Pharmacom Store


T Threshold Levels and LBM Targets Needed to Enhance Skeletal Muscle Strength and Function

Results 1 to 3 of 3
  1. #1
    Community Veteran
    ADMINISTRATOR

    heavyiron's Avatar


    Join Date
    Jun 2012
    Posts
    8,745

    Thanks Thanks Given 
    573
    Thanks Thanks Received 
    1,195
    Thanked in
    661 Posts
    Rep Points
    2147483647

    T Threshold Levels and LBM Targets Needed to Enhance Skeletal Muscle Strength and Function

    Testosterone Threshold Levels and Lean Tissue Mass Targets Needed to Enhance Skeletal Muscle Strength and Function

    Fred Sattler, Shalender Bhasin, Jiaxiu He, Chih-Ping Chou, Carmen Castaneda-Sceppa, Kevin Yarasheski, Ellen Binder, E. Todd Schroeder, Miwa Kawakubo, Anqi Zhang ... Show more
    Author Notes
    The Journals of Gerontology: Series A, Volume 66A, Issue 1, January 2011, Pages 122–129, https://doi.org/10.1093/gerona/glq183

    Abstract
    Background.
    In the HORMA (Hormonal Regulators of Muscle and Metabolism in Aging) Trial, supplemental testosterone and recombinant human growth hormone (rhGH) enhanced lean body mass, appendicular skeletal muscle mass, muscle performance, and physical function, but there was substantial interindividual variability in outcomes.
    Methods.
    One hundred and twelve men aged 65–90 years received testosterone gel (5 g/d vs 10 g/d via Leydig cell clamp) and rhGH (0 vs 3 vs 5 μg/kg/d) in a double-masked 2 × 3 factorial design for 16 weeks. Outcomes included lean tissue mass by dual energy x-ray absorptiometry, one-repetition maximum strength, Margaria stair power, and activity questionnaires. We used pathway analysis to determine the relationship between changes in hormone levels, muscle mass, strength, and function.
    Results.
    Increases in total testosterone of 1046 ng/dL (95% confidence interval = 1040–1051) and 898 ng/dL (95% confidence interval = 892–904) were necessary to achieve median increases in lean body mass of 1.5 kg and appendicular skeletal muscle mass of 0.8 kg, respectively, which were required to significantly enhance one-repetition maximum strength (≥30%). Co-treatment with rhGH lowered the testosterone levels (quantified using liquid chromatography–tandem mass spectrometry) necessary to reach these lean mass thresholds. Changes in one-repetition maximum strength were associated with increases in stair climbing power (r = .26, p = .01). Pathway analysis supported the model that changes in testosterone and insulin-like growth factor 1 levels are related to changes in lean body mass needed to enhance muscle performance and physical function. Testosterone’s effects on physical activity were mediated through a different pathway because testosterone directly affected Physical Activity Score of the Elderly.
    Conclusions.
    To enhance muscle strength and physical function, threshold improvements in lean body mass and appendicular skeletal muscle mass are necessary and these can be achieved by targeting changes in testosterone levels. rhGH augments the effects of testosterone. To maximize functional improvements, the doses of anabolic hormones should be titrated to achieve target blood levels.

    https://academic.oup.com/biomedgeron...A/1/122/532165



  2. #2
    Carpet-Chewer

    Augustine5I's Avatar


    Join Date
    Jan 2015
    Posts
    4,683

    Thanks Thanks Given 
    579
    Thanks Thanks Received 
    1,224
    Thanked in
    776 Posts
    Rep Points
    2147483647

    Quote Originally Posted by heavyiron View Post
    Testosterone Threshold Levels and Lean Tissue Mass Targets Needed to Enhance Skeletal Muscle Strength and Function

    Fred Sattler, Shalender Bhasin, Jiaxiu He, Chih-Ping Chou, Carmen Castaneda-Sceppa, Kevin Yarasheski, Ellen Binder, E. Todd Schroeder, Miwa Kawakubo, Anqi Zhang ... Show more
    Author Notes
    The Journals of Gerontology: Series A, Volume 66A, Issue 1, January 2011, Pages 122–129, https://doi.org/10.1093/gerona/glq183

    Abstract
    Background.
    In the HORMA (Hormonal Regulators of Muscle and Metabolism in Aging) Trial, supplemental testosterone and recombinant human growth hormone (rhGH) enhanced lean body mass, appendicular skeletal muscle mass, muscle performance, and physical function, but there was substantial interindividual variability in outcomes.
    Methods.
    One hundred and twelve men aged 65–90 years received testosterone gel (5 g/d vs 10 g/d via Leydig cell clamp) and rhGH (0 vs 3 vs 5 μg/kg/d) in a double-masked 2 × 3 factorial design for 16 weeks. Outcomes included lean tissue mass by dual energy x-ray absorptiometry, one-repetition maximum strength, Margaria stair power, and activity questionnaires. We used pathway analysis to determine the relationship between changes in hormone levels, muscle mass, strength, and function.
    Results.
    Increases in total testosterone of 1046 ng/dL (95% confidence interval = 1040–1051) and 898 ng/dL (95% confidence interval = 892–904) were necessary to achieve median increases in lean body mass of 1.5 kg and appendicular skeletal muscle mass of 0.8 kg, respectively, which were required to significantly enhance one-repetition maximum strength (≥30%). Co-treatment with rhGH lowered the testosterone levels (quantified using liquid chromatography–tandem mass spectrometry) necessary to reach these lean mass thresholds. Changes in one-repetition maximum strength were associated with increases in stair climbing power (r = .26, p = .01). Pathway analysis supported the model that changes in testosterone and insulin-like growth factor 1 levels are related to changes in lean body mass needed to enhance muscle performance and physical function. Testosterone’s effects on physical activity were mediated through a different pathway because testosterone directly affected Physical Activity Score of the Elderly.
    Conclusions.
    To enhance muscle strength and physical function, threshold improvements in lean body mass and appendicular skeletal muscle mass are necessary and these can be achieved by targeting changes in testosterone levels. rhGH augments the effects of testosterone. To maximize functional improvements, the doses of anabolic hormones should be titrated to achieve target blood levels.

    https://academic.oup.com/biomedgeron...A/1/122/532165


    So steroids DO work


    Sent from my iPhone using Tapatalk

  3. #3
    Senior Member

    chocolatemalt's Avatar


    Join Date
    Sep 2012
    Location
    Purple Mountains
    Posts
    5,706

    Thanks Thanks Given 
    427
    Thanks Thanks Received 
    542
    Thanked in
    347 Posts
    Rep Points
    2147483647

    Interesting piece to dig into. One tidbit:

    Total testosterone levels by liquid chromatography–tandem mass spectrometry were on average ∼130 ng/dL higher than those obtained by the automated platform immunoassays. It is possible that serum level targets may differ when other assays are used to quantify serum testosterone levels.


    That's LC/MS-MS vs. IA of course. We've noticed some variation between these two assays before but this is larger than I remember. We should lower our expectations of precision on the cheap IA panels.

    Also:

    Our data may also help explain why some testosterone trials, which used relatively low fixed doses of testosterone and achieved small (if any) increments in testosterone levels, reported relatively modest LBM gains and little or no change in muscle strength or physical function. Our data highlight the need for dose titration to target testosterone levels in clinical trials of testosterone for anabolic applications.

    That's their diplomatic way of saying lots of other studies suck.

Similar Threads

  1. Replies: 3
    Last Post: 08-27-2019, 05:06 PM
  2. Boost Irisin levels strength training
    By The Admin in forum Muscle Central
    Replies: 0
    Last Post: 10-28-2016, 01:10 PM
  3. Using Anabolic Steroids to Enhance Muscle Strength
    By The Admin in forum Muscle Central
    Replies: 0
    Last Post: 04-29-2014, 09:10 AM
  4. Replies: 0
    Last Post: 01-30-2014, 09:24 PM
  5. Replies: 0
    Last Post: 01-31-2013, 04:43 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Copyright© 2012-2019 Anabolic Steroid Discussion Forums