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basskiller's collection of Bodybuilding Peptide Articles

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PEGylated Mechano Growth Factor (MGF)

Quick summary: MGF is a splice variant of the IGF produced by a frame shift if the IGF gene. MGF increase the muscle stem cell count, so that more may fuse and become part of adult muscle cells. This is a process required for adult muscle cells to continue growing.

Why PEGylate MGF?
MGF exhibits local effects in skeletal muscle and without modification is not systemic (can’t travel through the body). The problem with synthetic MGF is that it is introduced IM and is water based so it goes into the blood stream. MGF is not stable in the blood stream for more than a matter of minutes. Biologically produced MGF is made locally and does not enter the bloodstream and is short acting so stability is not an issue. By PEGylating the MGF we can make synthetic MGF injected IM almost as efficient as local produced MGF. Clinically proven Advanced Pegylation, the technology of polyethylene glycol (PEG) conjugation, holds significant promise in maintaining effective plasma concentrations of systemically administered drugs. It does this by surrounding part of the peptide with a unique structure made of polyethylene glycol, which can be attached to a protein molecule. The result of a correct PEGylation is simlar to the protective mechanism of a turtle shell. The polyethylene glycol groups protect the peptide but don’t surround it completely. The active sites of the peptide are still free to do their biological function. In this case the shell is a negative charged shield against positively charged compounds that would affect the protein. This also provides a nice steric chamber for the peptide to reside in. So it’s a happy turtle

Neurological research has shown that utilizing PEGylated MGF resulted in a longer more stable acting version of the MGF peptide in serum/blood.

Bottom line
PEGylation can improve performance and dosing convenience of peptides, proteins, antibodies, oligonucleotides and many small molecules by optimizing pharmacokinetics, increasing bioavailability, and decreasing immunogenicity and dosing frequency. PEGylation also can increase therapeutic efficacy by enabling increased drug concentration, improved biodistribution, and longer dwell time at the site of action. As a result, therapeutic drug concentrations can be achieved with less frequent dosing—a significant benefit to patients who are taking injected drugs.

The PEG itself does not react in the body and is very safe. PEG has been approved by the US Food and Drug Administration (FDA) as a base or vehicle for use in foods and cosmetics and in injectable, topical, rectal and nasal pharmaceutical formulations. PEG has demonstrated little toxicity, is eliminated intact by the kidneys or in the feces and lacks immunogenicity. The risk associated with current PEGylated drugs are due to the way the drug itself acts not the PEG. MGF, as it is being currently sold, is getting a bad rep from people due to the fact they feel that they are not seeing gains from it. Many people believe that the use of MGF in their cycles or protocols just flat out won’t work, however, this is far from the truth.
More MGF information

Complete Overview of MGF or IGF-IEc

From its sequence, MGF is derived from the IGF-I gene by alternative splicing and has different 3′ exons to the liver or systemic type (IGF-IEa). It has a 49 base pair insert in the human, and a 52 base pair insert in rodents, within the E domain of exon 5. This insert results in a reading frame shift, with a different carboxy (C) terminal sequence to that of systemic IGF-IEa. MGF and the other IGF isoforms have the same 5′ exons that encode the IGF-I ligand-binding domain. Processing of pro-peptide yields a mature peptide that is involved in upregulating protein synthesis. However, there is evidence that the carboxy-terminal of the MGF peptide also acts as a separate growth factor. This stimulates division of mononucleated myoblasts or satellite (stem) cells, thereby increasing the number available for local repair

During the early stage of skeletal muscle development, myoblasts (muscle stem cells) fuse to form syncytial myotubes, which become innervated and develop into muscle fibres. Thereafter, mitotic proliferation of nuclei within the muscle fibres ceases. However, during postnatal (after development) growth, additional nuclei are provided by satellite cells (myoblast) fusing with myotubules. Muscle damage-recovery seems to have a similar cellular mechanism, in that satellite cells become activated and fuse with the damaged muscle fibres (reviewed by Goldring et al. 2002). This is also pertinent to certain diseases such as muscular dystrophy in which muscle tissue is not maintained and which have been associated with a deficiency in active satellite (stem) cells (Megeney et al. 1996; Seale & Rudnicki, 2000) and in myogenic factors (Heslop et al. 2000). Skeletal muscle mass and regenerative capacity have also been shown to decline with age (Sadeh, 1988; Carlson et al. 2001). The reduced capacity to regenerate in older muscle seems to be due to the decreased ability to activate satellite cell proliferation (Chakravarthy et al. 2000). The markedly lower expression of MGF in older rat muscles (Owino et al. 2001) and human muscle (Hameed et al. 2003) in response to mechanical overload has been associated with the failure to activate satellite cells, leading to age-related muscle loss (Owino et al. 2001). Your muscle cels can not grow once they have reached a certain size unless they obtain more nuclei from the myoblast. MGF increases the myblast available to donate their nuclei to the adult muscle cell.

“MGF appears to have a dual action in that, like the other IGF-I isoforms, it upregulates protein synthesis as well as activating satellite cells. However, the latter role of MGF is probably more important as most of the mature IGF-I will be derived from IGF-IEa during the second phase of repair. Nevertheless, it has been shown that MGF is a potent inducer of muscle hypertrophy in experiments in which the cDNA of MGF was inserted into a plasmid vector and introduced by intramuscular injection. This resulted in a 20 % increase in the weight of the injected muscle within 2 weeks, and the analyses showed that this was due to an increase in the size of the muscle fibres (Goldspink, 2001). Similar experiments by other groups have also been carried out using a viral construct containing the liver type of IGF-I, which resulted in a 25 % increase in muscle mass, but this took over 4 months to develop (Musaro et al. 2001). Hence, the dual role MGF plays in inducing satellite cell activation as well as protein synthesis suggests it is much more potent than the liver type or IGF-IEa for inducing rapid hypertrophy.”

These results are based on actual transplantation of the DNA coding for the peptides. This is a permanent effect and much more potent than IM injections of the peptide itself. You will not see a 20% increase in muscle mass through IM injections as claimed above.

PEGylated MGF dosing Protocols

The PEGylated version is going to be much longer lasting making a 1-2 dose per week procedure possible. I still think its best used with IGF or AAS to maximize the benefits so here are some sample protocols

Once a week PEG MGF/ IGF
Sunday 100-300 mcg MGF you can choose to site inject if you wish. I think splitting large doses may benefit.
Monday –Fri IGF 50mcg e/d

Twice a week PEG MGF / IGF
Sunday and Wed MGF 50-150 mcg
MT, ThF IGF 50 mcg

These protocols are just to start as this is brand new feel free to tweak them if you like. I will update them after we have done some testing.
 
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Hexarelin

Hexarelin*(HEX) is a peptide GH secretagogue, structurally similar toGHRP-6,* in the growth factor family which stimulates the release of growth hormone (GH).** It can be used medically to treat GH deficiency.**

Background

Although relatively new, Hexarelin is becoming a popular choice as a performance enhancement drug. Hexarelin is currently available from several research companies.

Action

Due to Hexarelin’s ability to increase secretion of natural Growth Hormone, most of its effects are similar to those of synthetic GH, although to a slightly lesser extent.* Effects of its use include:* increase in strength, growth of new muscle fibers, increase in the size of already existing muscle fibers, neural protection, joint rejuvenation, protection and healing.* Also, the GH receptors in adipose (fat) tissue allow for potential fat reduction with Hexarelin use.* The increase of circulating GH through Hexarelin use causes levels of*Insulin-Like Growth Factor (IGF-1) to rise in the liver.* IGF-1 is the prime cause of muscle growth in response to GH stimulation.

There is no appetite boost with Hexarelin use (as opposed to GHRP-6’s extreme appetite increase) due to its inability to drastically increase Ghrelin levels that are responsible for added hunger and quicker gastric emptying.

Technical Data

In studies where Hexarelin was injected subcutaneously, Growth Hormone, measured through plasma concentrations, increased significantly and within thirty minutes of injection.* GH levels decreased back to normal around four hours post injection (1).* The GH increase, has been found to be effective up to 2mg/kg, any further increase in dose was found to be ineffective in causing a GH response (2).

Results showed that Hexarelin’s effect on GH stimulation tapered between weeks 4 through 16.* Separating cycles by 4 week off periods, avoided the negative feedback loop and the next cycle of Hexarelin produced the same level of results as the first cycle (3).

User Notes

I used Hexarelin awhile back, at a dose of about 200mcg/day, and found it to be very good for healing my injuries, burning a bit of fat, and helped me gain a bit of muscle.

I also have a couple of friends who are powerlifters, and they were able to use Hexarelin to heal an old Pec injury and train pain free while on it. My bodybuilder friends (yes, not only do I have friends, but some are actually bodybuilders) have said that 400 mcg/day of Hexarelin gave them similar results to low doses of GH (maybe 1-2 iu/day would be a good equivalent).

Overall, Hexarelin is a good all purpose anabolic. Also,* since we know that IGF and GH use produces a shutdown of your endogenous levels of those hormones, Hexarelin also seems very useful for “GH-PCT” or “IGF-PCT”, as it can help restore your natural levels of those hormones after a cycle of them.
Borrowed from thinksteroids.com
 

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Synergy of GHRH + GHRP

Synergy of GHRH + GHRP


It is well documented and established that the concurrent administration of Growth Hormone Releasing Hormone (GHRH) and a Growth Hormone Releasing Peptide (GHRP-6, GHRP-2 or Hexarelin) results in synergistic release of GH from pituitary stores. In other words if GHRH contributes a GH amount quantified as the number 2 and GHRPs contributed a GH amount quantified as the number 4 the total GH release is not additive (i.e. 2 + 4 = 6). Rather the whole is greater than the sum of the parts such that 2 + 4 = 10.

While the GHRPs (GHRP-6, GHRP-2 and Hexarelin) come in only one half-life form and are capable of generating a GH pulse that lasts a couple of hours re-administration of a GHRP is required to effect additional pulses.

Growth Hormone Releasing Hormone (GHRH) however is currently available in several forms which vary only by their half-lives. Naturally occurring GHRH is either a 40 or 44 amino acid peptide with the bioactive portion residing in the first 29 amino acids. This shortened peptide identical in behavior and half-life to that of GHRH is called Growth Hormone Releasing Factor and is abbreviated as GRF(1-29).

GRF(1-29) is produced and sold as a drug called Sermorelin. It has a short-half life measured in minutes. If you prefer analogies think of this as a Testosterone Suspension (i.e. unestered).

To increase the stability and half-life of GRF(1-29) four amino acid changes where made to its structure. These changes increase the half-life beyond 30 minutes which is more than sufficient to exert a sustained effect which will maximize a GH pulse. This form is often called tetrasubstituted GRF(1-29) (or modified) and unfortunately &. If you prefer analogies think of this as a Testosterone Propionate (i.e. short-estered).

Note that some may also refer to this as CJC-1295 without the DAC (Drug Affinity Complex).

Frequent dosing of either the aforementioned modified GRF(1-29) or regular GRF(1-29)(serimorelin) is required and as previously indicated works synergistically with a GHRP.

In an attempt to create a more convenient long-lasting GHRH, a compound known as CJC-1295 was created. This compound is identical to the aforementioned modified GRF(1-29) with the addition of the amino acid Lysine which links to a non-peptide molecule known as a “Drug Affinity Complex (DAC)”. This complex allows GRF(1-29) to bind to albumin post-injection in plasma and extends its half-life to that of days. If you prefer analogies think of this as a Testosterone Cypionate (i.e. long-estered). However this is not accurate. CJC-1295 results in continual GH bleed. Although natural pulsation still occurs CJC-1295 does nothing to increase those pulses. Instead it raises base levels of GH and creates a more feminized pattern of release. This not desirable.

Modified GRF(1-29)however when combined with a GHRP brings about a substantial pulse which has desirable effects.

Growth Hormone Releasing Peptides (GHRPs) – A Quick Look

What are they?

Growth Hormone Releasing Peptides (GHRPs) are synthetic forms of the natural hormone Ghrelin. These simple short-chained amino acid peptide strings possess most of the positive characteristics of Ghrelin (such as effecting GH secretion) and few of the negative properties (such as Ghrelin’s lipogenic behavior (i.e. conversion of glucose to fatty acids)).

GHRPs belong to a broader class of compounds all of which share the common trait of being able to bind to the Growth Hormone Secretagogue Receptor (GHS-R) and effect GH release. These compounds include the synthetic peptides (GHRP-6, GHRP-1, GHRP-2, Hexarelin, Ipamorelin) and smaller synthetic non-peptide molecular compounds such as MK-0677 as well as the natural ligand Ghrelin. This broad class which includes all of the above but not Growth Hormone Releasing Hormone (GHRH) is termed Growth Hormone Secretagogues (GHSs).

These Growth Hormone Secretagogues (GHSs) exert their effect on increasing GH output in multiple ways.

First they INDIRECTLY increase growth hormone (GH) secretion by inducing Growth Hormone Releasing Hormone (GHRH) release from the hypothalamus in the brain. GHRH once released makes its way to the Growth Hormone Releasing Hormone Receptors (GHRH-R) in cells within the pituitary (a gland just below the brain) where it binds and exerts its direct influence in signaling GH release.

Second these GHS also make there way to those same pituitary cells where they themselves bind to a Growth Hormone Secretagogue Receptor (GHS-R) and exert a DIRECT influence in signaling GH release. This signaling uses a different mode of action distinct from that of GHRH. As a consequence both bound GHRH & bound GHS can exert their positive influence concurrently resulting in synergistic growth hormone (GH) release.

Third they INDIRECTLY increase GH secretion by reducing release of Somatostatin (the GH inhibiting hormone) from the hypothalamus and DIRECTLY by reducing the magnitude of Somatostatin’s inhibiting action once it binds to its receptor on the pituitary cells.

In essence Growth Hormone Secretagogues (GHS) turn up the positive signal to release GHRH, turn down the negative signal to release the inhibiting hormone Somatostatin, speak directly to the growth hormone releasing pituitary cells themselves to encourage them to release GH and speak directly to the growth hormone releasing pituitary cells themselves to encourage them to ignore Somatostatin’s message to stop releasing GH.




Based on the effectiveness of GHRPs smaller non-peptide molecules were created in an effort to mimic the GH releasing effects of GHRPs with the desire to develop a compound with high oral bioavailability. As a result MK-0677 was eventually created as a non-peptide compound with sustained GH release and higher oral bioavailability. Unfortunately desensitization was found to occur fairly rapidly. In addition the dose for the orally administered MK-0677 is measured in several milligrams while the effective dose for the injectable GHRPs is measured in micrograms making GHRPs more cost effective. Research is ongoing on non-peptide GHSs, particularly with Ipamorelin derivatives so perhaps an oral GHS devoid of desensitization will eventually be developed.

My own thought is that these molecular compounds appear to be small enough to be used in a transdermal formula. Also it would be nice to have these orally/transdermally active compounds available to use on a limited basis perhaps making usage when traveling convenient.

author =?







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MK-677 for Dieting

MK-677 for Dieting

In order for a diet – any diet – to work, an organism's expended energy must be greater than its caloric intake. Put simply, you need to eat fewer calories than you're burning. However, being in a hypocaloric state has unwanted consequences, which typically include the loss of hard-earned muscle mass.

However, MK-677, an oral compound that has been proven to increase the body's production of Growth Hormone (GH), can not only help the body hold onto muscle during periods of calorie restriction, but can actually reverse muscle loss (catabolism) under those conditions.

The Merck Company first began developing MK-677 over two decades ago, as a new class of, orally active growth hormone secretagogues. The “MK” - as you may have guessed - stands for Merck (ergo: Merck-677). Secretagogues are substances that cause the body to secrete something, in this case to increase its own natural Growth Hormone release. Here, we find that MK-677 mimics the effects of Growth Hormone Releasing Hormone (GHRH), which in turn causes the body to release GH, and eventually Insulin-like Growth Factor-1. This is beneficial because there's no catastrophic insult to the Growth Hormone/IGF-1 axis or feedback loop.

A study performed in 1998, calorically restricted eight healthy volunteers (ages 24-39 yr) were calorically restricted for two separate 14-day periods. For the first seven days, they simply had their calories restricted. For the second (the last seven days) of each diet period, they received a daily dose of 25mgs of MK-677, or a placebo. Between these 14-day test periods, they had a 14- to 21-day washout interval, of normal eating, after which the groups switched treatments. In other words, the guys received the MK-677 on the first trial, would now get the placebo, and vice-versa. This type of “double-crossover” design is useful to insure that the results are not only accurate, but repeatable.

Over the first week of caloric restriction, the scientists observed and measured the nitrogen (protein) losses in the subjects. The more lost nitrogen one experiences during dieting, the more protein, and consequently, muscle, is forfeit. Beginning with the second week, when half of the subjects received MK-677, those subjects improved their nitrogen balance for the remaining the seven days of treatment – in contrast, the group that received the placebo continued to lose muscle.

The group receiving MK-677 showed higher GH levels than the placebo group, as well as higher levels of Insulin-like Growth Factor-1. Because both GH and IGF-1 are well known to reduce body fat and build muscle, the long term effects of this type of treatment would be unlikely to end with simply allowing dieters (or anyone in a hypocaloric state) to retain muscle, but would most likely allow them to build more muscle and lose more fat.


The bottom line is that 20mgs per day of MK-677 is especially useful for anyone not eating enough calories, as it will certainly prevent muscle loss, perhaps aid in building more muscle, but will also accelerate fat loss as well.
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CJC-1295 Peptide Profile

CJC-1295 Peptide Profile

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CJC-1295 is an injectable peptide used to increase GH production. This peptide is a growth hormone releasing hormone (GHRH) mimetic, or analog. That is to say, it works in the same way as GHRH, and may be referred to as being a GHRH.

The principal use of CJC-1295 is to provide increased GH levels, which also results in increased IGF-1 levels. An increase in these levels can aid fat loss and in some instances can aid muscle gain as well. Generally, a product in the GHRH category, including CJC-1295, is chosen as an alternate to using GH, and only rarely is combined with GH.

The other principal GHRH product is Mod GRF 1-29, which in most instances I recommend over CJC-1295. The products differ in their duration of action. Mod GRF has an approximately-ideal short duration of action allowing pulsatile dosing, whereas CJC-1295 has an extended duration of action which prevents such dosing.

It’s important to avoid confusing CJC-1295 with “CJC-1295 w/o DAC.” The latter is not CJC-1295, but rather is misnamed Mod GRF. When a peptide doesn’t have DAC, it’s not CJC-1295.

CJC 1295 is sometimes marketed as “CJC-1295 with DAC.” This simply is CJC-1295.

When to use CJC-1295

This product is most suited to instances where an individual wishes to inject infrequently and is seeking substantive support for GH production rather than a maximum or near-maximum increase. This is because the flat blood levels it provides do not match up well with pulsatile dosing, which is needed for greatest effect. The steady levels can provide very good support for natural GH pulses, however.

Relatively rarely, adverse side effects associated with excessive GH use, such as pain from nerve compression (such as carpal tunnel pain), excessive water retention, or reduced insulin sensitivity can occur from CJC-1295 use. The cause is stimulation of a greater amount of GH production than is suitable for the individual case. The solution is to discontinue use until the problem is resolved, and to reduce dosage when resuming use.

For ongoing support of GH production, at doses recommended below, CJC-1295 does not need to be cycled.

How to use CJC-1295

CJC 1295 is typically provided in vials containing 2 or 5 mg of lyophylized powder, though the amount can vary. The contents should be reconstituted by adding a convenient amount of sterile or bacteriostatic water. If for example 2 mL is chosen and the dosing of the vial is 2 mg, the resulting solution then has a concentration of 1 mg/mL, or 1000 mcg/mL.
At time of dosing, an insulin syringe is used to draw and then inject the desired amount. In the above example, a 1000 mcg dose would require a volume of 1 mL, or “100 IU” as marked on an insulin syringe.

Injection may be subcutaneous, intramuscular, or intravenous according to personal preference. If desired, peptide solutions from other vials, such as a vial of a GHRP product, may also be drawn into the same syringe, if there is room. This reduces the total number of injections required.

When recommending CJC 1295, I ordinarily recommend a dosage of 1000 mcg at a time, twice per week.

Combined use of CJC-1925 and a GHRP

As with Mod GRF, CJC-1295 use can be combined with use of GHRP, but if using a GHRP, for superior results I recommend combining Mod GRF with it rather than CJC-1295.

The most important reason for this is observed results. The principal cause of it is that the DAC modification results in relatively lower levels of free peptide. In and of itself, this would be a bad thing, but it’s counterbalanced by the lower levels being sustained. However, if creating peaks with a GHRP, it’s more efficient to have higher levels of free GHRH peptide in, so to speak, “lock step” with those peaks. Mod GRF does this, while CJC-1925 does not.

If choosing CJC-1295 anyway to stack with a GHRP, dosing of the CJC-1295 remains as recommended above, while GHRP dosing will be typically 100 mcg at a time, or 50 mcg at a time if using hexarelin.

Pharmacological class of CJC-1295

CJC-1295 is in the class of growth hormone releasing hormone (GHRH) mimetics. GHRH is also the name of the naturally-occurring hormone in the body, but the natural compound is not used in bodybuilding or as a performance-enhancing drug due to its high cost of manufacture and its extremely brief duration of action.. CJC-1295 is a modified version of the first 29 amino acids of GHRH, together with addition of a “Drug Affinity Complex” or DAC. The combination of modifications provides a half life of about 1 week, and steady blood levels after injection.

CJC-1295 amplifies GH production in the same way that GHRH does. Administration does not initiate a pulse of GH release. Because CJC-1295 provides steady blood levels, it increases the amplitude of natural GH pulses on an ongoing basis. It does not combine especially efficiently with a GHRP, because the DAC modification results in relatively lower ongoing levels of free peptide

Conclusion

For maximal effect in increasing GH production, rather than CJC-1295 I recommend Mod GRF 1-29 in combination with a GHRP, but for support of natural GH production CJC-1295 can provide a convenient solution with injection frequency of only twice weekly. Many have been pleased with the results from CJC-1295 use in bodybuilding, performance enhancement, and “quality of life” applications.

by Bill Roberts

I have been reading Bill's work for well over 10 years now and as always.. I learn from him every single time!! ~ basskiller
 
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HGH Fragment it’s fat burning properties in conjunction with Clenbuterol & T3

HGH Fragment it’s fat burning properties in conjunction with Clenbuterol & T3


Growth hormone has many systematic effects, from improved strength, anti-aging effects on skin, tendon strengthening, increased IGF levels, better sleep, to name just a few.. but when Synthetic GH is taken.. most of these effects are minimized, as synthetic GH doesn't imitate the cascade of GH that your pituitary creates, and the effects it has…
So what if you could harness say one aspect of GH specifically lets say.. The profound effect it has on fat loss, and produce a peptide that imitates GH in that regard. Introducing HGH Fragment

Hgh fragment 176-191 is a stabilized analogue of the growth hormone-releasing factor (GRF) that induces Growth Hormone in a specific and physiological manner. To date, studies suggest that HGH Fragment 176-191 has several beneficial features: it reduces abdominal fat in particular visceral fat, without compromising glycemic control (blood glucose), it increases muscle mass and improves the lipid profile, so it looks to have a lot of key benefits.. but does it?
Studies that can be found easily show that at a dosage of 500mcg, HGH Fragment 176-191 was shown to increase lipolytic activity in adipose tissue ,this HGH Fragment potently burns body fat, especially stubborn adipose body fat, and at the same time as it doesn't spike glucose levels, or cause any problems with insulin sensitivity, and improving your lipid profile, this really should be part of any dedicated athletes fat loss regime.
Unlike GH, HGH fragment doesn't induce cell proliferation, it does not induce hyperglycemia or reduce insulin secretion. HGH fragment 176-191 does not compete for the hgh receptor, but of important note.. is the HGH Fragment’s ability to increase IGF-1 levels which translate into the HGH Fragment’s ability to give collateral anti-aging and anabolic effects along with its ability to induce fat loss in the most stubborn body fat (adipose tissue) while increasing energy expenditure and glucose and fat oxidation.

The good news is, your body is burning fat for fuel and energy!! And add to that a whole host of health benefits and everything looks great, However it does seem to cause the thyroid to become sluggish, not as potent as GH, but perhaps through its ability to increase cortisol it still slows the thyroid..
So i suggest that HGH fragment should be stacked.

CLENBUTEROL and T3

Everyone these days has probably heard of both supplements, and the scare mongering that goes along with them, so lets make a few things clear..
I have never seen a report with any evidence showing T3 shuts down your own pituitary, except when it has been abused, extremely large doses for long periods, 200mcg for 6 weeks or more without any proper tapering off the drug.

In the case of Clenbuterol, if it respected, it can give outstanding results in the fat loss department, help aid in preventing muscle loss and it stacks well with T3 and HGH fragment.

Cytomel is the most common brand name for a synthetic thyroid hormone- more specifically, it’s a synthetic version of T3 (triodothyronine ). T3 is not produced directly by your thyroid gland, is actually converted from the T4 thyroid hormone, it has potent fat burning effects, and T3will enhance your body’s ability to synthesize protein, even at very low doses which can actually help add muscle. T3 when used in conjunction with HGH fragment will reduce nitrogen retention, this is a fact, so if your looking to get big and ripped, you need to add in something else, and this is where personally clen is often i feel overlooked.
So you have the potent fat burning of HGH fragment, increased IGF levels, but without nitrogen retention, you will look flat, under perform, and find building any muscle close to impossible.. T3 will increase your ATP, ramp up your metabolism, burn fat.. and decrease your nitrogen levels that should be elevated by HGH fragment.
Clenbuterol a powerful fat burner working on stimulating Beta 2 receptors which helps you to release and then burn stored fat. But interestingly not only is it extremely potent in this regard, but it increases Nitrogen retention.. I'm sure anyone who has taken it has noticed the pumps, and the increased fullness on Clen.

On a side note Clen which should be run for 14 days at a time with 2 weeks break in my opinion should always be taken with at least 500mg of taurine daily, as it depletes taurine in the heart which can increase cardiovascular strain.

Suggested cycle..

Weeks 1-12 500mcg 2x ed HGH fragment.
Day 1-2 25mcg of t3
Day 3-30 50-75mcg of t3 depending on your own preference and tolerance…
Day 31-3 25mcg of T3
Day 34-9 12.5 mcg of t3 ( This should allow for your body to respond to decreased levels of thyroxin and increase its own production accordingly.

Clen should be tapered up by 20mcg every day until desired dose of between 80 – 100 is found
Clen should be ran 2 weeks on 2 weeks off, i don't believe in using ketotifen to reset beta 2 receptors.. the 2 weeks off helps the heart to recover and the body to function.
There is no need to taper off clen.

If dosed accordingly, This cycle can transform your physique and give you the sharp hardened features you desire, but only if your diet and training is on par with these exceptional supplements.

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Effectiveness of CJC-1295 Peptides

Effectiveness of CJC-1295 Peptides

CJC-1295 (Modified GRF 1-29)This 2005 Modified GRF 1-29 Study (referred to as GHRH 1-44) on women who injected the peptide for 90 days (3 months) indicated several key benefits of the peptide such as: an increase in Growth Hormone (GH) and IGF-1 levels; reduction in fat mass (stomach fat) and an increase in athletic physical performance (such as walking and stair climbing) – all of which occurred 100% as a result of simply taking the peptide (they did not do any special physical training or dieting in conjunction with the injections).

A 2004 Study, in men, indicated similar findings after 3 months of Modified GRF 1-29 injections: a 200% increase (doubling) of both GH and IGF-1 levels; an increase in fat free mass (muscle) as well as a reduction in abdominal fat; and an improvement of physical performance, measured by the time it took to walk 30 minutes and to ascend four flights of stairs. Once again these excellent results were achieved by the injections alone, no special diet and weight or cardio training were followed. So you can well imagine the sort of results which could be achieved with the addition of careful dieting and training.
Both studies serve to indicate 5 things:

1. CJC-1295 (Modified GRF 1-29) is anti-aging as it’s a potent increaser of GH and IGF-1 levels which decline with age

2. Results don’t happen overnight and you should take the product for 3 months minimum

3. The peptides are effective on their own (however results would be far superior with diet and exercise)

4. CJC-1295 Peptides are safe and have been used for many years in scientific circles

5. The peptides improve athletic performance, fat loss (particularly stomach fat) and increase muscle mass


CJC-1295 DAC

The following 2006 CJC-1295 DAC Study shows that the peptide is a potent and long-lasting stimulator of GH and IGF-1 levels. After just one injection of the product, GH levels increased by 200-1000% for 6 days and remained higher than normal for up to 1 month in healthy subjects aged 21-61 years
.
While no studies have been undertaken to test for the fat-loss, muscle building and performance enhancing effects of CJC-1295 DAC it would be safe to assume that since it is a potent and long-lasting increaser of Growth Hormone and IGF-1 levels, all of the associated benefits indicated in the CJC-1295 (Modified GRF 1-29) studies would be realized with long term use with the added benefit of fewer injections. Additionally, with the long half-life, there is no concern regarding any potential food interactions which might cause the peptide to be less effective.

CJC-1295 DAC, with its long half-life (i.e. 1-2 weekly injections) is therefore a much more convenient alternative to GRF 1-29 and/or GHRP peptides. Furthermore, feedback from experienced users indicates it is much more effective at achieving the desired results on body composition. Since however no long-term studies have been conducted using CJC-1295 DAC, we recommend never using it for more than 6 months at a time to give your pituitary gland a break from the continual pulses of GH.



Side Effects of CJC-1295 Peptides

CJC-1295 Peptides are generally very well tolerated by most individuals when used at the recommended dosages of 100mcg per injections for Modified GRF 1-29 and 2mg per week for CJC-1295 DAC.

The most common side effect noted is a head “rush” and throbbing of the temples which occurs about 10 minutes post injection and can last up to 20 minutes. The side effect is nothing to be concerned about and is simply caused by a release of GABA in the brain – a good sign the peptide is working to stimulate GH release.

The second most common side effect mentioned is a red lump at the injection site, which is more common with Modified GRF 1-29 but also can occur with CJC-1295 DAC. Similarly this is nothing serious and is simply due to a local histamine reaction in the skin.
It can possibly be combated by taking an anti-histamine a couple of hours prior to the injection. Either way, the red lump will subside within a few days or it can be avoided completely by injecting intramuscularly.

Water retention and increased tiredness are also noticed by some, especially with CJC-1295 DAC usage.
Water retention can be combated by reducing the sodium (salt) levels in your diet.

Both side effects tend to resolve themselves after a few weeks as the body has time to adapt. If these side effects are too bothersome, then you may need to consider only taking Modified GRF 1-29 and injecting only before bed (as morning injections are often the culprit for day-time tiredness).

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Ghrp-2

GHRP-2

CAS:
Formula: C45H55N9O6
Molecular weight: 817.9
Peptide purity: > 98.0%
Appearance: White powder
Related substance: Total Impurities(%) = 2.0%
Acetate content: = 15.0%
Bacterial Endotoxins: =5 IU/mg
Chain-Ala-D-ß-Nal-Ala-Trp-D-Phe-Lys-NH2


Uses

Improve sex drive and desire by stimulation of hypothalamus
Reduces belly fat through lipolysis
Increases energy and vitality
Improves skin elasticity, ridding wrinkles
Increases endurance
Accelerates healing from wounds or surgery
Strengthens the heart
Enhances the immune system
Increases IGF-1 production, by as much as 50% in first week
Improves sleep quality
Increases calcium retention, strengthens and increases the mineralization of bone, bone density
Increases protein synthesis,
Improves eyesight and vision
Reduces liver uptake of glucose, an effect that opposes that of insulin
Promotes liver glucogenesis
Contributes to maintenance and function of pancreatic islets

GHRP2 growth hormone releasing peptide2 therapy is considered one of a few medical means of reversing the effects of aging in adults deficient in growth hormone. This is because of the benefits resulting from the increased stimulation and secretion of human growth hormone by the pituitary gland hypothalamus,axis HPA.

GHRP-2 also known as KP 102 is a commercially synthesized, growth hormone releasing hexapeptide. It is a super-analog of the GHRP-6 which is capable of potent stimulatory effect on growth hormone (GH) secretion with slight stimulator effect in PRL, ACTH and levels of cortisol).

Growth Hormone Releasing Peptide 2(GHRP-2) substantially stimulates the pituitary gland’s increased natural production of the body’s own endogenous human growth hormone (hgH). This therapy consists of daily periodic sub-lingual dosing. Growth Hormone releasing peptide 2, GHRP-2 has shown on it’s own to robustly increase IGF-1 levels, and even greater results occurred when used with Growth Hormone Releasing Hormone (GHRH) to which also stimulates the pituitary gland to produce increased natural secretion of human growth hormone. This also boosts the hypothalamus function as well.

GHRP-2 is a true hgH secretagogue. It stimulates the body’s own secretion of hgH as explained herein. Human Growth hormone has been shown in studies to promote lean body mass and reduce adiposity (fat). GHRP2 has demonstrated that it is very effective at stimulating GH production in research test subjects. It has a short half life with peak concentrations occurring around 15 minutes and not longer than 60 minutes after administration.

Growth hormone releasing peptide is a commercially synthesized, non-natural super-analog of the GHRP-6 which is capable of potent stimulatory effect on growth hormone (GH) secretion with slight stimulator effect in PRL, ACTH and levels of cortisol (Arvat et al. 1997). It is also a synthetic agonist of ghreline that is binding with the growth hormone (GH) secretagogue receptor. GHRP-2 has been shown to affect and induce growth hormone secretion. The response of natural physiologic system includes increase in levels of calcium ion influx alongside with increased release of growth hormones in response to this peptide (Wu et al. 1994). Its chemical structure and other chemical properties are described below:



Furthermore, dose-dependent investigations have proven that this analog is similar in terms of potency with GRF and was even tenfold more potent than earlier generations of GH-releasing secretors such as GHRP-6 and GHRP-1 (Wu et al. 1994). Because of such effects, this hormone has been used for the treatment of different monkey deficiencies and catabolic states. Studies of Laferre et al. (2005) have shown that GHRP-2 acts like ghrelin which induces food intake in monkeys and also stimulates GH secretion. This has been demonstrated when GH levels rose significantly during GHRP-2 infusion (AUC 5550 ± 1090 µg/L/240 min vs. 412 ± 161 µg/L/240 min, p = 0.003). Also, GHRP-2 has shown to be inducing secretion of cAMP in cells in a manner similar to that of GRF. GHRP-2 supplication has also acted as an anti-inflammatory effect in arthritic rats and seems to be mediated by ghrelin receptors directly on immune cells (Granado et al. 2004). However, it is important to note that the level of results with the action of GHRP-2 differs accordingly with species specifically in the response of the pituitary somatotrophs probably because of differences in the subtypes of GHRP receptors (Wu et al. 1996). Its action however in the physiologic system is blocked by GRF receptor antagonist which acts through a different receptor to that employed by earlier GHRPs.
 
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Holy shit this thread along with the picture of syringe is literally what I've been looking for since 8 years

I'm a dumb fuck at Math and everything else


ANABOLIC AMERICA
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30%off by enter promo code: breakbones30
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Ipamorelin

Ipamorelin or NNC 26-0161, a polypeptide hormone, is a growth hormone secretagogue and ghrelin mimetic and analog developed by Novo Nordisk[3]. Ipamorelin belongs to the most recent generation of GHRPs from the mid 1990s and causes significant release of growth hormone by itself, due both to its suppression of somatostatin (an antagonist to GHRH) and stimulation of release of GH from the anterior pituitary, similar to GHRP-2 and GHRP-6 which are compounds from the same class (growth hormone releasing peptides).[1] The cells that produce and release GH are known as somatotropes.[2] Like GHRP-2 and GHRP-6, ipamorelin does not have ghrelin’s lipogenic properties. Like GHRP-2 and unlike GHRP-6 ipamorelin never induces hunger in mammals. Ipamorelin acts synergistically when applied during a native GHRH (growth-hormone releasing hormone) pulse or when coadministered with GHRH or a GHRH analog such as Sermorelin or GRF 1-29 (growth releasing factor, aminos 1-29).[1] The synergy comes both due to the suppression of somatostatin and the fact that ipamorelin increases GH release per-somatotrope, while GHRH increases the number of somatotropes releasing GH.[1,2]

There is also a secondary effect of neuronal excitation in the hypothalamus caused by ipamorelin, which lasts for approximately 3 hours after application, similar to GHRP-2 and GHRP-6.
Ipamorelin has a unique property among the GHRP class of peptides. That property is known as selectiveness. Raun et al demonstrated the selectiveness of ipamorelin for GH release only in a study:

The development and pharmacology of a new potent growth hormone (GH) secretagogue, ipamorelin, is described. Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2), which displays high GH releasing potency and efficacy in vitro and in vivo. As an outcome of a major chemistry programme, ipamorelin was identified within a series of compounds lacking the central dipeptide Ala-Trp of growth hormone-releasing peptide (GHRP)-1. In vitro, ipamorelin released GH from primary rat pituitary cells with a potency and efficacy similar to GHRP-6 (ECs) = 1.3+/-0.4nmol/l and Emax = 85+/-5% vs 2.2+/-0.3nmol/l and 100%).

A pharmacological profiling using GHRP and growth hormone-releasing hormone (GHRH) antagonists clearly demonstrated that ipamorelin, like GHRP-6, stimulates GH release via a GHRP-like receptor. In pentobarbital anaesthetised rats, ipamorelin released GH with a potency and efficacy comparable to GHRP-6 (ED50 = 80+/-42nmol/kg and Emax = 1545+/-250ng GH/ml vs 115+/-36nmol/kg and 1167+/-120ng GH/ml). In conscious swine, ipamorelin released GH with an ED50 = 2.3+/-0.03 nmol/kg and an Emax = 65+/-0.2 ng GH/ml plasma. Again, this was very similar to GHRP-6 (ED50 = 3.9+/-1.4 nmol/kg and Emax = 74+/-7ng GH/ml plasma). GHRP-2 displayed higher potency but lower efficacy (ED50 = 0.6 nmol/kg and Emax = 56+/-6 ng GH/ml plasma). The specificity for GH release was studied in swine.

None of the GH secretagogues tested affected FSH, LH, PRL or TSH plasma levels. Administration of both GHRP-6 and GHRP-2 resulted in increased plasma levels of ACTH and cortisol. Very surprisingly, ipamorelin did not release ACTH or cortisol in levels significantly different from those observed following GHRH stimulation. This lack of effect on ACTH and cortisol plasma levels was evident even at doses more than 200-fold higher than the ED50 for GH release. In conclusion, ipamorelin is the first GHRP-receptor agonist with a selectivity for GH release similar to that displayed by GHRH. The specificity of ipamorelin makes this compound a very interesting candidate for future clinical development.[3]

Whereas GHRP-6 and GHRP-2 cause a release and increase in cortisol and prolactin levels, ipamorelin only selectively releases GH at any dose. Further, a mega-dose of ipamorelin results in a concomitant mega-release of GH (up to the entire amount present in the pituitary), whereas GHRP-2 and GHRP-6 have limits of approximately 1mcg/kg in humans for their maximal GH release.[4,5]

Save on it by using the discount in my signature and you must go click through my banner
 
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Melanotan II and Libido

Melanotan II and Libido

MT-II can consciously be used as an advantage in the libido dept. Good times are right around the corner when used properly. Be aware that dosing too high too soon leads to a bad time. Dose escalation and assessing ones tolerance is crucial. For most users, getting sick and experiencing nausea is not high on the agenda.
To avoid the initial post injection nausea MT-II users carefully assess tolerance. Starting extremely low and escalating the dose is wise.

A 0.25mg dose is very small and for first time users it is advised to dose on a full stomach, an anti-histamine in your system, at around bedtime. This way a user has the odds on their side that they will experience nothing from the injection.
The injection site sometimes itches for a few minutes or can have some discomfort. A seasoned user will not likely encounter any side effects. The ultimate synthetic aphrodisiac experience can be seen with proper planned MT-II use.
When your body can handle and is ready for that 1-2mg dose, 2-4 hours before the encounter…game on!

There are many variables that come into play in regards to PT-141/MT-2/the synthetic aphrodisiac. Variables such as sex (male/female – works for both), timing, dose, stress/mood and expectations all are factors. Depending on your objectives, MT-II can increase one’s libido in a matter of hours or a week or two before realizing the effects. Many times users really don't pay attention or are aware of the libido properties.

Often men will share that their morning wood is something to take note of. Women claim the effects are long lasting, up to 3 days after administration. Others will be kept up at night with desire. Then some can be in sync with their MT-II libido tolerance and plan a aphrodisiac date night to be remembered

You can buy your MTII at a discount . Look to my signature below for the discount and you must click through my signature banner
 
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bodybuilding fat burning Frag 176-191 peptide


Frag 176-191 5MG is a very strong peptide which is basically the abbreviated form of the peptide Fragment 176-191. At TruePeptide this peptide is available in vials of 5MG. Research has shown that there are tremendous effects when these are consumed in doses.

However you must have the physician’s prescription before intake. These are also sold for research purposes. Best quality Fragment 176-191 available at TruePeptide This peptide has seen to have several impacts such as reducing the abdominal fat, increasing the mass of the muscles and so on.

This is why this is a very popular peptide among dieticians and body builders. Multiple doses can be consumed or injected within the body. Scientists and researchers who want to buy this peptide can order their requirements at our online source.

TruePeptide has been trusted for several years by many scientists and doctors. The quality of the peptides coupled with the low prices is one of the best in the market. The main function of Frag 176-191 5MG is to induce the growth hormone in a stable and perpetual manner. It improves the lipid profile and as already said removes abdominal fat but does so without increasing the blood glucose level. Taking these peptides in adequate doses helps to burn body fat potently.

Not only have that, but it also helps in burning down the stubborn adipose tissues. Mainly, this peptide has been seen to be a much safer option for burning body fat rather than its other Human Growth Hormone counterpart. Hence it is highly helpful in the effective treatment of obesity. If you are a medical practitioner or a scientist, you can purchase these items from TruePeptide. So whether you order them in bulk or for a limited amount you will receive them in best quality

. You will have it delivered at your doorstep, whether you live in USA or outside. The shipments are delivered to both national and international customers. TruePeptideis your most trusted online source if you are willing to buy Frag 176-191 5MG or other important peptides. The products we offer are intended for laboratory research use only. In purchasing any of these items, the customer acknowledges that there are risks involved with consumption or distribution of these products.

These chemicals are NOT intended to use as food additives, drugs, cosmetics, household chemicals or other inappropriate applications. The listing of a material on this site does not constitute a license to its use in infringement of any patent. All of the products will be handled only by qualified and properly trained professionals.

All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following: Government regulations regarding the use of and exposure to all products. The health and safety hazards associated with the handling of the products they purchase. The necessity of adequately warning of the health and safety hazards associated with any products -
 
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Estrogen on Cycle: The Good, The Bad, and The Proper Management of Both


The next progression in Estrogen management is the use of Aromatase Inhibitors to control overall Estrogen levels. This has been a huge advancement in the management of estrogen. Aromatase Inhibitors act upon the Aromatase enzyme. This is the enzyme responsible for the conversion of testosterone to estrogen within the body. Aromatase Inhibitors prevent the binding of Aromatase to testosterone so the process of Aromatozation of test to Estrogen cannot take place. This sounds like the ultimate solution to the problem of Estrogen Management on cycle and too a large degree it is. However there are different Aromatase Inhibitors that may make one a more prudent choice than the other for certain situations or individuals. Also the value of Serms and their role in estrogen management cannot be dismissed just yet.

So we see we have 2 categories of compounds that can be of use to us in properly managing Estrogen or its side effects, Serms and AIs. Let''s take a look at our options in categories, their differences and potential interactions with one another, and how they might be used together to accomplish our goal.

First we will look at AIs as in my opinion they are the core of our Estrogen Management program. We essentially have 2 types of AI''s to choose from. Type 1 AIs like Exemestane and Type 2 AI''s such as letrozole or Anastrozole (arimidex). The difference in these types is as follows. A Type 1 AI like Exemestane binds permanently to the site on the Aromatase Enzyme where it binds to testosterone allowing its conversion to Estrogen. This permanent binding renders the Aromatase totally and permanently inactive. In contrast Type 2 AIs temporarily bind to this site on the Aromatase Enzyme rendering it inactive as long as the AI is being used. Onçe use of type 2 AI stops the aromatase will reactivate. So whats the difference in these Ai types for our purposes? Well Due to the '"reactivation" if you will of existing Aromatase with a Type 2 AI, when you stop using it a spike in Estrogen (often referred to as rebound) will occur due to the sudden increase availability of Aromatase Enzyme. Another important distinction when it comes to Type 1 and Type 2 AI''s. A Type 1 AI like Exemestane remains unaffected by the introduction of a serm into your Estrogen management program. Type 2 AIs like letrozole and Arimidex suffer a reduced in blood levels and effectiveness with the introduction of some serms. I will touch more on why we may need to introduce a serm a little farther on in this article.

When it comes to the strength of these AI''s letrozole would be the strongest followed by Arimidex and then by Exemestane. Now people might be up in arms saying Exemestane is stronger than Arimidex however when one looks and compare data from studies done on MALES the order of strength is exactly as I stated it, quite often much confusion comes in to play when people recite data on AI's taken from studies on women. The fact is AI's behave differently in males, they are less effective in males, and for our purposes it is only prudent to compare data gathered from studies on males to portray an accurate picture.

The next aspect to be considered when looking at AIs are the effects they indirectly illicit in other areas. We stated the positive effects of Estrogen, we must realize by lowering Estrogen via Ai use some of these positive effects may be compromised. It is important to look at the various AI options available and possibly use the data to help pick which AI we use. letrozole is an extremely potent AI and its effects demonstrate this as would be expected. letrozole has an adverse effect on lipid profile and somewhat on IGF levels. On the other hand Arimdex has a small impact in the area of IGF and depending upon which studies you cite a small adverse impact on lipids to no adverse impact on lipids. Exemestane seems to have no clinical impact on either IGF or lipids.

It is important to realize that it may seem like Exemestane shines as a clear cut winner when it comes to choice of AI, however I do not necessarily believe this to be the case for everyone. In some cases or maybe better said in some people, an extremely powerful AI like letrozole must be used to manage Estrogen properly. Some may respond better to Arimidex than Exemestane. I believe there is a place for all 3 of these. That being said, if possible my personal first choice of AI is Exemestane due to its lack of interaction with other compounds we may need to introduce such as certain serms, its positive effects on IGF and Lipids over other options, and also its lack of potential "rebound"(although I think that is an overstated issue quite often).

Regardless of which AI you choose for the vast majority of us our goal can be accomplished of maintaining Estrogen levels in the normal range while on cycle. It might seem like the discussion is over. Why do we even need to look at Serms? Read on:

So we have our Estrogen levels managed, all should be good. Well yes in most cases it will be but what if it isn't? What if you start to get sensitive, itchy or painful nipples? What if you get a lump around your nipple area? What if you are so predisposed to gyno you still get symptoms using an AI? It shouldnt happen but if it does your immediate solution should be a serm.

So we know what serms do. As stated above they bind to the Estrogen receptor in breast tissue, preventing Estrogen from eliciting its effects, which in this case is undesired breast development and tissue growth. However all serms are not created equal for this purpose. I am of the opinion that Raloxifene and tamoxifen are the 2 best suited serms for this purpose.

Raloxifene is the serm with the highest binding affinity to the Estrogen receptor in breast tissue. tamoxifen would be second. This means Raloxifene is the most effective serm available for gyno treatment and or prevention. Another point that bears mentioning, when using a Type 2 AI like Arimidex or letrozole, tamoxifen reduces blood levels of both of these AI's. Raloxifene on the other hand has no effect on blood levels of these AI's, allowing them to be run in conjunction with Raloxifene with no decrease in AI effectiveness. As was mentioned above any serm can be run with Exemestane (a Type 1 AI) with no impact on Exemestane's effectiveness.

tamoxifen is the serm with probably the most clinical data supporting its use for gyno prevention and treatment, in all likelihood due to the age of the drug. It is very effective for this purpose and very versatile as it is equally if not more effective in the area of PCT as well, meaning often it is likely on hand so it is readily available for most to use in the case of gyno symptoms.

So let's begin to put this all together. An AI should be the core of your Estrogen management program; the goal should be Estrogen levels in the clinically normal range even while on cycle. Id say between 25-30. I cannot emphasize enough the importance of blood work as a management tool. It really is the only effective means of proper Estrogen management (hormone profile management for that matter).

All AI''s can effectively manage Estrogen. My preference in order for this purpose would be Exemestane , then Arimidex , then letrozole however as stated earlier they all have their place. If Exemestane works well for you you have the luxury of the least amount of undesirable side effects and the most versatility as far as combining with a serm should the need arise for gyno prevention and treatment.

The logical question is why do even need to worry about a serm if I mange Estrogen with an Ai? Well hopefully you don't however in some cases it may become necessary due to predisposition, preexisting gyno , very high dosages of aromatizing steroids and so on. For this purpose Raloxifene is in my opinion the top choice offering no reduction in effectiveness of any AI you are running and the most powerful protection against gyno due to its binding affinity to the E receptor in brest tissue. tamoxifen is also a very solid option especially if running Exemestane as your Ai. If you are running letrozole or arimidex a corresponding increase in the dosage of Ai may be required due to tamoxifen reducing blood levels and effectiveness of these 2 AIs.

Bringng it to theReal World:

1- Manage Estrogen levels with an AI: Exemestane offers the most versatility with fewest adverse effects.
2- Have a Serm on hand in case of Gyno flare up. Raloxifene is most effective and has no adverse interactions with any AIs.

Run a low dose AI with your cycle to try to keep estrogen in the clinically normal range so you can reap the benefits and reduce the deleterious effects. Have a serm on hand just in case gyno rears its head. If it does start a serm immediately. At this point you NEED blood work so you can properly assess your situation and possibly adjust AI dosage up which may allow discontinuation of serm. It may not. You may need to run a serm and AI in conjunction on cycle but it is very unlikely. An Ai should be able to manage Estrogen properly for the vast majority of us. If you do need to run a serm and AI together I cannot emphasize enough that you need to reevaluate your situation. Elevated estrogen has some serious effects as I mentioned above. You should consider this option as I would encourage many too do anyway. Reduce the amount of aromatizing steroids in your cycle and replace them with non-aromatizing compounds. I cannot emphasize this enough. For example a lower test dose will allow for easier estrogen management. This is probably the single biggest thing any of us can do to help ensure proper estrogen management (besides blood work', which again is essential).

One more topic I want to touch on is Gyno. Gyno is considered the worst side effect of elevated estrogen but the fact is it is far from it. There are many much more serious issues going on inside of you if you start growing breasts. That being said when it does occur or start to occur we want to stop it. So often I see people recommend letrozole to treat gyno. This is a horrible idea in my opinion. letrozole works to treat gyno by lowering overall Estrogen levels so much there is no circulating Estrogen to bind to the Estrogen receptor in breast tissue. If you paid attention above you saw the beneficial effects of Estrogen. Some aren't even beneficial, they are essential. I think to eliminate estrogen to this point throughout your entire body is foolish. Introduce a serm such as raloxifene, block the Estrogen receptor in the breast. The gyno then cannot grow. Then again using blood work adjust your AI dose to MANAGE estrogen levels while taking the serm to prevent the continuation of the gyno.

The above is an interesting topic. I hope this info proved useful to some and I would love to discuss it further.

JimiThing
 
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Bodybuilding Peptides: How they work and why would an athlete use them

So what are bodybuilding peptides?

Bodybuilding Peptides are a small chain of amino acids that isn’t quite long enough to be considered a full protein (less than 50 units).

They are, in essence, the building blocks that create protein.

In a supplement form peptides come in different chemical compounds. A few of these used within the sporting community are known as GHRP-2, GHRP-6 and CJC-1295.

IGF, MGF and SARMs are identified as commonly used peptides used in the bodybuilding community.



Why do athletes consider using peptides?

Peptides are used for their anabolic effect on an athlete’s muscle mass. (GHRP means growth hormone releasing hexapeptide, a type of growth hormone releasing hormone).



Bodybuilding peptides can be useful in a couple of ways.

Obviously an athlete will need to heal quickly and be productive soon after an injury. Peptides will help the muscle or soft tissue in this rebuilding healing process.

Supplements that provide an anabolic effect could also be used during pre-season and other periods where building muscle mass is important.

Muscle mass can be built quickly because the athlete can make small tears in a muscle and have it heal on a rapid schedule to continuously repeat the process – the end effect being increased muscle mass and reduced body fat in a shorter timeframe.

The bodybuilding community use peptides that are most effective in this second way as newer peptides don’t come with the side-effects of anabolic steroids.

Some peptides can induce fat loss when used correctly. Weight loss, more importantly, body fat in another key reason for using peptides. Greater weight loss at a faster pace than normally would be seen by exercise alone has been shown by many studies.

It is the links to bodybuilding and gym communities that help pro-athletes find new substances such as peptides to improve performance.

For some time now, the bodybuilding community has been aware of these supplements and the inability for testing to detect them in most cases.

This is especially the case if urine testing is the main form of detection.

Many peptides aren’t yet cleared for human use.

In fact, quickly perusing the peptide Wikipedia page , reveals they are mostly discussed in a scientific manner, not with reference to sports.

However, peptides are readily available on the sporting supplement market and aren’t very expensive.
Now we know what peptides are and what they can be used for.
 

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Clenbuterol increases lean muscle mass but not endurance

Clenbuterol increases lean muscle mass but not endurance

Abstract

Clenbuterol, a beta(2)-agonist with potent anabolic properties, has been shown to improve skeletal muscle function in healthy subjects, and in high doses, promotes cardiac recovery. In a small, randomized controlled study, we investigated the effect of clenbuterol on skeletal muscle function, cardiac function, and exercise capacity in patients with chronic heart failure. Clenbuterol was well tolerated and led to a significant increase in both lean mass and the lean/fat ratio. Maximal strength increased significantly with both clenbuterol (27%) and placebo (14%); however, endurance and exercise duration decreased after clenbuterol. Prior data support combining exercise training with clenbuterol to maximize performance, and on-going studies will evaluate this approach.



[PubMed - indexed for MEDLINE]
 

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MK-677 Restores Muscles, Fountain of Youth?


A daily dose of an investigational medication has been found to restore muscle mass in the arms and legs of older adults and improve some of their biochemistry to levels found in healthy young adults, suggesting an anti-frailty drug has been found.

The drug, called MK-677, was evaluated for its safety and effectiveness in a study that showed the drug restored 20 percent of muscle mass loss associated with normal aging. In fact, levels of growth hormone (GH) and of insulin-like growth factor I (IGF- I) in healthy seniors who took the drug increased to the levels found in healthy young adults, said Michael O. Thorner, a professor of internal medicine and neurosurgery at the University of Virginia Health System.

"Our study opens the door to the possibility of developing treatments that avert the frailty of aging," Thorner said. "The search for anti-frailty medications has become increasingly important because the average American is expected to live into his or her 80s, and most seniors want to stay strong enough to remain independent as they age."

Funded by the National Institutes of Health, the two-year, double-blind, placebo-controlled study involved 65 men and women ranging in age from 60 to 81. The results are detailed in the Nov. 4, 2008, issue of the journal Annals of Internal Medicine.

The drug mimics the action of ghrelin, a peptide that stimulates a growth hormone called secretagogue receptor (GHSR). Drug developers are focusing on GHSR because it plays an important role in the regulation of growth hormone and appetite. They think it may prove to be an excellent treatment target for metabolic disorders such as those related to body weight and body composition.

Drugs found to work in early trials don't always hold up to further testing, however.

The new research was a "proof-of-concept" study that sets the stage for a larger and longer clinical trial to determine whether MK-677 is effective in people who are frail and to assess its long-term safety.
 

BucoBob

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Ghrp 6

GH-releasing hexapeptide (GHRP-6) is a secratogue that stimulates the release of growth hormone (GH) by acting at both hypothalamic and pituitary sites which has been clinically documented in a wide variety of species in vivo and in vitro. GHRP-6 duplicates the way the growth hormone works in the body. In studies it not only has shown to enhance growth hormone levels, but also increased the pulsatile secretory bursts of GH. Another remarkable trait of GHRP-6 is its increase in normal pulsatile physiological secretion by its hypothalamic action. Initial studies with GHRP-6 suggested that this compound acted primarily on the pituitary gland and was absolutely specific for GH release. More recent studies have qualified both of these assumptions. This peptide has been clinically verified to increase GH levels, increase appetite, raise IGF-1 levels, help sleep cycles and more.

The GHRP-6 is enclosed in an antivirus capsule, which essentially the outer capsule of a virus that contains no actual viral DNA or RNA so it is completely safe. The Antivirus used has been engineered to contain special peptides on it that actually act like an adhesive glue to certain cells in your mouth.
These peptides are very important because by adhering to the mucosal cells in your mouth they ensure that the antivirus can inject the GHRP-6 into your cells. The antivirus signals the lipid membrane to open protein channels that actually take the peptide into the cell. Once in the cells the mucosal adhesion peptides are broken off from the peptide we added whether it be IGF, GHRP-6 or whatever. The peptide is now free to be release through the lymphatic system in its biological active form.
This means it is carried throughout the blood stream directly from the cells in your mouth. So there is no sudden spike of GHRP-6 your own cells actually regulate its release. It never reaches any digestive enzymes or acids beyond that of the mucus in your moth which is actually at about the same pH used to store GHRP-6 in acetic acid, so claiming that it’s broken down here is ridiculous.
The transport of the peptide to the lymphatic system is what results in a slower more controlled release of the peptide over time. A recent study has verified that a 24 hr constant iv infusion of GHRP-6 neurophysiologically (via the central nervous system) activated the GH-IGF-1 axis by activating GH secretory burst mass and amplitude by 7 -to 10-fold and increasing the basal (nonpulsitile) GH secretion by 4.5 fold.

For example, significant increases in plasma IGF-1 concentrations were noted after 7 days of GHRP-6 infusion and have even been reported after 7 days of intranasal administration in children and in adults after 7 to 14 days of intranasal hexarelin administration. It is also of interest that long-term administration of hexarelin has been shown to significantly increase circulating GH concentrations as well. The potential clinical utility of these GH secratogues is due to the consistent clinical verification of these findings in individuals of many ages.

Users often administer this product by placing it in a syring and squirting it into the cheeks on the side of the mouth. Users are urged not to do anything to induce excess saliva secretion because this will diminish the absorption rate of the drug by causing a larger portion of it to be flushed down the throat and dissolved by the stomach. Users are instructed not to take this product with food, because this will also greatly hinder the amount of the drug that is actually absorbed by the body. It is also important to note that users shouldn’t brush their teeth or do any kind of mouthwash 30 minutes before or after administration. The basic idea is to keep the mouth as undisturbed and as dry as possible while the hormone has time to seep into the pours on the inner lining of the mouth so that it can be properly absorbed.

unknown

What a great article ! This is why im here ! ! ! Thanks, Bass
 

BucoBob

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BassKiller,
This is Amazing how the articles u have posted "Hit" right on the subject's i've had so many questions for.... for a long time ! My appreciation for all the info is in fact Un repayable ! Thank You so very much as i continue to learn plenty here on this forum... thanks to you ! ! ! BB
 

basskiller

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BassKiller,
This is Amazing how the articles u have posted "Hit" right on the subject's i've had so many questions for.... for a long time ! My appreciation for all the info is in fact Un repayable ! Thank You so very much as i continue to learn plenty here on this forum... thanks to you ! ! ! BB

Thanks, Sorry I've been away.. Dealing with back issues
 

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Myths About Peptides

The purpose of this article is not to promote the recreational use of peptides, rather to debunk with facts some misconceived notions surrounding them. Also, to raise awareness of the mainstream media’s desire to sell newspapers, gain website traffic or viewership by using racy headlines and inflammatory articles, over the need to unbiasedly educate the general populace.


Peptides Are Dangerous And Possibly Deadly – There is NO scientific or even ancillary evidence that supports this assertion. Unfortunately, news organizations get higher readership from headlines such as “Illegal Peptides May Be Fatal” than headlines like “Peptides May Help Millions of People”. In fact, there have been dozens of studies performed worldwide involving peptides and the worst known side effects when ingested by human participants were nausea, flushing, fever, increased libido and intense erections. That doesn’t sound deadly, unless you ‘re a girl on the receiving end of that side effect.


A Woman Died in a Tanning Bed After Using MT-2 – This story is TRUE! Well, sort of… A woman did die in a tanning bed in England and yes authorities found she had Melanotan 2 in her system. However, the autopsy revealed that she died from heart failure linked to obesity. Also, that visit was her third visit in three days to the tanning bed (Sunbed death not linked to banned tanning jabs, n.d.). Melanotan 2 had NOTHING to do with her unfortunate demise; it was merely a coincidence.

As a matter of fact, there was a recorded case (NCBI.nlm.nih.gov, n.d.) of a gentleman ingesting ten to twenty times the amount used in case studies and he did become slightly ill suffering nausea, vomiting and sympathomimetic excess and rhabdomyolysis. He went to the hospital and after an I.V. treatment was released 3 days later. According to the NCBI report, he also tested positive for opiates in his system so determining the cause of illness is impossible. Matter of fact, If you take ten-twenty times the dose of just about any over the counter drug, I imagine you’d experience similar illness or far worse. Take 40 Aspirin and see how your stomach lining fairs.


Peptides Must Be Refrigerated At All Times – Most peptides are sold in a lyophilized state (that is simply a fancy word for freeze dried). In this state, they are presumed stable for up to approximately two years. Once the peptide is reconstituted (that’s a fancy word for mixed with water or a sterile solution of some sort) then the mixture begins to breakdown and it is recommended the peptide be refrigerated to help maintain its chemical structure. It’s said that once refrigerated the peptide will retain its integrity for up to 6 months. Therefor refrigeration is recommended once reconstituted but unnecessary prior.


Mannitol Is Bad Or Is A Sign Of Low Quality Peptides – Not True and not sure how this rumor got started. Perhaps because when ingested in fairly large quantities it may cause diarrhea. Or because of its appearance it’s a popular substance to cut illegal drugs like cocaine. (Sorbitol vs. Mannitol, n.d.)Mannitol is a sugar substitute manufactured from fructose of corn starch and is used only to give the appearance of more substance in a vial. That’s it. I suppose if unscrupulous companies are making fake peptides and using mannitol as a substitute, then that is obviously bad. Most labs however, add it to peptides that are under 5 mg to give them a look of having a little more in the vial, WITHOUT negatively altering the actual amount of the peptide. Otherwise the vial looks so empty some researchers may be under the assumption they have been ripped off. Also, the addition of sucrose or mannitol has been known to help stabilize the peptide (NCBI.gov, n.d.)


They’re Unapproved Or Banned Worldwide – Truth is many peptides have been approved and are currently available by prescription in many countries including Australia, Italy and Switzerland that have recognized their potential for a variety of applications. Other countries including the US have granted Phase III approval (ClinicalTrials.org, n.d.) for testing of many peptides and it would seem it’s only a matter of time before they gain approval.


Peptides Are Not FDA Approved Therefore They Are Unsafe – Well, there is some truth to this, if they’re not FDA approved, then perhaps there is a safety concern involving the use of peptides. Furthermore, and just as important, in the US the ingestion of peptides are illegal due to the fact they are considered drugs and there is still a need for more tests to exam their long term effects on humans. Having said that, consider that most of the supplements in your local big name supplement store are not FDA approved but they’re protected under the Dietary Supplement Health and Education Act of 1994. Therefore millions of Americans ingest products that are NOT FDA approved and seem to gain benefits from such products, myself included. It’s estimated that the supplement business is a 35 billion dollar a year business. Seems as though a lot of people are ingesting things not approved by the FDA and not dropping dead.


Nasal Sprays Are An Alternative Method Of Administering Melanotan 2 – When trying to get a drug approved, it is estimated that about 90% of all drugs don’t make it due to safety risks, side effects, lack of funding, miniscule potential for profitability, etc. Peptides in general are considered to be poor drug candidates for FDA approval due to their low oral bioavailability and their lack of potential profits (Vlieghe, Lisowski, Martinez, & Khrestchatisky, n.d.). Therefore alternative methods of administering the drugs have been explored in hopes of a more acceptable means rather than injecting. In this endeavor, scientist created a nasal spray of Melanotan 2 for this purpose. However, after studies were performed, it was determined that the particles of the peptide were too large to be properly absorbed through the membranes in the nasal passage rendering the drug ineffectual. Also, due to the method of ingestion, increased blood pressure and heart rate was observed in most candidates. This was not the case with candidates from the injected trials. Therefor the nasal sprays have been abandoned and sites selling them online should be avoided

Article by... not me
 

Makura

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Great info in this thread. Thanks. I ordered my peptides and this is my first time taking them. I'm 130 pound female and looking to lean out. I lift consistently and have for many years. Can you help me lay out the best dosages and time of day, frequency, etc. to take the following:

Cjc no dac
ghrp2
ipamorelim
Fragment

Do you prefer sub q or im injections?

Thanks for any help.
 

Makura

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Thank you. How would you fit the Fragment in the above mentioned cycle?
 

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Re: Pt 141

I am interested in some, ah, research with PT141, however in one particular case the, ah, lab rat has an established situation where any type of injection use is simply not an option.

My query in that regard is whether or not application via a 99.9% DMSO solution diluted down to 70% with distilled water and mixed with the prescribed amount of reconstituted PT141 would work?

I had been told that, contrary to information that DMSO carries ANYTHING across the skin barrier, that in fact DMSO only effectively transports small molecule substances across the skin barrier. And that the "approximate" size limit is 1000 g/mol. And, to make matters more interesting, the molecular size/weight of PT141 is something like 1025 g/ mol (!!!).

Basskiller, as you seem to be an obvious in-house peptide expert, do you have any information or thoughts in that regard?

Also (and this is a question that seems to have no answer by anyone, even the few manufacturers that I have contacted)... Once a peptide has been reconstituted (via BAC water) and has been refrigerated but then cannot be used for several weeks, can it be frozen in its liquid reconstituted state for a few months without loss of potency?

Thanks for any info / thoughts.
 

basskiller

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I am interested in some, ah, research with PT141, however in one particular case the, ah, lab rat has an established situation where any type of injection use is simply not an option.

My query in that regard is whether or not application via a 99.9% DMSO solution diluted down to 70% with distilled water and mixed with the prescribed amount of reconstituted PT141 would work?

I had been told that, contrary to information that DMSO carries ANYTHING across the skin barrier, that in fact DMSO only effectively transports small molecule substances across the skin barrier. And that the "approximate" size limit is 1000 g/mol. And, to make matters more interesting, the molecular size/weight of PT141 is something like 1025 g/ mol (!!!).

Basskiller, as you seem to be an obvious in-house peptide expert, do you have any information or thoughts in that regard?

Also (and this is a question that seems to have no answer by anyone, even the few manufacturers that I have contacted)... Once a peptide has been reconstituted (via BAC water) and has been refrigerated but then cannot be used for several weeks, can it be frozen in its liquid reconstituted state for a few months without loss of potency?

Thanks for any info / thoughts.

Can you post a link to that study? Because there are many out there in different journal sites such as http://www.ncbi.nlm.nih.gov that make claims just the opposite. One I just read about a man injecting way more than anyone should (6 times more) where it had an extreme averse effect. So if no injection was worth while, then that should have never happened to the man. The thing about studies, you can't really just go on one and assume a blanket effect.

As for the dsmo.. I'm not clear as to which side of the fence your on with your question
It could just be me and the way I'm reading it.. but reread your explanation and see if it's not as if your attempting to say one thing but it's coming across as both ways in the same sentance

While I do have some knowledge in transdermals, it is limited. And quite frankly as far as peptides are concerned, even less. I've just never thought of using transdermally. So I never thought about it.

Transdermals can help cross the skin barrier and size of molecule is a definite factor. But as far as any specifics.. I'm just not sure.
I do think it would make for a great discussion though and thank you for bringing it up.. something new to research. So I would suggest that we both try and research this more and revisit this

Lastly people have discussed the freezing of peptides after. In my eyes I've seen no company stand behind doing this. I really don't see a need for it.
 

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Hello, I am very new to the forums so forgive me if this is a dumb question.

I'm an athlete, never done a cycle before, however my main goals are strength and recovery. I'm considering skipping AAS and just going with peptides. I realize that the progress will be slower however the decreased sides, short detection times, and healing/joint benefits of peptides appeal to me.

Anyways I saw earlier in the thread you mentioned that they are usually not detected in urine drug tests. What exactly is the process of detecting peptides? I found this http://www.ncbi.nlm.nih.gov/pubmed/21298258 and honestly some of it is over my head. Does this mean that they will be testing for metabolites instead of the actual substance? And does this study say that after 20 hours I will no longer have the metabolites that they are testing for? If I was using peptides and wanted to be safe how long would you suggest I stop use before a drug test.

I would be tested by USADA however I would know when the test was.
 
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