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🔥The Official INJ YK-11 thread🔥. GYMnTONIC

Learningtopump said:
I've been wondering about timing to start this, so perfect timing for this thread.
I started a cycle of 125mg test C, 20mg test P (really just to clear out some old stock no other reason) and 15mg NPP for a few weeks now.
I moved from AG to another labs C and noticed a serious change, not sure if it was mental or not but... At the beginning of this week I added in 8mg of tren A subQ every day and will run for 10 weeks leading up to a meet. I'm hesitant to add another compound, but if the brain trust thinks it would be helpful. My calories are a smidge above maintenance, that number is going up every day it seams, I'm dropping weight, eating more and feeling better. 5 days in the gym every week. Slow and steady.
Click to expand...
Are you stating you felt the new labs Testosterone was much stronger than AG?

Thanks bro!!

Sent from my moto g 5G (2022) using Tapatalk
 
So this has an AR receptor leverage between DHT and YK11. Meaning the receptors actually allow YK11 to attach meaning you are going to see similar anabolic and androgenic effects potentially as DHT


This is why were all dropping water, seeing more strength and also seeing striations. Also why tendons dry out and this can put u at higher risk of tendon tears and injury.

So just don't go mega heavy and or explosive w weights. Hydrate well.

Also why we see a positive nitrogen balance which also means you are going to digest proteins more effectively aka turn them into lean muscle faster. Also we will see some fat loss as a result of this mechanism.

Some studies actually call YK11 an actual steroid due to its effects ..it's still SELECTIVE though so it should be still categorized as a sarm.

Doesn't mean the FDA and dea won't go after it eventually.

You know the important drugs..steroids and yk11 are " dangerous"...as fentanyl flows freely and kills hundreds of thousands and they do nothing about it.

Steroids will be decriminalized within a few years. Mark my words.

pubmed.ncbi.nlm.nih.gov

Differential DNA-binding and cofactor recruitment are possible determinants of the synthetic steroid YK11-dependent gene expression by androgen receptor in breast cancer MDA-MB 453 cells - PubMed

Recently, selective androgen receptor modulators (SARMs), which bind to AR and act in a tissue/effect-specific manner, have been developed, but the selective mechanism is not well understood. In this study, we investigated the selective mechanism using the synthetic steroid YK11, which showed...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
 
GYMnTONIC said:
So this has an AR receptor leverage between DHT and YK11. Meaning the receptors actually allow YK11 to attach meaning you are going to see similar anabolic and androgenic effects potentially as DHT


This is why were all dropping water, seeing more strength and also seeing striations. Also why tendons dry out and this can put u at higher risk of tendon tears and injury.

So just don't go mega heavy and or explosive w weights. Hydrate well.

Also why we see a positive nitrogen balance which also means you are going to digest proteins more effectively aka turn them into lean muscle faster. Also we will see some fat loss as a result of this mechanism.

Some studies actually call YK11 an actual steroid due to its effects ..it's still SELECTIVE though so it should be still categorized as a sarm.

Doesn't mean the FDA and dea won't go after it eventually.

You know the important drugs..steroids and yk11 are " dangerous"...as fentanyl flows freely and kills hundreds of thousands and they do nothing about it.

Steroids will be decriminalized within a few years. Mark my words.

pubmed.ncbi.nlm.nih.gov

Differential DNA-binding and cofactor recruitment are possible determinants of the synthetic steroid YK11-dependent gene expression by androgen receptor in breast cancer MDA-MB 453 cells - PubMed

Recently, selective androgen receptor modulators (SARMs), which bind to AR and act in a tissue/effect-specific manner, have been developed, but the selective mechanism is not well understood. In this study, we investigated the selective mechanism using the synthetic steroid YK11, which showed...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
Click to expand...
Don't they say technically tren is a sarm?
 
Chemicalreaction said:
Don't they say technically tren is a sarm?
Click to expand...
I've never heard that before, have you?

Guys here's some more info. Yk11 also works by improving Follistatin expression. It also works by affecting FST.

I'm right here w you guys learning as we go.. by no means am.i am expert on INJ yk11. But we will be by the end 😜


pubmed.ncbi.nlm.nih.gov

Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression - PubMed

The myogenic differentiation of C2C12 myoblast cells is induced by the novel androgen receptor (AR) partial agonist, (17α,20E)-17,20-[(1-methoxyethylidene)bis-(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11), as well as by dihydrotestosterone (DHT). YK11 is a selective...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Only study I have ever seen on injectable yk-11. In monkeys. Close enough for me.

Antagonists of myostatin, a blood-borne negative regulator of muscle growth produced in muscle cells, have shown considerable promise for enhancing muscle mass and strength in rodent studies and could serve as potential therapeutic agents for human muscle diseases. One of the most potent of these agents, follistatin, is both safe and effective in mice, but similar tests have not been performed in nonhuman primates. To assess this important criterion for clinical translation, we tested an alternatively spliced form of human follistatin that affects skeletal muscle but that has only minimal effects on nonmuscle cells. When injected into the quadriceps of cynomolgus macaque monkeys, a follistatin isoform expressed from an adeno-associated virus serotype 1 vector, AAV1-FS344, induced pronounced and durable increases in muscle size and strength

pubmed.ncbi.nlm.nih.gov

Follistatin gene delivery enhances muscle growth and strength in nonhuman primates - PubMed

Antagonists of myostatin, a blood-borne negative regulator of muscle growth produced in muscle cells, have shown considerable promise for enhancing muscle mass and strength in rodent studies and could serve as potential therapeutic agents for human muscle diseases. One of the most potent of...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
 
GYMnTONIC said:
So this has an AR receptor leverage between DHT and YK11. Meaning the receptors actually allow YK11 to attach meaning you are going to see similar anabolic and androgenic effects potentially as DHT


This is why were all dropping water, seeing more strength and also seeing striations. Also why tendons dry out and this can put u at higher risk of tendon tears and injury.

So just don't go mega heavy and or explosive w weights. Hydrate well.

Also why we see a positive nitrogen balance which also means you are going to digest proteins more effectively aka turn them into lean muscle faster. Also we will see some fat loss as a result of this mechanism.

Some studies actually call YK11 an actual steroid due to its effects ..it's still SELECTIVE though so it should be still categorized as a sarm.

Doesn't mean the FDA and dea won't go after it eventually.

You know the important drugs..steroids and yk11 are " dangerous"...as fentanyl flows freely and kills hundreds of thousands and they do nothing about it.

Steroids will be decriminalized within a few years. Mark my words.

pubmed.ncbi.nlm.nih.gov

Differential DNA-binding and cofactor recruitment are possible determinants of the synthetic steroid YK11-dependent gene expression by androgen receptor in breast cancer MDA-MB 453 cells - PubMed

Recently, selective androgen receptor modulators (SARMs), which bind to AR and act in a tissue/effect-specific manner, have been developed, but the selective mechanism is not well understood. In this study, we investigated the selective mechanism using the synthetic steroid YK11, which showed...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
Click to expand...
I've read some great information so far. I have a couple questions

1. It seems the injectable version is great and the oral version sucks?

2. What steroid(s) would you compare YK-11 to if you had to pick? Maybe a combo of compounds if you feel it has characteristics of x and y in these ways, but not these ways.

Sent from my moto g 5G (2022) using Tapatalk
 
CompoundLifts31 said:
Are you stating you felt the new labs Testosterone was much stronger than AG?

Thanks bro!!

Sent from my moto g 5G (2022) using Tapatalk
Click to expand...
Oh no just the opposite!!! LONG READ::::

A while ago I bought a number of vials of Test E form a well known lab, DP cough, cough. I have used their stuff for a number of things and liked the results so when there was a sale I bought a few. Never having used E and hearing some people get varying levels of PIP from E, I covered my bases with a couple vials of test C from AG. The AG came in and I thought I'd give a vial of AG a try before hitting the E to verify PIP levels, since I didn't get any from the other products I used from them, NPP, Prop... Mid way through the vial I did a blood draw for test levels capped at 3000 because I figured based on previous doses I'd be in the 1700-2000 range, WRONG! It was 3000+! When I finished that vial I moved to the E and notices a serious change. The AG is FIRE! I can't wait to need more. I'll be stocking up!
 
Learningtopump said:
Oh no just the opposite!!! LONG READ::::

A while ago I bought a number of vials of Test E form a well known lab, DP cough, cough. I have used their stuff for a number of things and liked the results so when there was a sale I bought a few. Never having used E and hearing some people get varying levels of PIP from E, I covered my bases with a couple vials of test C from AG. The AG came in and I thought I'd give a vial of AG a try before hitting the E to verify PIP levels, since I didn't get any from the other products I used from them, NPP, Prop... Mid way through the vial I did a blood draw for test levels capped at 3000 because I figured based on previous doses I'd be in the 1700-2000 range, WRONG! It was 3000+! When I finished that vial I moved to the E and notices a serious change. The AG is FIRE! I can't wait to need more. I'll be stocking up!
Click to expand...
Ok, I was surprised when I read that because because I've ran a lot of AG's compounds and never had any issues.

At least you had a different test to compare to. That's the glass half full outlook.

Sent from my moto g 5G (2022) using Tapatalk
 
CompoundLifts31 said:
I've read some great information so far. I have a couple questions

1. It seems the injectable version is great and the oral version sucks?

2. What steroid(s) would you compare YK-11 to if you had to pick? Maybe a combo of compounds if you feel it has characteristics of x and y in these ways, but not these ways.

Sent from my moto g 5G (2022) using Tapatalk
Click to expand...
They say oral has decent bio availability but imo it just didn't work well for me. I never mega dosed it though bc its very pricy oral version

2. Thats tough to say. Its kinda like a DHT blended with NPP for me and maybe low dose hgh. If i was mixing those 3 I would probably see a similar result. But that's just me personally. Its odd bc you drop water and add strength and add striations like a DHT say anavar. You gain water retention in the muscles, but not in the rest of the body aka you are fuller and how NPP is kinda like a mild tren, you see hardening of muscles, a tiny bit of oily skin for me, scalp like NPP or deca would and again muscle fullness.

Really tough to put it on paper versus other compounds.

Other guys may not agree with that comparison, but that comes to mind.

It's really a great compound and side effect free overall.

I will say this, I have had to urinate more at night. They say YK-11 doesn't affect prostate, but I don't completely buy that bc I truly think its aggravating it a tiny bit. I will simply go back on my Flomax script. I haven't been using it. Then again I am sensitive and prone to prostate irritation and inflammation so it literally might just be me responding this way?
 
CompoundLifts31 said:
Ok, I was surprised when I read that because because I've ran a lot of AG's compounds and never had any issues.

At least you had a different test to compare to. That's the glass half full outlook.

Sent from my moto g 5G (2022) using Tapatalk
Click to expand...
I'm not sure it's really a complaint, just that it might be overdosed if anything.
 
GYMnTONIC said:
They say oral has decent bio availability but imo it just didn't work well for me. I never mega dosed it though bc its very pricy oral version

2. Thats tough to say. Its kinda like a DHT blended with NPP for me and maybe low dose hgh. If i was mixing those 3 I would probably see a similar result. But that's just me personally. Its odd bc you drop water and add strength and add striations like a DHT say anavar. You gain water retention in the muscles, but not in the rest of the body aka you are fuller and how NPP is kinda like a mild tren, you see hardening of muscles, a tiny bit of oily skin for me, scalp like NPP or deca would and again muscle fullness.

Really tough to put it on paper versus other compounds.

Other guys may not agree with that comparison, but that comes to mind.

It's really a great compound and side effect free overall.

I will say this, I have had to urinate more at night. They say YK-11 doesn't affect prostate, but I don't completely buy that bc I truly think its aggravating it a tiny bit. I will simply go back on my Flomax script. I haven't been using it. Then again I am sensitive and prone to prostate irritation and inflammation so it literally might just be me responding this way?
Click to expand...

Funny you say that about the peeing at night. I’ve noticed that I’m up one more time than usual since starting. Didn’t put it together as it’s been holidays with the family here so just thought it might have been from a slightly different schedule and a later than usual casein shake before bed, but I definitely have noticed the same now that I track timing and all.

Overall, that’s the only thing I notice sides-wise, and I had to really think about it to connect it, so no complaints.


Sent from my iPhone using Tapatalk
 
GYMnTONIC said:
They say oral has decent bio availability but imo it just didn't work well for me. I never mega dosed it though bc its very pricy oral version

2. Thats tough to say. Its kinda like a DHT blended with NPP for me and maybe low dose hgh. If i was mixing those 3 I would probably see a similar result. But that's just me personally. Its odd bc you drop water and add strength and add striations like a DHT say anavar. You gain water retention in the muscles, but not in the rest of the body aka you are fuller and how NPP is kinda like a mild tren, you see hardening of muscles, a tiny bit of oily skin for me, scalp like NPP or deca would and again muscle fullness.

Really tough to put it on paper versus other compounds.

Other guys may not agree with that comparison, but that comes to mind.

It's really a great compound and side effect free overall.

I will say this, I have had to urinate more at night. They say YK-11 doesn't affect prostate, but I don't completely buy that bc I truly think its aggravating it a tiny bit. I will simply go back on my Flomax script. I haven't been using it. Then again I am sensitive and prone to prostate irritation and inflammation so it literally might just be me responding this way?
Click to expand...
Interesting... I've never heard of a compound that is good at adding fullness, but also adds hardness at the same time. I like it!!

Thanks for the review.

Sent from my moto g 5G (2022) using Tapatalk
 
CompoundLifts31 said:
Interesting... I've never heard of a compound that is good at adding fullness, but also adds hardness at the same time. I like it!!

Thanks for the review.

Sent from my moto g 5G (2022) using Tapatalk
Click to expand...
Look at the difference in my picture earlier in the thread night and day difference in just a week
 
Guys if you buy my speed kit to withdraw the yk and front load pins, it works like a charm but you must pull a tiny bit of air into the vial...when u inject use the air to push out all the oil.

You have to squeeze hard. Getting yk11 through a 30 g tip isn't impossible but ur gonna need to squeeze, hold the pressure and give it a solid 10 seconds to get .5mL into the muscle...you don't wanna shoot it in fast anyways. A small gauge shooting lightning fast can cause muscle irritation and PIP.
 
McPriimate said:
Funny you say that about the peeing at night. I’ve noticed that I’m up one more time than usual since starting. Didn’t put it together as it’s been holidays with the family here so just thought it might have been from a slightly different schedule and a later than usual casein shake before bed, but I definitely have noticed the same now that I track timing and all.

Overall, that’s the only thing I notice sides-wise, and I had to really think about it to connect it, so no complaints.


Sent from my iPhone using Tapatalk
Click to expand...
If it gets bad sir I have flomax on the store for sale.... .4mgs Ed before bed is life changing for me.

I haven't needed it in awhile but I'm on it now bc of the last week. Urine stream is weaker too for me which is also a pretty tale tell sign of prostate issue. For me it doesn't take much. Even too much caffeine messes w my prostate.

Funny bc in labs it's not enlarged..it's just very sensitive.

Annoying. But not a deal breaker
 

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