Pharmacom Store


Does Proviron Improve Anabolic Effect of Steroids?

Results 1 to 13 of 13
  1. #1
    Chucky
    ADMINISTRATOR

    The Admin's Avatar


    Join Date
    Jun 2012
    Posts
    15,708

    Thanks Thanks Given 
    353
    Thanks Thanks Received 
    5,132
    Thanked in
    2,882 Posts
    Rep Points
    2147483647

    Question Does Proviron Improve Anabolic Effect of Steroids?

    Does Proviron increase or reduce the anabolic effect of the steroids?

    At one time it was a commonly held belief that Proviron was an anti-anabolic steroid – that it reduced the anabolic effect of other steroids. I believe Dan Duchaine’s Underground Steroid Handbook II was the first to popularize this theory. In it, Dan comments that Proviron itself has little anabolic value. Noting that it is also binds the androgen receptor with high affinity, he further concluded that it must act as a blocking agent, incapable of imparting a strong anabolic effect, and at the same time preventing other (more anabolic) steroids from binding the receptor. The conclusion seemed logical, but it turned out that Dan was only partly correct. Proviron indeed has little anabolic value by itself. Studies that were uncovered much later, however, would give a different explanation as to why. As it turned out, the poor anabolic potency of Proviron was caused by the drug being very rapidly metabolized to inactive metabolites in skeletal muscle tissue, not issues with receptor activation or transcription. While Proviron could bind the androgen receptor very avidly and impart a normal anabolic message to the cell, in this area of the body very little drug will actually make it to the receptor to do so. So, alas, Proviron is not the anti-anabolic agent we once thought it to be (but it is still a weak anabolic).

    This leaves us with the other side of your question. Does it increase the anabolic potency of other steroids? The answer is that it may to some extent, but it depends on the context. The main trait we are looking at here is the high binding affinity Proviron has for SHBG (sex hormone binding globulin). SHBG is a protein that binds to and temporarily prevents anabolic/androgenic steroids from activating their receptors. The higher the percentage of unbound steroid in the blood, the more active the steroid is going to be in the body. Given that Proviron binds to SHBG so strongly, perhaps more strongly that any commercial steroid known, it may displace other steroids that also like to bind this protein. With Proviron beating the other molecules to the seat, so to speak, it is forcing a greater percentage to remain in a free (active) state. This is, of course, essentially the same thing Duchaine first proposed, but with a different target site and outcome.

    Testosterone is a good drug for stacking Proviron with in this regard, as it likes to bind SHBG. Many other synthetic steroids, however, bind with SHBG in much lower percentages. So depending on the other steroid(s) taken, the impact of Proviron will range from “noticeable” to “very slight if any at all”.

  2. #2
    Junior Member


    Join Date
    Jul 2019
    Posts
    25

    Thanks Thanks Given 
    1
    Thanks Thanks Received 
    8
    Thanked in
    8 Posts
    Rep Points
    80100

    Great read.

    Proviron works quite well for me with the test esters I run. Whenever I add 25 mg per day to my TRT, my SHBG drops from high to "low" levels on blood tests and Free Test is often a few points above the reference range. I can feel it in the gym and with the Mrs. I can only imagine what 50 mg or more per day might do.

    I've never tried Masteron but thinking of giving that a whirl in a few months. Not sure about the dosage, maybe you guys can suggest. I use about 160 mg Test Cyp per week. How much Masteron would be appropriate to add?

  3. #3
    Board Rep
    BOARD REP

    A.font401's Avatar


    Join Date
    Jan 2018
    Posts
    1,252

    Thanks Thanks Given 
    821
    Thanks Thanks Received 
    688
    Thanked in
    512 Posts
    Rep Points
    235197209

    Quote Originally Posted by kyushin View Post
    Great read.

    Proviron works quite well for me with the test esters I run. Whenever I add 25 mg per day to my TRT, my SHBG drops from high to "low" levels on blood tests and Free Test is often a few points above the reference range. I can feel it in the gym and with the Mrs. I can only imagine what 50 mg or more per day might do.

    I've never tried Masteron but thinking of giving that a whirl in a few months. Not sure about the dosage, maybe you guys can suggest. I use about 160 mg Test Cyp per week. How much Masteron would be appropriate to add?
    Masteron works great the lower the bf you are and usually a decent dose as well, being 500+mg. Idk if there’s much benefit of running it at 200mg or less. I’ve personally never ran it that low.


    Sent from my iPhone using Tapatalk

  4. #4
    Junior Member


    Join Date
    Dec 2019
    Posts
    25

    Thanks Thanks Given 
    0
    Thanks Thanks Received 
    2
    Thanked in
    2 Posts
    Rep Points
    20100

    slightly off topic, but has anyone seen any info/data for different steroids binding affinity to SHBG? I've seen info on aromatization and conversion to DHT/DHB, but not SHBG?

    I'm assuming only testosterone derivatives need to worry about this?


    thanks

  5. #5
    Senior Member

    Dukey's Avatar


    Join Date
    Sep 2017
    Location
    Planet Earth
    Posts
    787

    Thanks Thanks Given 
    1,747
    Thanks Thanks Received 
    371
    Thanked in
    270 Posts
    Rep Points
    330325874

    Interesting. It's known to enhance Test, does it do the opposite for other compounds? As of now i am running 700mg NPP wk, 900mg SUST wk, 50mg WINSTROL OIL ed, 5iu GH ed, 500iu HCG e4d, 50mg ANADROL ed for 21 days and 50 mg PROVIRON ed. So far so good, no complaints, especially in the bedroom. I have absolutely Zero sides from the nandrolone. I have to give proviron some credit for that. But my question is could i actually be doing better? Could i get more out of my gear by removing the PROVIRON? Chance the Nandro sides? After reading the article, i'm definately curious

  6. #6
    Junior Member


    Join Date
    Jul 2019
    Posts
    25

    Thanks Thanks Given 
    1
    Thanks Thanks Received 
    8
    Thanked in
    8 Posts
    Rep Points
    80100

    Cool, thanks for the insight.

  7. #7
    Senior Member


    Join Date
    Dec 2019
    Posts
    140

    Thanks Thanks Given 
    5
    Thanks Thanks Received 
    42
    Thanked in
    39 Posts
    Rep Points
    -653716

    Quote Originally Posted by Dukey View Post
    Interesting. It's known to enhance Test, does it do the opposite for other compounds? As of now i am running 700mg NPP wk, 900mg SUST wk, 50mg WINSTROL OIL ed, 5iu GH ed, 500iu HCG e4d, 50mg ANADROL ed for 21 days and 50 mg PROVIRON ed. So far so good, no complaints, especially in the bedroom. I have absolutely Zero sides from the nandrolone. I have to give proviron some credit for that. But my question is could i actually be doing better? Could i get more out of my gear by removing the PROVIRON? Chance the Nandro sides? After reading the article, i'm definately curious
    I run proviron constantly on cycle and if I have some left over I'll run it on trt. Love it

    Sent from my SM-S767VL using Tapatalk

  8. #8
    Senior Member

    Dukey's Avatar


    Join Date
    Sep 2017
    Location
    Planet Earth
    Posts
    787

    Thanks Thanks Given 
    1,747
    Thanks Thanks Received 
    371
    Thanked in
    270 Posts
    Rep Points
    330325874

    Quote Originally Posted by genixcon View Post
    I run proviron constantly on cycle and if I have some left over I'll run it on trt. Love it

    Sent from my SM-S767VL using Tapatalk
    I love the stuff also. Just curious if it's blocking other compounds like the article suggests.

    Sent from my Z839 using Tapatalk

  9. #9
    Senior Member


    Join Date
    Dec 2019
    Posts
    140

    Thanks Thanks Given 
    5
    Thanks Thanks Received 
    42
    Thanked in
    39 Posts
    Rep Points
    -653716

    Nah, proviron increases free test. I've never gotten deca dick since I started running with every cycle. I dont consider it a steroid as much a ancillary

    Sent from my SM-S767VL using Tapatalk

  10. #10
    Member


    Join Date
    Jan 2017
    Posts
    38

    Thanks Thanks Given 
    30
    Thanks Thanks Received 
    14
    Thanked in
    10 Posts
    Rep Points
    140100

    Good read! Thanks!

  11. #11
    Junior Member


    Join Date
    Jan 2020
    Posts
    21

    Thanks Thanks Given 
    0
    Thanks Thanks Received 
    10
    Thanked in
    7 Posts
    Rep Points
    2237740

    I always run Proviron....or mast when I run nandrolones. IMO it’s a must.


    Sent from my iPhone using Tapatalk

  12. #12
    Junior Member


    Join Date
    Jul 2019
    Posts
    25

    Thanks Thanks Given 
    1
    Thanks Thanks Received 
    8
    Thanked in
    8 Posts
    Rep Points
    80100

    I'm running 150 nandrolone now with 150 trt dosage, how much masteron would be useful do you think? Don't have the decca dick yet, but definitely don't feel as good as I did when I had proviron in my routine.

    [I always run Proviron....or mast when I run nandrolones. IMO it’s a must.]
    Last edited by kyushin; 01-14-2020 at 09:11 AM.

  13. #13
    Senior Member

    Dukey's Avatar


    Join Date
    Sep 2017
    Location
    Planet Earth
    Posts
    787

    Thanks Thanks Given 
    1,747
    Thanks Thanks Received 
    371
    Thanked in
    270 Posts
    Rep Points
    330325874

    Quote Originally Posted by genixcon View Post
    Nah, proviron increases free test. I've never gotten deca dick since I started running with every cycle. I dont consider it a steroid as much a ancillary

    Sent from my SM-S767VL using Tapatalk
    Nice. The Nandrolone isn't bothering me at all either. And it's definitely good NPP. Feral makes a great product. Thanks for the input brother...

    Sent from my Z839 using Tapatalk

Similar Threads

  1. What is the Effect of Anabolic Steroids on Burning Fat?
    By The Admin in forum Anabolic Steroids
    Replies: 5
    Last Post: 11-29-2019, 04:30 PM
  2. The effect of anabolic steroids on weight training
    By udit9191 in forum Anabolic Steroids
    Replies: 14
    Last Post: 01-21-2016, 05:51 PM
  3. Replies: 22
    Last Post: 07-28-2015, 03:41 PM
  4. Replies: 0
    Last Post: 01-30-2014, 03:55 AM
  5. The Anabolic Effect of Garlic
    By The Admin in forum Muscle Central
    Replies: 0
    Last Post: 01-31-2013, 04:43 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Copyright© 2012-2020 Anabolic Steroid Discussion Forums