45 year old here. Been taking MOTS at 2mg/day for about a month, with SS-31 at 4-5mg/day for the last 3 weeks. I added NAD+ today to see how that stacks with it.
For me, the MOTS by itself gave me a noticeable increase in stamina when lifting weights. I was able to get an extra set or an extra rep on a set pretty solidly across the board. When doing cardio (LISS, treadmill incline 130-140BPB) i was able to just go longer without feeling like i was ready to stop.
That said, the effects do become less over time as far as my "feel" of it. I still feel it, for sure, just not as intense as the first week or so. Probably just getting used to the new energy level.
I completely halted my daily caffeine intake alongside this stack too. Previously, i'd drink 2-3 cups black coffee in the morning, then 1-2 energy drinks throughout the day (alani 200mg caffeine). Now i might have a half cup in the morning for the taste and habit, but i usually don't finish it and it gets cold. I can also attribute a little bit of the caffeine reduction to reta, which i have been taking for a little bit too, at ~4.5mg/week.
As far as the NAD+ goes, took that today for the first time. 50mg. I do feel a bit more energized than i typically do, so there is a noticeable increase in energy from that too. Haven't had a chance to work out on it yet. Will know that part tomorrow.
As far as ISR and PIP, definitely worth mentioning. SS31 is totally fine, no issues whatsoever. The MOTS on the other hand gives me a little bee sting histamine reaction probably every 2-3 pins. Not really bad, but it has motivated me to pin glutes rather than belly just due to less sensitivity when i get a reaction. The NAD was a little spicy as i injected but no ISR, so so far so good. I reconned that one pretty strong too, at 200mg/mL. I did not want to inject more than 0.5cc when i titrate up to the 100mg dose (started at 50mg today)
