Tianeptine can be amazing for people with depression. It is generally used at 12.5-25mg dosed 3 times per day.
The first few times you take a large dose like this you will probably feel something for about an hour. However tolerance builds extremely fast, as far as inducing euphoria.
It lasts about 3-4 hours (about 4 hours at the doses in Vicaine), according to pretty much all user feedback. Furthermore, tolerance doesn't build much faster with tianeptine than with any other opiate...maybe 1-2 days faster. As long as it's not used too frequently (3-4X a week, max), its euphoric effects will be maintained.
Please be aware that tianeptine is harsh on the liver at doses exceeding the therapeutic range. This is not something you want to keep re-dosing attempting to chase a "high". Especially those already taking oral steroids.
This is completely untrue. You're parroting inaccurate information. Here's the facts. Tianeptine displays VERY mild hepatotoxic properties...nowhere NEAR oral AAS, alcohol or even Tylenol. The drug is so mild in this regard that it is regularly prescribed to those suffering from alcohol withdrawal; even those who are currently experiencing LIVER FAILURE!!! If the drug was even moderately hepatotoxic it would NEVER be used in this capacity. Clearly, the reason the medical community uses the drug in this fashion is because it is NOT hepatotoxic to any appreciable degree. Furthermore, tianeptine has been studied long-term at doses in excess of 500+ mg per day, with results showing MINIMAL increases in liver enzymes! To take it a step further, there have even been individuals who have used the drug long-term at the 1+ gram/day range...without experiencing any significant hepatotoxic effects. In nearly every case in which hepatoxicity was medically documented, the degree of liver stress noted was relatively mild, with all individuals making a rapid recovery without the need for medical intervention. I should also mention that in nearly every medically documented case of hepatotoxicity, the doses used were massive and/or combined with other liver toxic drugs. Even then, they made a rapid and full recovery on their own.
Also, for those of you out there that are unaware, the term hepatoxicity often sounds a lot scarier than it is. You see, technically, hepatotoxicity occurs as soon as one's liver enzymes rise outside of the normal range...even just a tiny bit. To give you a idea of how common hepatotoxicity actually is, let me put it this way. Every time you use an oral steroid, you are very likely in a hepatotoxic state. Every time you have a few beers, you are hepatotoxic. Every time you pop a few Tylenols you are hepatotoxic. A large percentage of people that use a prescription statin (which are prescribed to millions in the U.S alone) are experiencing hepatotoxicity. I could go on and on. What matters here is not whether someone is in a hepatotoxic state, but the "degree" of that hepatotoxicity. Hepatotoxicity can range from insignificant (some people live their entire lives in a hepatotoxic state due to certain prescription drugs, disease, alcohol, use, etc) to life-threatening. By and large, tianeptine is considered a very safe drug, with very few people displaying hepatotoxicity even when used at larger dosages.
So, to say that using tianeptine outside the normal therapeutic range is "harsh" on the liver is just not true. This comment bothers me because it implies I would sell a dangerous drug to unsuspecting buyers without informing them beforehand. I know you didn't mean it that way, but that's the way it comes across. I would never release a product without being extremely knowledgeable about its ingredients. In ths instance, I have studied tianeptine extensively--almost certainly more than anyone on this board...and maybe any bodybuilding board.
Products like this just scare me in a way (by using a huge dose of something in order to cause a short lived euphoria and getting said substance banned because people will inevitably abuse it). I have a family member who suffers from depression who is helped greatly by tianeptine where conventional medicine was of no relief or caused terrible side effects.
Don't kid yourself, Tianeptine "treatment" is nothing more than low-dose opiate therapy masked as anti-depressant treatment. The drug was originally marketed (falsely) as an anti-depressant because when it was first made researchers didn't know it activated opiate receptors. Rather, they thought it worked by manipulating serotonin. It was later discovered (decades later) that it doesn't work through serotonin at all...and that ALL (or close to all) of its anti-depressant effects are mediated via the opiate receptor. So, what this means is that for all those years, physicians were really just prescribing low-dose opiate therapy for people with depression.
Kratom is like weed. If you attempt to chase it you're going to make yourself sick and have a bad time, but you will survive just fine. Tianeptine is like Vicodin, you may not die from an "opiate od" but the acetaminophen is going to put you in the hospital with liver problems. That brings with it all the heat of some govt official needing to appear like they're saving the world.
I addressed this ignorance above.