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Pharmacokinetics of Subcutaneous Injection of Testosterone Undecanoate

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  1. #1
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    Pharmacokinetics of Subcutaneous Injection of Testosterone Undecanoate

    Pharmacokinetics and Acceptability of Subcutaneous Injection of Testosterone Undecanoate

    Leo Turner,1 Lam P Ly,1,2 Reena Desai,1,2 Gurmeet K S Singh,2,3 Timothy D Handelsman,1,2 Sasha Savkovic,1,2Carolyn Fennell,1 Veena Jayadev,1 Ann Conway,1,2 and David J Handelsman1,2

    Abstract

    Context
    Can injectable testosterone undecanoate (TU) be administered effectively and acceptably by the subcutaneous (SC) route?

    Objective
    To investigate the acceptability and pharmacokinetics (PK) of SC injection of TU.

    Design
    Randomized sequence, crossover clinical study of SC vs IM TU injections.

    Setting
    Ambulatory clinic of an academic andrology center.

    Participants
    Twenty men (11 hypogonadal, 9 transgender men) who were long-term users of TU. injections.

    Intervention: Injection of 1000 mg TU (in 4 mL castor oil vehicle) by SC or IM route.

    Main Outcome Measures: Patient-reported pain, acceptability, and preference scales. PK by measurement of serum testosterone, dihydrotestosterone (DHT), and estradiol (E2) concentrations with application of population PK methods and dried blood spot (DBS) sampling.

    Results

    Pain was greater after SC compared with IM injection 24 hours (but not immediately) after injection but both routes were equally acceptable. Ultimately 11 preferred IM, 6 preferred SC, and 3 had no preference. The DBS-based PK analysis of serum testosterone revealed a later time of peak testosterone concentration after SC vs IM injection (8.0 vs 3.3 days) but no significant route differences in model-predicted peak testosterone concentration (8.4 vs 9.6 ng/mL) or mean resident time (183 vs 110 days). The PK of venous serum testosterone, DHT, and E2 did not differ according to route of injection.

    Conclusions

    We conclude that SC TU injection is acceptable but produces greater pain 24 hours after injection that may contribute to the overall majority preference for the IM injection. The PK of testosterone, DHT, or E2
    did not differ substantially between SC and IM routes. Hence whereas further studies are required, the SC route represents an alternative to IM injections without a need to change dose for men for whom IM injection is not desired or recommended.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676071/


  2. #2
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    Glad to see you back Boss

  3. #3
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    hell yeah, Glad you're back... 1000mg SC, I bet that left a knot

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    Welcome back Heavy. Time to post some Jort pics brother!

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    So this question is a bit off but itís pertaining to TU. The oral version of test is test u suspended in castor oil. Not that I care to try this because I donít mind injecting I actually enjoy doing my injections but if one was to Make some TU raws in a suspension using castor oil would that work?

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    I knew he'd be back!

  7. #7
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    Hey Brother ....Tell us you're back for good....Been side lined for a couple of years (medical crap)...I come back and so much has changed...Not feeling the new vibe!!!

  8. #8
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    Hey Heavy.
    I've done Nebido for trt. It's like 4 CC s. It's a big pin for glutes, so I wouldn't go SQ. I stopped because you don't ' feel on '.

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    Quote Originally Posted by AMA rider View Post
    Hey Heavy.
    I've done Nebido for trt. It's like 4 CC s. It's a big pin for glutes, so I wouldn't go SQ. I stopped because you don't ' feel on '.
    I imagine there's alot of estrogen conversion or even just wasted testosterone since it's sitting in your body for so long with it's 33 day half life. If not then it would be great for long trips, truck drivers and oil rig workers who are out working for weeks or a month at a time. Or people who are terrified of pinning.

  10. #10
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    Good to see you posting up again Heavy, time to boot Arnold back into the shadows lmao.

    On topic this seems to be interesting to see how SC injections are...good or bad
    Last edited by MindlessWork; 08-25-2019 at 07:18 PM.

  11. #11
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    Glad to see some science back in the forum. Welcome back!

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