malfeasance
Registered
- Joined
- Jun 21, 2012
- Messages
- 7,813
- Reaction score
- 2,029
- Points
- 113
This ternary complex prolongs the half life of IGF-I in serum from less than 5 min to 16 hrs.
. . .
Under normal circumstances IGFBP-3 and 5 are saturated. Therefore abrupt changes in IGFBP-1 and -2 which are not saturated and which occur as a result of changes in either nutrient intake or insulin secretion, can result in major changes in free IGF-I and thereby regulate tissue responsiveness (13). Other hormones that regulate IGF-I bioactivity include cortisol which antagonizes the actions of IGF-I and therefore can result in an increase in serum concentrations, and thyroxine which is necessary for normal IGF-I biosynthesis and which can stimulate an increase in IGF-I concentrations in hyperthyroidism. Estrogens function to antagonize the ability of growth hormone to stimulate IGF-I synthesis in the liver and testosterone alters IGF binding protein concentrations.
. . .
Under normal circumstances IGFBP-3 and 5 are saturated. Therefore abrupt changes in IGFBP-1 and -2 which are not saturated and which occur as a result of changes in either nutrient intake or insulin secretion, can result in major changes in free IGF-I and thereby regulate tissue responsiveness (13). Other hormones that regulate IGF-I bioactivity include cortisol which antagonizes the actions of IGF-I and therefore can result in an increase in serum concentrations, and thyroxine which is necessary for normal IGF-I biosynthesis and which can stimulate an increase in IGF-I concentrations in hyperthyroidism. Estrogens function to antagonize the ability of growth hormone to stimulate IGF-I synthesis in the liver and testosterone alters IGF binding protein concentrations.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374394/
Estrogen is necessary for growth. You have heard it said that "Tren" is given to cows for weight gain prior to slaughter. What most do not tell you is that finaplex also has estrogen. There is a reason.
The last sentence of the quote above tells you why estrogen level affects your muscle growth.
Note Mr. Olympia's recent guest appearance. All of that bloat and water weight is from letting his estrogen run higher. There is a reason off season photos of large bodybuilders look like that. They use what we call "wet" compounds to increase estrogen, beyond the reference range we normally use for males on blood tests.
They can drop off that water weight in a few weeks when the time comes. They take out the wet compounds, increase the dry ones, increase the AI (even with letro), stop the growth hormone, and use diuretics leading into the show. The only exception to "wet" compounds I can think of is the use of anadrol when very lean to bring water into the muscle.
- - - Updated - - -
There are a few other nuggets in that quote, too (like the statement about thyroxine).