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Trenbolone for Androgen Replacement Therapy

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    Trenbolone for Androgen Replacement Therapy

    Trenbolone for Androgen Replacement Therapy

    The use of the anabolic steroid trenbolone has a long history in the bodybuilding but it has never really been considered a steroid suitable for therapeutic use in medicine. The U.S. Food and Drug Administration has not approved tren for use in humans. The media has often demonized it as a dangerous veterinarian steroid never intended for human use. However, the perception of trenbolone may soon change with the publication of a favorable study in a major scientific journal.

    Joshua Yarrow and his colleagues at the University of Florida feel that trenbolone may be a viable alternative to testosterone for androgen replacement therapy. They are set to publish their study results in the February 2011 issue of the American Journal of Physiology – Endocrinology and Metabolism.

    The researchers report that trenbolone enanthate may have certain advantages over testosterone that may make it an appealing treatment option for some individuals. Bodybuilders may be familiar with many of these findings.

    Trenbolone is not adversely affected by the aromatase or 5-alpha reductase enzymes that metabolize testosterone into estradiol and dihydrotestosterone, respectively. Bodybuilders have enjoyed tren for years precisely because they are able to avoid steroid side effects related to estrogen and DHT.

    Yarrow reports that low-dose trenbolone enanthate effectively produces anabolic effects in muscle size and partially maintains bone mineral density without causing prostate enlargement or polycythemia in castrated laboratory rats.

    Supraphysiological dosages of testosterone enanthate were required to produce anabolic effects similar to low-dose trenbolone administration. However, negative side effects of prostate enlargement and elevated hemoglobin became problematic at this dose of testosterone.

    Selective androgen receptor modulators (SARMs) may be the current darlings of scientific research into alternative options for androgen replacement therapy, but University of Florida researchers are excited by the “SARM-like potential” of trenbolone.

    They suggest that the actions of trenbolone are similar to selective androgen receptor modulators (SARMs). Low-dose trenbolone is called “SARM-like” because of the positive anabolic effects in muscle and bone without negative side androgenic side effects of prostate enlargement or polycythemia.

    Trenbolone may have benefits over testosterone in terms of androgen receptor activation, the upregulation of growth factors such as IGF-1 and fibroblast growth factor, and anticatabolic mechanisms.

    Competitive bodybuilders have often preferred using trenbolone in the weeks prior to a bodybuilding competition due to its purported effects at accelerating fat loss.

    The current study confirmed that trenbolone has more potent lipolytic effects on visceral adipose tissue than testosterone milligram per milligram. Furthermore, visceral fat loss increased in a dose-dependent manner with trenbolone. In other words, the more tren used, the greater the fat loss.

    Trenbolone’s lack of aromatization, while generally desirable, has often been problematic for bodybuilders who have used trenbolone as the only steroid in a cycle. Therefore, most bodybuilders include an aromatizable steroid such as testosterone or Dianabol in their trenbolone steroid stacks.

    Researchers also recognize that the lack of aromatization could be a potential problem if trenbolone is used alone in androgen replacement therapy. In their study, trenbolone only provided a partial bone protective effect when administered to castrated rats. The authors attribute this to the non-aromatizable nature of trenbolone.

    They conclude that low-dose trenbolone enanthate treatment has SARM-like effects on muscle/fat body composition. Androgen replacement therapy with low-dose trenbolone could potentially produce anabolic gains comparable to supraphysiological testosterone treatment without the associated side effects. The therapeutic risk-benefit profile of low-dose trenbolone appears superior to supraphysiological testosterone treatment; however, additional research into this treatment option is necessary.

    The researchers should be applauded for dispassionately and objectively researching the potential of trenbolone in androgen replacement therapy. Trenbolone is an anabolic steroid that has been demonized more than others due to its limited use (in pellet implants used by veterinarians to increase muscle growth in livestock). Fortunately, they looked past the political stigma associated with trenbolone to revisit a therapeutic use for an old steroid.

    Source:
    Yarrow JF et. al. 7{beta}-hydroxyestra-4,9,11-trien-3-one (Trenbolone) Exhibits Tissue Selective Anabolic Activity: Effects on Muscle, Bone, Adiposity, Hemoglobin, and Prostate. Am J Physiol Endocrinol Metab. 2011 Jan 25. [Epub ahead of print]

  2. #2
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    There's a lot of big boys over in the middle East area that do not use any testosterone and they use Trenbolone with other compounds.. from what I've heard they have amazing success with it..

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    Quote Originally Posted by Vision View Post
    There's a lot of big boys over in the middle East area that do not use any testosterone and they use Trenbolone with other compounds.. from what I've heard they have amazing success with it..
    I actually tried using tren as my hormone replacement regimen for a little while. You stay leaner and stronger than with test, but the major downside (outside of the unknown health issues) was the mental fog. Workout testosterone my brain just doesn't run on all cylinders. Makes me more forgetful than normal, analytical abilities suffer, and I had a bit of cognitive dissonance from reality, almost a little detached feeling.

    Physique wise it's great. Physical and mental health not so much, and there's a lot of unknowns. The researchers at the University of Florida were never able to finish the studies they were doing with it because their funding got pulled for some unknown reason...

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    Quote Originally Posted by GarlicChicken View Post
    I actually tried using tren as my hormone replacement regimen for a little while. You stay leaner and stronger than with test, but the major downside (outside of the unknown health issues) was the mental fog. Workout testosterone my brain just doesn't run on all cylinders. Makes me more forgetful than normal, analytical abilities suffer, and I had a bit of cognitive dissonance from reality, almost a little detached feeling.

    Physique wise it's great. Physical and mental health not so much, and there's a lot of unknowns. The researchers at the University of Florida were never able to finish the studies they were doing with it because their funding got pulled for some unknown reason...
    Sex drive suffers, ive tried several alternatives from proviron to halotestin and hex. For me i can attest i didnt have sex for 39 days nor masturbated or watched porn. Forgive the explicit information but i didnt feel like myself. I was out of test my source had issues. I got a bottle of t500 and 1 day later i went back to feeling like me and my wife went and ordered 5 more bottles so i dont try doing it again. Maybe its just me.


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    Quote Originally Posted by Anonim View Post
    Sex drive suffers, ive tried several alternatives from proviron to halotestin and hex. For me i can attest i didnt have sex for 39 days nor masturbated or watched porn. Forgive the explicit information but i didnt feel like myself. I was out of test my source had issues. I got a bottle of t500 and 1 day later i went back to feeling like me and my wife went and ordered 5 more bottles so i dont try doing it again. Maybe its just me.


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    Interesting. It didn't effect me like that at all. What dosage were you running?

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    On the hex i ran aroun 45-75 a week. I had had time off. Dont get me wrong i looked my best lean as it could be. Test gets me water retention. Then again i never had good effects from androgenic compounds sexually speaking. Its legitimate hex and i was amased towards its positives vs side effects per dosage. Acetate gives more sides per dose compared to the actual good effects it gives vs hex. Since trying it i will always aim for the hex although its less tren per dollar i was really impressed.


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    I was the dude that went for 1g of ace per week but ive done anything over 30mg and go flat. 30mg a day i keep the fullness decent anything over id have to use carbs like its out of style and its too much. Running 700 a week of tren isnt impossible but youd have to compensate in calories and that what makes it harder esp if insulin isnt used.


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    Nah....too many side effects

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    Quote Originally Posted by REHH View Post
    Nah....too many side effects
    Wether drug resistance or not the 2 things that scared me about tren was 1: the prostate 2: need for use of beta blockers from excessive noradrenalin many times found myself getting nervous shakes from arguments or performance situations.


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    Quote Originally Posted by GarlicChicken View Post
    I actually tried using tren as my hormone replacement regimen for a little while. You stay leaner and stronger than with test, but the major downside (outside of the unknown health issues) was the mental fog. Workout testosterone my brain just doesn't run on all cylinders. Makes me more forgetful than normal, analytical abilities suffer, and I had a bit of cognitive dissonance from reality, almost a little detached feeling.

    Physique wise it's great. Physical and mental health not so much, and there's a lot of unknowns. The researchers at the University of Florida were never able to finish the studies they were doing with it because their funding got pulled for some unknown reason...
    That is one of the factors that I stopped Trenbolone is the fact that it turns me into a full-blown retard.. I literally struggle with structuring sentences, or God forbid I have two give an estimate and crunch numbers for a client my brain completely shuts down.. noopept helped a great deal, but it wasn't enough.
    Quote Originally Posted by Anonim View Post
    Wether drug resistance or not the 2 things that scared me about tren was 1: the prostate 2: need for use of beta blockers from excessive noradrenalin many times found myself getting nervous shakes from arguments or performance situations.


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    Trenbolone would completely destroy me even when I wasn't even in a confrontation, in the most calm settings it would make me so socially awkward, if I was in a crowded area and I looked to the left or the right my head would shake and vibrate, my neck muscles would have spasms because of anxiety, I would avoid looking around just for that reason.. and just to think that once upon a time that was one of my go to compounds, I thought I had a pretty good relationship with it, out of nowhere it just let me know that we're not going to see eye-to-eye anymore..

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    tren as HRT I don’t know about that brother... I think that would be equivalent of living in your own alternate reality ... pretty scary shit right there cause you’ll be the last to know it lol

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    Trenbolone for Androgen Replacement Therapy

    Quote Originally Posted by Vision View Post
    That is one of the factors that I stopped Trenbolone is the fact that it turns me into a full-blown retard.. I literally struggle with structuring sentences, or God forbid I have two give an estimate and crunch numbers for a client my brain completely shuts down.. noopept helped a great deal, but it wasn't enough.

    Trenbolone would completely destroy me even when I wasn't even in a confrontation, in the most calm settings it would make me so socially awkward, if I was in a crowded area and I looked to the left or the right my head would shake and vibrate, my neck muscles would have spasms because of anxiety, I would avoid looking around just for that reason.. and just to think that once upon a time that was one of my go to compounds, I thought I had a pretty good relationship with it, out of nowhere it just let me know that we're not going to see eye-to-eye anymore..
    I hear this from lots of old tymers that tren did that out of nowhere. For me i build resistance after 3 weeks of high doses as far as gains and hardness is concerned. While adrenalin related sides only amplify. Beta blockers help but also counter it and give sleep related issues. Clonidine is also a saver if you know how to use it. Xanax and other benzos i wouldnt condone anyone mess with unless disciplined to use short term. Tren also pisses me off when you stop it you get soft its depressing. Low dose hex is a good idea if youre a magazine figure that does it for a living or a male stripper (seriosly speaking) but test has more effect on women generally. I still have my relationship with tren maybe not acetate but a bit of hex still gets me mooving


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