302
Board Rep
- Joined
- Jan 25, 2023
- Messages
- 6,430
- Reaction score
- 8,991
- Points
- 121
Some education on the effects of aging and endogenous Human Growth Hormone and why you may want to consider supplementing your TRT with exogenous HGH for its many benefits. SB Labs 100iu HGH kits are available w/Bacteriostatic water for easy use.
DM us for a price list
@302
@Astro95
@cdubw44
~~~~~~~~~~~~~~~~~~~~~
SOMATOPAUSE
Sarcopenia, another term for degenerative muscle loss, occurs as we age. It is also well established that levels of secreted GH and circulating IGF-1 gradually decline over one’s lifetime after peaking during puberty. The decline in hormone levels is quite severe, with GH secretion declining by as much as 10-15% every decade after the age of 20. It was suggested many years ago that these senescent changes in body composition and metabolic functions are directly related to the decrease in hormone levels within the GH/IGF axis. The term “somatopause” is used to describe this phenomenon.
THE SOMATOPAUSE HYPOTHESIS PROPOSAL:
Changes in lifestyle and genetic predispositions promote accumulation of body fat with advancing age
This increased fat mass increases FFA availability and thus induces insulin resistance
High insulin levels suppress IGFBP-1 resulting in a relative increase in free IGF-1 levels
Systemic elevations in FFA, insulin, and free IGF-1 suppress pituitary GH release, which further increases fat mass
Endogenous GH is cleared more rapidly in subjects with increased fat mass
As you can see, this is a chicken and egg scenario. We gain body fat as we age, which causes insulin resistance, which suppresses GH secretion, which makes us fatter. It is kind of interesting to see that GH pulse frequency remains essentially intact though. The age related attenuation is actually just a marked reduction in pulse amplitude alongside increased SRIF secretion.
The changes associated with somatopause very
much resemble those seen in younger adults
with clinical growth hormone deficiency (GHD).
Somatopause is not considered a disease state. Examples of some of the changes associated with somatopause include reduced muscle and bone mass, reduced strength, diminished exercise and cardiac capacity, increased body fat (particularly in the visceral region), and cognitive deterioration.
Because of the desire to reverse the many detrimental effects related to aging, there is wide spread speculation that GH administration may help as part of a complete hormone replacement therapy (HRT) program.
DM us for a price list
@302
@Astro95
@cdubw44
~~~~~~~~~~~~~~~~~~~~~
SOMATOPAUSE
Sarcopenia, another term for degenerative muscle loss, occurs as we age. It is also well established that levels of secreted GH and circulating IGF-1 gradually decline over one’s lifetime after peaking during puberty. The decline in hormone levels is quite severe, with GH secretion declining by as much as 10-15% every decade after the age of 20. It was suggested many years ago that these senescent changes in body composition and metabolic functions are directly related to the decrease in hormone levels within the GH/IGF axis. The term “somatopause” is used to describe this phenomenon.
THE SOMATOPAUSE HYPOTHESIS PROPOSAL:
Changes in lifestyle and genetic predispositions promote accumulation of body fat with advancing age
This increased fat mass increases FFA availability and thus induces insulin resistance
High insulin levels suppress IGFBP-1 resulting in a relative increase in free IGF-1 levels
Systemic elevations in FFA, insulin, and free IGF-1 suppress pituitary GH release, which further increases fat mass
Endogenous GH is cleared more rapidly in subjects with increased fat mass
As you can see, this is a chicken and egg scenario. We gain body fat as we age, which causes insulin resistance, which suppresses GH secretion, which makes us fatter. It is kind of interesting to see that GH pulse frequency remains essentially intact though. The age related attenuation is actually just a marked reduction in pulse amplitude alongside increased SRIF secretion.
The changes associated with somatopause very
much resemble those seen in younger adults
with clinical growth hormone deficiency (GHD).
Somatopause is not considered a disease state. Examples of some of the changes associated with somatopause include reduced muscle and bone mass, reduced strength, diminished exercise and cardiac capacity, increased body fat (particularly in the visceral region), and cognitive deterioration.
Because of the desire to reverse the many detrimental effects related to aging, there is wide spread speculation that GH administration may help as part of a complete hormone replacement therapy (HRT) program.
