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Possible Plaque Reversal?

OlePhart

OlePhart

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Trodusquemine

I searched this term to see if information had already been posted somewhere in the forum and it came up nill.

"Our findings are the first to demonstrate that PTP1B inhibitors could be used in prevention and reversal of atherosclerosis."

Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR−/− mouse model of atherosclerosis - PMC

Cardiovascular disease (CVD) is the most prevalent cause of mortality among patients with type 1 or type 2 diabetes, due to accelerated atherosclerosis. Recent evidence suggests a strong link between atherosclerosis and insulin resistance, due to ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
 
OlePhart said:
Trodusquemine

I searched this term to see if information had already been posted somewhere in the forum and it came up nill.

"Our findings are the first to demonstrate that PTP1B inhibitors could be used in prevention and reversal of atherosclerosis."

Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR−/− mouse model of atherosclerosis - PMC

Cardiovascular disease (CVD) is the most prevalent cause of mortality among patients with type 1 or type 2 diabetes, due to accelerated atherosclerosis. Recent evidence suggests a strong link between atherosclerosis and insulin resistance, due to ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Fascinating. The older I get, the more this stuff becomes relevant. From what I’ve seen there are more medications out there intended to lower plaque building materials (lipids, calcium, etc.) instead of clearing out pre-existing plaque build up.
 
Chuck Atlas said:
Fascinating. The older I get, the more this stuff becomes relevant. From what I’ve seen there are more medications out there intended to lower plaque building materials (lipids, calcium, etc.) instead of clearing out pre-existing plaque build up.
Click to expand...
Unfortunately that old saying "follow the money" is more than likely at the root of it. More money from treatment than remedies.
 
OlePhart said:
Unfortunately that old saying "follow the money" is more than likely at the root of it. More money from treatment than remedies.
Click to expand...
Indeed, this is following the money and let's treat the symptoms like most big pharma drugs.
The drug in question here is "trodusquemine". Apparently, this drug helps with insulin receptor sensitivity for those who are insulin resistant. So, the healthier approach is to cut out sugar and get on an insulin sensitive diet.
Disclaimer: I am not a real doctor; I only play one on TV.
 
Using a statin in a life threatening situation can reduce extreme cholesterol rapidly and modify the existing plaque at the same time so the plaque doesn't become mobile in the bloodstream and cause a heart attack or stroke and kill you. Modifying the plaque refers to the softer portions of the plaque. The remaining plaque is supposedly irreversible. The whole premise of this is that this "Trodusquemine" may be able to actually REVERSE plaque buildup. Get rid of it. That would be a HUGE advancement.
 
OlePhart said:
Using a statin in a life threatening situation can reduce extreme cholesterol rapidly and modify the existing plaque at the same time so the plaque doesn't become mobile in the bloodstream and cause a heart attack or stroke and kill you. Modifying the plaque refers to the softer portions of the plaque. The remaining plaque is supposedly irreversible. The whole premise of this is that this "Trodusquemine" may be able to actually REVERSE plaque buildup. Get rid of it. That would be a HUGE advancement.
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Plaque build up is nothing take lightly. I recently had a heart scan basically an x-ray on the heart, which showed some minor build up. Treating it now, but like you said, the existing plaque is basically static. That’s the scary part.
 
Chuck Atlas said:
Plaque build up is nothing take lightly. I recently had a heart scan basically an x-ray on the heart, which showed some minor build up. Treating it now, but like you said, the existing plaque is basically static. That’s the scary part.
Click to expand...
I hear you man. Been there. Had a stent put in. On the road to, I would say recovery, but, it's more like self education and treatment.

I'll get long winded real easy so I have to catch myself. Basically here for biohacking and efficacy. Learning a lot already in the short time I've been here. As I learn I'm trying to give back as I go for what it's worth.

Thanks to everyone in this forum for a wealth of life changing information. 🙏
 
Correct me if I'm wrong here. Just trying to understand. I watched the video and from what I gather it clears up the cholesterol issue and helps "prevent" plaque buildup, not "reverse" plaque buildup. Thus, it would be beneficial to use instead of statins.
 
OlePhart said:
Correct me if I'm wrong here. Just trying to understand. I watched the video and from what I gather it clears up the cholesterol issue and helps "prevent" plaque buildup, not "reverse" plaque buildup. Thus, it would be beneficial to use instead of statins.
Click to expand...
Ive been on statins since I was 16... and BP meds when I was 20. shitty genetics.
If there was a way to reverse plaque build up. We would all live long ass lifetimes and put
Cardiologists and big pharma out of biz
 
I'm watching the secondary video now. Thanks for that by the way. His emphasis on gut health makes me think of what I've learned about PPI's and how bad they are. What gets me is how you have to really DIG to get to the truth about these compounds that millions of people take DAILY. I'm on 80mg Atorvastatin, 10mg Ezitimibe, Plavix and 81mg low dose Aspirin right now. I absolutely HATE having to take this stuff but it was because of an emergency situation of my own making. I spend a LOT of my time studying in this area now. The video I posted about Dr. Nathan Bryan is really worth a watch. Quite revealing pertaining to a lot of things. I posted it the hopes it would help someone. I quit using PPI's after watching it. Thanks for you guys input it means a lot. 👍
 
Bolan said:
Ive been on statins since I was 16... and BP meds when I was 20. shitty genetics.
If there was a way to reverse plaque build up. We would all live long ass lifetimes and put
Cardiologists and big pharma out of biz
Click to expand...
Familial Hypercholesterolemia? If so, I’ve got the same thing going on. You ever do a cardiac score?
 
From my understanding statins help stabilize plaque. But that hardens the arteries. Which would seem that the heart would have to work harder in the future to move the same amount of blood. When i look at studies on longevity with statin use. It doesn't appear that there is and clear cut info that one is likley to live longer with it's use. 2 cardiologists i have talked to in the past year have said they have seen no studies where people live longer then those that don't use them.
Pine Bark and Gotu Kola have numerous studies showing they can reverse plaque build up to a degree. But there doesn't seem to be any large studies as ther is no monetary reason for companies to do studies as they really can't patent a natural product.
 
OlePhart said:
I'm watching the secondary video now. Thanks for that by the way. His emphasis on gut health makes me think of what I've learned about PPI's and how bad they are. What gets me is how you have to really DIG to get to the truth about these compounds that millions of people take DAILY. I'm on 80mg Atorvastatin, 10mg Ezitimibe, Plavix and 81mg low dose Aspirin right now. I absolutely HATE having to take this stuff but it was because of an emergency situation of my own making. I spend a LOT of my time studying in this area now. The video I posted about Dr. Nathan Bryan is really worth a watch. Quite revealing pertaining to a lot of things. I posted it the hopes it would help someone. I quit using PPI's after watching it. Thanks for you guys input it means a lot. 👍
Click to expand...
PPI's? Proton pump inhibitors?
 
ruffus said:
From my understanding statins help stabilize plaque. But that hardens the arteries. Which would seem that the heart would have to work harder in the future to move the same amount of blood. When i look at studies on longevity with statin use. It doesn't appear that there is and clear cut info that one is likley to live longer with it's use. 2 cardiologists i have talked to in the past year have said they have seen no studies where people live longer then those that don't use them.
Pine Bark and Gotu Kola have numerous studies showing they can reverse plaque build up to a degree. But there doesn't seem to be any large studies as ther is no monetary reason for companies to do studies as they really can't patent a natural product.
Click to expand...
In my case it was a need it right now thing. My LDL was 270 the day the ambulance came and got me in my front yard. BP was 196/134 (thank God for Nitroglycerin). I almost died. So, I'm thankful for the Atorvastatin getting it down to 146 in 3 weeks. Still high but they put me on 10mg Ezitimibe in conjunction to get it closer to 100. I know statins are bad but there are scenarios where it helps. When this gets under control I'm getting off of them and see if my lifestyle changes will be adequate. That's why when I found the study on Trodusquemine I got excited and posted it here. Maybe a light at the end of the tunnel? We'll see.
 
OlePhart said:
Yep. They do some bad things.
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How hard were they to get off of them. I understand it's a very long taper. You have to open up the capsules and remove the beads of meds. I take them once in a while but yes I had read that there bad for you.
 
I just quit cold turkey and got an NO2 supplement. My eating habits are very strict. I think that plays a large role in it. But I don't have GERD, acid reflux, heartburn, whatever you wanna call it anymore.
 
OlePhart said:
In my case it was a need it right now thing. My LDL was 270 the day the ambulance came and got me in my front yard. BP was 196/134 (thank God for Nitroglycerin). I almost died. So, I'm thankful for the Atorvastatin getting it down to 146 in 3 weeks. Still high but they put me on 10mg Ezitimibe in conjunction to get it closer to 100. I know statins are bad but there are scenarios where it helps. When this gets under control I'm getting off of them and see if my lifestyle changes will be adequate. That's why when I found the study on Trodusquemine I got excited and posted it here. Maybe a light at the end of the tunnel? We'll see.
Click to expand...
If there is truly a need for statins i have no issues with them or any other drug. But for the majority that are put on them there is no data that i have seen that it is a benefit in general if longer life is the objective.. My calcium score is high so by default 2 cardiologists wanted put me on a statin. Even though the highest total cholesterol i have ever had was 155 and highest LDL was 95. typically around 140/80 over my life time and 135/75 the previous couple years and those numbers are with no statins. The second cardiologist said that statin would likely not do me any good. But he was required to try to prescribe them as that was standard protocol. My BP, glucose #, diet etc have always been what Dr.s think is ideal. It seems to me that science is a long way from knowing what is actually happening in the body and what to do about it.
 
OlePhart said:
Correct me if I'm wrong here. Just trying to understand. I watched the video and from what I gather it clears up the cholesterol issue and helps "prevent" plaque buildup, not "reverse" plaque buildup. Thus, it would be beneficial to use instead of statins.
Click to expand...
Sadly statins don't actually remove plaque either, they just stop your body from producing cholesterol and coq10, which in my view can just worsen the issue. Cholesterol is like the fire truck trying to put out the fire.

Cholesterol sadly has been demonized for causing plaque build up which is an extremely vague view of everything happening in your body.

I would argue that nattokinase and serrapeptase can actually remove plaque at high doses. It is expensive though. But fuck if it can heal my peyronie's God willing. I'll be a happy man.
 
If you really want the deep scoop on PPI's and NO2 search for Dr. Nathan Bryan here. I already posted it so I won't repost it here. It's kinda lengthy but a TON of surprising information. Surprised me for sure.
 
Battousai said:
Sadly statins don't actually remove plaque either, they just stop your body from producing cholesterol and coq10, which in my view can just worsen the issue. Cholesterol is like the fire truck trying to put out the fire.

Cholesterol sadly has been demonized for causing plaque build up which is an extremely vague view of everything happening in your body.

I would argue that nattokinase can actually remove plaque at high doses. It is expensive though. But fuck if it can heal my peyronie's God willing. I'll be a happy man.
Click to expand...
They actually remove high concentrations of cholesterol from your blood and stabilize the existing plaque, not remove it. I also take a CoQ10 supplement now.
 
Bolan said:
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U actually believe dr berg? Just wondering as he has a ton of videos and if it were truly this simple… i dont think he would be suicidal? Mmm k


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