Factor V Leiden Blood Clotting Mutation

[Cajun boy]

I have plans to hop on AAS and blast and cruise at 29 years old. However, I have Factor V Leiden which is a blood mutation, which makes me more prone to clotting than the average person.

I found out about it at 17 when I went septic in a joint, got surgery, and was in the hospital. I clotted when they put a pic line in and that’s when I found out I had the mutation. No clotting issues before that or since. Not on any blood thinners either.

Aside from supplementing Nattokinase and some other preventative clotting supplements like Ubiquinol, Curcumin, what else can I do to keep tabs on my health once I’m on? What indicators should I be wary of specifically?

I can’t go to my doctor about this since I’ll be going the UGL route, so I want to be as informed as possible.

The few doctors that have answered my DMs have said I’d probably be fine but advised against orals and didn’t give me a reason as to why that’s the case.

Anyone else have FVL or is a doctor that could give some insight?

 

[Conmike41]

Looks like you had a provoked dvt post surgery at 17 and they found out about your factor V mutation . As far as I know, AAS don’t affect the coagulation cascade or clotting risk. While they can increase blood viscosity with increased HCT concentration, I don’t believe they inherently increase clotting risk . Most DVT occur in the setting of trauma, immobility and cancer. Having the Favtor V mutation increases the risk of both provoked and unprovoked dvt .

Seems like your off anticoagulants at the moment, likely your docs at the time figured it was secondary to Surgey/trauma and immobility with the factor v mutation contributing

If you were to have an unprovoked dvt in the future, that might warrant lifelong anticoagulation

I think the nattokinase and curcumin are
Good ancillaries to run. Aspirin decreases platelet inhibition, but doesn’t really prevent DVT very well

I would make sure to stay hydrated, get your cardio in as well

 

[codem]

On the orals thing—those docs are probably steering you clear because oral AAS (like dbol, anadrol, winny) are 17-alpha alkylated, meaning they hammer your liver way harder than injectables. Liver stress can crank up production of clotting factors and mess with your coagulation balance, stacking the deck even more with your mutation. Injectables like test, deca, or tren bypass the liver mostly on first pass, so they're "safer" in that sense for thrombophilia risks. Stick to pins, and you'll minimize that extra bullshit.


For keeping tabs without a doc: Get private bloodwork every 4-6 weeks on blast, maybe quarterly on cruise. Key shit to watch:

• Hematocrit and RBC count—gear can spike these, making blood thicker and clot-prone. Aim under 50-52% HCT; if it climbs, donate blood or dial back dose.
• Coagulation panel: PT/INR, aPTT, fibrinogen levels. These show if your clotting's getting wonky.
• D-dimer: Good marker for active clotting; if elevated, hit pause and check for symptoms.
• Estradiol: Since test aromatizes to estrogen, and high E2 amps up thrombotic risk. Keep it in check with an AI if needed.
• Liver enzymes (ALT/AST) just to be sure, even on injectables.

Symptoms to watch like a hawk: Leg swelling/pain (DVT vibes), chest pain/shortness of breath (PE red flag), unusual headaches or vision crap. If anything feels off, don't ignore it—better to ER it than regret.


Your supps sound solid—natto's a beast for fibrinolysis, curcumin and ubiquinol for anti-inflam/antioxidant. I'd toss in low-dose aspirin (81mg daily) for extra anti-platelet action, but start slow and monitor. Stay mega-hydrated, hit cardio to keep circulation popping, and avoid sitting still for hours (flights, long drives—get up and move).

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