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Vision Problems as a Side Effect of Nolvadex and Clomid

Arnold

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Vision Problems as a Side Effect of Nolvadex and Clomid

Question: “What is the situation with Nolvadex or Clomid use and vision problems? Is it okay to continue their use when problems first start, if they do, or should I discontinue immediately?”

Answer: It probably is the case that not only Nolvadex and Clomid but all SERMs can cause vision problems on a dose-dependent basis. The problems can include changes in color vision and appearance of “floaters.” These problems appear to occur from estrogen-receptor related effects on retinal and lens cells.

At the most basic level, these cells experience protective effects from activation of estrogen receptor beta. Ordinarily speaking, even a male with relatively low estrogen still has significant activation of this receptor, and the protective benefits are enjoyed. Where a SERM is used at relatively high dose and on top of this estradiol levels are low, receptor activation may be essentially abolished or certainly becomes abnormally low.

Where SERM dosage is high, as is often the case with breast cancer patients, the rate of vision problems is much higher than it is in bodybuilding, where doses are generally lower. As an example of dose dependency, in Documenta Ophthalmologica, Volume 120 (2) – Apr 1, 2010 no vision problems were found in their particular group women taking tamoxifen at 20 mg/day, while many papers have found a high rate of problems at higher doses.

I absolutely recommend ceasing SERM use immediately upon detecting any change in vision, regardless that the PCT program has not been completed.

While the anti-aromatase approach to PCT is inferior to the SERM approach, it becomes the remaining option and it can work (I’m assuming here that testicular function remains good; if not then this must be addressed with HCG treatment.) Use blood values to determine dosage providing blood E2 levels from the mid teens to no more than the low 20s. (Ordinarily, estradiol levels are best kept in the 20s, but in this situation the duration of low values will be short, and will aid recovery.)

To have high likelihood of avoiding any problem, other than the first day of frontloading, don’t exceed 20 mg/day Nolvadex use, or 50 mg/day Clomid use.
 
This is a scary feeling ..as ive had it ...while back.... in my left eye all shades and colors were darker for example the Moon look yellow in my left eye in my right eye would be more white and when I would close my right eye in my left eye everything would look smaller for example people's heads look like grapefruits instead of the normal size.... what's particularly scary for me being that I have a pituitary adenoma... non-functioning... as I thought it was growing after more cats cans and doctor's visits with the eye doctor I took the images of behind my eyes and all that stuff dilated them so that it was due to too much hormone imbalance took about six months or so for it to come back to normal...

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