New to TRT – Nipple Pain & Nodule After Lowering Dose (Need Advice)

[BingaDing]

Hey everyone,

I’m new to TRT and could use some guidance. I started at the end of May and have been experimenting with different doses trying to find what works best for me. I also started Reta at the same time.

Stats:

• Starting weight: 309 lbs
• Current weight: 272 lbs
• Height: 6’1”

So far, I’ve lost almost 40 lbs and dropped my A1C back into the normal range (no longer pre-diabetic ). That’s the good part.

Now for the concern — for the past couple of months, I’ve noticed some pain and a small nodule in my right nipple AFTER lowering my TRT dose to see if I could manage E2. I’ve been trying to avoid using an AI since I’ve read mixed things about them, but the nipple soreness has me second-guessing that decision.

Here’s my timeline and bloodwork:

5/23/25 (Natural)

• Total T: 634.8
• Free T: 11.62
• Estradiol: <24

7/21/25 (25mg Test Cyp Daily SubQ, HCG 750iu/week M/W/F)

• Total T: 1323.5
• Free T: 36.9
• E2: 83

9/03/25 (20mg Test Cyp Daily IM, HGH 2iu Daily)

• Total T: 1372.9
• Free T: 34.5
• E2: 98

10/07/25 (Current – 12.5mg Test Cyp Daily SubQ, HGH 2iu Daily)

• Total T: 794.27
• Free T: 16.5
• E2: 54

Like I said, I started noticing the nipple sensitivity after the first trt drop. My wife says she can't see anything but can feel a small bump (not the first time she’s said that ). Essentially, the nipples look the same lol

I’ve been holding off on starting my Aromasin because I’ve read AIs can do more harm than good long term, but I do also have Nolvadex on the way.

Other than the nipple issue, I feel great — libido is strong, joints feel amazing, energy is good, and overall I’m really happy with how I feel. Because of that, I’m keeping my protocol steady on the lower dose until I can get this nipple issue under control, because I felt great at the 1300.

Any advice or feedback from more experienced guys would be really appreciated — I know I’m probably making rookie mistakes as I figure this out.

Thanks in advance!

 

[Fat Mike01]

Take an AI. You talking like its gonna kill you. Being that over weight is gonna kill you. Get your weight under control and take your TRT and AI, or just throw in the towel.
With that latest blood work you posted as far as E2, take .25mg of ADEX day after each injection if you inject twice a week. If you only do once a week than take a half a pill. They come in 1mg pills. That should get you down to in range or high normal of 30

 

[BingaDing]

Take an AI. You talking like its gonna kill you. Being that over weight is gonna kill you. Get your weight under control and take your TRT and AI, or just throw in the towel.
With that latest blood work you posted as far as E2, take .25mg of ADEX day after each injection if you inject twice a week. If you only do once a week than take a half a pill. They come in 1mg pills. That should get you down to in range or high normal of 30

Awesome thanks.

 

[BingaDing]

Take an AI. You talking like its gonna kill you. Being that over weight is gonna kill you. Get your weight under control and take your TRT and AI, or just throw in the towel.
With that latest blood work you posted as far as E2, take .25mg of ADEX day after each injection if you inject twice a week. If you only do once a week than take a half a pill. They come in 1mg pills. That should get you down to in range or high normal of 30

Also you are right. Overthinking something after living unhealthy for years. I appreciate the response and your time.

 

[Fat Mike01]

Also you are right. Overthinking something after living unhealthy for years. I appreciate the response and your time.

You will be just fine brother