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Can someone explain how exactly Arimidex works ?

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    Question Can someone explain how exactly Arimidex works ?

    Arimidex is not a suicidal AI. Meaning it deactivates the aromatase for certain amount of time and later on aromatase will be active again. Because of that it can deactivate only so much of aromatase and the newly produced aromatase will be active no matter what. Since the body is producing aromatase continuously, eventually it will produce more than arimidex can deactivate. My question how arimidex helps to control it ? or I don't understand the process correctly ?

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    Anastrozole is an aromatase inhibitor. This means it blocks the enzyme aromatase (found in the body's muscle, skin, breast and fat), which is used to convert androgens (hormones produced by the adrenal glands) into estrogens.

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    Quote Originally Posted by Phill View Post
    Anastrozole is an aromatase inhibitor. This means it blocks the enzyme aromatase (found in the body's muscle, skin, breast and fat), which is used to convert androgens (hormones produced by the adrenal glands) into estrogens.
    Thatís exactly what I know. I need more details

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    Non-suicidal aromatase inhibitors such as Arimidex and Letro, however, are only bound to the aromatase enzyme for limited time periods before the aromatase inhibitors unbind either due to natural metabolism, or through competition with other substrates. If a non-suicidal aromatase inhibitor is halted too abruptly, the circulating inhibited aromatase enzymes that have not been metabolized out of the body will then become free again, and begin aromatizing androgens into Estrogens at an often rapid rate. This is why it is advised to slowly halt administration of Arimidex, and/or slowly reduce the dose and/or frequency of the dose when stopping.

    so it deactivates, and while itís deactivated body will metabolize it. Interesting.

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    Thatís why I like aromisin. It kills E2. Donít have to worry about it coming back.

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    Aromatase belongs to the cytochrome P450 family, and forms an electron-transfer complex with its partner, NADPH-cytochrome P450 reductase. Because of the membrane-bound character and heme-binding instability, no crystal structure of aromatase has been reported so far. Much remains to be investigated, including the 3-dimensional structure of aromatase, interaction between aromatase and reductase, catalytic mechanism of estrogen synthesis by aromatase, and the binding mechanism of aromatase inhibitors. This review will present current knowledge about structural and functional characteristics of aromatase to address unsolved mysteries about this enzyme.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253311/

    Probably more detail than you want, but, click on the link and read to your heart's content.

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    Here is a pretty good read if interested.
    http://theoncologist.alphamedpress.o.../13/8/829.full
    http://puritysourcelabs.ru
    MileHighKratom/StraightUpKratom - mace15 for 15% off!


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    Quote Originally Posted by malfeasance View Post
    Aromatase belongs to the cytochrome P450 family, and forms an electron-transfer complex with its partner, NADPH-cytochrome P450 reductase. Because of the membrane-bound character and heme-binding instability, no crystal structure of aromatase has been reported so far. Much remains to be investigated, including the 3-dimensional structure of aromatase, interaction between aromatase and reductase, catalytic mechanism of estrogen synthesis by aromatase, and the binding mechanism of aromatase inhibitors. This review will present current knowledge about structural and functional characteristics of aromatase to address unsolved mysteries about this enzyme.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253311/

    Probably more detail than you want, but, click on the link and read to your heart's content.
    So everyone can go to the link
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253311
    http://puritysourcelabs.ru
    MileHighKratom/StraightUpKratom - mace15 for 15% off!


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    Good read! So why would you want to lower estrogen knowing that it will eventually comeback rather than just eliminating it completely to the point where you have a good estrogen to test ratio?

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    Quote Originally Posted by M760 View Post
    Good read! So why would you want to lower estrogen knowing that it will eventually comeback rather than just eliminating it completely to the point where you have a good estrogen to test ratio?
    Not sure if I understood. Btw, I started aromasin today. Ran out of arimidex

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