🏋🏻*♀️NEW DRUG enhancing performance x 10🏋🏻*♀️

*NEW DRUG enhancing performance x 10*

How is this good for endurance athletes if it causes your body to consume more carbs for fuel than fat ?

i must be under the wrong impression when it comes to the amount of carbs the body is able to store to be used as fuel.

ROID said:

How is this good for endurance athletes if it causes your body to consume more carbs for fuel than fat ?

i must be under the wrong impression when it comes to the amount of carbs the body is able to store to be used as fuel.

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read this article

[h=1]Fats vs Carbs: What’s the Best Fuel for Athletes?[/h]


Pity the carbohydrate. For decades, serious athletes couldn't get enough of them, loading up on pancakes, bagels, and pasta before big races. But in recent years, a sexy new nutrient took center stage: fat. Athletes like LeBron James, Ironman triathlete Ben Greenfield, and the entire roster of the Los Angeles Lakers traded pasta and bread for steaks, eggs, and avocados. At the extreme end, some jocks were putting butter in their coffee and adding bacon to everything, while avoiding anything resembling a carb, including whole grains and even fruits.
But amid the frenzy, there was no actual science to support the idea that a high-fat diet was the best way to fuel performance. New research provides a clear verdict: Put some oats, quinoa, and berries back on your plate. And don't fear the occasional sandwich.
RELATED: The Case for Carb Loading

"For performance, low-carb diets do not work," says Iñigo San Millán, director of the exercise physiology lab at the University of Colorado Sports Medicine and Performance Center in Boulder. "We have more and more people coming in eating low-carb, and their performance is horrible. Restore their diets to normal and things improve."In a recent review of 61 studies, the vast majority showed that diets relying on more calories from carbs than from fats were optimal for performance. None found that carb-rich diets hurt performance.
You can't blame athletes. Pros will try anything to get an edge. And there is a compelling rationale to try a low-carb diet (typically drawing 10 to 30 percent of calories from carbs and 50 to 70 percent from fat; that's versus the 55 percent carb, 30 percent fat diets that most of us eat). Starve the body of carbs, and it turns to fat for fuel. This gives you a bigger reserve of energy to push through long slogs. Dip into the ketogenic diet, consuming less than 10 percent of calories from carbs and 80 percent from fat (whatever is left comes from protein), and the liver cranks out ketones, compounds proved to help fight inflammation and cellular damage. "Because of this, recovery after exercise is dramatically enhanced," says Dr. Stephen Phinney, co-author of The Art and Science of Low Carbohydrate Performance.
At the same time, Phinney concedes that no study has ever shown that these benefits translate to better finish times. And an Australian paper published last November cast doubt on the very idea. Trained runners were given a compound that prevented their bodies from burning fat and were then asked to hop on a treadmill and run a half-marathon. They ran just as fast as they did when their bodies could access fat freely for fuel. The takeaway: "It doesn't matter how good you are at using fat as a fuel source," says study co-author Jill Leckey. "If you are exercising at high intensity, your body is heavily reliant on carbs."
San Millán notes that a low-carb diet may indeed be a good, temporary choice for obese, diabetic, or sedentary individuals who need to shed pounds. And if you're exercising at low to medium intensities, it might not drain your performance. But if you need to push all-out — as almost all athletes do at some point — then fat can't provide enough fuel fast enough. Unlike carbs, fat requires more oxygen and multiple steps to be converted to energy. "At the very point when the competition could be decided, people run out of steam," San Millán says.
RELATED: Why Experts Now Think Most People Should Eat More Fat Cyclist Mitch Docker knows the feeling. He started experimenting with a low-carb diet in 2010, making his way from Atkins to Paleo to something akin to ketogenic. The upside: He got the junk off his plate. But he also hit a plateau. "I thought I'd reached my intensity limits," the 29-year-old WorldTour pro says. "Since the re-addition of carbohydrates, I have found I was still a long way away from them."
The fact is, says Boulder-based elite-cycling coach Ben Day, "people become lean, they recover well, and they can get to the end of a long ride and feel good — but they lose top-end power, and without that, you're nothing in this sport."
What's more, low-carb diets can take weeks for the body to adapt to, and in the meantime, people experience fatigue, brain fog, constipation, and mood swings. When an athlete trains, his carb-starved body may "eat itself to feed itself," says San Millán, tapping protein from muscles and leaving tissue vulnerable to injury. Low-carb plans can also lower testosterone and boost the stress-hormone cortisol. Steer clear of carbs too long and, Leckey says, the body "down-regulates" the enzymes associated with carb metabolism, so it can make less use of the carbs that you do give it.
Look back on the performance of James and the Lakers post-diet, and it appears things did not go according to plan. As James struggled through a bleak early 2014 season, fans tweeted at him to "start eating carbs again." Meanwhile the Lakers — held up as poster children of Paleo and ketogenic diets — set a franchise record in 2015 for the most losses in a single season.
The team's strength and conditioning coach, Tim DiFrancesco, says he tells athletes to be "carb-aware," steering them toward clean, unprocessed carbs (fruits and vegetables, yogurt, sprouted grains), healthy fats (avocado, nuts, and olive oil), and pasture-raised meats. When athletes tilt more drastically toward high-fat diets, he urges them to load up on carbs after a tough workout. And if they want to go Paleo to lose weight, he recommends they wait until off-season.
And that's what exercise physiologists say should be the goal — to be strategic, not restrictive, when it comes to carbs.
"We have gone from thinking we all need to load up on carbohydrates, like Kenyan marathon runners, to thinking we have to almost eliminate them," says San Millán. "We don't need to go to either extreme."

Meldonium is new to me. I’ve never personally used it, but my friend has. She reported an increase in endurance, decrease in recovery time, felt her heart didn’t pump as hard during her runs and wasn’t short of breath while running. Caught my attention for sure.


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possible counter to tren breathing sides? also, if it focuses the use of carbs more for energy, maybe a possible negative reaction to use in combination with slin? or possibly having to increase the carbs you're using with slin?

i understand about the tren breathing issues, i keep an advair script year round and it works flawlessly, I was just curious if this could be an alternative "treatment" for it. it doesn't really sound like it.

with the short half life of this particular drug and the cost, it definitely seems more short term prep (race, event, etc) for a few weeks prior to whatever you're competing in than something you would use every day for months on end based on the amounts tested in the studies it would be ~$25/day at .5g/day.

We also have oral forum!

[h=1]Meldonium (Mildronate)- 500mg/cap 60 caps[/h][FONT=&quot]$45.00[/FONT]
Condition: New product
Supplier:Grindex
Chemical Name:Mildronate
Comes In: 500mg cap
Dosage: 500- 1500 mg/day
Active time: 6-8 hours
[FONT=&quot]
Shipping from Europe

[/FONT]

Vision said:

We also have oral forum!

Meldonium (Mildronate)- 500mg/cap 60 caps

$45.00
Condition: New product
Supplier:Grindex
Chemical Name:Mildronate
Comes In: 500mg cap
Dosage: 500- 1500 mg/day
Active time: 6-8 hours

Shipping from Europe

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is there supposed to be a huge difference in injectable vs oral forms? any % of drug loss to account for due to digestive breakdown/ pass through?

friendofzeus said:

is there supposed to be a huge difference in injectable vs oral forms? any % of drug loss to account for due to digestive breakdown/ pass through?

Click to expand...

I think it will be fair to say, like most orals, there will be a % loss from liver pass.. how much? there is not many studies out there on this, so im sure its the same ratio like most orals

Meldonium (trade name of Mildronato) is a drug with a limited market, developed in the 70s by Ivars Kalviņš, and produced mainly by Grindeks in Latvia and by several manufacturers of generic drugs. It is distributed in Eastern European countries as an anti-ischemic drug. From a "niche" drug the Meldonium has become since the first months of 2016 the protagonist of the usual sports "scandals" (scapegoats is a more suitable term), in fact from 1 January 2016 has been included in the WADA list (World Anti-Doping Agency) of substances prohibited for use by athletes. However, there are debates about its use as a substance for the improvement of athletic performance, to objectively evaluate this molecule we must first know it.


The drug was invented in the mid-70s of the last century at the Institute of Organic Synthesis of the Latvian SSR Academy of Sciences by Ivars Kalviņš.


The chemical name of Mildronate is 2- (2-Carboxyethyl) -1,1,1-trimethylhydaziniopropionate, is a structural analog of γ-butyrobetaine, with an amino group replacing the C-4 methylene of γbutyrrobetaine, this is a precursor of biosynthesis of carnitine; in the medical field, Meldonium can be used for the treatment of coronary diseases.


It is thought that the action of Meldonium is expressed through its ability to increase the size of blood vessels and, therefore, to improve blood flow.


Although initial observations have suggested that Meldonium is a non-competitive and non-hydroxylated analogue of the γ-butyrobetaine, further studies have shown that Meldonium is a substrate for γbutirrobetaine dioxygenase.Crystallographic X-ray analysis and in vitro biochemical studies suggest that Meldonium binds to the substrate pocket of γ-butyrobetaine hydroxylase and acts as an alternative substrate and, therefore, behaves like a competitive inhibitor.


Normally, the action of this enzyme on its γ-butyrobetaine and 2-ketoglutarate substrates gives, in the presence of a further oxygen substrate, products such as L-carnitine, succinate, and carbon dioxide; in the presence of this alternative substrate, the reaction produces semialdehyde malonic acid, formaldehyde (similar to the action of histone dimethylase), dimethylamine, and (1-methylimidazolidin-4-yl) acetic acid, «an unexpected product with an additional carbon in the bond of carbon deriving from N-demethylation coupled with the oxidative rearrangement, probably through an unusual radical mechanism."


This unusual mechanism suggests that the molecule may involve a Stevens rearrangement reaction, the inhibition of meldonium on γ-hydroxylase butyrobetaine gives a mean value of the maximum inhibitory concentration (IC50) of 62 micromolar, which other study authors described as " powerful. "Meldonium is an example of an inhibitor acting as a non-peptide mimic substrate.


In further primary research reports, it has been demonstrated through nuclear magnetic resonance such as Meldonium has the ability to also bind to carnitine-acetyltransferase, a ubiquitous enzyme that plays a role in cellular energy metabolism; also inhibits this enzyme, even if still weaker (constant inhibition, KI, of 1.6 millimolar).



In December 2015, in a study published in the journal Drug Testing and Analysis, it was claimed that Meldonium "demonstrates an increase in athletes' endurance performance, better recovery after exercise, protection against stress, and improved activity. and functions of the central nervous system (CNS) ".


The producer, Grindeks, said in a statement that he did not believe the use of Meldonium should be banned for athletes, and that the drug mainly acts to reduce damage to cells that can be caused by certain carnitine by-products. Meldonium "is used to prevent cell death in ischemia and not to increase the performance of normal cells," says the note. "Meldonium can not improve athletic performance, but it can stop tissue damage in the case of ischemia," which is the lack of blood flow to an area of the body.



As previously mentioned, the drug in question was invented in the mid-1970s at the Institute of Organic Synthesis of the Latvian SSR Academy of Sciences by Ivars Kalviņš. Kalviņš criticized the petitions, saying that no scientific evidence had been presented to show that the drug could be used as a doping substance; according to the "father" of Meldonium, this molecule does not improve athletic performance in any way, and was used by athletes to avoid damage to the heart and muscles caused by lack of oxygen during high-intensity exercise. In his view, not allowing athletes to take care of their health is a violation of their human rights, and that the decision aims to remove athletes from Eastern Europe from competitions and its drug from the pharmaceutical market.


Liene Kozlovska, head of the anti-doping department of the Latvian sports medicine center, has rejected claims that the ban is in violation of the rights of athletes, saying that Meldonium is dangerous in high doses, and should only be used under medical check for the treatment of health conditions that require its use. He also speculated that Russian athletes may not have received adequate warnings that the drug was banned - due to the suspension of the Russian Anti-Doping Agency - at the end of 2015.

Forbes reported that the anesthesiology professor Michael Joyner at the Mayo Clinic in Rochester, Minnesota, who studies how humans respond to physical and mental stress during exercise and other activities, told them that tests are lacking for many compounds believed to improve athletic performance. Its use has a sort of element of urban legend and there is not much outside of what clearly demonstrates its effectiveness. I would be shocked if this stuff [Meldonium] has a greater effect than Caffeine or Creatine (a natural substance that, when taken as a supplement, is designed to improve muscle mass). "



Ford Vox, a US physician specializing in rehabilitation medicine, told a journalist that "there is not much scientific support for its use as an enhancer of athletic performance".



Meldonium, which is not approved by the FDA in the United States, has been registered and prescribed in Latvia, Russia, Ukraine, Georgia, Kazakhstan, Azerbaijan, Belarus, Uzbekistan, Moldova and Kyrgyzstan.
Il Meldonium è prodotto da Grindex, una società farmaceutica lettone, con sede in tredici paesi dell’Europa orientale come trattamento per disturbi cardiaci[30,31]; la società identifica il Meldonium come uno dei loro prodotti principali.

However, leaving aside the debates between supporters of the "innocence" or "guilt" of Meldonium as a doping substance, and the sterile speeches of those who accuse of treacherousness athletes positive results to the drug (among which stand out Maria Sharapova and Alexander Povetkin), this molecule shows, according to my personal opinion gained after reading the available data, a great protective potential rather than a performance, applicable to different sports disciplines including BodyBuilding, PowerLifting and Crossfit.

I can tell you from first hand experience that this stuff works!! Imagine your lung capacity increasing making it easier to breath when you typically would be breathing heavy trying to get oxygen during cardio. Or imagine your heart not feeling like it’s going to pound through your chest. Then imagine your stamina increasing by double. That is the effects this stuff gives you. It’s a phenomenal drug for endurance athletes or people wanting that extra edge to perform longer and more efficient with endurance period. This drug gets an A+ from me

how does it compare to EPO?

mackpatti said:

how does it compare to EPO?

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EPO? I don’t think I know what that is. So I couldn’t tell you

Sherk said:

EPO? I don’t think I know what that is. So I couldn’t tell you

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Erythropoietin or EPO is a glycoprotein hormone weighing about 34000 Dalton, produced in humans by the kidneys and to a lesser extent by the liver and brain, whose main function is the regulation of erythropoiesis (production of red blood cells by the bone marrow).