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I'm not a player I just cry a lot. (Crashed E2) confusing labs.

Zimbobwhey420

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SB Labs
Hello from a new member!

I've searched and haven't found my exact scenario so I thought I'd try throwing this out to the community.

To preface i am on TRT 41yrs old, taking about 80-90mg Enanthate weekly and for the past month 1000iu hcg MWF (3000 per week).

My doctor is useless for guidance and I basically treat him as a source for pharma HCG. I get bloods often. First cycle was at 16yrs old so I've built up a decent knowledge of at least the basics of how things work and what compounds do etc. That being said this I'm still a dumbass and to me this is an incredibly complex lifestyle to me.

So I believe I am a hyper responder because with even low dosages my test levels are always very high. I was off any PEDs for years and decided to hop on TRT 1.5years ago due to age, low drive, libido, etc despite a 495 natural level.

Things started great as they always do but I quickly experienced delayed ejaculation. Great for impressing my new GF but horrible for me actually enjoying the sex. I talked to my doctor about it and he basically said "oh that sucks" and left it at that. I was avoiding taking Ai on the recommended schedule but I took 1/4 Exesin every 9-10 days just to try to keep consistency with my levels.

Well after a long run of the delayed ejaculation I thought maybe it was because I wasn't taking the Ai as prescribed and decided for some reason to take the prescribed amount of Ai which was 1/4 Exesin twice per week. That completely decimated my E2 and the expected side effects came with it like ED.

I once again consulted with my doctor and he essentially said "oh that sucks" and told me it should bounce back in about three weeks without the use of an Ai.

That was months ago now and my estradiol bloods have been below the reference range of 13pg/ml ever since

At the holidays I used a different lab that tested Estradiol and they did an ultrasensitive test which i hadn't done before. This test came back high on their scale at 53pg/mL. So I thought great, I'm back to normal. But I still did not change anything in my protocol and kept the high HCG doses because I wanted one more 'normal' test to confirm I was good and knew if I felt spicy nips I would too high on e2.

I had my last follow up labs on 1/9/26 at my normal place and my estradiol was still reading low <13pg/ml.

My question to the community is what the actual fuck is going on here? ChatGPT and perplexity both say that high on ultrasensitive should translate to the normal estradiol tests but I may have been misunderstanding or asking it the wrong way.

I've read that dbol could help bounce back e2 but I'm not really interested in anything extra. I've tried slightly upping my dose for a few weeks several few months back but I didn't want to over-do it just to get my E2 back but that didn't have any effect.

I got my hands on some bayer 2mg estradiol tabs and took 1/4 a few days ago and plan to take 1/4 e2d then test again after one week (after taking only 1.5mg estradiol) to see if that small amount does anything. I'm just over here fucking around and was hoping for some guidance or at least someone to tell me to just keep taking the estradiol and turn myself into a woman. Thanks.

P.s. I have read that Exesin is too strong for trt purposes so I'll be getting some anastrazole for future purposes.

Labs:
5/7/25
Total T: 1351
Free T: 240.5
SHBG: 40
Estradiol: 33


7/18/25
Hormone Profile
• Testosterone
: 1373.94 ng/dL – Elevated
• Estradiol: <10 pg/mL – Below Reference Range
• Prolactin: 9.39 ng/mL – Within Normal Limits
• Prostate Specific Antigen (PSA, Total): 1.15 ng/mL – Within Normal Limits
Complete Blood Count (CBC)
• White Blood Cells (WBC): 7,930 /mm³ – Normal
• Red Blood Cells (RBC): 5.28 million/mm³ – Normal
• Hemoglobin: 14.7 g/dL – Normal
• Hematocrit: 45.0% – Normal


10/24/25
Testosterone Profile

• Albumin: 4.71 g/dL - Normal Sex Hormone Binding Globulin (SHBG): 35.40 nmol/L - Normal

Total Testosterone: 1266.00 ng/dL

(12.66 ng/mL) - High (Reference for males 21-49 years:

2.40–8.71 ng/mL)

Free Testosterone

(Calculated): 29.60 ng/dL (2.3%) - High

(Reference for males 20-49 years: 5.71–17.84 ng/dL, 1.53–2.88%)

Bioavailable Testosterone (Calculated): 757.00 ng/dL (59.8%)

- High

(Reference for males 20-49 years: 125.65-412.10 ng/dL, 35.0–66.3%)

5. Thyroid Panel:

• FT3: 5.43 pg/mL - High

FT4: 1.17 ng/dL - Normal

TSH: 2.062 uIU/mL - Normal

6. Tumor Markers:

AFP: 7.89 ng/mL - Normal

PSA (Total): 1.58 ng/mL - Normal

7. Hormonal Panel:

Estradiol: <10 pg/mL - Below male reference range

FSH: 0.06 mIU/mL - Low

LH: <0.09 mIU/mL - Low

Prolactin: 7.81 ng/mL - Normal

Homocysteine: 9.43 µmol/L - Normal

8. DHEA-S (Out Lab):

DHEA-S: 139.20 µg/dL - Low (Ref: 139.70-484.40 µg/dL)


12/4/25

(Estradiol only lab)
Hormonal Panel

Estradiol: <10 pg/mL - Low


12/28/25
Total T: 1116

Free T: 213.3

Testosterone Bioavailable: 429.4

SHBG: 28

Estradiol ULTRASENSITIVE: 53

TSH: 1.85


1/9/26
Total T: 1138.73
Estradiol: <13
 
I would stick with ultrasensitive E2. That is mass spec based and much more accurate. The ELCIA antibody based tests are not accurate at all, especially at the low end for a man. Low E2 has other markers. If your joints hurt or are more achy than normal then that is another one. Sexual function is more complex than just E2. Oral estradiol converts 90% to estrone so probably not the best approach.
 
I would stick with ultrasensitive E2. That is mass spec based and much more accurate. The ELCIA antibody based tests are not accurate at all, especially at the low end for a man. Low E2 has other markers. If your joints hurt or are more achy than normal then that is another one. Sexual function is more complex than just E2. Oral estradiol converts 90% to estrone so probably not the best approach.
Thank you for your input! I'll look to find a reliable lab for ultrasensitive e2. I'm in thailand and had the ultrasensitive in the states while visiting family.

I do have joint pain quite often I've grown accustomed to it.

Thanks for the feedback on the oral estradiol. I'll chuck it for now. Only took 1/4 so far.
 
Why such a dose of HCG? That could potentially give issues, I would try to lower to 500iu 2x week. Unless your HCG is for anything else than testicular function, even 250iu 2x week should be enough.
 
Why such a dose of HCG? That could potentially give issues, I would try to lower to 500iu 2x week. Unless your HCG is for anything else than testicular function, even 250iu 2x week should be enough.
I agree it is very high HCG dose. My HCG was at a normal dose about 300 MWF but the crashed estradiol led me to increase it hoping it would bounce back. But that hasn't occurred at least on the normal estradiol tests.
 
I agree it is very high HCG dose. My HCG was at a normal dose about 300 MWF but the crashed estradiol led me to increase it hoping it would bounce back. But that hasn't occurred at least on the normal estradiol tests.
Why HCG in general? Do you plan for more kids or did your doctor randomly prescribe it?
 
Why HCG in general? Do you plan for more kids or did your doctor randomly prescribe it?
Originally I started to keep the door open for kids and also for aesthetic purposes and to try to keep my balls from sucking up into my stomach 😅.

My last cycle years ago I didn't use hcg and had a good experience other than my little raisins. I now have some us pharma 25mg enclomiphene that I bought for pct thinking if I cant fix this I'll come off and restart but I don't want to put myself through that for no reason.

The clinic in the US in bought the enclo from suggested switching from HCG to 25mg enclo 2-3 times per week.
 
SB Labs
I agree it is very high HCG dose. My HCG was at a normal dose about 300 MWF but the crashed estradiol led me to increase it hoping it would bounce back. But that hasn't occurred at least on the normal estradiol tests.
I’m not sure about your issues but I think it would be an idea to lower your HCG and see if that helps.
 
I would lower the HCG to a range that is more typical. But doubt that will do much for low E2.
 
I cant understand how someone can take 3000iu per week of HCG and have low e2, I was taking 250 mwf and had the worst e2 swings are you sure its legit stuff? Dhea will raise e2 levels and its cheap
 
Yea man it is crazy to me too. I would have thought for sure that it would rebound. I'm still confused about having the high reading on ultrasensitive and low on traditional estradiol. I'm getting E2 test again this Friday so we'll see.
My HCG is LG Chem IVF-C.
 

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