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The Genetics of GH Response
By: Type-IIx
Are You A Hypo- or Non- Responder to GH?
GHR gene polymorphisms
HGH at 4 IU daily increases IGF-1 for most, but some people are hypo- or even non- responders. This fact depends on SNPs in the growth hormone receptor (GHR) gene.
Those who are hyper-responders possess the d3-GHR polymorphism. Population variance in this gene polymorphism can be as high as 50% in some populations. For details on this, buy and read his book – Bolus: A Practical and Reference Guide for the Use of Human Growth Hormone and GH Secretagogues
But even for d3-GHR GH hyper-responders, rhGH requires 16 – 20 weeks to produce visible physique changes. That's not "slow working" – that's the actual timeline for collagen synthesis and hyperplasia.
Growth hormone stimulates hepatic IGF-1 production, which triggers satellite cell proliferation and differentiation. New muscle cell formation takes 12+ weeks. Collagen deposition in connective tissue requires 20+ weeks of elevated GH/IGF-1.
Guys run GH for 8 weeks and say "it doesn't work." You spent $2000 to barely start the adaptation process. GH effects are dose-dependent AND time-dependent – you need both a sufficient dose (4+ IU daily) and a sufficient duration (6+ months).
For actual results: 4 IU daily for 6 months minimum. Split AM/PM dosing to mimic pulsatile secretion. Add MK-677 (12.5 mg nightly) to amplify endogenous pulses. If you're not seeing results, find out whether you're d3 null in the GHR gene with genetic testing. There are at least two SNPs that 'tag' the d3-GHR (hyper-response) allele with near certainty, at least in Caucasian/European populations (and perhaps others), and that are also present on most genotyping chips.
ncbi.nlm.nih.gov/pubmed… ncbi.nlm.nih.gov/pubmed….
These SNPs, shown below with the tagging (minor) allele correlated with the d3-GHR allele, are:
rs6873545(C); in 23andMe and other data
rs4590183(C) in ancestry dot com and other data
By: Type-IIx
Are You A Hypo- or Non- Responder to GH?
GHR gene polymorphisms
HGH at 4 IU daily increases IGF-1 for most, but some people are hypo- or even non- responders. This fact depends on SNPs in the growth hormone receptor (GHR) gene.
Those who are hyper-responders possess the d3-GHR polymorphism. Population variance in this gene polymorphism can be as high as 50% in some populations. For details on this, buy and read his book – Bolus: A Practical and Reference Guide for the Use of Human Growth Hormone and GH Secretagogues
But even for d3-GHR GH hyper-responders, rhGH requires 16 – 20 weeks to produce visible physique changes. That's not "slow working" – that's the actual timeline for collagen synthesis and hyperplasia.
Growth hormone stimulates hepatic IGF-1 production, which triggers satellite cell proliferation and differentiation. New muscle cell formation takes 12+ weeks. Collagen deposition in connective tissue requires 20+ weeks of elevated GH/IGF-1.
Guys run GH for 8 weeks and say "it doesn't work." You spent $2000 to barely start the adaptation process. GH effects are dose-dependent AND time-dependent – you need both a sufficient dose (4+ IU daily) and a sufficient duration (6+ months).
For actual results: 4 IU daily for 6 months minimum. Split AM/PM dosing to mimic pulsatile secretion. Add MK-677 (12.5 mg nightly) to amplify endogenous pulses. If you're not seeing results, find out whether you're d3 null in the GHR gene with genetic testing. There are at least two SNPs that 'tag' the d3-GHR (hyper-response) allele with near certainty, at least in Caucasian/European populations (and perhaps others), and that are also present on most genotyping chips.
ncbi.nlm.nih.gov/pubmed… ncbi.nlm.nih.gov/pubmed….
These SNPs, shown below with the tagging (minor) allele correlated with the d3-GHR allele, are:
rs6873545(C); in 23andMe and other data
rs4590183(C) in ancestry dot com and other data
