• Hello, please REGISTER and become a member of our community! You will then be able to start threads, post comments and send messages to other members. Thanks!

Stimulation of (GH)-insulin-like growth factor by oral administration of mk677

macedog24

Board Rep
Board Rep
Joined
Jan 9, 2013
Messages
14,215
Reaction score
2,270
Points
113
Get Shredded!

Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects.




Chapman IM1, Bach MA, Van Cauter E, Farmer M, Krupa D, Taylor AM, Schilling LM, Cole KY, Skiles EH, Pezzoli SS, Hartman ML, Veldhuis JD, Gormley GJ, Thorner MO.
Author information

1Department of Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA.

Abstract

Aging is associated with declining activity of the GH axis, possibly contributing to adverse body composition changes and increased incidence of cardiovascular disease. The stimulatory effects on the GH-insulin-like growth factor I (IGF-I) axis of orally administered MK-677, a GH-releasing peptide mimetic, were investigated. Thirty-two healthy subjects (15 women and 17 men, aged 64-81 yr) were enrolled in a randomized, double blind, placebo-controlled trial. They received placebo or 2, 10, or 25 mg MK-677, orally, once daily for 2 separate study periods of 14 and 28 days. At baseline and on day 14 of each study period, blood was collected every 20 min for 24 h to measure GH, PRL, and cortisol. Attributes of pulsatile GH release were assessed by 3 independent algorithms. MK-677 administration for 2 weeks increased GH concentrations in a dose-dependent manner, with 25 mg/day increasing mean 24-h GH concentration 97 +/- 23% (mean +/- SE; P < 0.05 vs. baseline). This increase was due to an enhancement of preexisting pulsatile GH secretion. GH pulse height and interpulse nadir concentrations increased significantly without significant changes in the number of pulses. With 25 mg/day MK-677 treatment, mean serum IGF-I concentrations increased into the normal range for young adults (141 +/- 21 microgram/L at baseline, 219 +/- 21 micrograms/L at 2 weeks, and 265 +/- 29 micrograms/L at 4 weeks; P < 0.05). MK-677 produced significant increases in fasting glucose (5.4 +/- 0.3 to 6.8 +/- 0.4 mmol/L at 4 weeks; P < 0.01 vs. baseline) and IGF-binding protein-3. Circulating cortisol concentrations did not change, and PRL concentrations increased 23%, but remained within the normal range. Once daily treatment of older people with oral MK-677 for up to 4 weeks enhanced pulsatile GH release, significantly increased serum GH and IGF-I concentrations, and, at a dose of 25 mg/day, restored serum IGF-I concentrations to those of young adults.


PMID: 8954023 DOI: 10.1210/jcem.81.12.8954023
[Indexed for MEDLINE]

 
Last edited:

REHH

Super Moderator
Staff member
Super Moderator
Joined
Oct 20, 2014
Messages
14,604
Reaction score
5,019
Points
113
So it say that 25mg a day it restored igf and serum gh levels into the normal range. I would think that much would increase to supra levels
 

PartManPartBeast

Registered Member
Joined
Sep 8, 2019
Messages
38
Reaction score
21
Points
8
I love running Mk & hgh together... U literally watch your body transform before your eyes day by day.
 

A.font401

Board Rep
Board Rep
Joined
Jan 2, 2018
Messages
5,013
Reaction score
3,376
Points
113
This is next on my list!


Sent from my iPhone using Tapatalk
 
Top