Curcumin Makes Fat Cells Kill Themselves

Results 1 to 6 of 6
  1. #1
    Numero Uno 💪
    ADMINISTRATOR
    Arnold's Avatar


    Join Date
    Jun 2012
    Posts
    24,591

    Thanks Thanks Given 
    664
    Thanks Thanks Received 
    15,337
    Thanked in
    7,380 Posts
    Rep Points
    2147483647

    Curcumin Makes Fat Cells Kill Themselves

    New research shows that curcumin prevents baby fat cells from becoming adults while also causing adult fat cells to commit suicide.

    It started off as an effective pain reliever and anti-inflammatory, but then we found out it also fights cancer, blocks estrogen, boosts testosterone, improves heart health, makes you stronger, dissolves arterial plaques, stops your knees from aching, reduces the risk of diabetes, and even helps prevent mosquito-born malaria.

    And now there’s new research showing that curcumin causes fat cells to undergo apoptosis, which is the term for cellular suicide. When apoptosis begins, the surface of the cell starts to bubble and churn, almost like it’s boiling. Then, its nucleus starts to fragment. Eventually, the cell tears asunder, spilling its disassociated guts into the interstitial sea of fluid.

    A cellular clean-up crew of phagocytes, one accustomed to wet work, arrives to dispose of the corpses and there’s no investigation because they know curcumin was to blame.

    This new curcumin research also shows that curcumin prevents pre-adipocytes – baby fat cells – from developing into full-blown adipocytes. These baby fat cells are urged to go into a different profession… or else.

    THE STUDY, SHORT AND SWEET
    The Taiwanese researchers who conducted this study already knew from a few recent studies that curcumin supplementation reduces a high-fat diet-induced increase in body fat, but they didn’t know the mechanism behind curcumin’s hate for plumpness.

    To figure it out, they exposed mouse pre-adipocytes to varying concentrations of curcumin for varying time frames. They also exposed pre-adipocytes to a low dosage of curcumin for an hour, followed by a 24-hour incubation period.

    They found that curcumin inhibited adipocyte differentiation. In other words, the supplement prevents fat cells from maturing and fulfilling their ultimate function, which is to store fat.

    The high doses of curcumin actually caused fat cells to commit suicide, while the lower doses prevented the maturation of the baby fat cells. They suspect it had to do with curcumin’s modulating effects on something known as the Wnt/beta-catenin signaling pathway, which helps determine the fate of cells.

    The authors, despite seemingly being tight-lipped PhD guys, seemed pretty jazzed, writing:

    “These findings suggest that curcumin supplementation could be an effective strategy for treating or preventing development of obesity by a curcumin-induced reduction in the number or pre-adopocytes and the fat mass of adipocytes.”

    WHAT TO DO WITH THIS INFO
    When you think about it, curcumin’s effects on fat cells may have something to do with many of the other benefits listed in the opening paragraph of this article.

    Collectively, our fat cells are considered to be a major endocrine organ with a powerful impact on things like the regulation of appetite, insulin sensitivity, immunological responses, and vascular disease, so if curcumin causes fewer fat cells to form while causing others to expire, it makes sense that it would have so many beneficial side effects.

    As far as how much curcumin to take to experience any reduction in fat mass, it’s difficult to say.

    The scientists exposed the fat cells to a concentration of up to 50 micrograms of curcumin to make them commit hari-kari, and 30 micrograms to keep pre-adipocytes from forming into full-fledged adipocytes, but given that the body weights of us human is so diverse, it’s hard to extrapolate a suitable dosage.

    But, given that 30 micrograms is awfully small (a thousand micrograms equals 1 milligram), I feel confident in suggesting that the standard Biotest dosage of curcumin would bring the average person into therapeutic range.

    Even so, this and other studies make me suspect that curcumin might be more useful in preventing further fat gain than reducing it, but that’s just a guess. Regardless, I don’t think you can go wrong taking curcumin, especially when you consider all its other healthful effects.

    Source:
    Liang-Yi Wu, et al. “Curcumin Attenuates Adipogenesis by Inducing Preadipocyte Apoptosis and Inhibiting Adipocyte Differentiation,” Nutrients 2019, 11(10), 2307.
    PLEASE SUPPORT OUR SPONSORS



  2. #2
    Carpet-Chewer
    Augustine5I's Avatar


    Join Date
    Jan 2015
    Posts
    7,040

    Thanks Thanks Given 
    1,757
    Thanks Thanks Received 
    3,704
    Thanked in
    2,071 Posts
    Rep Points
    2147483647

    Okay...so this was posted awhile back.

    I thought it was interesting. Did research to find the actual study...and how much was given etc. Turns out you actually take it with peperine which makes the curcumin bioavailable.

    Using it now for several months and trust me, I have plenty of fat cells.

    So I call bullshit.

    I still like using this supplement for the anti-inflammatory effects but it has not done anything for fat IMO.

  3. #3
    NO LIMITS.
    SUPER MOD
    HFO3's Avatar


    Join Date
    Feb 2013
    Posts
    11,011

    Thanks Thanks Given 
    2,992
    Thanks Thanks Received 
    7,083
    Thanked in
    4,141 Posts
    Rep Points
    2147483647

    Quote Originally Posted by Augustine5I View Post
    Okay...so this was posted awhile back.

    I thought it was interesting. Did research to find the actual study...and how much was given etc. Turns out you actually take it with peperine which makes the curcumin bioavailable.

    Using it now for several months and trust me, I have plenty of fat cells.

    So I call bullshit.

    I still like using this supplement for the anti-inflammatory effects but it has not done anything for fat IMO.

    its much easier and more effective to go with what we know works, train and eat for a lean body, no extra supps needed but some are welcome.


    My gainz are fueled by PSL's EP brand gearz.


    Please Read The Forum Rules...
    http://www.anabolicsteroidforums.com...ules-Must-Read

    https://puritysourcelabs.ru



  4. #4
    Carpet-Chewer
    Augustine5I's Avatar


    Join Date
    Jan 2015
    Posts
    7,040

    Thanks Thanks Given 
    1,757
    Thanks Thanks Received 
    3,704
    Thanked in
    2,071 Posts
    Rep Points
    2147483647

    Quote Originally Posted by HFO3 View Post
    its much easier and more effective to go with what we know works, train and eat for a lean body, no extra supps needed but some are welcome.
    Yeah, but I REALLY wanted this to work!

  5. #5
    NO LIMITS.
    SUPER MOD
    HFO3's Avatar


    Join Date
    Feb 2013
    Posts
    11,011

    Thanks Thanks Given 
    2,992
    Thanks Thanks Received 
    7,083
    Thanked in
    4,141 Posts
    Rep Points
    2147483647

    Quote Originally Posted by Augustine5I View Post
    Yeah, but I REALLY wanted this to work!

    Lol I feel ya !


    My gainz are fueled by PSL's EP brand gearz.


    Please Read The Forum Rules...
    http://www.anabolicsteroidforums.com...ules-Must-Read

    https://puritysourcelabs.ru



  6. #6
    Registered User
    maxmuscle1's Avatar


    Join Date
    Apr 2015
    Posts
    21,373

    Thanks Thanks Given 
    33,988
    Thanks Thanks Received 
    19,532
    Thanked in
    11,794 Posts
    Rep Points
    727291140

    Quote Originally Posted by Augustine5I View Post
    Okay...so this was posted awhile back.

    I thought it was interesting. Did research to find the actual study...and how much was given etc. Turns out you actually take it with peperine which makes the curcumin bioavailable.

    Using it now for several months and trust me, I have plenty of fat cells.

    So I call bullshit.

    I still like using this supplement for the anti-inflammatory effects but it has not done anything for fat IMO.
    I have used it for 3 years and it definitely reduces pain/inflammation. If you take regularly and stop; then you realize how much it does. I added 2g black seed oil (thymoquinone) is the active . It is made from the black cumin seed. Great stuff but pass on the drinkable one . Hoobach is my new “go to” for saving $$. I used Solgar Circumin 185x for 2 years until the Amazon scandal with their softgels .

    Max

Similar Threads

  1. Replies: 1
    Last Post: 06-02-2021, 10:53 AM
  2. These Echinacea components kill cancer cells
    By Arnold in forum Supplements
    Replies: 1
    Last Post: 08-05-2020, 04:54 PM
  3. Curcumin Makes Fat Cells Kill Themselves
    By Arnold in forum Supplements
    Replies: 25
    Last Post: 12-05-2019, 11:14 AM
  4. Replies: 0
    Last Post: 07-27-2016, 10:40 AM
  5. Replies: 0
    Last Post: 05-01-2013, 08:30 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Copyright© 2012-2021 Anabolic Steroid Discussion Forums