Your assumption of my taking Omnadren 250mg a week split into Sun / Thr is spot on. I got the idea to split the dosage into two .5 in this very forum a while back! No more yo-yo effects with moods, sleeping patterns, etc etc. I have been on Methadone for around 4~ish years now and from the looks of it, I may never have an opportunity to get off this crap, unless a better method of pain control is achieved. Sometimes I wonder if it's the methadone and a few other medications, coupled with my testicular failure to blame for my high E2 levels. I wasn't even aware of my endocrinological issues, until one day I noticed a *bump* forming under my nipple, nipple tenderness and emotional instability, and coming from a weight lifting lifestyle, I picked up on it rather fast, what that deal was. I had it surgically removed, it wasn't anything big, 1 8mm and one 5mm if I recall correctly ? I had my complete blood work done and I had the free test and total test levels that of a postmenopausal woman in her 70s. Imagine my surprise!