Pharmacom Store


Pharmacokinetics of Subcutaneous Injection of Testosterone Undecanoate

Results 1 to 11 of 11
  1. #1
    Community Veteran
    ADMINISTRATOR
    heavyiron's Avatar


    Join Date
    Jun 2012
    Posts
    8,535

    Thanks Thanks Given 
    384
    Thanks Thanks Received 
    985
    Thanked in
    556 Posts
    Rep Points
    2147483647

    Pharmacokinetics of Subcutaneous Injection of Testosterone Undecanoate

    Pharmacokinetics and Acceptability of Subcutaneous Injection of Testosterone Undecanoate

    Leo Turner,1 Lam P Ly,1,2 Reena Desai,1,2 Gurmeet K S Singh,2,3 Timothy D Handelsman,1,2 Sasha Savkovic,1,2Carolyn Fennell,1 Veena Jayadev,1 Ann Conway,1,2 and David J Handelsman1,2

    Abstract

    Context
    Can injectable testosterone undecanoate (TU) be administered effectively and acceptably by the subcutaneous (SC) route?

    Objective
    To investigate the acceptability and pharmacokinetics (PK) of SC injection of TU.

    Design
    Randomized sequence, crossover clinical study of SC vs IM TU injections.

    Setting
    Ambulatory clinic of an academic andrology center.

    Participants
    Twenty men (11 hypogonadal, 9 transgender men) who were long-term users of TU. injections.

    Intervention: Injection of 1000 mg TU (in 4 mL castor oil vehicle) by SC or IM route.

    Main Outcome Measures: Patient-reported pain, acceptability, and preference scales. PK by measurement of serum testosterone, dihydrotestosterone (DHT), and estradiol (E2) concentrations with application of population PK methods and dried blood spot (DBS) sampling.

    Results

    Pain was greater after SC compared with IM injection 24 hours (but not immediately) after injection but both routes were equally acceptable. Ultimately 11 preferred IM, 6 preferred SC, and 3 had no preference. The DBS-based PK analysis of serum testosterone revealed a later time of peak testosterone concentration after SC vs IM injection (8.0 vs 3.3 days) but no significant route differences in model-predicted peak testosterone concentration (8.4 vs 9.6 ng/mL) or mean resident time (183 vs 110 days). The PK of venous serum testosterone, DHT, and E2 did not differ according to route of injection.

    Conclusions

    We conclude that SC TU injection is acceptable but produces greater pain 24 hours after injection that may contribute to the overall majority preference for the IM injection. The PK of testosterone, DHT, or E2
    did not differ substantially between SC and IM routes. Hence whereas further studies are required, the SC route represents an alternative to IM injections without a need to change dose for men for whom IM injection is not desired or recommended.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676071/


  2. #2
    Monster Labs Lead Rep
    BOARD REP
    GGG's Avatar


    Join Date
    Sep 2013
    Posts
    8,502

    Thanks Thanks Given 
    1,017
    Thanks Thanks Received 
    993
    Thanked in
    708 Posts
    Rep Points
    2147483647

    Glad to see you back Boss

  3. #3
    NO LIMITS.
    SUPER MOD
    HFO3's Avatar


    Join Date
    Feb 2013
    Posts
    5,850

    Thanks Thanks Given 
    816
    Thanks Thanks Received 
    1,729
    Thanked in
    1,127 Posts
    Rep Points
    2147483647

    hell yeah, Glad you're back... 1000mg SC, I bet that left a knot

  4. #4
    Board Rep
    BOARD REP
    Mick's Avatar


    Join Date
    Mar 2014
    Posts
    4,136

    Thanks Thanks Given 
    803
    Thanks Thanks Received 
    494
    Thanked in
    315 Posts
    Rep Points
    2147483647

    Welcome back Heavy. Time to post some Jort pics brother!

  5. #5
    Senior Member


    Join Date
    Dec 2017
    Location
    Earth ��
    Posts
    3,684

    Thanks Thanks Given 
    641
    Thanks Thanks Received 
    1,617
    Thanked in
    1,142 Posts
    Rep Points
    2147483647

    So this question is a bit off but itís pertaining to TU. The oral version of test is test u suspended in castor oil. Not that I care to try this because I donít mind injecting I actually enjoy doing my injections but if one was to Make some TU raws in a suspension using castor oil would that work?

  6. #6
    EuroPharmacies Ambassador
    SUPER MOD
    Vision's Avatar


    Join Date
    Aug 2013
    Location
    Anabolic Erudite
    Posts
    14,525

    Thanks Thanks Given 
    2,032
    Thanks Thanks Received 
    3,233
    Thanked in
    2,120 Posts
    Rep Points
    2147483647

    I knew he'd be back!

  7. #7
    Senior Member
    zionoir626's Avatar


    Join Date
    Dec 2013
    Location
    Blue Ridge
    Posts
    1,682

    Thanks Thanks Given 
    0
    Thanks Thanks Received 
    73
    Thanked in
    56 Posts
    Rep Points
    2147483647

    Hey Brother ....Tell us you're back for good....Been side lined for a couple of years (medical crap)...I come back and so much has changed...Not feeling the new vibe!!!

  8. #8
    Lame 80s knowledge
    AMA rider's Avatar


    Join Date
    Sep 2012
    Location
    Motocross track
    Posts
    311

    Thanks Thanks Given 
    18
    Thanks Thanks Received 
    11
    Thanked in
    9 Posts
    Rep Points
    1474323385

    Hey Heavy.
    I've done Nebido for trt. It's like 4 CC s. It's a big pin for glutes, so I wouldn't go SQ. I stopped because you don't ' feel on '.

  9. #9
    Senior Member
    ArgonCoagulator's Avatar


    Join Date
    Jun 2018
    Posts
    657

    Thanks Thanks Given 
    228
    Thanks Thanks Received 
    230
    Thanked in
    174 Posts
    Rep Points
    443337935

    Quote Originally Posted by AMA rider View Post
    Hey Heavy.
    I've done Nebido for trt. It's like 4 CC s. It's a big pin for glutes, so I wouldn't go SQ. I stopped because you don't ' feel on '.
    I imagine there's alot of estrogen conversion or even just wasted testosterone since it's sitting in your body for so long with it's 33 day half life. If not then it would be great for long trips, truck drivers and oil rig workers who are out working for weeks or a month at a time. Or people who are terrified of pinning.

  10. #10
    Senior Member
    MindlessWork's Avatar


    Join Date
    Mar 2017
    Posts
    7,643

    Thanks Thanks Given 
    4,733
    Thanks Thanks Received 
    1,377
    Thanked in
    1,137 Posts
    Rep Points
    2147483647

    Good to see you posting up again Heavy, time to boot Arnold back into the shadows lmao.

    On topic this seems to be interesting to see how SC injections are...good or bad
    Last edited by MindlessWork; 08-25-2019 at 06:18 PM.

  11. #11
    Senior Member
    chocolatemalt's Avatar


    Join Date
    Aug 2012
    Location
    Purple Mountains
    Posts
    5,392

    Thanks Thanks Given 
    190
    Thanks Thanks Received 
    331
    Thanked in
    214 Posts
    Rep Points
    2147483647

    Glad to see some science back in the forum. Welcome back!

Similar Threads

  1. Replies: 17
    Last Post: 01-30-2017, 04:23 PM
  2. testosterone undecanoate
    By MrHowie in forum The Pit
    Replies: 28
    Last Post: 10-12-2016, 12:21 PM
  3. Testosterone Undecanoate
    By GSRacer in forum Testosterone Replacement Therapy
    Replies: 4
    Last Post: 05-14-2013, 08:58 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Copyright© 2012-2019 Anabolic Steroid Discussion Forums
Google Authenticator verification provided by Two-Factor Authentication v1.0.4 (Free) - vBulletin Mods & Addons Copyright © 2019 DragonByte Technologies Ltd.