Winstrol and Collagen Synthesis

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  1. #1
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    Winstrol and Collagen Synthesis

    Stimulation of Collagen Synthesis by the Anabolic Steroid Stanozolol

    There is evidence that anabolic steroids, which are derived from testosterone and have markedly less androgenic activity, promote tissue growth and enhance tissue repair; however, the mechanisms involved in their anabolic activities remain unclear. In this report, we measured the effect of the anabolic steroid stanozolol on cell replication and
    collagen synthesis in cultures of adult human dermal fibroblasts. Stanozolol (0.6255 μg per ml) had no effect on fibroblast replication and cell viability (p = 0.764) but enhanced collagen synthesis (p < 0.01) in a dose-dependent manner (r = 0.907). Stanozolol also increased (by 2-fold) the mRNA levels of α1(I) and α1(III) procollagen and, to a similar extent, upregulated transforming growth factor-β1 (TGF-β1) mRNA and peptide levels (p < 0.001). There was no stimulation of collagen synthesis by testosterone. The stimulatory effects of stanozolol on collagen synthesis were blocked by a TGF-β1 anti-sense oligonucleotide, by antibodies to TGF-β, and in dermal fibroblast cultures derived from TGF-β 1 knockout mice. We conclude that collagen synthesis is increased by the anabolic steroid stanozolol and that, for the most part, this effect is due to TGF-β1. These findings point to a novel mechanism of action of anabolic steroids.

    https://www.sciencedirect.com/scienc...22202X15403409


    You can't strengthen the weak by weakening the strong

  2. #2
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    MMMM, thinking I know why deca/winny/test is so popular...
    You can't strengthen the weak by weakening the strong

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    Meanwhile, winstrol dries out my elbows and makes it feel like I have glass inside when lifting. Go figure?

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    Quote Originally Posted by Augustine5I View Post
    Meanwhile, winstrol dries out my elbows and makes it feel like I have glass inside when lifting. Go figure?
    Me too bro. Maybe it's an age thing w/winny. I used to love that shit after doing a massive bulker- we would do var, winny and a smidge of test and cut up like crazy- veins everywhere. But i did some oral winny about a year ago and my shoulders,wrists, elbows ALL started killing me. BUT- only when I was lifting. And stopped almost immediately after quitting the winny. Shit I was even doing deca and still felt like someone was sticking me w/ a pin. Weird

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    I get it, its counterintuitive. Its why I posted it! Personally if I run 400 deca with winny no whinning from joints, I'm 51. Ran winny 4 mos ago.
    BUT everyone is different. I just don't do winny tren w/out some deca, never tried less than 200 mg weekly.
    You can't strengthen the weak by weakening the strong

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    Quote Originally Posted by Augustine5I View Post
    Meanwhile, winstrol dries out my elbows and makes it feel like I have glass inside when lifting. Go figure?
    At 58 I will never use winny again. Even with deca it buggered up my shoulders so bad I needed 3 months off. I feel much better now 😀

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    Quote Originally Posted by RoyKeane View Post
    At 58 I will never use winny again. Even with deca it buggered up my shoulders so bad I needed 3 months off. I feel much better now
    Same here... 52 and my shoulder and elbow got jacked up while on winny. I got the same affect on T-bol... Never using either again.


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    Quote Originally Posted by Bdawg View Post
    Same here... 52 and my shoulder and elbow got jacked up while on winny. I got the same affect on T-bol... Never using either again.


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    Winny turns my joints into full blown rust, it's God awful.

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