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Human chorionic gonadotropin (hCG) is a hormone produced by trophoblast tissue, which is found in early embryos and eventually becomes part of the placenta. It plays a crucial role in pregnancy and has various medical applications.
HCG is a glycoprotein composed of two subunits:
Benefits of combining HCG with TRT:
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HCG is a glycoprotein composed of two subunits:
- Alpha subunit: Identical to other glycoprotein hormones like LH, FSH, and TSH
- Beta subunit: Unique to hCG, providing its specific biological activity
- Maintaining the corpus luteum during early pregnancy
- Promoting progesterone production
- Supporting fetal growth and development
- Modulating maternal immune response to prevent rejection of the fetus
- 1920s: Selmar Aschheim and Bernhard Zondek first described hCG and its presence in pregnant women's urine.
- 1930s: Dr. Georgeanna Jones discovered that hCG was produced by the placenta, not the pituitary gland as previously thought.
- 1960s: The development of immunoassays allowed for more accurate hCG detection without using animals.
- 1972: Judith Vaitukaitis and Glenn Braunstein at the National Institutes of Health developed a sensitive hCG assay that could distinguish between hCG and LH, making early pregnancy detection possible.
- 1978: The first home pregnancy test based on hCG detection became available to consumers.
- Qualitative tests: Detect the presence of hCG in urine or blood
- Quantitative tests: Measure exact hCG levels, useful for monitoring early pregnancy progress
- Gestational trophoblastic diseases
- Testicular and ovarian germ cell tumors
- Triggering ovulation in assisted reproductive technologies
- Supporting luteal phase in some fertility protocols
- Stimulating testosterone production in men with certain types of hypogonadism
- Ectopic pregnancy
- Miscarriage
- Multiple gestation
- Gestational trophoblastic disease
- Some female cancers can Elevate hCG levels (False positive Pregnancy Test)
Standalone Treatment:
HCG monotherapy can be used to boost testosterone levels in some men, particularly those with borderline low testosterone. Benefits of HCG monotherapy:- Stimulates natural testosterone production
- Promotes sperm production
- May improve fertility
- Potentially fewer side effects compared to TRT
HCG in Combination with TRT
HCG is often used alongside TRT to mitigate some of the side effects associated with exogenous testosterone use.Benefits of combining HCG with TRT:
- Preserves testicular function: HCG helps maintain testicular size and function by mimicking luteinizing hormone (LH).
- Maintains fertility: HCG can help preserve spermatogenesis in men undergoing TRT by maintaining intratesticular testosterone levels.
- Improves libido and sexual function: Some men report enhanced libido and penile sensitivity when using HCG with TRT.
- Potential cognitive benefits: HCG may contribute to improved cognitive function when used alongside TRT.
- Holistic well-being: The TRT-HCG combination often results in improved mood, energy, and overall vitality
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