• 👋Hello, please SIGN-UP FOR A FREE account and become a member of our community!
    You will then be able to start threads, post comments and send messages to other members. Thanks!
  • 💪IronMag Labs® 30% Off Easter Sale👉www.ironmaglabs.com Coupon code: EASTER30🐰

basskiller's collection of Bodybuilding Peptide Articles

Thanks brother, will keep in contact and you have some great products on your site my friend!!

the cjc-1295 + ghrp-2 is an excellent cycle. I will be running it again before summer.
Right now im waiting on a sarm cycle. Looking forward to trying this
 
Still learning myself.... what would you recomend to help with joints and skin and leaning out? You put alot of good info in here. Thank you.
 
Activation of the GH/IGF-1 axis by CJC-1295

Activation of the GH/IGF-1 axis by CJC-1295


Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects.

Abstract OBJECTIVE:

To identify biomarkers of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) action in human serum.
BACKGROUND:

The search for new markers of GH activity has received extensive attention given that the current biomarkers (IGF-1, IGFBP-3 and collagen peptides) show substantial variability in the population, and are not reliably predictive of either the physiologic effects of GH therapy or the detection of GH abuse by athletes. GH releasing hormone (GHRH) is a polypeptide synthesized in the hypothalamus that binds to receptors on pituitary somatotropes to promote the synthesis and release of GH. Serum GH and IGF-1 levels have been shown to increase with administration of GHRH or CJC-1295, a long-acting GHRH analog.
DESIGN:

Sera from 11 healthy young adult men before and one week after CJC-1295 injection were analyzed by two-dimensional gel electrophoresis for proteomic changes. Serum proteins displaying significant changes before and after treatment were subsequently identified using mass spectrometry. In addition, correlations between these proteins and GH or IGF-1 levels were evaluated.
RESULTS:

Two protein spots that displayed decreased intensities after treatment were identified as an apolipoprotein A1 isoform and a transthyretin isoform. Three protein spots upregulated by CJC-1295 treatment included beta-hemoglobin, a C-terminal fragment of albumin, and a mix of an immunoglobulin fragment and another C-terminal albumin fragment. A linear relationship was found between the spot containing immunoglobulin and albumin fragments and IGF-1 levels.
CONCLUSIONS:

Although the molecular mechanisms linking the identified proteins to GH and IGF-1 biological activity remain to be clarified, the results suggest that they represent potential biomarkers of GH and/or IGF-1 action.

Sackmann-Sala L, Ding J, Frohman LA, Kopchick JJ.
Source

Department of Biological Sciences, Ohio University, Athens, Ohio 45701, United States.

PMID:
19386527
[PubMed - indexed for MEDLINE]
PMCID:
 
Last edited:
Bremelanotide PT-141 Instruction

Light: .5mg
Common: 1mg
Large: 2mg
Trusted Supplier: PT-141
Bremelanotide PT-141 was developed from Melanotan 2 (MT-II). PT-141 is a metabolite of melanocyte stimulating hormone that targets desire.

PT-141 Bremelanotide molecule research chemical
Treatment: PT-141 is the only synthetic aphrodisiac. The aphrodisiac effects of Bremelanotide are in a class of its own. Studies have shown Bremelanotide to be effective in treating sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). Nine out of ten volunteers experienced sexual arousal in clinical trials. Unlike Viagra and other related medications (PDE5s – blood pushers), PT-141 acts upon the nervous system. Viagra, Cials and Levitra are not considered aphrodisiacs as they do not have any direct effect on the libido. However, treatment with PDE5 inhibitors and PT-141 have known synergy.
Men’s Journal Magazine: …it took hold. I felt a great surge of affection (greater than any regular level of arousal). My body tingled and I developed an erection that wouldn’t quit. For two hours the drug wouldn’t let me out of its grasp — nor my wife out of mine.

Men’s Journal PT-141

Females: Women who took part in trials said that they felt a “tingling and a throbbing” along with “a strong desire to have sex.” An initial flush occurs post injection, followed by nausea which is dose dependent. For most, effects generally do not take place until a couple hours post injection, peaking around the four hour mark. Men said PT-141 made them feel “younger and more energetic” as well as sexually interested and aroused. “You’re ready to take your pants off and go,” said user “a product that makes you not only able to but eager to.”
Window of Opportunity: Bremelanotide, injected (subcutaneously), has a unique window of opportunity lasting six to 72 hours. In lab trials female rats exposed to PT-141 began “flirting” with male rats for sex. Postures and movements left no doubt in the male rats minds that they were in the mood. The human PT-141 date is one where the dosage precedes the activity by at least a couple hours. When the stars align, hours after the injection, …this is your window of opportunity, enjoy.
Bremelanotide PT141 Peptide: Bremelanotide sold online comes in 10mg vials. As a lifestyle melanocortin research peptide, the 10mg product is a lot to consume and may offer up to 20+ doses when dosing PT-141 conservatively. Quality PT141 reconstituted with bacteriostatic water remains potent and preserved for months.

Mixing PT-141: Bacteriostatic water is used for reconstitution.

Example- 1ml(cc) bacteriostatic water per 10mg PT-141 vial equates to a 1mg dose approximately each 10 units on a U100 insulin syringe.
Example- 1ml(cc) bacteriostatic water per 2mg PT-141 vial equates to a 1mg dose approximately every 50 units on a U100 insulin syringe.
Recommended strategy for mixing and dosing would be to reconstitute with the volume that yields a .1ml injection.
Example- 1ml(cc) bacteriostatic water per 10mg PT-141 vial equates to a 1mg dose approximately each 10 units on a U100 insulin syringe.
Example- .2ml(cc) bacteriostatic water per 2mg PT-141 vial equates to a 1mg dose approximately every 10 units on a U100 insulin syringe.

PT141 Dosing:

Read as much as possible to gain clarity and align expectations. Gradually dosing melanotan peptides increases likelihood for success without sides (desensitization occurs rapidly). Test PT-141 dosage of .25-.5mg on first attempt is recommended. 1mg, give or take a quarter, is the efficacious dose yielding most positive reports.
 
GHRP-2 vs GHRP-6 vs Ipamorelin

GHRP-2

Growth-Hormone-Releasing-Peptide-Two (GHRP-2) is a synthetic ghrelin analogue. It causes the release of endogenous (internal) Growth Hormone (GH) from somatotropes in the anterior pituitary gland. It works synergistically with GHRHs and lacks the lipogenic properties (fat creation/storage) of ghrelin. GHRP-2 excites the hypothalamus and causes a high release of GH which tapers back to baseline by the third hour post admin. This pulse closely represents that of the natural pulse of the human body giving it an advantage over synthetic GH use.


Benefits and Potential of GHRP-2


Similar to Ipamorelin, GHRP-2 has great benefit and potential in athletes and wellness. GHRP-2 has been studied and shown to be effective in treating age-related GH decline when used in combination with a GHRH such as CJC-1295. GHRP-2 when use with an equal dose of a GHRH creates a 3-hour pulse of GH that is double the amplitude of 8IU of synthetic GH. This makes it a more effective, healthier substitute to synthetic Growth Hormone with the added safety and lower cost benefits.




GHRP-6


Growth-Hormone-Releasing-Peptide-6 (GHRP-6) is a Growth Hormone (GH) secretagogue and ghrelin mimetic.


The peptide GHRP-6 works similarly to GHRP-2 and Ipamorelin, however it induces hunger consistently in mammals. It also does have some lipogenic properties that are dependent on the status on insulin and glucose. GHRP-6 may cause weight and adipose tissue gain if insulin is present. So don't eat for 30 mins post injection, nothing, nada. You'll be starving but dont eat.


Benefits and Potential of GHRP-6


Again, similar to GHRP-2 and Ipamorelin, GHRP-6 has many benefits and uses. Due to the increased GH release, the following benefits may be observed:


Increased Energy
Improved Sleep
Increased Lean Body Mass
Decreased Body Fat
Increased Collagen Production
Increased Healing Capability



Ipamorelin


Ipamorelin or NNC 26-0161, a polypeptide hormone, is a growth hormone secretagogue and ghrelin mimetic and analog developed by Novo Nordisk[3]. Ipamorelin belongs to the most recent generation of GHRPs from the mid 1990s and causes significant release of growth hormone by itself, due both to its suppression of somatostatin (an antagonist to GHRH) and stimulation of release of GH from the anterior pituitary, similar to GHRP-2 and GHRP-6 which are compounds from the same class (growth hormone releasing peptides).[1] The cells that produce and release GH are known as somatotropes.[2] Like GHRP-2, ipamorelin does not have ghrelin’s lipogenic properties. Like GHRP-2 and unlike GHRP-6 ipamorelin never induces hunger in mammals. Ipamorelin acts synergistically when applied during a native GHRH (growth-hormone releasing hormone) pulse or when coadministered with GHRH or a GHRH analog such as Sermorelin or GRF 1-29 (growth releasing factor, aminos 1-29).[1] The synergy comes both due to the suppression of somatostatin and the fact that ipamorelin increases GH release per-somatotrope, while GHRH increases the number of somatotropes releasing GH.[1,2] There is also a secondary effect of neuronal excitation in the hypothalamus caused by ipamorelin, which lasts for approximately 3 hours after application, similar to GHRP-2 and GHRP-6.


Ipamorelin has a unique property among the GHRP class of peptides. That property is known as selectiveness. Whereas GHRP-6 and GHRP-2 cause a release and increase in cortisol and prolactin levels, ipamorelin only selectively releases GH at any dose. Further, a mega-dose of ipamorelin results in a concomitant mega-release of GH (up to the entire amount present in the pituitary), whereas GHRP-2 and GHRP-6 have limits of approximately 1mcg/kg in humans for their maximal GH release.[4,5]



Now comes some scientific study info. If you cant follow it, just as i'll translate it for you...



Raun et al demonstrated the selectiveness of ipamorelin for GH release only in a study:
The development and pharmacology of a new potent growth hormone (GH) secretagogue, ipamorelin, is described. Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2), which displays high GH releasing potency and efficacy in vitro and in vivo. As an outcome of a major chemistry programme, ipamorelin was identified within a series of compounds lacking the central dipeptide Ala-Trp of growth hormone-releasing peptide (GHRP)-1. In vitro, ipamorelin released GH from primary rat pituitary cells with a potency and efficacy similar to GHRP-6 (ECs) = 1.3+/-0.4nmol/l and Emax = 85+/-5% vs 2.2+/-0.3nmol/l and 100%). A pharmacological profiling using GHRP and growth hormone-releasing hormone (GHRH) antagonists clearly demonstrated that ipamorelin, like GHRP-6, stimulates GH release via a GHRP-like receptor. In pentobarbital anaesthetised rats, ipamorelin released GH with a potency and efficacy comparable to GHRP-6 (ED50 = 80+/-42nmol/kg and Emax = 1545+/-250ng GH/ml vs 115+/-36nmol/kg and 1167+/-120ng GH/ml). In conscious swine, ipamorelin released GH with an ED50 = 2.3+/-0.03 nmol/kg and an Emax = 65+/-0.2 ng GH/ml plasma. Again, this was very similar to GHRP-6 (ED50 = 3.9+/-1.4 nmol/kg and Emax = 74+/-7ng GH/ml plasma). GHRP-2 displayed higher potency but lower efficacy (ED50 = 0.6 nmol/kg and Emax = 56+/-6 ng GH/ml plasma). The specificity for GH release was studied in swine. None of the GH secretagogues tested affected FSH, LH, PRL or TSH plasma levels. Administration of both GHRP-6 and GHRP-2 resulted in increased plasma levels of ACTH and cortisol. Very surprisingly, ipamorelin did not release ACTH or cortisol in levels significantly different from those observed following GHRH stimulation. This lack of effect on ACTH and cortisol plasma levels was evident even at doses more than 200-fold higher than the ED50 for GH release. In conclusion, ipamorelin is the first GHRP-receptor agonist with a selectivity for GH release similar to that displayed by GHRH. The specificity of ipamorelin makes this compound a very interesting candidate for future clinical development.[3]



Cititations:
[1] Bowers CY, Momany F, Reynolds GA. In vitro and in vivo activity of a small synthetic peptide with potent GH releasing activity. 64th Annual Meeting of the Endocrine Society, San Francisco, 1982, p. 205.
[2]Bowers CY, Momany F, Reynolds GA, Sartor O. Multiple receptors mediate GH release. 7th International Congress of Endocrinology, Quebec, Canada, 1984, p. 464.
[3] Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998 Nov;139(5):552-61.
[4] Brosnan-Cook, M. et al. (1998) Iontophoretic delivery of ipamorelin, a growth hormone secretagogue. Proceedings of 80th Annual Meeting Endocrine Society, New Orleans, USA. Abstract Pp1-186.
[5] Jogarao V S Gobburu; Henrik Agerso; William J Jusko . Pharmacokinetic-Pharmacodynamic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide in Human Volunteers. Lars Ynddal Pharmaceutical Research: Sep 1999; 16, 9; ProQuest Nursing & Allied Health Source p. 1412.


I've included my citations from the articles i've studied. Ive read hundreds of articles on the peptides but this is just what ive used for the Ipam stuff


See why i always suggest Ipam to everyone, yet no one wants to try it. The GH benefits with it are tremendous.

written/compiled by Mike Ross
 
Bodybuilding Peptides Guide

Bodybuilding Peptides Guide


PeptideGuide
With the launch of a peptide range immanent, now is the time to understand the differences and function of the main peptides we will be able to get our hands on.
Peptides are short polymers of amino-acids linked by peptide bonds. They have the same protein-peptide bonds as those in proteins, but are usually shorter in length. The shortest peptides are called di-peptides consisting of two amino acids joined by a single peptide bond. There can also be, tetrapipteds, pentapeptides, etc. Research Peptides have an amino end and a carboxyl end, unless they are cyclic peptides. A polypeptide is a single linear chain of amino acids bonded together by peptide bonds. Protein molecules consist of one or more polypeptides put together typically in a biologically functional way and sometimes have non-peptide groups attached. These groups are called prosthetic groups or co-factors.

Peptides, by definition must maintain certain characteristics. One of those being that the peptide chains must be short enough to be made synthetically from the constituent amino acids. Then they are considered to be called peptides rather than proteins. However, with the advent of better synthetic techniques, peptides as long as hundreds of amino acids can be made, including full proteins like uniquitin. Native chemical ligation has given access to even longer proteins, so this convention of definition seems to be outdated.
Another definition places an informal dividing line at approximately 50 amino acids in length (some people claim shorter lengths). This definition is somewhat arbitrary. Long peptides, such as the amyloid beta peptide linked to Alzheimer’s, can be considered proteins; and small proteins, such as insulin, can be considered peptides.

In simple terms and in a way all bodybuilders would understand – Synthetic Growth Hormone is a complete protein and 191 amino acid chain where as CJC1295 has a 30 amino acid peptide chain.

GHRP-6
Growth hormone releasing peptide-6 (GHRP6) is a growth hormone releasing hormone. GHRP 6 is a true hGH secretagogue. Which means it stimulates the body's own secretion of hGH after subcutaneous administration (carefully measured).

GHRP-2, GHRP-6, Ipamorelin and Hexarelin are replaceable ghrps sharing similar mechanisms of action. GHRP peptides for sale however have small differences and therefore different athletes have preferences (ie.: GHRP-6 stimulates strongest response assoc w/ ghrelin..stimulating hunger often in users).

GHRP-6 up to 100mcg has no increase of cortisol and prolactin levels.
5000mcg per vial
Reconstitute - with 1ml or 2ml of water (but with the small measurements we suggest you use 2ml) depending on the brand used.
GHRP-6 Dosage:
100mcg to 300mcg as many as 5 times a day.
Usually between 3 to 5 times per day before meals. Always take your last injection at bed time.
If you mix your GHRP6 5000mcg with 2ml of water then a 100mcg dose will measure 4 ticks on your insulin syringe.
Because of the frequency of injections it would be best to use the precise insulin syringes, the smaller the pin the better.

Tips:
- GHRP2 and GHRP6 works best if coupled with CJC-1295 to get the most out of the peptides.
- Intramuscular and subcutaneous routes lead to different onset times but roughly similar peaks and declines.
- It can be used alone or in conjunction with Growth Hormone.
Post-injection: 30 minutes after administrating injection is usually when GHRH stimulation of GH release is complete, meaning it's safe to consume food/beverages after this time without worrying that they will cause your injection to be less effective. Consuming a high protein/carbohydrate meal at this time will create an insulin spike and therefore assist with the anabolic (muscle building) effects of HGH. Those looking to burn fat should wait as long as possible before eating and when you do, only eat high protein, low fat and low carbohydrate meals to allow growth hormone's fat burning effects to stretch as long as possible.
- Alternatively you can inject gh peptides at 1 to 1.5 hours after a meal.
- Do not combine GHRP-6 and GHRP-2 in a cycle. It has very similar effects with small differences and preferences from person to person.

Functions
Increases muscle mass and reduce body fat. Increases appetite but not as dramatically as GHRP-2. GHRP-6 keeps your endogenous (natural) GH production flowing. It also strengthens the joints, connective tissue and bone mass.

GHRP2
It is a growth hormone releasing hormone. GHRP-2 is a synthetic ghrelin analogue. Unlike ghrelin (that plays a large role in inducing hunger), GHRP-2 is not lipogenic and does not induce fat storage.

GHRP-2, GHRP-6, Hexarelin and Ipamorelin are replaceable research peptides in the ghrp dept having similar mechanisms of action as well as brief acting growth hormone results. GHRP Effects they do however have small differences and therefore different athletes have their preferences according to best suit the individuality of each lifestyle.

GHRP-2 has a medium increase of cortisol and prolactin levels and is therefore the best-selling GHRP2 for experts (many see value in ghrp-6 with the misconception that the higher # equates to value/results).
5000mcg per ghrp2 vial
Constitute - with 1ml or 2ml of water (but with the small measurements we suggest you use 2ml) depending on the brand you use.
Ghrp-2 Dosage:
100mcg to 300mcg 2 to 4 times daily. Always take your last injection at bed time.

First time in the morning when you wake up on an empty stomach 15 minutes before eating. Post workout directly after training 15 minutes before eating or having your protein drink. Before bedtime, 15 minutes before taking a pure protein. Do not take a protein carb mix and go to bed because that will make you fat.
If you mix your GHRP2 5000mcg with 2ml of water then a 100mcg dose will measure 4 ticks on your insulin syringe. Not 40 but the small 4 ticks. 200mcg will be 8 ticks if you use 2ml of water and so on.

Because of the frequency of injections it would be best to use the insulin syringes with a 8mm x 30 gauge (0,30mm) needle on. This is the smallest needle you can get.
Tips:
- GHRP2 and GHRP6 works best if coupled with CJC-1295 to get the most out of the peptides purchased.
- Intramuscular and subcutaneous routes lead to different onset times but roughly similar peaks and declines.
- It can be used alone (GHRP advisably) or (both GHRP/GHRH) in conjunction with Growth Hormone (191aa GH).

Post-injection: 30 minutes post-injection is usually when GHRH stimulation of GH release is complete, meaning it's safe to consume food/beverages after this time without worrying that they will cause your injection to be less effective. Consuming a high protein/carbohydrate meal at this time will create an insulin spike and therefore assist with the anabolic (muscle building) effects of GH. Those looking to burn fat should wait as long as possible before eating and when you do, only eat high protein, low fat and low carbohydrate meals to allow GH's fat burning effects to last as long as possible.
- Alternatively you can inject it 1 to 1.5 hours after a meal.
- Do not combine GHRP-6 and GHRP-2 in a cycle. It has very similar effects with small differences and preferences from person to person.

Functions:
Increases muscle mass and reduce body fat. Increases appetite dramatically. GHRP6 keeps your endogenous (natural) GH production flowing.

CJC-1295
CJC1295 has a very long half-life and therefore it has no dietary restrictions or specific times that you. Because of its long half life it has long term benefits on your body’s basal GH levels.
CJC1295 is a 30 amino acid peptide hormone where synthetic growth hormone contains a 191 amino acid chain. It attaches itself to the albumim receptor and this increases its half life oppose to the normal growth hormone releasing hormones.
2000mcg per vial
Reconstitute - with 1ml of water depending on the brand you use.
CJC-1295 Dosage:
1000mcg (1mg) twice a week or 2000mcg (2mg) once a week.
Dose per injection: 2mg or 1mg x 2

Injections per vial: 1 x 2mg dosages or 2 x 1mg dosages per week.
Amount to Inject: If you have used 1ml of water for mixing then a 2mg dosage = 1ml (or 100 units on Insulin Syringe). If you want to inject 1mg twice a week and you have used 1ml of water then a 1mg dosage = 0.5ml (or 50 units).
Because of the frequency of injections it would be best to use the insulin syringes with a 8mm x 30 gauge (0,30mm) needle on. This is the smallest needle you can get.
Tips:
Because of its long acting properties this product works best in conjunction with short acting growth hormone releasing hormones like GHRP-2 and GHRP-6 to take advantage of the short-term GH pulse created after a CJC1295 injection.
Intramuscular and subcutaneous routes lead to different onset times but roughly similar peaks and declines.

Functions:
This product was initially developed for AIDS patients that were obese. It increases muscle mass and decrease body fat. Increase lean muscle mass. Decrease body fat percentage. Increase growth hormone secretion of the pituitary gland.

Hexarelin
Hexarelin is the strongest of the GHRP peptides. It has a potent ability to stimulate growth hormone secretion. It has even reported to be able to reduce neonatal brain injuries in newborn babies.
GHRP-2, GHRP-6 and Hexarelin are replaceable peptides for research and have similar mechanism of action. Hexarelin has a high increase of cortisol and prolactin levels. Cheap hex is often 2000mcg per vial.
Reconstitute - with 1ml or 2ml of water (but with the small measurements we suggest you use 2ml) depending on the brand/size.

Hexarelin Dosage:
25mcg to 50mcg - 1 to 6 times a day. Cycles last for as long as three months. The time between injections should be 3-4 hours. Always take your last injection at bed time.
If you constitute your 2000mcg of Hexarelin with 2ml of water 50mcg of Hexarelan will amount to 5 ticks on the insulin syringe. 25mcg will then be 2.5 ticks on the syringe. Not 50 marks on the syringe but the small 5 ticks.
-
Because of the frequency of injections it would be best to use the insulin syringes with a 8mm x 30 gauge (0,30mm) needle on. This is the smallest needle you can get.
Tips:
- The main difference of Hexarelin from GHRP-6 is that Hexarelin does not promote appetite, because it does not increase the level of ghrelin in the body.
- The fact that Hexarelin it does not increase the appetite means it is better for athletes busy dieting who wants to suppress their appetite where GHRP-6 and GHRP-2 (to a extent) is better for athletes wanting to bulk and need the increase in appetite.
- Post-injection: 30 minutes post-injection is usually when GHRH stimulation of GH release is complete, meaning it's safe to consume food/beverages after this time without worrying that they will cause your injection to be less effective. Consuming a high protein/carbohydrate meal at this time will create an insulin spike and therefore assist with the anabolic (muscle building) effects of GH. Those looking to burn fat should wait as long as possible before eating and when you do, only eat high protein, low fat and low carbohydrate meals to allow GH's fat burning effects to last as long as possible.
- Alternatively you can inject it 1 to 1.5 hours after a meal.
Functions:
- The main effects of Hexarelin include increase of strength, growth of new muscle fibers, improving of vessels state, reduction of fat mass.
- Medicinally, Hexarelin can be used to treat GH deficiency induced diseases.
- This drug proved to be a great healer of wounds and can be administered as a multipurpose anabolic and with the purpose to stimulate endogenous GH secretion inhibited with the use of synthetic GH. In other words where synthetic growth does not increase the body’s ability to manufacture more GH the Hexarelin does.

Sermorelin
Sermorelin is used for its anti aging properties. It is one of the weakest peptides on the market. This is a grf 1-29 amino acid chain peptide where synthetic growth hormone contains a 191 amino acid chain. Sometimes Sermorelin is referred to as GRF 1_29. It is also a growth hormone releasing hormone (GHRH) acting for a very brief window of opportunity.
2000mcg per vial
Reconstitute - with 1ml of bac water.
Sermorelin Dosage:
300mcg to 600mcg per day. This is similar to taking 1IU to 2IU of growth hormone per day. (1IU = 333mcg).

Similar to synthetic growth hormone you take Sermorelin before you go to bed for fat burning and anti aging properties. Alternatively you can take it when you wake up in the morning and this will have more of a bulking effect.
If you constitute your 2000mcg of Sermoralin with 1ml of water 300mcg will amount to 15 ticks on the insulin syringe. 600mcg will then be 30 ticks on the syringe.
Tips:
- Sermorelin is the same as CJC-1295 but without the long acting properties.
- Very similar to growth hormone it takes a couple of weeks to kick in.
- Many charactaristics of Sermorelin is similar to that of synthetic growth hormone.
- Sermorelin is basically a natural alternative to synthetic growth hormone and gets administered the same way.
Functions:
Sermorelin (GRF 1-29) is a natural alternative to growth hormone and was found to contain the most evident 29 amino acids that stimulates the pituitary gland to increase growth hormone levels. This compound is mainly used for the rejuvenation of cells and anti aging purposes. Sermorelin reduces body-fat and increases lean muscle the same way growth hormone does.

As per normal synthetic growth hormone Sermorelin (GRF1-29) has the following functions:
- Increased energy & strength
- Increases natural production of Human Growth Hormone HGH
- Improves Physical and Mental Performance
- Improves Immune Function
- Increases IGF-1
- Improved wound healing
- Improved heart function
- Increased calcium retention and bone density
- Improves sleep quality and combats insomnia


author= Unknown
 
Still learning myself.... what would you recomend to help with joints and skin and leaning out? You put alot of good info in here. Thank you.

Ghrp-2 and cjc would work. I want to try ipam inplace of the ghrp2. The key is taking a ghrp/GHRH combo to mimic gh pulse and release.
There is another that I used years ago.. but it's damn hard to find. Adequan.
 
a couple times you state the cjc 1295 has an 8 day half life and other say 30 mins? im assuming they are talking about w/o dac because one article cliams we dont want dac because it causes bleed
 
Get Shredded!
IGF-1 The Bodybuilder’s Dream

Grow Young With HGH

The most abundant hormone made by the pituitary gland is human growth hormone, also called somatotrophin. Growth hormone production hits its peak during adolescence. Most HGH is secreted into the bloodstream in brief bursts, and most HGH secretion takes place during the early hours of REM (deep) sleep.

Once in the bloodstream, human growth hormone stays there for only a short time, only a few minutes, just long enough to stimulate its uptake into the liver, where it is then converted into growth factors. The most important of these growth factors is called IGF-1, short for Insulin-like Growth Factor-1. IGF-1 is also known as somatomedin C.




Growth hormone exerts its actions either directly or indirectly through its intermediary insulin growth factors (IGF-1) to every organ system of the body. Almost nothing escapes its magic touch. In the same ways that it grows the bones of young children, it increases the size of most organs and tissue. Even the brain is affected. The latest studies in animals show that it can regenerate damaged brain tissue.

It is IGF-1, rather than growth hormone itself, which can vary widely through the day, that is used as a measurement of how much growth hormone is being secreted by the body. IGF-1 is directly responsible for most of the benefits and actions associated with HGH. IGF-1 is 10 times more potent than human growth hormone and is now under investigation as a separate drug for many of the same indications of human growth hormone. Phil Micans of International Aging Systems in London believes that IGF-1 will be the hormone of choice in a few years.



HGH and IGF-1 Get at the Blueprint of Aging



“The blueprint of aging is in the DNA under the hood of the telomere”, the “clock” at the end of every chromosome that is shortened with each cell division, says noted plastic surgeon and antiaging researcher, Vincent Giampapa, MD, director of clinical research at the Longevity Institute International in Montclair, New Jersey. To actually reverse aging at the cellular level, we will need a substance that will restore telomere length and like a genie turn old cells into young ones. That is not yet available, although Giampapa believes it will be in less than a decade. Until then, growth hormone and its attendant hormone IGF-1 can do the next best thing, help keep the cell in as healthy a state as possible.

The cell’s ability to function depends on the genetic material, the DNA, in the nucleus of the cell which codes for all the proteins, hormones, and enzymes that make the cell run. The DNA is like an army under constant attack from oxygen free-radicals, ultraviolet light, the heat of the body, and other damaging factors. Although the DNA has the ability to repair itself, it falls down on the job with age, a victim of the same aging process that affects the cell. At the same time, damage is accumulating in the energy center of the cell, the mitochondria, which has its own DNA. Up until now, one of the few ways we could limit the damage to the DNA was to take antioxidant supplements such as vitamin C and E to bolster our own defenses.

But, according to Dr. Giampapa and Thierry Hertoghe, MD, a physician specializing in hormone replacement therapy in Brussels, the latest European research shows that human growth hormone and IGF-1 can go further than antioxidants and can do what antioxidants cannot. Human growth hormone and IGF-1 act like carriers to bring the cell the raw materials it needs for renovation and repair. IGF-1 launches the delivery of the nucleic acids, DNA and RNA, right into the cell nucleus, where the DNA resides. The nucleic acids are used to repair damage to the DNA and stimulate cell division. Growth hormone initiates the transport of amino acids, the building blocks of protein, and nucleic acids into the cytoplasm of the cell, the area outside the nucleus. This includes the cell membranes and intracellular organelles, such as the mitochondria. In this way, human growth hormone and IGF-1 don’t just minimize the damage to the DNA and cellar structures, they help heal the cell and the DNA. These two hormones actually treat the blueprints of aging.



Information on IGF-1



IGF-1 is the other end of the growth hormone chain, the downstream player that actually exerts most of the effects we associate with human growth hormone. IGF-1 is causing a great deal of excitement among two groups, researchers who are exploring its vast potential and bodybuilders who are already using it and claiming eyepopping gains in muscle.



IGF-1 More Potent Than Human Growth Hormone



Human growth hormone exerts most of its effects through IGF-1. Therefore, it is not surprising that IGF-1 injections will do for you what human growth hormone does–and then some, according to its proponents. It increases lean body mass, reduces fat, builds bone, muscle, and nerves. By taking it directly, you bypass the pituitary gland, which may be “burnt out” with aging.

IGF-1 appears to be even more potent than growth hormone in its anti-aging action. According to Keith Kelly, Ph.D., who did the work showing that growth hormone reversed the shrinking of the thymus, when he does his experiments on cells in culture, only IGF-1–and not growth hormone– works. But both IGF-1 and growth hormone work in the living animal. “I know that both growth hormone and IGF-1 are substantially elevated in the old animals treated with growth hormone,” he says, “but my prediction is that the main player is going to be IGF-1.”

IGF-1 and It’s Potentials

IGF-1 Preventing Brain Aging and Disease
One of the spectacularly exciting uses of growth hormone and IGF-1 may be to prevent and treat the effects of brain aging. In an experiment that has momentous implications for brain injury, stroke, aging, and neurodegenerative disease, a team of scientists in New Zealand showed that IGF-1 can stop the death of cells in the brain. Barbara Johnston, Peter Gluckman, and their colleagues at the University of Auckland found that injections of IGF-1 given 2 hours after brain injury in fetal lambs rescued the damaged neurons and salvaged cells that would otherwise have died during apoptosis, which is the programmed cell death that is believed to cause the loss of brain cells for up to 3 days after the original injury. The treatment was effective in stopping the cell death throughout the brain, including the hippocampus, the cortex, the areas associated with thinking and memory. The treatment was also effective in the striatum, the part of the brain that plays a role in Parkinson’s disease in humans. IGF-1 replacement was also found to reduce seizures in animals with brain damage.

These researchers also suggest that IGF-1 might be used to inhibit the effects of neonatal hypoxia during birth (lack of oxygen to the brain) which can leave a baby with permanent brain damage. If IGF-1 can stop the programmed death of cells, then this opens up a world of undreamed-of-possibilities. For instance, the programmed death of cardiac cells after a heart attack leaves the victim with a heart full of dead tissue that before could not be repaired. Brain tissue is destroyed due to a stroke (CVA), and this cell death many times leaves the victim unable to walk, talk, or think clearly. It may also play a role in other neurodegenerative diseases such as Alzheimer’s disease, muscular dystrophy, and multiple sclerosis. For the first time we may have a weapon against death at the cellular level.

IGF-1 Improving Glucose Metabolism
As its name indicates IGF-1, or insulin-like growth factor-1, has similar properties to insulin, and it has been shown to improve blood sugar profiles in type 2 diabetic patients. High doses of growth hormone have been shown to increase insulin resistance, but IGF-1 administration actually normalized the insulin resistance in a group of healthy volunteers.

In the latter study, Nelly Mauras and Bernard Beaufrere of the Nemours Children’s Clinic in Jacksonville, Florida, were looking at several different things: the effect of IGF-1 on protein metabolism; its ability to stop the protein-wasting caused by glucocorticosteroid drugs like prednisone, and its effect on insulin and glucose metabolism. They divided the volunteers into three groups who got one of the following: IGF-1 alone, IGF-1 plus prednisone, and prednisone alone. The study found that IGF-1 at 100 micrograms per kilogram of body weight given twice daily enhanced the body’s protein metabolism in the same way as growth hormone. Like growth hormone, it markedly decreased the protein breakdown in the volunteers who were taking prednisone. But whereas growth hormone in an earlier study caused carbohydrate intolerance and insulin resistance when given in combination with prednisone, IGF-1 did not cause these diabetes-like effects. Instead, those subjects who received IGF-1 along with prednisone had normal glucose metabolism. This was remarkable, say the researchers, in light of the fact that glucocorticoids are known to suppress circulating insulin and decrease insulin sensitivity. As a result of this and previous studies, the researchers believe that IGF-1 offers promise in the treatment of protein catabolic states, such as patients who require IV feedings after surgery.

IGF-1 Helping Diabetes
Two 1997 double-blind clinical studies showed that recombinant IGF-1 injections can markedly reduce the need for insulin by up to 45% in patients with insulin-dependent diabetes mellitus. One study involved 8 adults between ages 24 and 49 and the other 43 children and adolescents between the ages of 8 and 17. In the adult trial, IGF-1 also lowered the total cholesterol and triglycerides after only four days of treatment.

While these were short term trials lasting nineteen days and four weeks, respectively, that fact that the insulin requirement dropped markedly and there were no serious side effects make IGF-1 a promising drug for the treatment of diabetes. While it does not do away with the need for insulin, it improved the control of blood sugar and thus may help prevent the dire complications of diabetes, including heart disease, blindness, and peripheral nerve damage that can lead to amputation.

IGF-1 Regenerating Nerves
Another exciting potential use of IGF-1 is in the repair of peripheral nerve tissue that has been damaged by injury or illness. If a nerve is torn in the arm or leg, it means that the connection to the muscle may be impaired, and as a result there is loss of movement and the muscle atrophies. While peripheral nerves can regenerate to some extent, severe tears of more than a few millimeters may result in permanent injury. Now IGF-1 has repaired and reconnected severed nerve endings of up to a distance of 6 millimeters, a feat previously unheard of.

Swedish scientist Hans-Arne Hansson of the Institute of Neurobiology at the University of Goteborg found that IGF-1 in combination with other growth factors could stimulate even more dramatic regeneration. “IGF-1 by itself and in combination with other growth factors is likely to be of importance in promoting healing and repair processes in clinical practice within a few years,” he writes.

In studies of cells in culture and in animals, IGF-1 has been shown to have remarkable effects on the spinal cord motor neurons. It increased motor neuron activity in spinal cord cultures by 150 to 270 percent. And it significantly decreased programmed cell death in developing chick embryos. In animal studies, it enhanced the sprouting of axons of the spinal cord motor neurons. And it increased intramuscular nerve sprouting a whopping ten fold when it was given to normal adult rats. In fact, according to a group of researchers at Cephalon, Inc., in West Chester, Pennsylvania, IGF-1 may be the “long-sought endogenous motor neuron sprouting factor.”

The implications of this work for helping people is nothing short of mind-boggling. If IGF-1 can regenerate spinal cord motor neurons, it may be useful in treating amyotrophic lateral sclerosis (ALS), a devastating disease in which the loss of spinal cord and cortical motor neurons results in complete paralysis and death. It may also be useful for peripheral neuropathies, such as Charcot-Marie-Tooth syndrome.

John Wittig, MD, of UCLA has been using IGF-1 to prevent AIDS wasting in HIV infected patients. IGF-1 may allow more aggressive chemotherapy of certain cancers, since drugs like vincristine and cisplatin can cause peripheral neuropathies at higher doses.

The Growth Factor Army
IGF-1 is only one of the body’s many growth factors that are now being identified, isolated, and cloned using genetic engineering technology for use as drugs. As growth factor researcher Eric Dupont, Ph.D., says, “Growth hormone is the general and growth factors are the foot soldiers.” Growth factors function like hormones, hooking onto the receptors of cells and sending a biochemical signal across the cell’s interior. Whereas hormones usually send long distance messages, growth factors for the most part do local calls.

IGF-1, The Bodybuilder’s Dream
A number of world-class bodybuilders are using IGF-1 and reporting massive muscle magnification of up to 20 pounds. An article in Muscle Mass 2000 trumpets IGF-1 as “Possibly the Most Potent Bodybuilding Drug Ever!” According to author T.C. Luoma, “IGF-1 is out there on the streets of America right now; it’s being sold out of the trunks of cars in Venice and brown paper packages containing it are being discreetly handed out at Southern California gyms.” While there are no controlled studies supporting the musclemen’s claims, the anecdotal evidence is building up. “Bodybuilders are claiming they are experiencing drops of 5% body fat in a month, while increases in lean body mass and strength are ‘incredible.’ Statements like, ‘It’s the most wonderful stuff in the world, and ‘I couldn’t believe it man’ are the norm.”

There are skeptics, such as Mauro Di Pasquale, MD, an expert in performance-enhancing compounds, but there is a rationale for the belief that HGH taken with IGF-1 will work better. There is a feedback mechanism between the human growth hormone in the pituitary gland and the IGF-1 in the liver. The human growth hormone stimulates the release of IGF-1, but when the levels of IGF-1 rise to a certain point in the circulation, it signals the shutdown of growth hormone. But there is a lag time in all of this, which means that growth hormone levels increase at night and IGF-1 levels increase during the day. Bodybuilders hope that taking the two together will have a double-fisted effect on protein synthesis

by Ronald Klatz, MD, president of the Academy of Anti-Aging Medicine
 
Last edited:
cjc 1295 can have a half life lasting up to 8 days and some articles say that it can cause a gh bleed
cjc 1295 is very much shorter
hence the reason you will see some guys running cjc w/dac once every couple of days up to once a week.
While peptides aren't exactly new.. they are to the bodybuilding world. Or I guess I should say that they have become more prominent
 
GHRH – GHRP – GH a comprehensive dosing protocol

GHRH – GHRP – GH a comprehensive dosing protocol

In effort to list a protocol for the use of GHRP / GRF / and in combo with GH if desired I thought I would post my current protocol based upon the research I have done within the last year or so. Obviously the information I gathered is not based on medical studies completed by me but I do use the following protocol myself and have been pretty damed impressed with the results. Recovery from injury is very impressive to me (any kind of injury). Example, 5 days ago I was lifted by the butt of a tree I cut down (long story). I had bruising and some serious raspberry on my under arm, left quad and my abs ( the but of the tree ran right up the front of my once it got under my arm it lifted me and tossed me about 10 feet through the air). Its been 5 days and all that is left of the raspberries are some faint red marks……amazing IMO.

Also: I encourage others to do their own research. Don’t think all that I have written below is gospel or the only / best way to run these peptides. This is nothing more than my interpretation of what I have read and what I perceive as the best way to use peptides.

Best Choices for GHRP’s.
GHRP-6 Good GH spike when used with a GRF, large increase in hunger. Elevates prolactin and cortisol levels
GHRP-2 Good GH spike, when used with a GRF, on par with GHRP-6 without the hunger. Elevates prolactin and cortisol levels
Ipamorelin good GH spike when used with a GRF. GH spike is not as high as GHRP-2 or 6 but it does not elevate prolactin or cortisol.
Note: in order for a GHRP to have a positive affect and create a GH spike alone one as to be very lucky in the timing and hope it is injected at time when Somatostatin is low in the body. Somatostatin blunts GH release in the presence of just GHRP. Using GRF will override the signal presented by Somatostatin so you will get a very dramatic GH pulse.

GRF’s (GHRH)
Two choices
Mod GRF 1-29, higher GH peaks, short half life (30 minutes) most closely mimics your bodies own GH pulses but far greater amplitude
CJC 1295 long half life (7days). Lower GH amplitude when used with GHRP, raises the troughs in the bodies GH level profile, the downside is it creates GH bleed. Think of the GH as being stored in a jar until someone (thing) opens up the faucet. It is best if the jar is full and then dumps. CJC does not allow the jar to fill. Current recommendations are to avoid CJC

Saturation dose for any of the GHRH’s or GHRP’s including Ipamorelin is 100mcg (or 1mcg / kg of bodyweight) so this is all based on a 100mcg dose.
As you may know, it is best to pin 1.5 to 2 hours after eating any fats or carbs and then after you pin don’t eat any fats or carbs for 20-30 minutes as they will blunt the GH release. pure protein is OK but I try to avoid all foods. Also, pure protein is OK anytime prior to pinning.

Dosings should be 3 hours apart or more.
Mornings upon waking pre cardio (if you are doing any), afternoon (or PWO) and before bed pin mod GRF 1-29 / GHRP (or Ipamorelin) @ 100mcg / 100mcg. (2 pinnings per day are also adaquate for improvements in recovery, better sleep etc. 3 will make you a bit more anabolic than 2 and you can even go 4 if the pocket book allows.
If you include GH in this protocol it should be 10 minutes after the peptides. So, first pin the peptides, wait 10-15 minutes and then pin your GH. Reason being is that Exogenous GH administration can also blunt GH release.

Wait 20-30 minutes after pinning the peptides and you are free to eat.

When you recon your peptides use as little BW as you can. I don’t go as low as some people because I figure I don’t want to leave a drop of highly concentrated peptide in the vial that I can not get out.

The less BW used for recon the less the degradation of the peptide over time.

If you premix a shot ahead of time, don’t let it sit mixed for more than 8 hours or so. When mixed they will exchange ions and who know what the final compound would be called . I actually have a way to preload without mixing the peptides until I am ready to pin it.

Do not pin IGF within 1 hour of pinning your peptides. IGF has a feedback loop that inhibits GH release.
With the above for pinning around workouts to get the most of your investment….

Pin insulin (humalin R) immediately PWO wait 10 minutes pin peptides

If using GH wait 10 more minutes and pin the GH (see above for reasoning)

If using IGF wait approx. 1 hour PWO and pin the IGF.

IGF blunts GH release. another reason to wait is in effort to keep the IGF local you want to wait until you lose your pump. Blood flow is reduced in teh area of injection. if you pin IGF immediately PWO blood flow is still very high so the IGF get transported away too quickly..

For convenience…
Pin insulin Pre work out…. Humalin R is active for 4-5 hours
PWO pin peptides (or if you want to pin slin and peps at the same time PWO)
10 minutes after peps pin GH if you are using GH
30-60 minutes PWO pin IGF if using IGF




Click on my banner below for all your peptide needs and remember to add my code for your discount
 
Last edited:
Melanotan II – PT141

Melanotan II – PT141


Melanotan II also known as PT-141 was developed by researchers at the University of Arizona College of Medicine. Melanotan II is an analog of the peptide hormone alpha-melanocyte stimulating hormone (MSH), this hormone provides a therapeutic tan with the ability to lower the risk of skin cancer, (MSH) also plays an important role in regulating sexual arousal in men and women. Melanotan II has the additional effect of decreasing body fat mass. Melanotan II It is a cyclic lactyam analog of alpha-MSH with the amino acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2.

Melanotan II is in a class of peptide hormone known as Melanocortin (MCs). Melanocortins (MCs) are multifunctional peptide hormones that regulate a diversity of physiological functions. MCs have been implicated in sexual function in animals.
A MC analog, Melanotan II (MTII), can enhance sexual function in human males (erectile activity) and females (increased levels of sexual desire and genital arousal). Unlike other sexual-enhancement drugs, MTII works at the level of the brain, thus eliciting a rather natural sexual response with minimal or no undesirable side effects. The actions of the peptide were discovered accidentally while studying the effects of the peptide and related analogs on human skin pigmentation (tanning). Hadley ME (2005).

Melanotan II, PT-141, a cyclic heptapeptide melanocortin analog, was evaluated following subcutaneous administration to healthy male subjects and to patients with erectile dysfunction (ED) who report an inadequate response to Viagra. The erectile response induced by PT-141 was statistically significant at both doses. PT-141 was safe and well tolerated in both studies. The erectogenic potential of PT-141, its tolerability profile and its ability to cause significant erections in patients who do not have an adequate response to a PDE5 inhibitor suggest that PT-141 may provide an alternative treatment for ED with a potentially broad patient base. Rosen RC, Diamond LE, Earle DC, Shadiack AM,Molinoff PB (2004).
In addition to the sexual enhancement and tanning effects of Melanotan II, MT-II has also exhibited the potential to decrease body fat mass and reduce food intake.

MT-II has tanning activity in humans given only 5 low doses every other day by subcutaneous injection.
The recommended single MT-II dose for future Phase I studies is 0.025 mg/kg/day.


Synonym: Ac-[Nle4Asp5D-Phe7Lys10]?-MSH-(4-10)-NH2
Amino Acid Sequence: Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2
Molecular Formula: C50H69N15O9 ? xC2HF3O2
Molecular Weight: 1024.18 (free base basis)

RESEARCH DOSAGE 0.025 mg/kg/day
 
Last edited:
appreciate the help!

Yea I am not really good at math and been searching for someone to dummy proof some measurements as you did with the posting you have on IGF and really thankful for it. Just one thing if you could help me with PEG MGF ? I am gonna try to do 80 mcg if that sounds right, the peptide vile consist of Net Qty: 2.0 mg and I am planing to use the same style of syringe you have posted, 1 ml insulin syringe, the same thing. I have read that you're only suppose to reconstitute it with bacteriostatic water only, can I use acetate acid instead? Just wanna know two things if the markings are the same from IGF to PEG MGF? Only using of course 1 ml of either bacteriostatic water or acetate acid, and which leads me to my next question, do I use bacteriostatic water or acetate acid? I know I have read most people say water, but would it make any difference if I use acetate acid? Thank you for any input you will give me, and will follow more of your postings.
 
you can use AA to reconstitute it, but why do it.. You will still need the bacteriostatic water to cut the AA. You really don't want to inject straight AA/peg/mgf mix.

you have a 2mg vial, add 2 mls of water or AA.. I would use the water for ease and one less step you have to do before injection.

now once added, you now have 2000mcgs of peg/mgf
you would use this picture to show you just how much you need


attachment.php




2mgs is = to 2000mcgs

Now as for dosage.. normally you would hit both muscles.. Right bi left bi, and you would use 80mcgs in each

Now if you do use AA to reconstitute, once you draw up the desired amount, You now need to draw up some Bac water to dilute the AA that is now in the syringe.
The amount doesn't really matter as long as you use some.. Your still getting that 80mcgs no matter how much bac water you now drawing into the syringe
 
Last edited:
BPC 157 the healing peptide

BPC 157 the healing peptide


Bpc 157: specifications
Molecular Formula : C62H98N16O22 Molecular Weight : 1419.5355 purity>99%
Sequence: L-Valine, glycyl-L-alpha-glutamyl-L-prolyl-L-prolyl-L-prolylglycyl-L-lysyl-L-prolyl-L-alanyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alanylglycyl-L-leucyl-; glycyl-L-alpha-glutamyl-L-prolyl-L-prolyl-L-prolylglycyllysyl-L-prolyl-L-alanyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alanylglycyl-L-leucyl-L-valine


BPC 157 Stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419) may be the new drug stable in human gastric juice, effective both in the upper and lower GI tract, and free of side effects. BPC 157, in addition to an antiulcer effect efficient in therapy of inflammatory bowel disease (IBD) (PL 14736) so far only tested in clinical phase II, has a very safe profile, and exhibited a particular wound healing effect. It also has shown to interact with the NO-system, providing endothelium protection and angiogenic effect, even in severely impaired conditions (i.e., it stimulated expression of early growth response 1 gene responsible for cytokine and growth factor generation and early extracellular matrix (collagen) formation (but also its repressor nerve growth factor 1-A binding protein-2)), important to counteract severe complications of advanced and poorly controlled IBD. Hopefully, the lessons from animal studies, particularly advanced intestinal anastomosis healing, reversed short bowel syndrome and fistula healing indicate BPC 157's high significance in further IBD therapy. Also, this supportive evidence (i.e., no toxic effect, limit test negative, LD1 not achieved, no side effect in trials) may counteract the problems commonly exercised in the use of peptidergic agents, particularly those used on a long-term basis.

what is BPC 157 used for in humans/bodybuilders?
well BPC 157 is known for super quick and professional Joint/tendon/ligament healing in all phases of clinical trials.. studies are shown here: BPC 157 has been shown in studies to heal torn quadriceps muscles, detached achilles tendon, muscles that have been damaged/crushed. Demonstrating dramatic fast recovery from muscle tears. Tendon to bone healing - increased ligament healing, BPC 157 has a variety of protective effects in the organs.

Clinical trials demonstrate healing and prevention of stomach ulcers and it is being studied as a burn treatment. Trials show it may help repair some liver damage after prolonged chronic alcohol exposure. No adverse reactions have been seen in clinical trials.

BPC 157 peptide has been shown to heal a variety of wounds in all areas researched, including internal organs, muscles, ligaments, tendons, skin, internal lacerations from surgery, etc.

it can have a use in the medical industry help heal and get rid of stomach ulcers caused by people abusing NSAID drugs


how long can i wait to see some effective results/benefits from this product?
well personally for me ive been using for 1 week and the results are astounding! my right hip is now moveable im almost at a point where i can go in the gym and smash legs harder then before, my right bicep IM injections with it has had immaculate results thus far the pain is greatly diminished and im able to pick up things mildy heavy whereas 4 injections previously i was in bad pain/weakness and now... its feeling strong/harder then previous.

usually results will take 4-6 weeks, because yes of course your injecting the drug but the human body has a set healing rate, but with BPC 157 the healing will be imo 100% faster then regular and the also the healing will be more complete whereas before you would only get around 80% of what you had before.



How long can i run BPC 157 for?
BPC 157 can be run for 4 weeks, followed by a 2 week rest. after this if you are still not feeling 100% itll be safe to run another course of BPC 157.


How do you reconstitute BPC 157?
simply pop the cap off, gently alchol swab the stopper, then let it dry, same goes with the BAC water vial. then dose out the correct amount of BAC water. then slowly put the needle in... then slowly but surely inject the BAC water along side the vial making sure you do not indirectly inject on the peptide powder, however once you have done the first dose and the powder i essentially mixed you can inject on the bac water, that is fine. Note* this is done with 2mls of bac water, that would be 2 whole 1ml/1cc insulin syringes.

How do i Dose BPC 157 for optimal results?
you can use anywhere from 200mcg being a medium dose up to 500mcg ... depending on severity of issue ( if severe) dose 2x a day at 350 mcg totaling 700 mcg.

Is BPC 157 IM or sub q injection?BPC 157 is both, you can do IM or subq as close as you can to the injection site, preferably around 1-4 inches away to yield the most benefit to the injured area.


what are the side effects of BPC 157?
there are absolutely none that i know of well No one knows, however the first time i used it i got a head ache and felt generally sick, however this was only for a day. I'm now 100% this is most likely a coincidence, most probably a body reaction to the first time. to be honest there are no side effects, its in clinical trial phase 2 ATM and they have reported 0 effects, only positives.

what syringe/needle size is good for this peptide?
all needles would be good for this peptide depending on where you want to inject, however a 1ml/1cc 29 and half inch insulin syringe is optimal for most sites on the body.

what is the cost of BPC 157?
bpc 157 is relatively inexpensive and the results are worth the money as it could permanently strengthen your weak joints/connective tissues/muscles unlike a placebo supplement where it yields good results and once you come off, your joints are crying out for mercy. the general price is around $25-50 USD.

How long will 1 bottle last?
generally if run at the baseline 200mcg dose, 1 5mg vial will last 25 consecutive days. $25 usd for 1 bottle, is well worth it!

where do i store this?
just like another peptide keep it away from UV/sunlight. it can stay in room temp for up to 10 weeks, however for best storage/results store in a fridge and use until vial is run out then discard of it. For other BPC 157, they can stay in the fridge too as they;ll last up to 6 months, whereas if you had more you can store in the freezer( up to 2 years).

thats everything you need to know about BPC 157 guys! hope you enjoy the read and this will help noobs/future injured athletes or current injured gym addicts try it.


Huge thanks to HarryBrah for putting this all together
by harrybrah
 
Last edited:
Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic agent, safe in inflammatory bowel disease clinical trials (GEPPPGKPADDAGLV, M.W. 1419, PL 14736) and wound healing, stable in human gastric juice and has no reported toxicity. We focused on BPC 157 as a therapy in peridontitis, esophagus, stomach, duodenum, intestine, liver and pancreas lesions. Particularly, it has a prominent effect on alcohol-lesions (i.e., acute, chronic) and NSAIDs-lesions (interestingly, BPC 157 both prevents and reverses adjuvant arthritis). In rat esophagitis and failed function of both lower esophageal sphincter (LES) and pyloric sphincters (PS), BPC 157 increased pressure in both sphincters till normal and reduced esophagitis. However, in healthy rats, it may decrease (PS) or increase (LES) the pressure in sphincters. It has strong angiogenic potential, it acts protectively on endothelium, prevents and reverses thrombus formation after abdominal aorta anastomosis, affects many central disturbances (i.e., dopamine and 5-HT system), the NO-system (either L-arginine and L-NAME effects), endothelin, acts as a free radical scavenger (counteracting CCl4-, paracetamol-, diclofenac-injuries) and exhibits neuroprotective properties. BPC 157 successfully heals the intestinal anastomosis, gastrocutaneous, duodenocutaneous and colocutaneous fistulas in rats, as well as interacting with the NO-system. Interestingly, the fistula closure was achieved even when the BPC 157 therapy was postponed for one month. In short-bowel syndrome escalating throughout 4 weeks, the constant weight gain above preoperative values started immediately with peroral and parental BPC 157 therapy and the villus height, crypth depth and muscle thickness (inner (circular) muscular layer) additionally increased. Thus, BPC 157 may improve gastrointestinal tract therapy.
 
Basskiller you always have some of the best info out there. Everyone always appreciates what you do for all the community's. It's been awhile bro hope you are doing good.
 
IML Gear Cream!
Basskiller you always have some of the best info out there. Everyone always appreciates what you do for all the community's. It's been awhile bro hope you are doing good.
I am.. and thank you.. Absolutely loved that test Enanthate from that contest.. quality gear!!!
 
Melanotan 2 information

Melanotan 2 information




Melanotan II is a cosmetic sunless tanning product that stimulates melanin production. Melanin is the main determinant of skin color in humans, a brown pigment which causes skin to become darker in appearance, instead of red when exposed to UV rays. Melanotan II users develop a gradual, natural looking tan with minimal exposure to the sun. It is particularly useful for fair-skinned individuals who find that they cannot tan naturally in the sun.

Melanotan 2 peptide is not a treatment or cure for any disease, nor should it be used with the aim of preventing skin cancer. While melanin is known to have excellent photo protective properties, no clinical studies have ever indicated the efficiency of Melanotan II specifically in reducing UV damage.


It is estimated that more than 90% of Melanotan users are familiar with the injectable Melanotan II. Melanotan I is usually only preferred by a small amount of long-term users who feel that Melanotan II makes them too dark, nauseated, and/or those who find the aphrodisiac side effect of Melanotan II to be a nuisance. These problems can be avoided by taking Melanotan II in lower dosages, administering before bed and using sunscreen and clothing to control tanning.

Since Melanotan I has a large body of clinical evidence supporting its safety and efficacy, new users in particular often feel that it would be the better and safer option for usage. Unfortunately this is not the case when it comes to skin darkening and most new users who choose Melanotan I find themselves very disappointed at lack of tanning results since Melanotan I is not intended to be used for this purpose. To achieve similar cosmetic tanning results as seen with Melanotan II, a dose of 10x more per injection is required. Melanotan I is more expensive for tanning.
Melanotan II Storage

In powder (lyophilized) form vials should be stored at refrigerator temperature (2-8 degrees Celsius) where they will remain stable for up to 12 months. Reconstituted (mixed) vials should also be stored in the refrigerator, but use within 8 weeks or they may begin to degrade. They will still be safe to use after this time, but they may not be as effective as new vials.
When to take Melanotan II

The frequency of Melanotan II injections will depend largely on your skin type to begin with, therefore you should identify with which Fitzpatrick skin type you are

Type 1: Pale skin, many freckles, blue/green eyes, red hair, never tans, always burns
Type 2: Fair skin, few freckles, blue/hazel eyes, blonde/sandy hair, tans poorly, usually burns
Type 3: Darker white skin, brown hair/eyes, usually tans, rarely burns
Type 4: Light brown skin, darker brown hair/eyes, tans easily, burns minimally
Sunless Tanning

Loading: Take your Melanotan II dose 1 time per day and continue with daily injections until you are happy with the color of your tan.
Maintenance: To maintain your desired tan, inject your Melanotan II dose just 2-3 times per week Cessation: You can continue the maintenance dosing indefinitely; however, if you choose to stop your Melanotan II injections, your tan will fade back to its pre-Melanotan II shade in 1-2 months.

Assuming the right amount of UV exposure (sun or sun bed) is combined with your Melanotan II usage, then the amount of time it takes to achieve your desired tan (i.e. the loading phase) will usually take 4-8 weeks for skin types 1 and 2 and as little as 2-3 weeks for skin types 3 and 4.

Melanotan II and UV Exposure
The tanning activity of Melanotan II without the need for UV exposure has been proven by clinical trial; however, the majority of users report that results are achieved much quicker, and that the tan is a more natural color, when Melanotan II is combined with a small amount of UV exposure.

Tanning should start after the third injection and occur 2-3 times per week if you wish to see tanning results quickly; otherwise one tanning session per week is sufficient to gradually build your tan

Melanotan Advice

If you are not seeing results then you need to increase the frequency of your outdoor or indoor UV exposure (especially if you are skin types 1 or 2). Never increase your recommended Melanotan II dose.

Tanning sessions should be short, 5-10 minutes in a sun bed or 30-40 minutes in the sun on a warm day is sufficient each time. DO NOT overexpose yourself to UV rays.

When starting out always use 30+ sunscreen on sensitive areas such as the face and neck. Because these areas are frequently exposed to UV rays they are more responsive to the melanin producing effects of Melanotan II and therefore will become darker quicker than the rest of the body. Covering these areas initially will allow other parts of the body to tan first, ensuring you achieve a well balanced tan.

Melanotan II and UV exposure complement each other, so if you spend a lot of time tanning you will need less frequent injections of Melanotan II to obtain and maintain your tan. If you don't spend much time in the sun or sun beds then you will need frequent dosages of Melanotan II to develop and keep your tan ..

Fair skinned folks who never tan, always burn in the sun, can achieve a natural tan when using Melanotan 2. For people with sun allergies these discoveries are life changing. The best defense against skin cancer is a natural tan developed over time. MT-2 was designed to reduce skin cancer rates and be effective as a sunless tanner.

Athletes and fitness enthusiasts use Melanotan for sunless tanning, Libido increase and and appetite suppression. MT-2 was dubbed the Barbie drug and has been highlighted in wired magazine. Synthetic melanocortin use helps attain a tan with the least amount of exposure to harmful ultraviolet radiation.
Fitzpatrick skin type: Skin type I and II, the lower of the skin types on the Fitzpatrick scale are the best candidates for Melanotan 2 who see the most dramatic results.

Treatment: Melanotan stimulates melanin effectively, in particular those with low skin types.


Shipping and Handling: Melanotan Peptides are durable and stable. Highlighted in study, the reconstituted MT-2 was shown to be stable at 37 degrees Celsius (98 degrees Fahrenheit) for at least 28 days. Shipping MT-2, even in summer months, is not a problem. Do not pay for cold shipping as it is not a premium. When receiving MT-2 it is recommended to store in the refrigerator.

Mixing: Add BW to the vial when you are ready to begin MT-2 research.

Remove plastic flip top from vial to expose rubber stopper. needle will pierce the stopper making way inside the vial to turn the white ****** into a clear liquid.

Calculator: Add 100 units (1ml) of water to the vial. 1ml/100 units will minimize the volume that you have to inject and will simplify the arithmetic in your MT-2 experiment. Dosing measurements are often mentioned in both milligram (mg) and microgram (mcg). Example: .5mg = 500mcg

Peptide Calculator

Peptide Measurement

1ml syringe (U100), 1ml BW to reconstitute
Calculations for a desired 0.5mg dose:
Step 1= 1ml
Step 2= 10mg MT-II
Step 3= 1ml bac water
Step 4= 500mcg dose
2-3 ticks on your insulin pin (approximately 1/20th of a U100 syringe)

Some prefer to add more diluent which works fine, take note of the volume increase.

Needles: 29-31 gauge X 1/2", 1 CC (100 unit). That is a typical insulin needle used to mix as well as inject. Use needles one time only. Once your technique perfected, injections are almost painless.

Starting dose: Your first injection should be a very small dose, for example .25mg (250mcg). See how you react. Goal should be to feel nothing. Dose after dinner, before bed. Any dosing chart stating that you should take a high dose (according to your weight) is outdated and potentially dangerous.

Loading dose: Load with 0.5-1mg once a day. People who have used doses in this range generally report getting excellent results. Don’t worry if you miss occasional days. It will not make much difference, focus on the cumulative effects.

Maintenance dose: Maintenance is taking doses less frequently than daily to avoid becoming darker than you want. Yes, that will happen. With enough UVR, you will get much darker than you have even been before. A maintenance dose can help prolong super-physiological photo-protection MT-2 delivers.

UV Radiation: Melanotan is a poor sunless tanner. UV (from sun or a tanning bed) light is necessary to develop a tan. Without it, almost nothing happens. In other words, NO UV = NO TAN. Well, user will pigment depending on skin type.... If you have loaded for a full month and then start UV exposure, you (and your friends) will be astounded by how fast you tan and how dark you get. Moreover, it is advisable to keep areas of your skin that ordinarily get exposure covered up with a towel and/or zinc oxide (nose/lips/face) and let less exposed areas develop pigmentation first. Areas of skin that are typically sun-exposed in your day to day life will respond more readily to the effects of the Melanotan Peptides.

Fat Loss: The melanocortin (MC) system is a signaling pathway for leptin and insulin. The MC system is important for control of food intake and body weight. MT-2 treatment results in adipocyte lipolysis. MT-2 increases fatty acid oxidation(FAO) in which the MC5R plays a significant role. MT-2 improves insulin sensitivity through stimulating FAO in skeletal muscle tissue. Reduced food intake from the anorectic response of MT-2 is primarily responsible for weight loss.

Watch yourself: Your tan can sneak up on you. A tan generally sets in 3 days after UV rays. Dose and expose yourself gradually to UVR when tanning. Love your skin.

Avoid burning: You are protected from burning mostly by your tan, not the MT-2 peptide. Therefore, don’t overdo the rays at first. Start with only as much UV that you could tolerate without burring before you began Melanotan. It should not take many weeks before you can tolerate hours of strong sun without burning. Truly incredible for those who have never experienced freedom to enjoy the sun.

Continue your regular dosing protocol until you have reached your desired tan and do not want to become darker. Cut injection frequency to once every 2, 3, 4, or even 7 days. Experiment to find the frequency that gives the tan you want.

Storage: Store freeze dried and reconstituted (mixed) Peptides in the refrigerator.

Do you have to inject MT-II?
Yes. The best, most efficient method of administering Melanotan Peptides are subcutaneous (subq) injections. Nasal sprays are inconsistent and inefficient. No detectable levels were observed following oral dosing - pills do not work.

when you start supplementing (Melanotan II) to tan keep in mind that tanning is literally a side effect. The tanning response is, in reality, a physiological repair mechanism to instant UV damage of the skin cells (. Melanocyte stimulating hormone is not going to color your skin, it is going to make your own skin create its own tan and that in turn creates protection. If you are looking to be some bronzed beach God with perfectly uniform and specific color then you are better off to going to mystic tan. Redheads, for example, naturally produce a variant form of melanin that is yellowish-red . Do not expect a brown tan on a ginger body right away.

Know your skin type: Knowing your skin type is just one detail which will help create a public user log. There are 10s of thousands of Melanotan users worldwide who share the experience. Raise awareness and help others who want to hear success stories, complications and failures.
Am I a good candidate for MT-II?
Melanotan is best suited for the folks with skin types I & II. Prior sun damage, scars, tattoos, freckles, moles, hair color, etc are deciding factors prospective MT-2 users consider.

How should I dose MT-II?
Melanotan II dosage it is recommended to start out small and build up. A typical starting dose is around .25mg and max dose reaching 1mg. Desensitization happens quick, the first administration is an opportunity to dose low to avoid Melanotan 2 side effects. Same goes for Bremelanotide (PT-141) dosage unfortunately.

Melanotan Instructions: There is no magic pill or formula. Instructions do not exist for research Peptides. Few dermatologists are familiar with Melanotan. The skin is a large, unpredictable organ. Feel comfortable and confident with MT-II before use. Check out as many before and after photos and user logs as you can. A skin type I individual may have to commit months of dedication before dialing in their desired results, be patient and ask questions.

How much MT-II should I buy and how long will it last?
Skin type I: 30-50mg
Skin type II: 20-30mg
Skin type III: 10mg
Should last entire summer or season

How soon will I begin to see results from Melanotan II?
You should notice a change in your skin tone after three weeks. If you have freckles, expect them to get darker before your actual skin color changes.

How long will the tan last?
A tan developed using Melanotan 2 lasts much longer than an ordinary tan. A well-tanned person returning from a beach holiday will lose most of the tan in a month if they stop getting sun. But if they had been using Melanotan 2 and continued on maintenance after returning, they would still have most of their tan 3 months later.
author ???
 
Last edited:
Bodybuilders use Ipamorelin Peptide For Building solid Muscle

Bodybuilders use Ipamorelin Peptide For Building solid Muscle

Ipamorelin is a fascinating new muscle building discovery that is getting a lot of attention in the bodybuilding world. Like the GHRP-6 peptide (growth hormone releasing hexapeptide), it is a synthetic peptide that has powerful Growth Hormone releasing properties. And these GH releasing properties are what is of interest to athletes and bodybuilders since they can make a tremendous difference in the amount of muscle you can grow and how quickly you burn fat. Both Ipamorelin and GHRP-6 as well as numerous other peptides and research chemicals can be found at TruePeptide.com



Whereas GHRP-6 is a hexapeptide, Ipamorelin is a penta-peptide. (Aib-His-D-2-Nal-D- Phe-Lys-NH2) And, the strength it displays may very well make regular old Growth Hormone (GH) obsolete. But what athletes and bodybuilders really want to know is what is this wonder peptide capable of doing, how is it used, and how does it compare to the other GHRP peptides?
Athletes are taking Ipamorelin in a 200mcg -300mcg dosage, two or three times daily, using a tiny insulin needle to inject. They usually start with the lower dose since side effects can include headaches or what feels like a head-rush. Ipamorelin can be taken at anytime but taking it about 30-45 minutes before a workout would seem ideal because of the pulse in Growth Hormone (GH) it creates allowing for maximum growth.


Studies on the effects of Ipamorelin on bone growth, body weight, and GH release showed some interesting conclusions.
In one experiment, various doses were administered over the course of 15 days to test the group’s reactions.
There was a distinct and dose-dependent effect on body weight gain however, the treatment group did not show a change in total IGF-I levels. Nor did the treatment group produce serum markers of bone development. For example, the number of cells in the wide portion of the tibia (the shinbone) did not change significantly. This is a good thing because it suggests muscle growth with less potential for deformity of bone or cartilage.


The reaction of the pituitary to an aggressive i.v. dose of Ipamorelin showed that plasma GH levels were notably reduced whereas they were unchanged after a comparable dose of GHRH. This is actually a good thing as it suggests that Ipamorelin may not decrease your body’s natural GH production – further demonstrating that Ipamorelin is a selective GH releaser.

GHRP-2 Unlike GHRP-6, Ipamorelin does not induce hunger making it advantageous to those on a restricted calorie diet. And obviously, Ipamorelin’s side-effects are enhanced when combined with anabolic steroids since they too influence Growth Hormone/Insulin Growth Factor release and production.

In another study in rats, Ipamorelin released GH from rat pituitary cells as effectively as GHRP-2.
Another document states that in healthy swine, Ipamorelin released GH with a consistency that is very comparable to GHRP-6. Also noteworthy was that none of the GH releasers tested affected FSH, LH, PRL or TSH blood serum plasma levels.

Ipamorelin in theory may increase Acetylchloine or Cortisol when used in higher dosages. However, and increase in Acetylchloine or Cortisol is even more likely with GHRP-2 and GHRP-6. In fact, in the case of Ipamorelin, there was little to no rise in Acetylcholine and Cortisol blood plasma levels even at injections more than 200 times higher than the effective dosage for comparable GH release.


This clearly proves that Ipamorelin is the first successful GHRP receptor agonist or chemical that binds to a receptor of a cell and triggers a response by that cell with a specific selectivity for the promotion of GH release by itself.

Another advantage to Ipamorelin is that it doesn’t cause sudden spikes in prolactin or cortisol as does GHRP-2 and GHRP-6. Ipamorelin is slower in its delivery unlike GHRP’s which spike GH levels at a more rapid rate. The slower release is more natural and has a more sustained effect.
All in all it looks as if Ipamorelin is the new wave in GH releasing peptides. It appear to be more potent, longer lasting and potentially safer to use in the long run. More studies are being conducted all the time but as it stands, Ipamorelin looks like a serious contender in the arsenal of anabolic advancement.

Both Ipamorelin and GHRP-2 as well as numerous other peptides and research chemicals can be found at " Check my signature"
 
Last edited:
Growth Hormone Administration vs. CJC-1295/GHRP-6

Growth Hormone Administration vs. CJC-1295/GHRP-6

Units of Measurement
Growth Hormone (GH) like other biologically active substances is measured in International Units (abbreviated as IU) which are based on the measured biological activity for that substance the establishment of which is determined by international agreement. International Units are specific to each substance and so one IU of one substance has no equivalence to one IU of another substance.

While it is fairly straightforward to compare the amount of GH among various dosing administrations (a two (2) iu dose is twice the amount of a four (4) iu dose) and it is easy to ask the manufacture the weight of each iu (Nutropin reveals that 1 iu of their GH is equal to 333 mcg) it is not so simple to compare Growth Hormone to other "Growth Hormone Releasing" compounds such as CJC-1295 and GHRP-6.


Practically all studies that use Growth Hormone (GH) or Growth Hormone Releasing Hormone (GHRH) or its analog CJC-1295 or Growth Hormone Releasing Peptides all take blood samples to measure the amount of GH present in blood plasma at various points in time. The unit of measurement is a standardized unit which can be used to make comparisons across different compounds.
The studies either report results as "nanograms (ng) per milliliter (ml)" or "micrograms (ug) per liter (L)". For the reason that ng = 1/1000 ug and ml = 1/1000 L, ng/ml will always equal ug/L. So no matter how the studies report results comparison is straightforward. In making the cross-comparisons contained herein for simplicity I have chosen to report results as ng/ml.
Therefore this examination will look to several studies involving administration of the compounds of interest and compare the blood plasma levels of IGF-1 and both peaks and total amount of GH blood plasma levels as a result of administration of each tested compound. The result of this cross-study examination will reveal the efficaciousness of various doses of GH, CJC-1295 and GHRH + GHRP-6 in increasing GH & IGF-1 in blood plasma.


Studies used for comparison

Growth Hormone Administration
In "Pharmacokinetics and Metabolic Effects of High-Dose Growth Hormone Administration in Healthy Adult Men", Toshiaki Tanaka, et al., Endocrine Journal 1999, 46 (4), 605-612, fifteen healthy normal Japanese adult males aged from 20 to 27 years were administered various doses of recombinant GH (Norditropin). The GH was administered in a single dose at 9:00 a.m. after overnight fasting. Blood samples were collected at 0, 1, 2, 3, 4, 5, 6, 9, 12 and 24 hours after the single injection.
The doses administered were: .075iu/kg; .15iu/kg and .30iu/kg
When the average weight of each test subject is accounted for the doses administered approximated: 5iu; 10iu and 20iu


CJC-1295 Administration
In "Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults", Sam L. Teichman, et al. Journal of Clinical Endocrinology & Metabolism 91(3):799-805, sixty-six healthy normal men and women aged 21-61 were administered various doses of CJC-1295 (long-lasting GHRH analog). The CJC-1295 was administered in a single dose and again in some groups 7 days later and other groups 14 days later. For the reason that we are only examining a week's worth of data only the initial dose is of interest. Blood samples were collected before dosing and then at 15, 30, and 60 minutes and 2, 3, 4, 6, 8, 10, 12, and 24 hours afterdosing; and then every 8 hours on days 2–3, then daily on days 4, 5, 6, 7.
The doses administered were: 30mcg/kg; 60mcg/kg; 125mcg/kg; 250mcg/kg

GHRH + GHRP-6 Administration
While we are limited in our choice of GH administration studies (because no other study administered such high doses in normal men) and CJC-1295 studies (there are only two, the results of which are available to the public) we have many available studies measuring the effects of co administration of GHRH and GHRPs.
So we will briefly look at the results from two studies to give us an idea of how much GH release is contributed by the enhanced pulse brought on by this synergistic combination.
They are, "Inhibition of growth hormone release after the combined administration of GHRH and GHRP-6 in patients with Cushing's syndrome", Alfonso Leal-Cerro, et al., Clinical Endocrinology 1994, 41 (5) , 649–654 and "Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone", Bowers, C.Y., et al. J. Clin. Endocrinol. Metab. 70, 975–982.

What's Normal?
Before we look at the studies lets take a brief look at how much growth hormone (GH) is secreted naturally. There is a large variability among age groups, gender, fitness level and among individuals within a single age group. So the best we can do is generalize. The charts below are derived from GH blood plasma data collected over a 24 hour period for a normal man, a normal man after a fast, a normal woman and a normal woman after a fast. All ages were mid-20s.
Note that the night-time GH pulse peak for a man was about 20 ng/ml (aprox. 85% of 24hr GH release normally occurs at night).
Total GH release was as follows:
Men (Fed):
Area Under the Curve (AUC): 94 ng/ml per 24 hours
Men (Fasted):
AUC: 274 ng/ml per 24 hours
Women (Fed):
AUC: 168 ng/ml
Women (Fasted)
AUC: 264 ng/ml per 24 hours


Comparing GH administration to CJC-1295 administration
It is difficult to compare based on the following GH release graphs so let's examine the numbers.



Total GH Release:
When GH was administered at 5iu, 10iu & 20iu the total GH levels (area under the curve (AUC)) were respectively:
AUC: 311.5; 836.9; 1778.5 ng/ml per 24 hours

When CJC-1295 was administered at 30mcg/kg; 60mcg/kg; 125mcg/kg and 250mcg/kg the total GH levels (area under the curve (AUC)) were respectively:
AUC: 758; 969; 977; 1370 ng/ml per hour

NOTE: This is per hour while the GH study is per 24 hours

So based on the total GH concentration in blood plasma the lowest dose of CJC-1295 on a per hour basis results in more than twice the 24 hour GH secretion level of a 5iu dose of GH.

Peak Concentration:
However the GH release pattern results in a much higher mean maximum concentration for the GH administration than the CJC-1295 administration.
The GH study resulted in dose respected peaks of 55.4; 93.8; 180 ng/ml

The CJC-1295 study resulted in dose respected peaks of 6.6; 9.6; 9.9; 13.3 ng/ml

The graph indicates that for the GH study the bulk of the peak lasts about 12 hours followed by low levels of GH. As an aside clearly GH administration would be better if it were administered in at least two doses per day.

But even IF 5iu of GH were administered in the morning followed by 5iu twelve hours later the total amount of GH released would be less than a low dose of CJC-1295 (311.5 + 311.5 < 758 ng/ml). Furthermore the CJC-1295 was dosed just once in seven days while the GH would need to be dosed every one of those 7 days.

IGF-1 Levels:

CJC-1295 elevates IGF-1 within the first day or two where it stays elevated for seven days.
GH elevates IGF-1 levels immediately where it stays elevated throughout the rest of the day.
Both the GH & CJC-1295 studies demonstrated a dose dependent increase in elevated IGF-1 levels. The highest GH dose of 20iu resulted in a similar IGF-1 level as the highest CJC-1295 dose. The lowest GH dose of 5iu resulted in an IGF-1 level not much different then the lowest CJC-1295 dose.
Again the CJC-1295 elevated IGF-1 for seven days from a single administration while GH would likely need to be dosed everyday (perhaps every other day) to match CJC-1295's chronic elevation of IGF-1.



Can CJC-1295 plus GHRP-6 match GH adminstration's peaks?
Adding GHRPs to CJC-1295 three times a day can amplify peaks and greatly add to the total GH secretion level.
The Alfonso Leal-Cerro study demonstrated the following GH release:
GHRH by itself dosed at 100mcg resulted in:
(AUC) 120 minutes = 1420 * 330 ng/ml
GHRP-6 by itself dosed at 100mcg resulted in:
(AUC) 120 minutes = 2278 * 290 ng/ml
GHRH + GHRP-6 dosed together at 100mcg each resulted in:
(AUC) 120 minutes = 7332 * 592 ng/ml
By adding GHRP-6 to CJC-1295 (long-lasting GHRH) it may be possible to add almost 6000 ng/ml of GH release at each GHRP-6 dosing. [Figure arrived at by taking synergy amount 7332 and subtracting GHRH's contribution of 1420]
But what about those peaks?



Clearly adding GHRP-6 has the effect of matching GH's peaking power as measured by amplitude. The difference is that GH results in big hills lasting up to 12 hours. This really amounts to an elevation rather than a pulse. GH does not mimic the physiological pulsatile release of GH that naturally occurs while GHRP-6 particularly in the presence of GHRH does result in such a natural pulse. These pulses last for about 2 hours. If dosed three times a day the result would be three 2-hour pulses each of which exceed GH's 5iu and 10iu elevations and approach GH's 20iu elevation.
However 6 hours total of peak for the CJC-1295/GHRP-6 combination would be half of the 12 hours total of peak for the GH.
I do not know if it matters. I do not know if these two different peaking characteristics would result in different effects concerning growth.


In CONCLUSION, CJC-1295 appears to result in higher concentrations of GH in blood plasma than does GH administration. When CJC-1295 is combined with GHRP-6 the total GH release is exacerbated.
GH administration results in higher GH maximum concentration or peaks then CJC-1295 alone. However when CJC-1295 is combined with GHRP-6 the peaking amplitude exceeds the 5iu & 10iu GH doses and approaches the 20iu dose. GH administration's peaks however last for 12 hours while CJC-1296/GHRP-6 results in a natural 2 hour peak at each dosing (i.e. 6 hours total).
Both CJC-1295 and GH appear equally effective at elevating and sustaining IGF-1 levels.
 
Last edited:
Hgh fragment 177-191, Clenbuterol & T3 fat burning synergy

Hgh fragment 177-191, Clenbuterol & T3 fat burning synergy

Growth hormone has many systematic effects, from improved strength, anti-aging effects on skin, tendon strengthening, increased IGF levels, better sleep, to name just a few.. but when Synthetic GH is taken.. most of these effects are minimized, as synthetic GH doesn't imitate the cascade of GH that subjects pituitary creates, and the effects it has…

So what if you could harness say one aspect of GH specifically lets say.. The profound effect it has on fat loss, and produce a peptide that imitates GH in that regard. Introducing HGH Fragment



Hgh fragment 177-191 is a stabilized analogue of the growth hormone-releasing factor (GRF) that induces Growth Hormone in a specific and physiological manner. To date, studies suggest that HGH Fragment 177-191 has several beneficial features: it reduces abdominal fat in particular visceral fat, without compromising glycemic control (blood glucose), it increases muscle mass and improves the lipid profile, so it looks to have a lot of key benefits.. but does it?



Studies that can be found easily show that at a dosage of 500mcg, HGH Fragment 177-191 was shown to increase lipolytic activity in adipose tissue ,this HGH Fragment potently burns body fat, especially stubborn adipose body fat, and at the same time as it doesn't spike glucose levels, or cause any problems with insulin sensitivity, and improving your lipid profile, this really should be part of any dedicated athletes fat loss regime.

Unlike GH, HGH fragment doesn't induce cell proliferation, it does not induce hyperglycemia or reduce insulin secretion. HGH fragment 177-191 does not compete for the hgh receptor, but of important note.. is the HGH Fragment’s ability to increase IGF-1 levels which translate into the HGH Fragment’s ability to give collateral anti-aging and anabolic effects along with its ability to induce fat loss in the most stubborn body fat (adipose tissue) while increasing energy expenditure and glucose and fat oxidation.

The good news is, the subjects body is burning fat for fuel and energy!! And add to that a whole host of health benefits and everything looks great, However it does seem to cause the thyroid to become sluggish, not as potent as GH, but perhaps through its ability to increase cortisol it still slows the thyroid..
So i suggest that HGH fragment should be stacked.


CLENBUTEROL and T3

Everyone these days has probably heard of both supplements, and the scare mongering that goes along with them, so lets make a few things clear..
I have never seen a report with any evidence showing T3 shuts down subjects own pituitary, except when it has been abused, extremely large doses for long periods, 200mcg for 6 weeks or more without any proper tapering off the drug.

In the case of Clenbuterol, if it respected, it can give outstanding results in the fat loss department, help aid in preventing muscle loss and it stacks well with T3 and HGH fragment.

Cytomel is the most common brand name for a synthetic thyroid hormone- more specifically, it’s a synthetic version of T3 (triiodothyronine ). T3 is not produced directly by your thyroid gland, is actually converted from the T4 thyroid hormone, it has potent fat burning effects, and T3will enhance your body’s ability to synthesize protein, even at very low doses which can actually help add muscle. T3 when used in conjunction with HGH fragment will reduce nitrogen retention, this is a fact, so if your looking to get big and ripped, you need to add in something else, and this is where personally clen is often I feel overlooked.

So you have the potent fat burning of HGH fragment, increased IGF levels, but without nitrogen retention, you will look flat, under perform, and find building any muscle close to impossible.. T3 will increase your ATP, ramp up your metabolism, burn fat.. and decrease your nitrogen levels that should be elevated by HGH fragment.
Clenbuterol a powerful fat burner working on stimulating Beta 2 receptors which helps you to release and then burn stored fat. But interestingly not only is it extremely potent in this regard, but it increases Nitrogen retention.. I'm sure subjects who has taken it has noticed the pumps, and the increased fullness on Clen.

If dosed accordingly, This cycle can transform your subjects physique and give them the sharp hardened features you desire, but only if your diet and training is on par with these exceptional supplements.
By chris
 
Last edited:
Peptide Guide Information

Peptide Guide Information



Peptides come in the form of lyophilized (freeze dried) powder. The amount of powder/product is stated in International Units (IU’s) or in Milligrams (MG).


Melanotan peptides (Melanotan 1 & Melanotan 2), PT-141 Bremelanotide, GH Fragment, Ipamorelin, CJC-1295 & GHRPs (GRHP-2 & GHRP-6), HGH, HCG, et cetera use Bacteriostatic Water (BW). Bacteriostatic Water for injection, USP is a sterile, nonpyrogenic preparation of water for injection containing 0.9% of benzyl alcohol added as a bacteriostatic preservative. It is supplied in a multiple-dose container from which repeated withdrawals may be made to dilute or dissolve drugs for injection. The pH is 5.7 (4.5 to 7.0)

For IGF use an acetic acid solution (.6%) which is 7 parts distilled water and 1 part vinegar to reconstitute. You must filter the distilled water and white wine vinegar through a sterile 20 micron syringe filter before use. Sodium Chloride (NaCl) is used to buffer the injection.

1.) Take an alcohol swab to the stopper of both your peptide vial and the vial of the diluent.
2.) Draw your preferred diluent (BW) with a 1cc syringe. Choose an amount that will make measuring the final product simple.
1ml(cc) per 10 mg vial of Melanotan would mean each 10 tick marks on a U100 slin syringe would equal 1mg of Melanotan
1ml(cc) per 10 IU vial of HGH would mean each 10 tick marks on a U100 slin syringe would equal 1 IU of HGH
3.) Take the syringe with the diluent and push it into the vial of lyophilized powder letting the diluent dissolve the peptide. Many (not all) peptides are sealed with vacuum pressure, be careful
4.) After diluent has been added to the vial, gentling swirl the vial until the lyophilized powder has dissolved and you are left with a clear liquid. The peptide is now reconstructed, ready for measurement and usage.
5.) Store your now reconstituted research peptides in the refrigerator.





Peptide Measurement
After successfully reconstituting your peptide, measure the desired amount out for injection. Use a U100 insulin syringe to draw out and inject your product.

Since you know the amount of IU’s/MG’s in your vial, we divide this out as follows:
You will need to know the following to be successful: 1ml = 1cc = 100 IU’s

We take our dose from the label of the dry lyophilized powder and we divide that into the amount of diluent used.

Example- We used 1cc(ml) of water. We have a 10 IU vial of HGH.
From our formula above we know that 1cc = 100 IU’s, so we have 100 IU’s of water.
We now divide the 100 IU’s (the amount of our water) by 10 IU’s (the amount of our HGH)
100 IU / 10 IU = 10

This 10 will perfectly correspond with the markings on a U100 insulin syringe. In our example every 10 mark on our syringe will equal 1 IU of HGH. Want to draw out 2 IU’s of GH? ….draw out to the 20 mark on the syringe (1/5th of the syringe).

Say you have a 1mg vial and you add 1ML you get
1000mcg/1mL: 10 mcg per IU
1000mcg/2mL: 5 mcg per IU







Say you have a 10mg vial and you add 1ML you get
10mg/1mL: 1 mg per 10 IU
10mg/2mL: .5 mg per 10 IU

Say you have a 20mg vial and you add 1ML you get
20mg/1mL: 2 mg per 10 IU
20mg/2mL: 1 mg per 10 IU

Say you have a 10iu vial and you add 1ML you get
10iu/1mL: 1 iu per 10 IU (on the syringe – 1/10th the product)
10iu/2mL: 1 iu per 20 IU (on the syringe – still 1/10th the product)
Say you have a 5000iu vial and you add 1ML you get
5000iu/1mL: 500iu per 10 IU
5000iu/2mL: 250iu per 10 IU
 
Last edited:
Lgd-4033

Lgd-4033


One of the members of the Selective Androgen Receptor Modulator category, also known as SARM, is LGD-4033. It is an oral product that is non-steroidal, but it can offer many of the same benefits as some of the anabolic steroids. The use of LGD-4033 medically includes treatment of muscle wasting. This can be due to issues with cancer or muscle loss due to the natural aging process.

The same benefits astestosterone are also offered with LGD-4033. The difference though is that the user doesn’t have to worry about potential side effects. With testosterone, there can be the risk of the body not responding well or even damage to the liver. Even though this product is taken orally, it isn’t toxic to the liver.

This is one of the most common SARMS used due to how powerful it is. Yet it is also gentle on the body when compared to steroids. For the individual that wants the results but not all of the hassles, this could be exactly what they were looking for.


How does it Work?
This SARM works by binding the androgen receptors selectively. The results of anabolic activity in the muscles and bones occur rather than adversely affecting the glands or the prostate which can occur with the use of steroids. LGD-4033 was recently involved in a study involving volunteers called Phase I Multiple Ascending Dose. This was a random, double blind testing phase that involved a placebo. The goal was to establish that the use of LGD-4033 was safe and easy to tolerate with a dose not to exceed 22 mg per day.

When to use LGD-4033
For many bodybuilders and athletes, the use of LGD-4033 occurs for a bulking phase in order to offer lean body mass and to reduce overall body fat. The use of it can also increase overall strength which allows the individual to take on more challenging workout sessions. When used for bulking, an efficient diet that is high in protein is also necessary. Higher calorie intake may be necessary too if the person will be bulking up by 10 pounds or more. The recommended dose is 5 to 10 mg per day, for a period of 8 weeks.

For a cutting cycle, it may be best to use LGD-4033 along with other SARMS including GW-501516 and S-4. This is called a SARMS triple stack. The goal is to add more size while cutting fat. The dose recommended for this type of cycle is 3 to 5 mg, for a period of 8 weeks.




Risk Factors
The results of various studies indicate that there is very little risk in regards to possible side effects associated with the use of LGD-4033. This is encouraging for those that would like to gain muscle and cut fat without using steroids that do have some harsh side effects associated with them.

The fact that that SARMS don’t harm the liver is also another reason to consider taking them instead of steroids. They are also inexpensive so the average person can use them without worrying about their budget.
 
Last edited:
About CJC-1295

About CJC-1295



CJC-1295 was developed for clinical trials in the year 2000. The drug was originally synthesized to remove visceral fat deposits in AIDS patients. CJC 1295 was ultimately successful on all research subjects, as increasing the level of growth hormone in the body proved to increase fat loss.
Various experiments have been conducted to test the effectiveness of CJC-1295 in vivo and the Journal of Clinical Endocrinology & Metabolism has reported dose-dependent increases in mean plasma GH concentrations by 2-10 fold for more than 6 days and increased IGF-1 concentrations 1.5-3 fold for 9-11 days after a single injection
.

Not only that but they proved the mean half life to be 5.8-8.1 days and after multiple doses showed mean IGF-1 levels remained above baseline for up to 28 days following! No serious adverse reactions were reported in any group.

Another very positive benefit of CJC-1295/CJC-1293 is its ability to promote slow wave sleep. Slow wave sleep is also known as deep sleep and is the portion of sleep responsible for the highest level of muscle growth and memory retention. SWS are decreased significantly in older adults and also with people who tend to exercise later in the evening.

This peptide has a benefit to side effect ratio that exceeds all others currently being legally sold and would make a great addition to ones training regimen or post cycle therapy.

CJC-1295 has the ability to make the body produce its own GH as compared to using synthetic HGH. GHRP-6 in conjunction with CJC-1295 is synergistic, amplifying the GH pulse considerably. Studies have shown that CJC-1295 also promotes slow-wave sleep, the kind of sleep responsible for muscle growth and increased memory retention.

There are three popular and clinically proven GHRH analogs on the market today, CJC-1293, CJC-1295, CJC-1295 DAC, and Sermorelin. CJC-1293 is a longer lasting peptide- it is sometimes also referred to as tetrasubstituted GRF(1-29) or Modified Sermorelin.

The half life of Research peptide CJC1295 is more desirable and establishes a significant enough of a GH pulse to increase IGF-1 levels and GH levels. However, it's pulsatile release is more of a sustained-consistent release that does not necessarily mimic that of the pituitary gland.

The CJC-1295 & the total 24 hour dosing of GHRP-6 together comprise a single comparison with exogenic GH administration.
 
Last edited:
Healing Peptides

Healing Peptides

ACT1 PEPTIDE: this peptide is cleaved from thymosin, it was created from a section of the thymosin (TB-500) amino acid chain.
ACT1 is a synthetic peptide derived from the carboxyl-terminal sequence of the cellular gap junction protein connexin43. This novel peptide has recently been shown to modulate cutaneous wound healing, reduce scarring, and promote regenerative repair of the skin following injury. In this study, the authors investigated the ability of the ACT1 peptide to modulate the wound-healing response to biomedical device implantation.
ACT1 PEPTIDE
- promotes skin wound healing
- closure at the wound site
- reduced scarring at the site of injury
- reduced inflammation at injury site
- research is being conducted in healing of the heart(tons of successful studies on heart post injury), spinal cord, cornea.



BPC 157:
- BPC 157 has been shown in rat studies to heal torn quadriceps muscles, detached achilles tendon, muscles that have been damaged/crushed
- dramatic fast recovery from muscle tears
- tendon to bone healing
- increased ligament healing
- has a variety of protective effects in the organs
- human trials demonstrate healing and prevention of stomach ulcers
- no adverse reactions have been seen in human trials.
Both ACT1 PEPTIDE and BPC 157 have been shown to heal a variety of wounds in all areas researched, including internal organs, muscles, ligaments, tendons, skin, internal lacerations from surgery, etc. Anyone at MHQ research these peptides?



Thymosin beta4 wound healing: visions of the future.

Abstract
Persistent corneal epithelial defects and inflammation within the central cornea can directly distort visual acuity and may lead to permanent visual loss. Therefore, treatments with agents that enhance corneal reepithelialization and regulate the inflammatory response without the deleterious side effects of currently used agents such as corticosteroids would result in improved clinical outcome and would represent a major advance in the field. Despite much progress in the areas of corneal wound healing research, clinically available pharmacological therapies that can promote repair and limit the visual complications from persistent corneal wounds are severely limited and remains a major deficiency in the field. Prior studies from our laboratory have demonstrated the potent wound healing and anti-inflammatory effects of thymosin beta 4 (TB-500); TB500 in numerous models of corneal injury. We are studying the mechanisms by which Thymosin beta 4 suppresses inflammation and promotes repair. Herein, we discuss some of our new basic scientific directions that may lead to the use of tb-500 as a novel corneal wound healing and anti-inflammatory therapy.
 
Last edited:
CJC-1295 Shows Promise HGH Release

CJC-1295 Shows Promise HGH Release




If you have used CJC-1295 please post your results below. What dose did you use?
CJC-1295 is a peptide analogue of GHRH. Because of the way CJC-1295 is engineered its half life has been extended from ~7 minutes to greater than 7 days!
Due to the extremely long half life of CJC-1295 it is plausible to use this peptide once per week with outstanding results. It would be wiser to use ½ dosages twice per week to keep serum levels high and to get maximal.

Various experiments have been conducted to test the effectiveness of CJC-1295 in vivo and the Journal of Clinical Endocrinology & Metabolism has reported dose-dependent increases in mean plasma GH concentrations by 2-10 fold for more than 6 days and increased IGF-1 concentrations 1.5-3 fold for 9-11 days after a single injection.

Not only that but they proved the mean half life to be 5.8-8.1 days and after multiple doses showed mean IGF-1 levels remained above baseline for up to 28 days following! No serious adverse reactions were reported in any group.

Another very positive benefit of CJC-1295 is its ability to promote slow wave sleep. Slow wave sleep is also known as deep sleep and is the portion of sleep responsible for the highest level of muscle growth and memory retention. SWS are decreased significantly in older adults and also with people who tend to exercise later in the evening. This peptide has a benefit to side effect ratio that exceeds all others currently being legally sold and would make a great addition to ones training regimen or post cycle therapy.

Quotes:
CJC 1295 is expensive whereas the GRF 1 – 29 & GHRP 6 are not, so I use GRF 1- 29 & GHRP 6 at doses of 100 mcg’s each morning. Before bedtime I inject 150 mcg’s of CJC 1295 & 100 mcg’s of GHRP 6. This seems to provide a good sleep & I wake in the morning feeling quite fresh & ready for another day at the uni.

The most popular dosage used by body builders seems to be 100 mcg injections of both CJC 1295 & GHRP 6 * 3 times each day. It really depends on a person’s goals, because some people use what I consider to be massive doses once or twice each week. The general opinion, however, seems to be that regular small doses are healthier & more effective. I’ve found that better sleep, & better digestion are the obvious results of using these products.


GHRP-6 is great for appetite stimulation and works very well taken with CJC-1295 and testosterone,Especially for those who have difficulty in gaining weight.
My vote goes to real hgh,lots of chinese brands have popped up these days.And like Sly Stallone said,hgh and testosterone should really be over the counter.


your best way to go is to take 100mcg of GRF1-29 and 100mcgs GHRP6 in the morning upon waking up, post workout and pre-bed. The 2 peptides has a synergistic effect without the other it would be not 100% effective.

A GRF1-29 only wont do such…
A GHRP6 only will be a better choice…
But both will increase GH release 100%…

Try not to eat for about 30 minutes after administering the following peptides as fat affects the GH pulsations
Chris White
 
Last edited:
Back
Top