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The best method for administering testosterone

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  1. #1
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    The best method for administering testosterone

    Efficacy of combined treatment of intramuscular testosterone injection and testosterone ointment application for late-onset hypogonadism: an open-labeled, randomized, crossover study

    Tsukasa Narukawa,Jintetsu Soh,Noriyuki Kanemitsu,Shunji Harikai &Osamu Ukimura

    Received 07 Aug 2019, Accepted 09 Sep 2019, Published online: 18 Sep 2019
    Abstract

    Introduction: The best method for administering testosterone replacement therapy (TRT) for late-onset hypogonadism (LOH) remains controversial. This study aimed to compare the efficacy and safety of a combined treatment (CT) involving intramuscular testosterone injection and testosterone ointment application [GlowminŽ (GL)] with intramuscular injection monotherapy (IMIM).

    Materials and methods: Patients were randomly assigned as follows: Group 1 received IMIM for 12 weeks and CT for 12 weeks and Group 2 received CT for 12 weeks and IMIM for 12 weeks. Patients were then asked about their treatment preferences: (A) IMIM, (B) a combination of IMIM and ointment, or (C) either A or B.

    Results: Patients (n = 43) completed the study without any adverse effects. No significant differences between each treatment period were found. In Group 1, most patients chose B (n = 13) while in Group 2, most chose A (n = 10). In each group, patients preferred the second treatment phase; however, statistical significance was not reached between A and B (Group 1, p = 0.11 and Group 2, p = 0.47, respectively).
    Conclusion: TRT by CT is compatible with TRT by IMIM. Patients who cannot continue TRT because of polycythemia from IMIM may be suited to CT.


    https://www.tandfonline.com/doi/full...eedAccess=true















  2. #2
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    So....ointment causes less polycythemia? How is that? Because the test levels drop or some other function?

  3. #3
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    I've always been curious about topicals, my dad has been on topical TRT for years and said his test levels have always been pretty good on bloods. But, according to my step mom he has a lot of ups and downs (obviously)

  4. #4
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    I was expecting a bunch of sick bastards to chime in with that title ................Like Custom,maybe !!

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