Resveratrol turns vitamin C into an even more effective skinceutical
According to animal studies, vitamin C supplementation keeps aging skin young and free from wrinkles. And if you also attach some value to the in vitro study that Japanese cell scientists from the Prefectural University of Hiroshima published in Molecular and Cellular Biochemistry, vitamin C works even better in combination with good old resveratrol.




Study

The researchers exposed human skin cells - the Japanese used HaCaT keratinocytes - to an active and a less active form of vitamin C. At the same time, the researchers exposed the cells to resveratrol.The active or reduced form of vitamin C was ascorbic acid, the less active or oxidized form was dehydoascorbic acid.
In the body, ascorbic acid, the active form of vitamin C, after neutralizing harmful molecules, changes to the less active dehydoascorbic acid. The reaction can also go in the opposite direction if the cells change dehydoascorbic acid back to its active form.





Results
Resveratrol increased the concentration of the active form of vitamin C in the skin cells.








Mechanism
So, in combination with vitamin C, resveratrol does two things. Resveratrol makes skin cells absorb more vitamin C, and resveratrol stimulates the conversion of less active dehydoascorbic acid into active ascorbic acid in the cells.

How this happens, reveals the figure below.





Resveratrol activates vitamin C transporters, causing the skin cells to absorb more vitamin C. Activation of thioredoxins by resveratrol allows cells to convert more dehydoascorbic acid into ascorbic acid.
Conclusion
"Resveratrol might be useful for maintaining substantial ascorbic acid accumulation in skin keratinocytes, and the combination of resveratrol with ascorbic acid is expected to be efficient for maintaining and / or protecting skin functions", the researchers write.

Their study was not paid for by a cosmetic manufacturer, but by the Japanese government.
Source:
Mol Cell Biochem. 2020 Apr;467(1-2):57-64.