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Bromergon - 2.5mg/tab 30tabs/box
Supplier: Pharmacia&Upiohn
Chemical Name: Bromocriptini mesylas
Comes In: 30 tabs/box
Dosage: 2.5-7.5 mg/week
Active time: 10-14 days
Class:anti-prolactin
Bromocriptine was first used in the 1970's for treatment of Parkinson's, and to suppress HGH when high dosages were used. Since the late 80's its been used off label for cocaine withdrawal; in addition, in 2009, it was approved by the FDA for treatment of type 2 diabetes for its effect at improving glycemic control. Many of its uses involve how bromo is related to dopamine increasing effects.
How it Works
Bromocriptine mesylate is a dopamine agonist. It activates dopamine receptors in the absence of that receptor's physiological ligand, the neurotransmitter dopamine. Essentially, it will forcefully increase dopamine in the body.
Understanding Dopamine
Dopamine is a hormone and neurotransmitter, which plays an important role in the human brain and body. With the brain, dopamine functions as a neurotransmitter: a chemical released by nerve cells to send signals to other nerve cells. When a person is addicted to drugs, dopamine levels will be increased.
Parkinson's disease involves a dysfunction of the dopamine system, which will result in tremors and motion impairment. There is also evidence that schizophrenia involves altered levels of dopamine activity. Furthermore, ADHD and restless legs syndrome are believed to be associated with decreased dopamine activity.
Bodybuilding
There are a couple ways Bromocriptine is used in bodybuilding.
Prolactin inhibition: Whenever a progestin based compound is used (trenbolone and nandrolone decanoate), prolactin levels will rise. Using bromocriptine to bring down prolactin levels will keep prolactin based gynecomastia away and also keep libido strong.
Calorie restricted dieting: When a bodybuilder cuts calories, leptin levels will drop and the body will respond by holding onto nutrient stores. It is believed that bromocriptine will help normalize the slowing metabolism during this time, and it will help maintain normal leptin stimulation. This phenomenon is connected to its dopamine effects.
Prolactin
Prolactin is a hormone protein that plays the role of enabling females mammals to produce milk. It is not fully understood why males have prolactin, but we do know that it provides sexual gratification after ejaculation. After ejaculation, the male loses interest in sex, this is called the sexual refractory period, where prolactin levels go up. Therefore, lower prolactin levels should decrease the refractory period. In general, high prolactin levels can cause impotence and loss of interest in sex (low libido).
Side Effects
There is no shortage of possible side effects with Bromo, and many bodybuilders have avoided this drug for that reason.
Nausea is one of the most common side effects and is usually the first thing noticed. Guys will feel terrible when using bromocriptine, sick like they want to throw up. Low blood pressure, dizziness and confusion can also occur. There are a host of less likely sides including: anxiety, dry mouth, fatigue, headache, and lethargy.
Dosage
The normal starting dose in bodybuilding is 2.5 to 5mg, either split during the day or everyday. If side effects become too great then cutting the dose in half can be effective.
Cabergoline (brand name Dostinex, cabaser, caber), a fungi derivative, is a potent dopamine receptor agonist. Numerous studies have shown that cabergoline inhibits prolactin. Currently, it is the preferred choice in medicine over the older bromocriptine because of its longer half-life and minimal side effects.
History
The the early 1980's, cabergoline was invented by an Italian drug company called Farmitalia Carlo Erba, which is now owned by Pfizer. Scientists discovered the drug while experimenting with ergot (fungus) alkaloids. The FDA approved the drug in 1996, and it went generic in 2005 after its patent expired in the US.
Uses in medicine
There are many uses that the medical world is discovering for dostinex. They include hyperprolactinemia, prolactin producing tumors, Parkinson's disease, Cushing's disease, and a myriad of other ailments.
One of the best known uses for cabergoline is in tumors and cancers related to high prolactin levels. In fact, it's been an industry leading drug when it comes to shrinking prolactin-secreting macroadenomas.
How it works
Cabergoline is a long acting dopamine D2 receptor agonist. Rat studies show it inhibits prolactin secretion in the pituitary's lactotroph cells. Prolactin is a protein hormone which is best known for enabling female mammals to produce milk; however, there are many other functions for prolactin in both males and females.
When taking cabergoline, the prolactin doesn't get secreted from the pituitary, which causes prolactin levels to drop. In males, the most well known effect of prolactin is during and after ejaculation. This is called the sexual refractory period; during this time, the male will lose interest in sex and feels satisfied. We'll go more into this later.
Bodybuilding Uses
There are several ways we can use caber in bodybuilding. Since it is a dopamine agonist, some athletes believe they can take it to give themselves an adrenaline rush during a sporting event. Also, the addition of dopamine can improve motor skills and give you an edge over your competition. In theory, you will be able to workout much harder and be able to ignore pain pushing your muscles to the limit.
The main way bodybuilders use cabergoline is when they run a compound which increases prolactin levels in the body. Trenbolone will turn into prolactin, and, when abused, you can get prolactin based gynecomastia. In addition, a spike in prolactin can cripple your sex drive. Even when you do not run a compound that increases prolactin, caber can still help normalize your libido when you are playing with your hormones.
Another way caber can be used in bodybuilding is by its mechanism of mimicking dopamine being produced from food intake. Ever had a craving for New York style greasy pizza, oreo ice cream or some other treat you know you shouldn't have? Well, when you take cabergoline, the dopamine being released can act as the pleasure chemical, which can make a bite of that pizza satisfy you rather than eating the whole pie. This aids weight loss goals and helps you stay lean.
And finally, sleep! Many bodybuilders who take cabergoline report improved sleep thanks to the dopamine mimic. This allows you to sleep more, deeper and longer.
Cabergoline and Sex
As mentioned earlier, when a man ejaculates during sex, his prolactin levels spike up causing him to lose interest in sex. Rat studies have proven that cabergoline actually reduces prolactin in the body, so when you take the caber you will be able to regain your sex drive quicker.
When we are on a cycle or when coming off a cycle, our sex drive can be altered. Sometimes in good ways, but many times in bad ways; especially, when trenbolone is involved. In this instance, if libido and sex drive is an issue, caber can be added to your cycle or post cycle therapy (PCT) to aid in prolactin level re-balancing.
Why do men have prolactin if we don't breast feed?
Mother nature is smarter than you think. As stated earlier in the article, female mammals have increased prolactin levels, which causes milk to be produced, so they can breast feed their baby. My theory is that mother nature decided to give men prolactin as we evolved, to prevent overpopulation of humans. If a man ejaculates, he is satisfied and loses interest in sex, then he won't want to have sex again for a certain period of time. This is why guys like to have sex then kick the girl out of their bed afterward. When a man takes cabergoline, it reduces the refractory period and you will be ready for sex again much sooner.
Side effects
Some bodybuilders complain about stomach pains on caber; however, when taken at a proper dose and with food, this isn't a problem. I recommend taking caber before bed with a light meal, that seems to be the best way.
Half-life and Dosages
As mentioned beforehand, cabergoline blows away bromocriptine because it has a much longer half-life of 3 days vs. 12 hours. This is why the medical community prefers it and so should you. Many guys complain that caber is expensive, this is more due to ignorance on their part. Most bodybuilders don't understand that you only need to take it twice a week and the dosage can be very low. I recommend a quarter mg (0.25mgs) per dose, which is fairly moderate. Caber is a very potent drug and should be run very conservatively, make sure you know what you're doing with it.
Cytomel T3 (chemical name: liothyronine sodium) is a synthetic form of thyroid hormone that is mostly used to treat hypothyroidism and myxedema coma. These conditions can be triggered by thyroid cancer, Graves' disease, and even by an unhealthy lifestyle.
Liothyronine sodium is also widely used in psychiatric circles. When combined with other drugs, T3 can be fairly effective in the treatment of major depressive disorders.
Hypothyroidism
The term hypothyroidism comes from the word 'reduced' (hypo) plus thyroid. It is the opposite of hyperthyroidism, which is the condition of an over-active thyroid. Both of these conditions can be diagnosed with blood work. However, one can also pay attention to such indicators of hypothyroidism as tiredness, weight gain and poor ability to tolerate cold. If these symptoms are experienced, one should do a blood test.
Hypothyroidism has grown substantially in the USA due to poor lifestyle choices, overuse of prescription and recreational drugs, stress, and daily routines. Today, even children are not an exception because hypothyroidism is frequently found among them. In fact, it is thought to occur in almost 9% of the population in western countries.
How it Works
In simple terms, when you use synthetic T3, you are increasing your overall thyroid hormone levels, which causes metabolism to speed up. Unfortunately, when you do this, your body will stop producing T3 naturally until you cease usage of Cytomel and the body recovers.
A similar situation occurs when bodybuilders inject testosterone that suppresses natural production of testosterone in their bodies.
Effects of Metabolic Activity
T3 is a regulator of the oxidative metabolism of energy. When you take liothyronine sodium it will increase the uptake of nutrients into the mitochondria, which raises activity in the oxidative metabolic pathway. This causes everything to work harder within the organism and makes the body demand more fuel.
Bodybuilding
The increase of ATP and metabolic activity leads the body to burn fat. This is why bodybuilders use T3 as a part of their anabolic steroid stacks. Furthermore, T3 is popular among bodybuilders because it can help burn those stubborn 1 to 2% of body fat that won't come off through just diet and cardio.
Another interesting property of Cytomel is that it can enhance growth hormone (GH) production. However, using Cytomel solely for this purpose is not recommended.
Side Effects
Very high levels of T3 will stress the heart and can be dangerous, so correct dosages are very important.
Hyperthyroidism, which is the opposite of hypothyroidism, will occur when T3 is abused. The symptoms of hyperthyroidism include:
Weight loss
Strong Headache
Body Tremor
Stomach issues
Increased Irritability
Sporadic Insomnia
Excessive sweating
Appetite Increase
Heat Sensitivity
Post Use
High levels of T3 suppress the release of thyrotropin releasing hormone (TRH), which will reduce thyroid signaling hormone (TSH).
There is the risk of being sluggish when you come off T3, and your metabolism may grind to a screeching halt. Therefore, it is important to run supplements to help your thyroid levels recover quickly.
Essentially, this means you must come off the Cytomel for as much time as you were on, and run such supplements as zinc, selenium, ashwagandha and vitamin B-12. Luckily, there is a supplement that has all of these elements, and even more. It is called T3-PCT, sold by N2BM, and it is extremely affordable.
Dosing
When used for treatment of hypothyroidism, the dosage will be determined on an individual level by the attending doctor. On the other hand, bodybuilders have several ways to run this compound, ranging from a very conservative method, to an aggressive method focusing on rapid weight loss. Cycle length is also a factor.
The conservative approach is 12.5-25 micrograms (mcg) per day (either single in the morning or split dose) for 4-6 weeks. This dosage will cause minimal thyroid suppression, as well as minimal side effects while on.
The more aggressive approach is 50-75mcg per day (usually split dose AM/PM) for 2-3 months. This approach may potentially cause side effects and suppress natural thyroid production. Therefore, post use supplement therapy is very important to help the body rebound quicker.
It is recommended to run T3 with anabolic steroids in order to avoid loss of muscle mass.
Half Life
According to medical literature, liothyronine sodium's half life is around 1.5-2 days. Hence, it will be necessary to dose daily, or even twice per day to maintain steady levels of the active substance in the blood.
Trade Names
Cytomel
Tertroxin in Australia
T3
Liothyronine sodium
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