unwanted continuing loss.

At a stable “maintenance” dose, you don’t feel anything. No appetite suppression, no sides, no delayed gastric emptying. Just normal, with an appetite roughly matched to your caloric requirements. IE, a properly functioning appetite. You still get all the direct health benefits of GLP/GIP/Glucagon agonism, and there are a lot, better insulin sensitivity, anti-inflammation, lower BP, lower cholesterol(all beyond what weight loss is responsible for), less brain fog etc, but unless you “eat beyond your appetite” and regain weight, appetite suppression and side effects won’t return.

You’re essentially using hormones to correct a malfunctioning appetite, like insulin corrects for a malfunction pancreas or TRT for malfunctioning balls.

So I didn't follow the protocol which was done in the studies. I started at 3mg/week which worked fantastic for appetite suppression. As the appetite suppression faded, I very slowly titrated up to 5mg/week. I'm 7 weeks in right now, appetite suppression is still good. I'm at the point where I am hungry enough to eat all the macros I need but suppressed enough where I'm not tempted to eat more than I should. Food noise is very low. I have 5 more weeks of this on this cut and don't plan to increase the dose any further.

Afterwards, I wanted to stay on a maintenance dose for Reta's metabolic benefits. A little confused on what that maintenance dose should be though.

Also, at 5mg/week, Reta has tanked my sex drive. Desire is completely gone. Can get elections still but have a very hard time trying to orgasm. I'm on Test E as well. This side effect I do not like.

 

[Nick Baskakov]

Been on Reta for a while now wanna say since July so 6 months lost over 80 lbs, been on 1500 cals and doing 30 mins cardio everyday. I look pretty lean wanna say like sub 10-12% BF, how do I drop into the single digis without dropping my cals to 1000, at this point 10mg of Reta is still making me feel hungry I don’t gain any weight but I end up messing up on some days and not taking it as serious as I was on a lower dose 5mg where I was eating the same thing and locked in for 8-10 weeks straight. Do I switch to tirz? I’ve heard it’s better for appetite suppression. Pretty much just wanna get shredded and be able to maintain so need you guys advice/help.

Hey bro where did u buy looking for a good source

 

[GYMnTONIC]

Hey bro where did u buy looking for a good source

I sell a very good lab tested option and code ASF gets 10% off at checkout
www.gymntonic.com

 

[Subject 21]

Hey bro where did u buy looking for a good source

I just got a 50mg kit “500mg” for $350.. And a couple months ago got 30mg “300mg” kit for $220.. This isnt really the place for good deals on GLP’s honestly. But I wont step on vendors toes, telegram is your friend when it comes to peptides.