CJC 1295 with Drug Affinity Complex
CJC-1295 is a synthetic modification of growth hormone releasing factor (GRF) with D-Ala, Gln, Ala, and Leu substitutions at positions 2, 8, 15, and 27 respectively. These substitutions create a much more stable peptide with the substitution at position 2 to prevent DPP-IV cleavage, position 8 to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, position 15 to enhance bioactivity, and position 27 to prevent methionine oxidation. By applying the Drug Affinity Complex (DAC) technology to GRF, the peptide selectively and covalently binds to circulating albumin after subcutaneous (SC) administration, thus prolonging its half-life. These substitutions are key in increasing the overall half life of CJC-1295 but there lies an even greater reason as to why the half life has been extended from ~7 minutes to greater than 7 days.
CJC-1295 is a Long acting GHRH analog. Growth-hormone-releasing hormone (GHRH), also known as growth-hormone-releasing factor (GRF or GHRF) or somatocrinin, is a 44-amino acid peptide hormone produced in the hypothalamus by the arcuate nucleus. GHRH stimulates growth hormone (GH) secretion from the pituitary. GHRH is released in a pulsatile manner, stimulating pulsatile release of GH respectively. This substance also promotes slow wave sleep. The active portion of this GRF or GHRH peptide can be found as a 29 amino acid long peptide and is appropriately named GHRH1-29. This pulsatile release of various peptides is due to the negative feedback loop that is part of the hGH axis and controls the amount of hGH that your body produces to keep it in a homeostatic environment.
Various experiments have been conducted to test the effectiveness of CJC-1295 in vivo and the Journal of Clinical Endocrinology & Metabolism has reported dose-dependent increases in mean plasma GH concentrations by 2-10 fold for more than 6 days and increased IGF-1 concentrations 1.5-3 fold for 9-11 days after a single injection
So you want to look like the Hulk or maybe you just want to be lean and muscular. So what’s actually stopping you? Genetics… but what exactly is limiting your muscle growth, while at the same time limiting the burning of fat. Quite simply the answer is Myostatin. Myostatin is a direct negative regulator of the amount of skeletal muscle you have and how lean you are. Studies have proven this using mice with the myostatin knock out gene in which they don’t have myostatin to limit muscle growth. These Mighty lean ripped mice are called double muscled and they look like mice on steroids, all without working out. The prized winning Belgian Blue and Piedmontese cattle have mutations of myostatin resulting in double muscling. Mutations in humans have been shown too have the same results.
So what is CJC-1295 and what does it have to do with myostatin you ask… CJC-1295 is a long acting synthetic version of Growth Hormone Releasing Hormone (GHRH). 30mcg/kg to 60mcg/kg doses can increase gh levels up to 10X normal for 6 days or more with plasma IGF-1 concentrations by 3X for 9-11 days. The estimated 1/2 life is 5.8-8.1 days. After multiple doses the mean IGF-1 levels remain above base level for up to 28 days. Results show that 30mcg/kg CJC-1295 is equal to 5iu’s of gh without the normal negative side effects from taking gh. In essence its much better to use CJC-1295 to make your body produce its own gh instead of taking a synthetic gh that also shuts down your normal production. So how does CJC-1295 and Myostatin relate. Growth hormone directly regulates myostatin. As growth hormone rises, myostatin lowers, which unleashes your potential for muscle growth. As myostatin lowers glucocorticoids effect on fat storage and muscle breakdown lowers. CJC-1295 dramatically raises gh levels which will dramatically lower myostatin which in turn will lower the effects of glucocorticoids fat storage and muscle breakdown. Now you know what has changed that has turned the Pro’s into Freaks.
Steroids GH Myostatin Link
Read this study carefully, it will show that raising testosterone to supraphysiological levels increased pulsatile gh secretion. Supraphysiological is the key word here, cause anything less has no effect. Supraphysiological Test Levels increase GH
This study shows that androgens directly increase gh output without estrogen. Androgens directly increase GH
Raising Testosterone levels lowers Growth Hormone Binding Protein. This protein binds up excess gh. Testosterone lowering GHBP if you read the full text you will figure out that it’s the spike in Test levels above normal from the shots that lowers GHBP proving that supraphysiological test levels raise gh and lowers GHBP
As you can see androgens can directly and indirectly raise growth hormone levels resulting in lowering Myostatin which you already learned increases muscle mass. On a side note leptin has a huge role in fat storage and as gh raises, leptin lowers. I won’t delve into discussing leptin cause it can be complicated so do a search to learn more…
Lets go beyond muscle building and fat loss and discuss the well documented anti-aging benefits of growth hormone. Since this info is so plenty full online I’ll only outline the known benefits and let you fulfill you quest for Anti-Aging by doing your own research. The rate of GH secretion from the pituitary gland is at its peak around puberty, declining progressively as we age beyond that point. Around the late 30s and throughout the 40s, GH levels continue to dip considerably, causing the telltale signs of aging to appear. Fat tissue begins to collect in areas where it may have not before, the skin begins to lose thickness, bone mass becomes depleted, energy levels drop, and mental clarity may become clouded.
For the purposes of anti-aging therapy, GH treatment functions to re-stimulate cell production to youthful levels restoring form and function to the entire body, from the inside out. Those who have undergone successful anti-aging treatment with GH or a combination of GH and other diminishing hormones such as testosterone have been reported to experience improvement in the skin’s appearance, renewed energy, mental acuity, invigorated health, enhanced sexual function, an overall sense of well being and a more youthful lean muscled look. Hundreds of studies have been done on the controlled administration of true HGH in adults. It has been shown to raise energy levels, enhance lean muscle development, decrease body fat, strengthen the heart, improve cholesterol and triglyceride levels and HDL/LDL ratios, fortify bones, smooth out skin wrinkles, sharpen memory, improve sexual function, regenerate damaged tissue, strengthen the immune system as well as improve sleep.
Somatotropin (HGH) from the pituitary gland works by stimulating protein production and synthesis in all tissues of the body. This results in an increase in organ healing and regeneration, which is associated with increase resistance to illness and injury.
In the skin, documentation regarding somatotropin (HGH) supplementation has shown increased collagen synthesis, which makes the skin thicker and smoother. In the bone, these studies showed increased bone density. In the internal organs and sex organs, research showed increased size and markedly improved function.
The immune system, research also showed increased immune system regulation and activity, resulting in fewer infectious illnesses. In adults, HGH is necessary for proper repair and regeneration of injured tissues.
One of the widely reported results of somatotropin (HGH) supplementation is the effect it has on the body’s sexual centers. Research shows heightened desire and function in both men and women.
Beginning around the age of 20 years old, our natural production of somatotropin (HGH) begins to decline at the average rate of 14% per decade.
By the age of 40, somatotropin (HGH) production has decreased 30% over our youthful production level, and by the age of 60, by 80% on average. The decline in somatotropin (HGH) correlates with many of the effects of aging including loss of lean body mass (muscle, bone, skin and internal organs), increase in total body fat, thinning and wrinkling of skin, decreased immune function and decreased sexual desire and function.
As a result of the decline in somatotropin (HGH), and because it is the master hormone, other hormones also decline with age, such as Testosterone, Estrogen, Progesterone and DHEA, as well as many other important mood-elevating hormones. Examples of other hormones that also decrease are thyroid and thymus hormones, which can cause menopause in women and andropause in men.
Growth Hormone can:
Restore muscle loss
Increase skin thickness
Reduce total body fat
Improve bone density
People have seen specific improvements from using HGH in:
Skin tightness and moisture
Mental speed and clarity
Enhanced sexual function
Elevated mood and energy levels
Improved aerobic capacity
Significantly greater immune function
Increased wound healing capacity
So, gh therapy sounds great for anti-aging so what’s the catch… The catch is keeping your levels in a physicological level and to not exceed youthful levels. As with any hormone, raising levels above youthful normal levels can cause unwanted side effects which are easily noticed like joint problems, the development of carpel tunnel and excess water weight gain. Its simple, just lower your dose if you notice a problem. There is a huge difference between keeping levels well above normal for years for anti-aging and doing a cycle with gh/cjc-1295 that exceed normal levels. Short term higher levels have much less potitential to cause long term problems… Ok, so you are interested in anti-aging with cjc-1295, what dose should you use. When taking into consideration the studies on it’s outcome of gh production, as little as 1mg weekly is needed and no more then 2mg a week. This makes CJC-1295 extremely cost effective. Vials could be shared with fellow researchers if only 1mg is used weekly. The lab states after reconsituting cjc-1295 it can be refrozen to be used later but is best used without refreezing, so there may be a slight potiency loss by doing this.
Dosing for Muscle Growth
In the studies 30mcg/kg or 60mcg/kg were used resulting in 2-10 fold in gh production. A 200lb man weighs aprox 90kg… thats 200 divided by 2.2 = 90 so thats 30mcg X 90=2700mcg=2.7mg or 60mcg X 90=5400mcg=5.4mg weekly these doses showed safety… I believe a minimum 2mg a week should be used and no more then 6mg… You decided but I say start low and work your way up to the dose you are comfortable with and remember to keep this short term to reach a specific goal and then go on an anti-aging dose between cycles which would also preserve the muscle growth you build during the cycle.
Stop Wasting Your Money On GH
..CJC-1295 Is More Effective
..costs much less
..less side effects because its your natural gh
..doesn’t shut you down
..Increase Natural GH 10X
Storage: Refrigerate… 1yr + storage in the fridge
Reconstituted:After reconstituting with Bacteriostatic Water use within 3-5 day
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