basskiller's collection of Bodybuilding Peptide Articles

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  1. #91
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    Thanks for putting this together man - you saved me a ton of research time.

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    CJC 1295 with Drug Affinity Complex

    CJC 1295 with Drug Affinity Complex

    CJC-1295 is a synthetic modification of growth hormone releasing factor (GRF) with D-Ala, Gln, Ala, and Leu substitutions at positions 2, 8, 15, and 27 respectively. These substitutions create a much more stable peptide with the substitution at position 2 to prevent DPP-IV cleavage, position 8 to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, position 15 to enhance bioactivity, and position 27 to prevent methionine oxidation. By applying the Drug Affinity Complex (DAC) technology to GRF, the peptide selectively and covalently binds to circulating albumin after subcutaneous (SC) administration, thus prolonging its half-life. These substitutions are key in increasing the overall half life of CJC-1295 but there lies an even greater reason as to why the half life has been extended from ~7 minutes to greater than 7 days.

    CJC-1295 is a Long acting GHRH analog. Growth-hormone-releasing hormone (GHRH), also known as growth-hormone-releasing factor (GRF or GHRF) or somatocrinin, is a 44-amino acid peptide hormone produced in the hypothalamus by the arcuate nucleus. GHRH stimulates growth hormone (GH) secretion from the pituitary. GHRH is released in a pulsatile manner, stimulating pulsatile release of GH respectively. This substance also promotes slow wave sleep. The active portion of this GRF or GHRH peptide can be found as a 29 amino acid long peptide and is appropriately named GHRH1-29. This pulsatile release of various peptides is due to the negative feedback loop that is part of the hGH axis and controls the amount of hGH that your body produces to keep it in a homeostatic environment.

    Various experiments have been conducted to test the effectiveness of CJC-1295 in vivo and the Journal of Clinical Endocrinology & Metabolism has reported dose-dependent increases in mean plasma GH concentrations by 2-10 fold for more than 6 days and increased IGF-1 concentrations 1.5-3 fold for 9-11 days after a single injection

  3. #93
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    TB-500 Healing Peptide


    TB-500 is an injectable peptide drug which can be used to promote healing, enhance range of motion in cases of injury, or reduce pain in case of injury by reducing inflammation. As yet its human use has been relatively uncommon and limited to individuals who like to experiment. Use in race horses has been more widespread, though it’s not a prescription veterinary drug.

    When to use TB-500

    I’d recommend considering TB-500 in cases of acute injury where, as judged from experience, healing might otherwise be slow, or in cases of chronic injury where healing otherwise simply isn’t occurring.

    The types of injury that are aided include tendinitis and muscle tears or strains, but may include many types of muscle and connective tissue injury, as well as skin injury. Where muscle injury results in impaired flexibility, TB-500 can provide substantial improvement. With regard to racing horses, it’s claimed to prevent the formation of adhesions. Whether this is true in humans or even horses I cannot say, but there’s substantial indication that it helps treat existing adhesions.

    Possible increased effect from combining TB-500 with GH, or a GHRP

    While TB-500 can be remarkably effective administered alone, at least some persons will experience better results with TB-500 taken together with GH than with TB-500 alone.

    Alternately, compared to using TB-500 alone, healing effect can be improved by combining TB-500 with a GHRP (such as GHRP-2, GHRP-6, ipamorelin, or hexarelin), or a GHRP / Mod GRF stack.

    Of those two approaches, from results I presently believe the TB-500 / GH stack to be the more effective.

    How to use TB-500

    TB-500 is typically provided as lyophilized (freeze-dried) powder in vials of 2.0 mg. A convenient amount of sterile or bacteriostatic water will be added, such as 1.0 mL. In the most common dosing protocol, the entire vial is taken at one time. If taking the entire vial, the entire amount will be drawn into a syringe, typically an insulin syringe, and injected. Injection may be subcutaneous, intramuscular, or intravenous, according to personal preference.

    The most common dosing protocol is to take 2.0 or 2.5 mg of TB-500 twice per week for four to six weeks, and then reduce to a lower dosing rate such as once or twice per month for maintenance.

    The body of knowledge is as yet limited with regard to TB-500 dosage. The above protocol may or may not be the most efficient, but it is the protocol with the most track record. It’s entirely possible that as knowledge is gained, method of use will change. A reasonable possibility, for example, is to increase dosing frequency to 3x/week (which I have done personally to good effect), or to increase dosing to 4 or 5 mg twice per week. Before going to such a program, however, I recommend trying the standard protocol first.

    If interested in animal uses, a typical dosing protocol for horses is a course of six 10 mg injections at 7-10 day intervals. For more intensive treatment, 20 mg is used weekly. For racing dogs, a typical protocol is a course of six 5 mg injections taken weekly.

    Pharmacological class of TB-500

    TB-500 is a short peptide segment or fragment of the naturally-occurring thymosin beta-4 hormone (TB-4.) To be clear, TB-500 most emphatically is not TB-4, although it’s often sold under that name. TB-4 itself is as yet an extremely pricey, rare research material that is not yet available to bodybuilding or to equine enhancement.

    In the body, TB-4 is produced is the thymus, a gland which is at its largest in children, atrophies as adulthood progresses, and is virtually non-existent in the elderly. It is also produced locally in various cells, and is particularly found in wound fluids, as well as in fairly high concentration in the cytoplasm of some cells. In various studies, TB-4 has been found able to promote various forms of wound healing, to promote differentiation of stem cells, and to reduce inflammation.

    Protein hormones such as TB-4 do not bind in their entirety to a receptor site, as they are too large to fit. Instead, an active region of the protein fits into receptor sites.

    The TB-500 peptide sequence is identical with the active region area of TB-4 and shares many and possibly all of the properties of TB-4, in a form which is more economical to produce.

    Other activities of TB-500

    TB-500 has been known to promote at least partial regrowth of hair which has been lost to male-pattern baldness, to darken at least a portion of hair which has grayed, and is reported to enhance muscle mass in horses. The latter effect may be due to promoting differentiation of satellite cells. Bodybuilders who have used TB-500 for healing purposes have however generally not reported such an effect. However, it might be that the effect occurred, but was attributed to other causes, or that effect did not occur because TB-500 is generally used only when injured, which tends not to be a time of training for best gains.

    I wouldn’t use TB-500 for the purpose of mass gains, but while using it would keep in mind that uninjured body parts might obtain a benefit from its use, and would train uninjured weak body parts especially hard while doing a TB-500 course, on the chance of benefit. In my personal use, it does seem likely there was some such effect, without having had the knowledge beforehand of muscle gain in horses. I had no expectation of muscle size or “quality” benefit at all.

    Conclusion

    TB-500 is a peptide which can be quite beneficial for healing of injuries, both acute and chronic, and for treatment of tendinitis. It can also improve flexibility where this has been impaired by injury, and in some cases has partially regrown lost hair. The ordinary course of treatment is 2.0 or 2.5 mg taken by injection twice per week for 4-6 weeks, followed by monthly or twice-monthly injection of 2.0 or 2.5 mg as needed

    by Bill Roberts writer and anabolic expert for thinksteroids.com

  4. #94
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    this is AWESOME Subbed so I don't lose it

  5. #95
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    Impact of pentadecapeptide BPC 157 on muscle healing

    The effect of systemic and local peptide treatment effective in muscle contusion and then on counteraction of corticosteroid-induced impairment was tested. The pentadecapeptide BPC 157, given without a carrier, improved the healing of transected quadriceps muscle. It also improved muscle healing in rats with muscle crush injury when applied systemically or locally. Importantly, it counteracted corticosteroid-impairment in tendon to bone healing. Thus BPC 157 is proposed as an effective treatment that can improve muscle healing in spite of corticosteroid treatment.

    MATERIAL/METHODS:
    After the gastrocnemius muscle complex had been injured, rats received BPC 157 (intraperitoneally or locally as a cream) and/or 6alpha-methylprednisolone (intraperitoneally) only once (immediately after injury, sacrifice at 2 h) or once daily (final dose 24 hours before sacrifice and/or
    assessment procedure at days 1, 2, 4, 7, and 14). Muscle healing was evaluated functionally, macroscopically, and histologically.

    RESULTS:
    Without therapy, crushed gastrocnemius muscle complex controls showed limited improvement. 6alpha-methylprednisolone markedly aggravated healing. In contrast, BPC 157 induced faster muscle healing and full function restoration and improved muscle healing despite systemic corticosteroid treatment when given intraperitoneally or locally and demonstrated functionally, macroscopically, and histologically at all investigated intervals.

    CONCLUSIONS:
    BPC 157 completely reversed systemic corticosteroid-impaired muscle healing.

  6. #96
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    peg-MGF + IGF1-LR3

    Mechano Growth Factor (MGF). We know things like IGF creates new muscle cells
    and helps drop body fat and MGF helps facilitate this muscle growth and fat loss.
    Most of us are familiar with the peptides Insulin-Like Growth Factor (IGF) and

    Read the rest http://www.anabolicsteroidforums.com...1-lr3?p=607740

  7. #97
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    Subbed😀

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    It has been estimated that most people lose between 35% and 45% of skeletal muscle in the 6 decades between the ages of 20 and 80. This progressive loss of muscle is known as sarcopenia and, combined with osteoporosis, is responsible for the loss of strength, increasing frailty, and loss of independence seen in many elderly people

    MK-677 Increases Lean Muscle Mass in Elderly

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    Increasing the size and strength of muscles represents a promising therapeutic strategy for musculoskeletal disorders, and interest has focused on myostatin, a negative regulator of muscle growth. Various myostatin inhibitor approaches have been identified and tested in models of muscle disease with varying efficacies, depending on the age at which myostatin inhibition occurs. Here, we describe a one-time gene administration of myostatin-inhibitor-proteins to enhance muscle mass and strength in normal and dystrophic mouse models for >2 years, even when delivered in aged animals. These results demonstrate a promising therapeutic strategy that warrants consideration for clinical trials in human muscle diseases.

    Read More...

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    BassKiller.... As a long time lurker and now newly registered I wanted to say thank you for putting all this together. I've learned a ton from reading your articles in this thread over the last several months. In fact I keep coming back and re-reading / studying all the time. I believe peps have made a massive difference in my life and I enjoy playing with different combinations. My current protocol is as follows 4x per day:

    100 mcg Mod GRF
    100 mcg GHRP2
    100 mcg GHRP6/Semorelin
    300 mcg Ipam

    I don't feel any sides at all besides occasional hand tingling and hand numbness / sleeping during the night. I know for a fact it's working, but it does take time. The only down side is going through a ton of slin pins.

  11. #101
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  12. #102
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    What types of Growth Hormone Releasing Hormones are there

    Growth Hormone Releasing Hormones (GHRH) (amplifies the Growth Hormone Releasing Peptides (GHRP) initiated pulse):

    - GRF(1-44) - half-life is less than 5-10 minutes

    - GRF(1-29) Sermorelin - half-life is less than 5-10 minutes

    - Modified GRF(1-29) or CJC-1295 w/o the DAC - Half-life at least 30 minutes

    - CJC-1295 (with DAC) - Half-life measured in days


    Growth Hormone Releasing Hormone (GHRH) pulses can only last less than 30 minutes before your body has used out the potential for a single growth hormone pulse. Since another pulse won't be generated for about 2.5 - 3 hours hormones that last more than 30 minutes up to 3 hours are not any more beneficial.


    The administration of Growth Hormone Releasing Hormone (GHRH) creates a pulse of growth hormone release which will be small if administered during a natural growth hormone trough and higher if administered during a rising natural growth hormone wave.


    What types of Growth Hormone Releasing Peptides are there?

    Growth Hormone Releasing Peptides (GHRP) (Growth hormone pulse initiators):

    - Ipamorelin is potent but the weakest growth hormone releaser. It does not increase cortisol or prolactin at any dose.

    - GHRP-6 is very potent in effecting growth hormone release. It does not effect cortisol or prolactin up to a 100mcg dose, but does so minimally above 100mcg.

    - GHRP-2 is a little bit more potent then GHRP-6. It also has a stronger effect on these hormones at all dosing levels rising to the high normal range for cortisol and prolactin.

    - Hexarelin the strongest is a little more potent then GHRP-2. At all dosing levels it has the strongest impact on cortisol and prolactin with levels in the upper bounds of normalcy.


    Growth Hormone Releasing Peptides (GHRP) can become desensitized with constant usage throughout the day. Ipamorelin and GHRP-6 do not desensitize as long as there are short breaks between doses minimal 2 hours. GHRP-2 does not desensitize in the lower dose ranges without short breaks. At high dose it is unclear, but some desensitization may occur. Hexarelin has been shown to desensitize without regard to dose and even with short breaks between doses. This effect shows up after 14 days of continuous use and may be avoided by either keeping doses low or taking a full day or two off every two weeks.


    Growth Hormone Releasing Peptides (GHRP) are capable of creating a larger pulse of growth hormone on their own than Growth Hormone Releasing Hormone (GHRH) and they do this with much more consistency and predictability without regard to whether a natural wave or trough of growth hormone is currently taking place.


    How much Growth Hormone Releasing Hormone (GHRH) should be used?

    The saturation dose in most studies is defined as 100mcg or 1mcg/kg per growth hormone pulse.


    How long should Growth Hormone Releasing Hormone (GHRH) be used?

    In most studies no adverse side effects were reported with use for 4-8 weeks (per the dosage limits in the above answer) followed by 4 weeks of non-use.


    How much Growth Hormone Releasing Peptides (GHRP) should be used?

    The saturation dose in most studies on Growth Hormone Releasing Peptides (GHRP) is defined as either 100mcg or 1mcg/kg. However that would assume a 100% pure peptide. Note: In general you it is recommended that your dose is rounded up to 150mcg unless the manufacturer advises otherwise.


    This means that 100mcg will saturate the receptors fully, but if you add another 100mcg to that dose only 50% of that portion will be effective. If you add an additional 100mcg to that dose only about 25% will be effective. Perhaps a final 100mcg might add a little something to growth hormone release but that is it.


    If 100mcg is the saturation dose, you could add more (up to 300-400mcg) and get a little more effect. A 500mcg dose will not be more effective than a 400mcg, perhaps not even more effective than 300mcg.


    The additional problems with higher dosages are desensitization and cortisol/prolactin side-effects.


    Ipamorelin and GHRP-6 at the saturation dose of 100mcg does not really increase prolactin & cortisol but may do so slightly at higher doses. This rise is still within the normal range. It can be used at saturation dose (100mcg) three or four times a day without risk of desensitization.


    GHRP-2 is more effective then GHRP-6 at causing growth hormone release but at the saturation dose of a 100mcg or higher may produce a slight to moderate increase in prolactin & cortisol. This rise is still within the normal range although doses of 200 - 400mcg might make it the high end of the normal range. It can be used at saturation dose several times a day will not result in desensitization.


    Hexarelin in general is the most effective at causing an increase in growth hormone release. However it has the highest potential to also increase cortisol & prolactin. This rise will occur even at the 100mcg saturation dose. This rise will reach the higher levels of what is defined as normal. It has been shown to bring about desensitization but in a long-term study the pituitary recovered its sensitivity so that there was not long-term loss of sensitivity at saturation dose. Even at 100mcg three times a day will likely lead to some down regulation within 14 days.


    If desensitization were to ever occur for any of these Growth Hormone Releasing Peptides (GHRP) simply stop administering them for several days and this will remedy the effect.


    How long should Growth Hormone Releasing Peptides (GHRP) be used?

    In most studies no adverse side effects were reported with continuous use per the dosage limits in the above answer.


    Does Growth Hormone Releasing Hormone (GHRH) and Growth Hormone Releasing Peptides (GHRP) work together better?

    It is well documented and established that the concurrent administration of Growth Hormone Releasing Hormone (GHRH) and Growth Hormone Releasing Peptides (GHRP) results in synergistic release of growth hormone from pituitary.


    In other words if Growth Hormone Releasing Hormone (GHRH) contributes a growth hormone amount quantified as the number 2 and Growth Hormone Releasing Peptides (GHRP) contributed a growth hormone amount quantified as the number 4 the total growth hormone release is not additive (i.e. 2 + 4 = 6). Rather the whole is greater than the sum of the parts such that 2 + 4 = 12.


    Can Growth Hormone Releasing Hormone (GHRH CJC-1295) be used alone?

    The problem with using only Growth Hormone Releasing Hormone (GHRH) (even the stronger analogs) is that they are only effective when somatostatin is low (the growth hormone inhibiting hormone). So if you administer it in a trough (or when a growth hormone pulse is not naturally occurring) you will add very little growth hormone release. If however you administer it during a rising wave or growth hormone pulse (somatostatin will not be active at this point) you will add to growth hormone release.



    Can Growth Hormone Releasing Peptides (GHRP) be used alone?

    Yes. They are capable of creating a larger pulse of growth hormone on their own than Growth Hormone Releasing Hormone (GHRH) and they do this with much more consistency and predictability without regard to whether a natural wave or trough of growth hormone is currently taking place.


    What is a typical protocol for Growth Hormone Releasing Hormone (GHRH) and Growth Hormone Releasing Peptides (GHRP)?


    Studies have suggested the following:

    A typical conservation protocol would be:

    100-200mcg of Growth Hormone Releasing Peptides (GHRP)

    Approximately 5-7 days a week - subcutaneous injections


    This can be used once, twice, three or four times a day to make it more effective.

    When dosing multiple times a day at least 3 hours should separate the administrations.


    A more aggressive protocol would be:

    100-200mcg of Growth Hormone Releasing Peptides (GHRP) plus

    100-300mcg of Growth Hormone Releasing Hormone (GHRH).

    Approximately 5-7 days a week - subcutaneous injections


    This can be used once, twice, three or four times a day to make it more effective.

    When dosing multiple times a day at least 3 hours should separate the administrations.


    Studies suggest that a once a day dosing pre-bed will give a restorative amount of growth hormone while multiple dosing and/or higher levels will give higher growth hormone & IGF-1 levels which will lead to muscle gain, fatloss and/or injury repair.


    Should food be consumed before or after the injection of Growth Hormone Releasing Hormone (GHRH) and/or Growth Hormone Releasing Peptides (GHRP)?

    Studies have shown that administration should ideally be done on either an empty stomach or with only protein in the stomach. Fats and carbohydrates blunt growth hormone release. After administering the peptides wait about 20 minutes (no more than 30 but no less than 15 minutes) to eat. At that point the growth hormone pulse has reached its peak and you can eat what you want.


    Synthetic Growth Hormone


    What is Human Growth Hormone (HGH) Fragment 176-191?

    The HGH Fragment is a modified form of amino acids 176-191 at the C-terminal region of the human growth hormone (HGH). Studies have shown that it works by mimicking the way natural HGH regulates fat metabolism but without the adverse effects on insulin sensitivity (blood sugar) or cell proliferation (muscle growth) that is seen with unmodified HGH. Like unmodified GH, the HGH fragment 176-191 stimulates lipolysis (breaking down of fat) and inhibits lipogenesis (the formation of fatty acids and other lipids in the body).





    HGH fragment 176-191 is meant to be 12.5 times stronger than human growth hormone (HGH) for weight loss than standard human growth hormone (HGH).


    Of particular note is that in studies HGH fragment 176-191 had the ability to increase IGF-1 levels which translates into the fragments ability to give anti-aging effects.


    How much Human Growth Hormone (HGH) Fragment 176-191 should be used?


    In most studies favorable results have been shown with dosages between 500-1000mcg or 5-10mcg/kg split into multiple dosages per day.


    How long should Human Growth Hormone (HGH) Fragment 176-191 be used?

    In most studies no adverse side effects were reported with continuous use per the dosage limits in the above answer.


    What is a typical protocol for Human Growth Hormone (HGH) Fragment 176-191?

    Studies have suggested the following:

    A typical conservation protocol would be:

    250mcg in the morning plus

    250mcg pre lunch plus

    250mcg in the evening (pre-bed).

    Approximately 5-7 days a week - subcutaneous injections


    A more aggressive protocol would be:

    350mcg in the morning plus

    350mcg 30 minutes prior to training

    350mcg in the evening (pre-bed).

    Approximately 5-7 days a week - subcutaneous injections


    When dosing multiple times a day at least 3 hours should separate the administrations.


    Should food be consumed before or after the injection of Human Growth Hormone (HGH) Fragment 176-191?


    Studies have shown that administration should ideally be done on either an empty stomach or with only protein in the stomach. Fats and carbohydrates blunt growth hormone release. After administering the peptides wait about 20 minutes (no more than 30 but no less than 15 minutes) to eat. At that point the growth hormone pulse has reached its peak and you can eat what you want
    author Unknown

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    Hey, I read through this post but was unable to locate any information on Follistatin 344. Know of anyone using it? Any information on it would be great or point me in the right direction! Thanks!!

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    I'll be trying the HGH Frag/T3/Clen cycle laid out here to get back to competition weight after this last bulk. I might try to be a little less aggressive with the T3, but I shouldn't have a ton to lose.

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    YK11 – Highly Powerful SARM that changes your Genetic Muscle-Building Potential

    Selective Androgen Receptor Modulators (SARMs) are highly popular in the bodybuilding world because they provide muscle-gain and fat-loss results similar to anabolic-androgenic steroids (AAS), only without the same level of harsh side effects (i.e. HPTA shutdown, high blood pressure, liver problems). SARMs can do this because, unlike AAS, they are more selective when activating androgen receptors to produce muscle gains and fat loss.

    YK11 Of course, like anabolic steroids, some SARMs are far more effective than others. And YK11 – one of the newest SARMs on the market – definitely fits into the upper-echelon of these compounds. In fact, YK11 has been proven to change your genetic potential for building muscle! This being said, let’s discuss how YK11 accomplishes this as well as why it might be the most powerful SARM available.



    YK11: both a Potent Androgen and Myostatin Inhibitor

    So what makes YK11 so special, other than its value as a powerful SARM? You see, in addition to being a SARM and acting as a potent androgen with minimal adverse side effects, YK11 also acts as an effective myostatin inhibitor!

    Myostatin is a protein that, when present, limits the growth and production of muscle tissue. By inhibiting myostatin, you can literally increase your genetic potential to build muscle tissue! Sounds almost too good to be true, but it is not only true but scientifically proven (1)!

    ResultsJapanese researchers at Toho University further studied YK11’s role as a myostatin inhibitor (2). The scientists wanted to know why YK11 was so much more anabolic than other SARMs, so they deactivated follistatin (a naturally occurring myostatin inhibitor).Once the researchers did this, YK11 lost a significant amount of its anabolic properties. This proved that, in addition to acting as an androgen and an anabolic via androgenic pathways, YK11 also acted as a truly effective myostatin inhibitor, significantly boosting its anabolic effects!



    More Anabolic than DHT, without the Side Effects

    Studies have shown YK11 to be significantly more anabolic & androgenic than the steroid dihydrotestosterone (DHT) – WITHOUT the adverse side effects of DHT, such as hair loss and prostate enlargement (3). In fact, with YK11, the prostate appears unaffected, and your hair actually grows!

    YK11 truly does have the potential to revolutionize not only SARMs but anabolics in general. Its dual mechanism of action and anabolism via dual pathways makes it a truly unique, one-of-a-kind compound. And it has the potential to literally increase the genetic potential for building muscle while acting as an anabolic that will effectively build muscle at the same time – and all this with an excellent safety profile!

    Assuming you’re looking to experience the incredible anabolic effects of YK11 in your research, you only have to dose subjects with 5-10mg/day. And given all the benefits we’ve discussed so far, it’s definitely worth giving YK11 a try.



    References
    1. Biol Pharm Bull. 2011;34(3):318-23.(17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11) is a partial agonist of the androgen receptor. Kanno Y1, Hikosaka R, Zhang SY, Inoue Y, Nakahama T, Kato K, Yamaguchi A, Tominaga N, Kohra S, Arizono K, Inouye.
    2. Biol Pharm Bull. 2013;36(9):1460-5.Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression. Kanno Y1, Ota R, Someya K, Kusakabe T, Kato K, Inouye Y.
    3. The effects of a myostatin inhibitor on lean body mass, strength, and power in resistance-trained males. Matthew Sharp, Ryan P Lowery, Kevin Shields, Jacob Ormes, Sean A McCleary, Jacob Rauch, Jeremy Silva, Ned Arick and Jacob M Wilson**Corresponding Author: Jacob M Wilson The University of Tampa, Tampa, Florida, USA.

    author George Spellwin

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