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Anavar - Let's review some literature written by numerous creditable sources. 3 studies included
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Euro-Pharmacies Anavar at Puritysourcelabs.ru
https://puritysourcelabs.ru/oral-steroids-usa/587-oxandrolone-anavar-10mgtab-50-tabsbag-ep-usa.html
Euro-Pharmacies.net
https://puritysourcelabs.ru/
The wonder drug that everyone is always buzzing about. Anavar (OXANDROLONE) - 10mg/tab Euro-Pharmacies
History: Anavar, first released by Searle Laboratories in 1964, was indicated in the treatment of a variety of medical conditions and due to its weak androgen component,
was the first drug approved for use in both women and children. It was discontinued by Searle under its original brand name 1989,
but was later re-introduced by Bio-technology General Corporation in 1995 under the name Oxandrin.
It is now prescribed for the treatment of H.I.V related weight loss, corticosteroid induced muscle atrophy, and Turner Syndrome.
Method of Administration: Anavar is administered in oral form.
Steroid Class: Oxandrolone is a DHT derivative, belonging to the DHT-family of steroids.
Primary Use: Similar to Winstrol, Anavar is not a great mass-builder, but is well-suited to cutting/pre-contest usage, as well as lean-bulk cycles. In fact,
these two drugs are often used interchangeably, as both impact the appearance of the physique in very similar ways. From a cosmetic standpoint,
Anavar increases muscle hardness, muscle density, and vascularity. Clinically speaking, Anavar has been proven to reduce bodyfat, increase bone density,
enhance collagen production, and build lean muscle tissue. While Anavar, like all methylated steroids, is prone to causing adverse alterations in one’s lipid profile,
it demonstrates a reduced level of toxicity in comparison to other methylated AAS and is considered one of the mildest steroids in terms of side effects.
Anavar’s total lack of estrogenic, androgenic, and progestagenic side effects makes it an ideal drug for those who desire a pure muscle-building effect,
without having to worry about things such as gynecomastia, hair loss, acne, water retention, etc.
For those of you looking to maximize your strength to bodyweight ratio, you can’t go wrong with Anavar.
When used at higher dosages, Anavar is one of the most effective pure strength drugs on the market.
This makes it useful for powerlifters and other athletes attempting to remain within a predetermined weight class.
Anavar possesses amazing collagen and elastin synthesis properties "fibrous glycoprotein" (which is found in connective tissue). If you're attempting achieve a HARDER,
LEANER and more VASCULAR look all while increasing strength and performance, then this is compound is for you.
Anabolic-Androgenic Ratio: 630:24
Aromatizable: No.
Progestagenic Activity: No.
Methylated: Yes. Methylation serves as a protective feature of most oral AAS, allowing the molecule the pass through the liver and enter the bloodstream intact,
after which it can travel to muscle tissue and exert its muscle-building effects.
Standard Dosing Range and Cycle Length: Oxandrolone is most commonly dosed at between 40-100 mg per day for a period of 4-12 weeks in length.
Frequency of Administration: Daily use; split into 2 equally divided doses.
((CLICK HERE TO PURCHASE))
Euro-Pharmacies.net
https://puritysourcelabs.ru/oral-steroids-usa/587-oxandrolone-anavar-10mgtab-50-tabsbag-ep-usa.html
Study #1
A little testosterone and a little oxandrolone as effective as a good dose of testosterone (JAMA. 1999 Apr 14; 281 (14): 1282-90.)
Let your men train for 20 weeks with weights and inject them with 600 mg of testosterone enantate, then, according to studies, it yields 8 kilos of extra lean body mass. It is also possible with less,
doctors of the University of California discovered. You can achieve almost the same result with a pronounced mild course of oxandrolone and testosterone enantate - which only lasts 8 weeks.
The researchers published a trial in chic JAMA in 1999 in response to the studies in which researchers gave men with HIV large doses for medical purposes, such as 600 mg of nandrolone decanoate per week.
The HIV men also trained with weights. The researchers do not think that high doses are necessary.
That is why they decided on a trial in which they gave 22 HIV patients 20 mg oxandrolone daily
and a 100 mg testosterone enantate injection every week. The course lasted 8 weeks.
The men trained 3 times a week with weights. Under the guidance of a trainer, they took care of the most important muscles of the upper body with 6 basic exercises,
and trained the lower body with 3 basic exercises. They trained with weights that were 80 percent of the weight with which they could just make 1 rep [1RM].
Eleven men only received a 100 mg testosterone enantate injection every week and took a placebo.
Eleven other men took 20 mg of oxandrolone every day.
The figure below shows that after 8 weeks the oxandrolone group had gained nearly 8 kilos of lean body mass.
A little "test" and a little oxandrolone as effective as a GOOD dose of "test"-STUDY
The men in the oxandrolone group also became stronger faster than the other men. For the bench press and leg press,
the maximum weight for the men in the placebo group increased by 10 and 20 pounds respectively. For the men in the oxandrolone group that was 20 and 30 kilos.
The men in the oxandrolone group also lost a few ounce more fat than the men in the placebo group
It is therefore not necessary at all to cure 20 weeks with 600 mg if you want to gain 8 kilos of lean body mass,
the researchers conclude. It is also possible with lower doses.
Moreover, the mild oxandrolone testosterone treatment was not entirely without side effects. In the oxandrolone group,
1 patient had to drop out because his liver started to act strange.
Blood tests also showed that the addition of oxandrolone to the modest testosterone course further reduced the body's own production of testosterone.
The production of the hormones LH and FSH decreased extra in the oxandrolone group, the researchers discovered. LH and FSH have the testes produce testosterone.
Some men used virus inhibitors. These drugs did not influence the effects of the steroids.
"The combination of resistance exercise with a moderately supraphysiologic androgen regimen that included oxandrolone increased significantly increased lean tissue and
muscle strength than resistance exercise with physiologic testosterone replacement alone in eugonadal HIV-infected men with prior weight loss,
" conclude the researchers. " The use of protease inhibitor therapy did not affect the lean tissue response".
(Bonus read)
Study #2
Did you know that a few hundred mils of caffeine boost the anabolic effect of oxandrolone?
Read this study below -Incorporate 10g of creatine 5g X 5 twice daily (intra-workout and post workout) along with and coffee/caffeine with the Anavar intake throughout the day..
Oxandrolone (Anavar) GREATLY increases creatine synthesis therefor you can peel down on adipose tissue yet keeping the muscle bellies full with that rounded pump appearance,
the combo with Anavar/creatine are VERY synergestic with great pumps!
Imagine: you're a careful user of anabolic steroids. You occasionally take a course of oxandrolone only, and that's all you want. If this is your way of doing things,
then Portuguese doping researchers may have discovered something that'll interest you.
They suspect that you can get more out of oxandrolone if you take extra caffeine.
Caffeine-oxandrolone
The Portuguese, who work for the doping lab Laboratorio de Analises de Dopagem, were tipped by the police that some Portuguese steroids users swear by a combination of caffeine and oxandrolone.
The researchers were curious to know more about the potential use of this combination,
so they consulted the literature.
They came across studies which show that caffeine can boost the uptake and effect of paracetamol. [J Clin Pharmacol. 2007 Jun;47(6):715-26.] So, they reasoned, might caffeine have the same effect when taken with oxandrolone?
Study
Imagine: you're a careful user of anabolic steroids. You occasionally take a course of oxandrolone only, and that's all you want. If this is your way of doing things,
then Portuguese doping researchers may have discovered something that'll interest you.
They suspect that you can get more out of oxandrolone if you take extra caffeine.
To answer this question the researchers performed an experiment in which they gave a subject, whose caffeine consumption was a normal three small espressos a day,
a miniscule quantity [0.4 mg] of oxandrolone.
Results
The researchers then monitored the amount of caffeine, oxandrolone and the inactive oxandrolone metabolite epioxandrolone [structural formula shown here] in the subject's urine for the next 40 hours.
The figure below shows the amounts found in the first 14 hours. Click on it for the full figure.
The researchers then repeated the experiment, but gave the subject 300 mg caffeine in pill form.
The figure above [click on it for a complete figure] shows that the amount of oxandrolone and epioxandrolone rose by a factor of 20 and 15 respectively.
Conclusion
The researchers think their experiment may show that caffeine causes a considerable improvement in the uptake of oxandrolone by the body.
"Practically this means that similar concentrations/effects may be achieved using lower dosages", they write. "Other anabolic steroids should also be investigated."
randomized, controlled trial of treatment of alcoholic hepatitis with parenteral nutrition and oxandrolone. I. Short-term effects on liver function.
Bonkovsky HL1, Fiellin DA, Smith GS, Slaker DP, Simon D, Galambos JT.
Author information
Abstract
The present studies were designed to provide careful measures of effects of oxandrolone, an anabolic steroid, intravenous nutritional supplementation,
and the combination of these two treatments on liver functions, metabolic balances, nitrogen metabolism, and nutritional status in patients with moderate to severe alcoholic hepatitis. Of 43 patients originally recruited, 39 (19 men, 20 women) with typical clinical and laboratory features of alcoholic hepatitis (11 Child's-Pugh class B; 28 class C) were admitted to a metabolic unit and
completed a 35-day three-phase protocol. Phase I was a 10-day baseline period of observation, during which routine and special quantitative tests of liver function
(galactose and antipyrine metabolism), a 7-day elemental balance study, and a 15N, 13C-leucine metabolism study were done.
Phase II was a 21-day treatment period during which patients were randomly assigned to receive one of four regimens: 1) standard therapy, consisting of abstinence, a balanced, nutritionally adequate diet,
and multivitamins; 2) oxandrolone (20 mg orally four times a day) plus standard therapy; 3) nutritional supplementation, consisting of 2 L daily of 3.5% crystalline amino acids (in 5% dextrose),
given by peripheral vein; or 4) a combination of oxandrolone and nutritional supplementation, along with standard therapy.
Metabolic balances were repeated during phase II. Phase III was 2 or 3 days posttreatment, during which special studies of liver functions and volumes and leucine metabolism were repeated. All patients who completed phase I of study and were randomly allocated to one of the four treatment groups completed the subsequent two phases.
Overall, with time, patients showed highly significant improvements in most clinical and laboratory features. For most standard laboratory tests (e.g.,
serum albumin, transferrin, prothrombin time) improvements were more marked in patients treated with nutritional supplementation and/or oxandrolone than in those given standard therapy alone. Liver volumes fell in all treatment groups, with greater improvement in those treated with nutritional supplementation. Improvements in galactose and antipyrine metabolism rates were significant only in those treated with nutritional supplementation or oxandrolone.
Effects of treatments on metabolic balances, nitrogen metabolism, and measures of nutrition are described in this issue in a companion paper.
We conclude that the addition of nutritional supplementation and oxandrolone to standard therapy of moderately severe or severe alcoholic hepatitis is well tolerated, and leads to more rapid improvement in the laboratory parameters measured.
___________
Study #3
High doses of Anavar is NOT liver toxic -
A randomized, controlled trial of treatment of alcoholic hepatitis with parenteral nutrition and oxandrolone. I. Short-term effects on liver function.
Bonkovsky HL1, Fiellin DA, Smith GS, Slaker DP, Simon D, Galambos JT.
Author information
Abstract
The present studies were designed to provide careful measures of effects of oxandrolone,
an anabolic steroid, intravenous nutritional supplementation,
and the combination of these two treatments on liver functions, metabolic balances, nitrogen metabolism, and nutritional status in patients with moderate to severe alcoholic hepatitis. Of 43 patients originally recruited, 39 (19 men, 20 women) with typical clinical and laboratory features of alcoholic hepatitis (11 Child's-Pugh class B; 28 class C) were admitted to a metabolic unit and completed a 35-day three-phase protocol.
Phase I was a 10-day baseline period of observation, during which routine and special quantitative tests of liver function (galactose and antipyrine metabolism),
a 7-day elemental balance study, and a 15N, 13C-leucine metabolism study were done. Phase II was a 21-day treatment period during which patients were randomly assigned to receive one of four regimens: 1) standard therapy, consisting of abstinence, a balanced, nutritionally adequate diet, and multivitamins; 2) oxandrolone (20 mg orally four times a day) plus standard therapy; 3) nutritional supplementation,
consisting of 2 L daily of 3.5% crystalline amino acids (in 5% dextrose), given by peripheral vein; or
4) a combination of oxandrolone and nutritional supplementation, along with standard therapy. Metabolic balances were repeated during phase II.
Phase III was 2 or 3 days post-treatment, during which special studies of liver functions and volumes and leucine metabolism were repeated. All patients who completed phase I of study and were randomly allocated to one of the four treatment groups completed the subsequent two phases. Overall, with time, patients showed highly significant improvements in most clinical and laboratory features. For most standard laboratory tests (e.g., serum albumin, transferrin, prothrombin time) improvements were more marked in patients treated with nutritional supplementation and/or oxandrolone than in those given standard therapy alone.
Liver volumes fell in all treatment groups, with greater improvement in those treated with nutritional supplementation. Improvements in galactose and antipyrine metabolism rates were significant only in those treated with nutritional supplementation or oxandrolone. Effects of treatments on metabolic balances,
nitrogen metabolism, and measures of nutrition are described in this issue in a companion paper. We conclude that the addition of nutritional supplementation and
oxandrolone to standard therapy of moderately severe or severe alcoholic hepatitis is well tolerated,
and leads to more rapid improvement in the laboratory parameters measured.
https://puritysourcelabs.ru/oral-steroids-usa/587-oxandrolone-anavar-10mgtab-50-tabsbag-ep-usa.html
Brought to you by Puritysourcelabs.ru
~Click the banner below for direct store access~
Locally available 50ct 10mg tabs for $60 USD
Euro-Pharmacies.net
https://puritysourcelabs.ru/
Euro-Pharmacies Anavar at Puritysourcelabs.ru
https://puritysourcelabs.ru/oral-steroids-usa/587-oxandrolone-anavar-10mgtab-50-tabsbag-ep-usa.html
Euro-Pharmacies.net
https://puritysourcelabs.ru/
The wonder drug that everyone is always buzzing about. Anavar (OXANDROLONE) - 10mg/tab Euro-Pharmacies
History: Anavar, first released by Searle Laboratories in 1964, was indicated in the treatment of a variety of medical conditions and due to its weak androgen component,
was the first drug approved for use in both women and children. It was discontinued by Searle under its original brand name 1989,
but was later re-introduced by Bio-technology General Corporation in 1995 under the name Oxandrin.
It is now prescribed for the treatment of H.I.V related weight loss, corticosteroid induced muscle atrophy, and Turner Syndrome.
Method of Administration: Anavar is administered in oral form.
Steroid Class: Oxandrolone is a DHT derivative, belonging to the DHT-family of steroids.
Primary Use: Similar to Winstrol, Anavar is not a great mass-builder, but is well-suited to cutting/pre-contest usage, as well as lean-bulk cycles. In fact,
these two drugs are often used interchangeably, as both impact the appearance of the physique in very similar ways. From a cosmetic standpoint,
Anavar increases muscle hardness, muscle density, and vascularity. Clinically speaking, Anavar has been proven to reduce bodyfat, increase bone density,
enhance collagen production, and build lean muscle tissue. While Anavar, like all methylated steroids, is prone to causing adverse alterations in one’s lipid profile,
it demonstrates a reduced level of toxicity in comparison to other methylated AAS and is considered one of the mildest steroids in terms of side effects.
Anavar’s total lack of estrogenic, androgenic, and progestagenic side effects makes it an ideal drug for those who desire a pure muscle-building effect,
without having to worry about things such as gynecomastia, hair loss, acne, water retention, etc.
For those of you looking to maximize your strength to bodyweight ratio, you can’t go wrong with Anavar.
When used at higher dosages, Anavar is one of the most effective pure strength drugs on the market.
This makes it useful for powerlifters and other athletes attempting to remain within a predetermined weight class.
Anavar possesses amazing collagen and elastin synthesis properties "fibrous glycoprotein" (which is found in connective tissue). If you're attempting achieve a HARDER,
LEANER and more VASCULAR look all while increasing strength and performance, then this is compound is for you.
Anabolic-Androgenic Ratio: 630:24
Aromatizable: No.
Progestagenic Activity: No.
Methylated: Yes. Methylation serves as a protective feature of most oral AAS, allowing the molecule the pass through the liver and enter the bloodstream intact,
after which it can travel to muscle tissue and exert its muscle-building effects.
Standard Dosing Range and Cycle Length: Oxandrolone is most commonly dosed at between 40-100 mg per day for a period of 4-12 weeks in length.
Frequency of Administration: Daily use; split into 2 equally divided doses.
((CLICK HERE TO PURCHASE))
Euro-Pharmacies.net
https://puritysourcelabs.ru/oral-steroids-usa/587-oxandrolone-anavar-10mgtab-50-tabsbag-ep-usa.html
Study #1
A little testosterone and a little oxandrolone as effective as a good dose of testosterone (JAMA. 1999 Apr 14; 281 (14): 1282-90.)
Let your men train for 20 weeks with weights and inject them with 600 mg of testosterone enantate, then, according to studies, it yields 8 kilos of extra lean body mass. It is also possible with less,
doctors of the University of California discovered. You can achieve almost the same result with a pronounced mild course of oxandrolone and testosterone enantate - which only lasts 8 weeks.
The researchers published a trial in chic JAMA in 1999 in response to the studies in which researchers gave men with HIV large doses for medical purposes, such as 600 mg of nandrolone decanoate per week.
The HIV men also trained with weights. The researchers do not think that high doses are necessary.
That is why they decided on a trial in which they gave 22 HIV patients 20 mg oxandrolone daily
and a 100 mg testosterone enantate injection every week. The course lasted 8 weeks.
The men trained 3 times a week with weights. Under the guidance of a trainer, they took care of the most important muscles of the upper body with 6 basic exercises,
and trained the lower body with 3 basic exercises. They trained with weights that were 80 percent of the weight with which they could just make 1 rep [1RM].
Eleven men only received a 100 mg testosterone enantate injection every week and took a placebo.
Eleven other men took 20 mg of oxandrolone every day.
The figure below shows that after 8 weeks the oxandrolone group had gained nearly 8 kilos of lean body mass.
A little "test" and a little oxandrolone as effective as a GOOD dose of "test"-STUDY
The men in the oxandrolone group also became stronger faster than the other men. For the bench press and leg press,
the maximum weight for the men in the placebo group increased by 10 and 20 pounds respectively. For the men in the oxandrolone group that was 20 and 30 kilos.
The men in the oxandrolone group also lost a few ounce more fat than the men in the placebo group
It is therefore not necessary at all to cure 20 weeks with 600 mg if you want to gain 8 kilos of lean body mass,
the researchers conclude. It is also possible with lower doses.
Moreover, the mild oxandrolone testosterone treatment was not entirely without side effects. In the oxandrolone group,
1 patient had to drop out because his liver started to act strange.
Blood tests also showed that the addition of oxandrolone to the modest testosterone course further reduced the body's own production of testosterone.
The production of the hormones LH and FSH decreased extra in the oxandrolone group, the researchers discovered. LH and FSH have the testes produce testosterone.
Some men used virus inhibitors. These drugs did not influence the effects of the steroids.
"The combination of resistance exercise with a moderately supraphysiologic androgen regimen that included oxandrolone increased significantly increased lean tissue and
muscle strength than resistance exercise with physiologic testosterone replacement alone in eugonadal HIV-infected men with prior weight loss,
" conclude the researchers. " The use of protease inhibitor therapy did not affect the lean tissue response".
(Bonus read)
Study #2
Did you know that a few hundred mils of caffeine boost the anabolic effect of oxandrolone?
Read this study below -Incorporate 10g of creatine 5g X 5 twice daily (intra-workout and post workout) along with and coffee/caffeine with the Anavar intake throughout the day..
Oxandrolone (Anavar) GREATLY increases creatine synthesis therefor you can peel down on adipose tissue yet keeping the muscle bellies full with that rounded pump appearance,
the combo with Anavar/creatine are VERY synergestic with great pumps!
Imagine: you're a careful user of anabolic steroids. You occasionally take a course of oxandrolone only, and that's all you want. If this is your way of doing things,
then Portuguese doping researchers may have discovered something that'll interest you.
They suspect that you can get more out of oxandrolone if you take extra caffeine.
Caffeine-oxandrolone
The Portuguese, who work for the doping lab Laboratorio de Analises de Dopagem, were tipped by the police that some Portuguese steroids users swear by a combination of caffeine and oxandrolone.
The researchers were curious to know more about the potential use of this combination,
so they consulted the literature.
They came across studies which show that caffeine can boost the uptake and effect of paracetamol. [J Clin Pharmacol. 2007 Jun;47(6):715-26.] So, they reasoned, might caffeine have the same effect when taken with oxandrolone?
Study
Imagine: you're a careful user of anabolic steroids. You occasionally take a course of oxandrolone only, and that's all you want. If this is your way of doing things,
then Portuguese doping researchers may have discovered something that'll interest you.
They suspect that you can get more out of oxandrolone if you take extra caffeine.
To answer this question the researchers performed an experiment in which they gave a subject, whose caffeine consumption was a normal three small espressos a day,
a miniscule quantity [0.4 mg] of oxandrolone.
Results
The researchers then monitored the amount of caffeine, oxandrolone and the inactive oxandrolone metabolite epioxandrolone [structural formula shown here] in the subject's urine for the next 40 hours.
The figure below shows the amounts found in the first 14 hours. Click on it for the full figure.
The researchers then repeated the experiment, but gave the subject 300 mg caffeine in pill form.
The figure above [click on it for a complete figure] shows that the amount of oxandrolone and epioxandrolone rose by a factor of 20 and 15 respectively.
Conclusion
The researchers think their experiment may show that caffeine causes a considerable improvement in the uptake of oxandrolone by the body.
"Practically this means that similar concentrations/effects may be achieved using lower dosages", they write. "Other anabolic steroids should also be investigated."
randomized, controlled trial of treatment of alcoholic hepatitis with parenteral nutrition and oxandrolone. I. Short-term effects on liver function.
Bonkovsky HL1, Fiellin DA, Smith GS, Slaker DP, Simon D, Galambos JT.
Author information
Abstract
The present studies were designed to provide careful measures of effects of oxandrolone, an anabolic steroid, intravenous nutritional supplementation,
and the combination of these two treatments on liver functions, metabolic balances, nitrogen metabolism, and nutritional status in patients with moderate to severe alcoholic hepatitis. Of 43 patients originally recruited, 39 (19 men, 20 women) with typical clinical and laboratory features of alcoholic hepatitis (11 Child's-Pugh class B; 28 class C) were admitted to a metabolic unit and
completed a 35-day three-phase protocol. Phase I was a 10-day baseline period of observation, during which routine and special quantitative tests of liver function
(galactose and antipyrine metabolism), a 7-day elemental balance study, and a 15N, 13C-leucine metabolism study were done.
Phase II was a 21-day treatment period during which patients were randomly assigned to receive one of four regimens: 1) standard therapy, consisting of abstinence, a balanced, nutritionally adequate diet,
and multivitamins; 2) oxandrolone (20 mg orally four times a day) plus standard therapy; 3) nutritional supplementation, consisting of 2 L daily of 3.5% crystalline amino acids (in 5% dextrose),
given by peripheral vein; or 4) a combination of oxandrolone and nutritional supplementation, along with standard therapy.
Metabolic balances were repeated during phase II. Phase III was 2 or 3 days posttreatment, during which special studies of liver functions and volumes and leucine metabolism were repeated. All patients who completed phase I of study and were randomly allocated to one of the four treatment groups completed the subsequent two phases.
Overall, with time, patients showed highly significant improvements in most clinical and laboratory features. For most standard laboratory tests (e.g.,
serum albumin, transferrin, prothrombin time) improvements were more marked in patients treated with nutritional supplementation and/or oxandrolone than in those given standard therapy alone. Liver volumes fell in all treatment groups, with greater improvement in those treated with nutritional supplementation. Improvements in galactose and antipyrine metabolism rates were significant only in those treated with nutritional supplementation or oxandrolone.
Effects of treatments on metabolic balances, nitrogen metabolism, and measures of nutrition are described in this issue in a companion paper.
We conclude that the addition of nutritional supplementation and oxandrolone to standard therapy of moderately severe or severe alcoholic hepatitis is well tolerated, and leads to more rapid improvement in the laboratory parameters measured.
___________
Study #3
High doses of Anavar is NOT liver toxic -
A randomized, controlled trial of treatment of alcoholic hepatitis with parenteral nutrition and oxandrolone. I. Short-term effects on liver function.
Bonkovsky HL1, Fiellin DA, Smith GS, Slaker DP, Simon D, Galambos JT.
Author information
Abstract
The present studies were designed to provide careful measures of effects of oxandrolone,
an anabolic steroid, intravenous nutritional supplementation,
and the combination of these two treatments on liver functions, metabolic balances, nitrogen metabolism, and nutritional status in patients with moderate to severe alcoholic hepatitis. Of 43 patients originally recruited, 39 (19 men, 20 women) with typical clinical and laboratory features of alcoholic hepatitis (11 Child's-Pugh class B; 28 class C) were admitted to a metabolic unit and completed a 35-day three-phase protocol.
Phase I was a 10-day baseline period of observation, during which routine and special quantitative tests of liver function (galactose and antipyrine metabolism),
a 7-day elemental balance study, and a 15N, 13C-leucine metabolism study were done. Phase II was a 21-day treatment period during which patients were randomly assigned to receive one of four regimens: 1) standard therapy, consisting of abstinence, a balanced, nutritionally adequate diet, and multivitamins; 2) oxandrolone (20 mg orally four times a day) plus standard therapy; 3) nutritional supplementation,
consisting of 2 L daily of 3.5% crystalline amino acids (in 5% dextrose), given by peripheral vein; or
4) a combination of oxandrolone and nutritional supplementation, along with standard therapy. Metabolic balances were repeated during phase II.
Phase III was 2 or 3 days post-treatment, during which special studies of liver functions and volumes and leucine metabolism were repeated. All patients who completed phase I of study and were randomly allocated to one of the four treatment groups completed the subsequent two phases. Overall, with time, patients showed highly significant improvements in most clinical and laboratory features. For most standard laboratory tests (e.g., serum albumin, transferrin, prothrombin time) improvements were more marked in patients treated with nutritional supplementation and/or oxandrolone than in those given standard therapy alone.
Liver volumes fell in all treatment groups, with greater improvement in those treated with nutritional supplementation. Improvements in galactose and antipyrine metabolism rates were significant only in those treated with nutritional supplementation or oxandrolone. Effects of treatments on metabolic balances,
nitrogen metabolism, and measures of nutrition are described in this issue in a companion paper. We conclude that the addition of nutritional supplementation and
oxandrolone to standard therapy of moderately severe or severe alcoholic hepatitis is well tolerated,
and leads to more rapid improvement in the laboratory parameters measured.
https://puritysourcelabs.ru/oral-steroids-usa/587-oxandrolone-anavar-10mgtab-50-tabsbag-ep-usa.html
