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I pulled this a book called “Anabolic Pharmacology”. It's one of the best books ever written on steroids. I read this book for the first time back in 2009.
”In most cases, 5-alpha reduction results in a more potent androgen. In the case of nandrolone and nandrolone derivatives, 5-alpha reduction results in less potent derivative. In this case, nandrolone is converted to dihydronandrolone CDHN). DHN has less affinity for the AR than nandrolone. This is positive in the sense that for a given dose of nandrolone, there will be greater activation in muscle than in the prostate. However, at higher doses, nandrolone will overcome the capacity of 5AR resulting in higher levels of prostate AR activation. A-ring substituents, such as a 2-methyl or a 4-chloro, result in some protection of the molecule from the action of5AR.”
We all know that 19-nor steroids have the highest affinity for the AR receptor of any steroid made; if you didn’t know now you do. So you have three factors:
1. Deca isn’t very androgenic to begin with
2.5 alpha reduces it to an even less potent androgen
3. 19-nor steroid ( deca and all it’s metabolites) they love the AR receptor. You know that old saying the early bird gets the worm? This is that in action.
Final product an environment where the androgen to estrogen ratio is off balance. You have to restore this balance to make your member work again. Test isn’t the best option due to its aromatization rate. You DHT derivatives are were you go to for help specifically masteron or proviron. My experience is that masteron works better. Even what would normally be acceptable E2 levels can offset the balance with deca which is why you can’t look to E2 as a cause or solution. It’s definitely a contributing factor but it’s not the solution.
”In most cases, 5-alpha reduction results in a more potent androgen. In the case of nandrolone and nandrolone derivatives, 5-alpha reduction results in less potent derivative. In this case, nandrolone is converted to dihydronandrolone CDHN). DHN has less affinity for the AR than nandrolone. This is positive in the sense that for a given dose of nandrolone, there will be greater activation in muscle than in the prostate. However, at higher doses, nandrolone will overcome the capacity of 5AR resulting in higher levels of prostate AR activation. A-ring substituents, such as a 2-methyl or a 4-chloro, result in some protection of the molecule from the action of5AR.”
We all know that 19-nor steroids have the highest affinity for the AR receptor of any steroid made; if you didn’t know now you do. So you have three factors:
1. Deca isn’t very androgenic to begin with
2.5 alpha reduces it to an even less potent androgen
3. 19-nor steroid ( deca and all it’s metabolites) they love the AR receptor. You know that old saying the early bird gets the worm? This is that in action.
Final product an environment where the androgen to estrogen ratio is off balance. You have to restore this balance to make your member work again. Test isn’t the best option due to its aromatization rate. You DHT derivatives are were you go to for help specifically masteron or proviron. My experience is that masteron works better. Even what would normally be acceptable E2 levels can offset the balance with deca which is why you can’t look to E2 as a cause or solution. It’s definitely a contributing factor but it’s not the solution.
