hGH dose equivalence QD vs EOD

[McPriimate]

Quick question that I can’t find anything on is dose equivalence (or differences) at EOD vs daily. Is, for example, 4iU every other day roughly equivalent to 2iU daily? Or is there a different rule of thumb?

Started hGH a month ago (as did the Mrs) as the plus to our HRT protocols and just wondering what to target for an EOD dose. Plan to pull bloods a bit later this month and then roughly monthly (more to track other stuff, but I’ll have IGF-1 in there as well), so I should get an idea of what EOD does for me, but I was hoping for a rule of thumb so I don’t have to go to every day just to compare. Any thoughts appreciated

Thanks all
McP


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[Bolan]

Quick question that I can’t find anything on is dose equivalence (or differences) at EOD vs daily. Is, for example, 4iU every other day roughly equivalent to 2iU daily? Or is there a different rule of thumb?

Started hGH a month ago (as did the Mrs) as the plus to our HRT protocols and just wondering what to target for an EOD dose. Plan to pull bloods a bit later this month and then roughly monthly (more to track other stuff, but I’ll have IGF-1 in there as well), so I should get an idea of what EOD does for me, but I was hoping for a rule of thumb so I don’t have to go to every day just to compare. Any thoughts appreciated

Thanks all
McP


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Why not just dose it ED?
Pre bed if your older, early AM injects for the large cortisol spike thats highest in the morning hours. For the younger crowd.

 

[Nood]

Just do ED why over think it.

 

[Astro95]

You can’t find an answer because no one is doing what you’re doing. Yes, there’s people pinning eod, but not comparing the differences between the 2. If you’re doing EOD yes double the dose you would take daily. Do you have baseline igf1 scores before starting? Those would be golden in your research.

 

[McPriimate]

Overthinking is a specialty. Mostly curious as it’s our first run with hGH so after reading a good bit of literature I’m looking for the extras that this group of self experimenters might be able to add. Not too many studies on either body building or “longevity” dosing protocols get funded, so it’s back to citizen scientists for the edge cases.

The reason for trying EOD is tenuous but there’s a pediatric study showing EOD spared target tissue desensitization more than ED (doses same iU per week, so double on EOD). Figured since it’s our first run, I’d try it this way so if we just pure hate it we can pop off and be none the worse. I’ll admit it probably doesn’t matter… but easy enough to try it this way first

We do dose at night, as we’re older (mid to not so mid 50’s… don’t tell the wife I said she was over 28 tho) and not trying for max gains but more the health outcomes

My baseline IGF-1 has been mid-150’s (like within a couple points each of I think 4 times now). And that was both on and off sermorelin (300 to 600 mcg per day on two different runs). That stuff was awesome - at lightening my wallet. So, said fuck it and we’re going with the real deal as we can afford it.

Will pull bloods in a couple weeks (for a different reason - to see where I land on 180 test cyp per week, which is the highest I’ve run as I was doing 120-150 as my TRT doses previously - well, except for the first couple weeks on the “200/wk, 1 mg of adex and 25 enclomiphine each TIW” bullshit the first doc put me on - until I switched docs and mostly took into my own hands after realizing how little most docs actually know about TRT/HRT) and will include an IGF-1, so will see what 4iU EOD for about 5 weeks does.

Might then try ED if not in the next 8 weeks then perhaps the 8 weeks after. Will report back if there’s anything to report lol

Thanks y’all. Just trying to figure it out - and prolly trying too hard lol

McP


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[taylercoooper]

Overthinking is a specialty. Mostly curious as it’s our first run with hGH so after reading a good bit of literature I’m looking for the extras that this group of self experimenters might be able to add. Not too many studies on either body building or “longevity” dosing protocols get funded, so it’s back to citizen scientists for the edge cases.

The reason for trying EOD is tenuous but there’s a pediatric study showing EOD spared target tissue desensitization more than ED (doses same iU per week, so double on EOD). Figured since it’s our first run, I’d try it this way so if we just pure hate it we can pop off and be none the worse. I’ll admit it probably doesn’t matter… but easy enough to try it this way first

We do dose at night, as we’re older (mid to not so mid 50’s… don’t tell the wife I said she was over 28 tho) and not trying for max gains but more the health outcomes

My baseline IGF-1 has been mid-150’s (like within a couple points each of I think 4 times now). And that was both on and off sermorelin (300 to 600 mcg per day on two different runs). That stuff was awesome - at lightening my wallet. So, said fuck it and we’re going with the real deal as we can afford it.

Will pull bloods in a couple weeks (for a different reason - to see where I land on 180 test cyp per week, which is the highest I’ve run as I was doing 120-150 as my TRT doses previously - well, except for the first couple weeks on the “200/wk, 1 mg of adex and 25 enclomiphine each TIW” bullshit the first doc put me on - until I switched docs and mostly took into my own hands after realizing how little most docs actually know about TRT/HRT) and will include an IGF-1, so will see what 4iU EOD for about 5 weeks does.

Might then try ED if not in the next 8 weeks then perhaps the 8 weeks after. Will report back if there’s anything to report lol

Thanks y’all. Just trying to figure it out - and prolly trying too hard lol

McP


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Sounds like a thoughtful and well-reasoned approach, especially with the EOD dosing based on receptor sensitivity—very few people even look that deep into the research. It’s smart to ease into it, especially since you're prioritizing long-term health markers over quick gains. Curious to see where your IGF-1 lands after 5 weeks on 4 IU EOD—definitely share the results if you’re up for it.

 

[McPriimate]

Sounds like a thoughtful and well-reasoned approach, especially with the EOD dosing based on receptor sensitivity—very few people even look that deep into the research. It’s smart to ease into it, especially since you're prioritizing long-term health markers over quick gains. Curious to see where your IGF-1 lands after 5 weeks on 4 IU EOD—definitely share the results if you’re up for it.

Thanks - I'm tryin'.

I go for labs tomorrow to see what a stable 180mg/wk of test cyp and 4iu hGH EOD show (I have good baselines, but a couple are testosterone via IA rather than MS, so wanted a more accurate baseline at 180mg - same with E2 (and now also will have all my results from LC/MS and the same lab - Quest - rather than some from LabCorp). Plus, as I plan to try a few different types of compounds over the next year or two, starting with just increasing test a bit, I want a second set of baselines for all the other stuff (it's a long list this time!).

I'm going to try either 2iU or 4iU ED of hGH for a bit to see what that does, with the dose depending on what my IGF-1 looks like currently. If I like where it is, I'll try the 2iU ED and see if it's equivalent (maximize the fat burning from HG while keeping IGF same-ish). If it's lower than I'm targeting, I might up the ED dose. Then take bloods after 6-8 weeks on that protocol and decide whether to go ED or EOD.

Likely overthinking it, but this is more out of curiosity than anything. Just want to know how I respond to different dosing regimens and then can dial in further. At these doses, I'm going to guess it won't matter much to health outcomes, but I'll be curious to see how BG tracks, as well as the IGF-1.

Will post it up when I get the results.

McP

 

[tyzride]

I’ve taken hgh for several years and I do ED. Back in the day some guys said to do only M-F or EOD because it was so expensive. If you can afford it just do ED. The pokes are small needles and in the skin so not a big deal.

 

[McPriimate]

Got most of my test results back. Was surprising/interesting - and sent me on a pubmed expedition lol

IGF-1 after 4iU eod for just under a month was… 159. Exactly the same. It was the second morning after a GH dose. So, was wondering about the kinetics of IGF-1 after exogenous hGH administration and found an interesting paper from 1988 (necro-citing).

It compared 2, 4 and 6iU of ED dosing of GH and looked at IGF-1 levels as the read out. With 2iU subjects maintained a normal diurnal rhythm and levels right after stopping. With 4 and 6, they maintained a steady, elevated IGF-1 level for a time. Conclusion was that 2iU was insufficient to generate a maintained IGF response. So, I’m betting that 4iU EOD (avg of 2 a day, obvs) might not have been either. And testing two mornings after an evening dose, I might have been back to baseline on that diurnal cycle.

One could also interpret it as (or add to the interpretation that) eod dosing maintaining the axis and didn’t suppress endogenous hGH, but that’s admittedly a stretch/conjecture (although it was the reason I tried eod to start with).

So, I’m going to try 4iU ED and test again in a month or so and see if my igf-1 pops - or not. If not, I’ll wonder about the gear, but I suspect that’s not the issue here. While I am still concerned about long term suppression going ED, there are a couple other protocols/tests I might try before picking the final one (including ED for long term, try+ and tapering and then eod as like a pct or weaning and see what happens, should I ever want to stop hGH for some reason). Plan is to stay on indefinitely, as the cost isn’t an issue, but more if supply dries up or if some other reason has me thinking about dropping it.

Anyway, that’s the update I said I’d drop. Make if it what you will - even if it’s nothing lol

McP


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[BBruce]

Thanks for that update. I also just recently started HGH, I’m at 3iu eod. I use it for anti aging so no need for bb dosing. I am sleeping/dreaming better and have been leaning out nicely without changing my diet. About 6 weeks in, for me is no need to dose ED since EOD seem to work fine, for now at least.

If you pull bloods on your ED dosing and it’s a different result pls post.

 

[McPriimate]

Thanks for that update. I also just recently started HGH, I’m at 3iu eod. I use it for anti aging so no need for bb dosing. I am sleeping/dreaming better and have been leaning out nicely without changing my diet. About 6 weeks in, for me is no need to dose ED since EOD seem to work fine, for now at least.

If you pull bloods on your ED dosing and it’s a different result pls post.

Great that it’s working for you so well! Anecdotally, I do notice the sleep is great - seems sounder - and also that the dreams are more vivid. Plus I swear the love handles - my sore spot for fat - are reducing.

I’m not going for BB doses either - also more anti aging and leaning out. Have noticed the latter, but it’s hard to separate from diet, etc. The reason I’m going to try ED for a bit now is to see if it has an effect on IGF-1. Hope so, as that’s a reasonable readout of it working at all. It not, I’ll have to wonder about the gear (but as I said above, I suspect it’s the dosing regimen and when the test was taken, but we’ll get a read on that in a month or two).

The other bit about ed vs eod is that the fat liberation part is a gh function, not an igf-1 function (if I recall the literature correctly), so in theory an ed dosing would work better for fat reduction (in combo with diet and exercise, of course - not on its own) than eod.

In the end, I’m not sure which I’ll use long term. Might be ED if that works better on igf-1 and might be eod if it’s just the feels and the fats It’s all a science experiment at this point, which I admit I kinda love doing

Will post up after next labs

McP


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[Doncoyote]

Your igf levels didn't go up. You sure about the quality of your product? Very suspect based on my experience using gh

 

[McPriimate]

Your igf levels didn't go up. You sure about the quality of your product? Very suspect based on my experience using gh

In short, no. Not sure outside of Pharma sourced how you can be sure. But it’s from a “trusted source” to many (my first run with hGH). I hope it’s just the dosing regimen and not the gear, as I have nearly a year’s worth of it lol. I’m on 4iU QD now so will know soon enough. Should be interesting either way. If igf comes up, that’s interesting physiology. If it doesn’t, then I learned something else. All good - this whole ride is enjoyable and I’m feeling/looking/performing better than ever, so am more than willing to accept the bumps in the road along the way as learn more.


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[taylercoooper]

Thanks - I'm tryin'.

I go for labs tomorrow to see what a stable 180mg/wk of test cyp and 4iu hGH EOD show (I have good baselines, but a couple are testosterone via IA rather than MS, so wanted a more accurate baseline at 180mg - same with E2 (and now also will have all my results from LC/MS and the same lab - Quest - rather than some from LabCorp). Plus, as I plan to try a few different types of compounds over the next year or two, starting with just increasing test a bit, I want a second set of baselines for all the other stuff (it's a long list this time!).

I'm going to try either 2iU or 4iU ED of hGH for a bit to see what that does, with the dose depending on what my IGF-1 looks like currently. If I like where it is, I'll try the 2iU ED and see if it's equivalent (maximize the fat burning from HG while keeping IGF same-ish). If it's lower than I'm targeting, I might up the ED dose. Then take bloods after 6-8 weeks on that protocol and decide whether to go ED or EOD.

Likely overthinking it, but this is more out of curiosity than anything. Just want to know how I respond to different dosing regimens and then can dial in further. At these doses, I'm going to guess it won't matter much to health outcomes,Dive into Aussie games online casino but I'll be curious to see how BG tracks, as well as the IGF-1.

Will post it up when I get the results.

McP

It sounds like you have a well-thought-out plan to monitor how different doses of testosterone and hGH affect your body, especially with detailed labs for accuracy. Tracking IGF-1 and blood glucose over time will definitely give you valuable insight to fine-tune your regimen safely.

 

[McPriimate]

Quick update. Got labs again, now after several weeks of running hGH ED. Dose was 3iU if dosed "as labeled" and ~4.5iU if dosed "as tested" by the lab. My IGF-1 has gone from a very (as in, almost oddly) steady 157-159 over 4 testing cycles (Z-score of 0.3 each time), including the last one dosing EOD with a similar dose and one on sermorelin a while back, to 190 and Z-score of 0.7. So, a modest increase over baseline, EOD and sermorelin, but still an n of one.

I plan to increase the dose to 4-6 iU as labeled for the next couple months (finishing a summer mini-run) and will retest at that point. Will now probably throw direct hGH into the testing cart and track that over time, as well.

I am sending a number of products out for testing in the coming week or two (too much chatter about bunk gear out there not to - although not from any of the sources I've used... just out of an abundance of caution and bottomless curiosity about aas), so will have a comparison to dial in the dosing in terms of iU's, also.

McP

 

[Glycomann]

just for comparison, my baseline IGF-1 was 100. the highest I tested was at age 50 and it was 130. I am in my 60s. I first did 1 iu EOD and it went up to 225. four years later at 2.25 iu EOD I am at 200 - 225. That is very close to the top of the range for my age and that's where I aim. I see better nutritional partitioning, fullness in the muscles, and leaning effect. I can eat more and be leaner, which means I am getting better nutrition into my body. At one point I was missing days and maybe getting in 2-3 pokes a week and I still tested at 190.

I definitely see a fuller look, veins out, effect the day after an inject, sometimes within a couple hours. I am really just using GH for anti-aging and overall well being. I think I am a good responder to GH. As a rule of thumb, on average, 1 iu should increase IGF-1: 50 - 100 ng/mL. Here is a guide by age What are Normal IGF-1 Levels by Age & Gender And How to Test. I am doing ~1.25 iu/d average injected EOD and I get a boost of 100 ng/mL after using it this way for 2 years or more straight.

If your stuff is good you will get numb fingers and carpel tunnel when you increase the dose. If not probably the product is suspect.

 

[McPriimate]

just for comparison, my baseline IGF-1 was 100. the highest I tested was at age 50 and it was 130. I am in my 60s. I first did 1 iu EOD and it went up to 225. four years later at 2.25 iu EOD I am at 200 - 225. That is very close to the top of the range for my age and that's where I aim. I see better nutritional partitioning, fullness in the muscles, and leaning effect. I can eat more and be leaner, which means I am getting better nutrition into my body. At one point I was missing days and maybe getting in 2-3 pokes a week and I still tested at 190.

I definitely see a fuller look, veins out, effect the day after an inject, sometimes within a couple hours. I am really just using GH for anti-aging and overall well being. I think I am a good responder to GH. As a rule of thumb, on average, 1 iu should increase IGF-1: 50 - 100 ng/mL. Here is a guide by age What are Normal IGF-1 Levels by Age & Gender And How to Test. I am doing ~1.25 iu/d average injected EOD and I get a boost of 100 ng/mL after using it this way for 2 years or more straight.

If your stuff is good you will get numb fingers and carpel tunnel when you increase the dose. If not probably the product is suspect.

Super helpful info - thanks! Everyone is different, of course, but it's helpful to see comparison responses for context - especially over a long timeline like yours

Even with the fairly low IGF-1 response, I do "see" a difference (same weight but more vascularity and definitely re-comped a but over the same time). Hard to discern how much is from good diet/training vs TRT vs hGH each/in combo, though

It's as likely I'm a lower responder than you are as it is that the gear is under-dosed or low concentration. But a round of Jano and a couple months at a higher amount will be telling - both about my physiology and the product. I sure hope it's me, as I have a ton of it lol

McP