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    basskiller's collection of Bodybuilding Peptide Articles



    I will be posting my collection of different peptide articles that I have come across in the time that I have been researching them. This will be done over time.. so keep checking back.
    If you like it, rate the thread!

    I thought that maybe some of you could benefit from my finds. That doesn't mean that I agree 100% with all of them. In some, I found parts useful..

    I will try my best as always to give credit where credit is due. If you see an article and know the author, Please let me know so I can attach their name.

    I lay no claim to any article that isn't mine. I have written a few under different pseudonyms for various reasons. Don't ask, don't tell.

    This first post will be reserved for the list linked to each post in the thread . I'm doing it this way so you can see the titles and read what you want. It should make it easier

    Peptide Calculator for ease of calculating bodybuilding peptide doses


    Bremelanotide (PT-141)
    Bremelanotide PT-141 Instruction
    Bremelanotide PT-141 Instruction
    Melanotan II – PT141

    CJC-1295
    CJC 1295 with Drug Affinity Complex
    CJC -1295 Peptide Profile
    CJC-1295 + GHRP-2 reconstitution + dosing schedule
    CJC-1295 Peptide Dosage
    MEDLINE - CJC-1295 Peptide Studies
    Growth Hormone Administration vs. CJC-1295/GHRP-6
    CJC-1295 unleashing The Beast by increasing GH 10 times
    Growth Hormone Secretagogues (Why cjc+ghrp is effective)
    Activation of the GH/IGF-1 axis by CJC-1295
    About CJC-1295
    Effectiveness of CJC-1295 Peptides

    Fragment 176-191
    HGH fragment 176-191
    Hgh fragment 177-191, Clenbuterol & T3 fat burning synergy
    HGH Fragment it’s fat burning properties
    bodybuilding fat burning Frag 176-191 peptide

    GHRP/GHRH
    Ghrp-2
    GH-releasing hexapeptide GHRP-6
    Growth Hormone Secretagogues (Why cjc+ghrp is effective)
    CJC-1295 + GHRP-2 reconstitution + dosing schedule
    Growth Hormone Administration vs. CJC-1295/GHRP-6
    Basic guide to GHRP/GHRH Peptides
    GHRP-2 vs GHRP-6 vs Ipamorelin
    GHRH – GHRP – GH a comprehensive dosing protocol
    Synergy of GHRH + GHRP

    Healing Peptides
    Healing Peptides
    BPC 157 the healing peptide
    TB-500 Healing Peptide
    Impact of pentadecapeptide BPC 157 on muscle healing

    Hexarelin
    Hexarelin profile

    HGH
    HGH + IGF-1 + Insulin - A basic guide

    IGF-1
    Reconstituting IGF-1 with 1 or 2mls with acetic acid
    Insulin like growth factor-1 (IGF-1)
    Bodybuilding IGF-1
    HGH + IGF-1 + Insulin - A basic guide
    Bodybuilding Peptides Guide
    IGF-1 The Bodybuilder’s Dream

    Insulin
    HGH + IGF-1 + Insulin - A basic guide

    Ipamorelin
    Ipamorelin Basics
    GHRP-2 vs GHRP-6 vs Ipamorelin
    Bodybuilders use Ipamorelin Peptide For Building solid Muscle
    Ipamorelin

    Melanotan)
    Melanotan II
    Melanotan 2 – An in depth study
    Melanotan 2 information
    Melanotan II – PT141
    Melanotan II and Libido

    MK-677
    MK-677 Increases Lean Muscle Mass in Elderly

    Myostatin Inhibitors
    enhancement of muscle mass/strength by myostatin inhibitors


    PEG-MGF
    PEGylated Mechano Growth Factor (MGF)
    PEG-MGF + IGF-I

    Peptide Guides
    Complete step-by-step guide for peptide beginners
    Reconstituting IGF-1 with 1 or 2mls with acetic acid
    A Simple Guide to understanding peptide reconstitution
    Peptides Explained
    The Truth about Bodybuilding Peptides
    What are peptides
    Peptide Guide Information
    What types of Growth Hormone Releasing Hormones are there


    SARMs
    MK-677 for Dieting
    MK-677 Restores Muscles, Fountain of Youth
    YK11 – Highly Powerful SARM that changes your Genetic Muscle-Building Potential




    Others
    Estrogen on Cycle: The Good, The Bad, and The Proper Management of Both
    Bodybuilding Peptides: How they work and why would an athlete use them
    Clenbuterol increases lean muscle mass but not endurance
    Anti-aging Growth Hormone Peptide



    more to come






    .
    Last edited by basskiller; 03-23-2016 at 08:20 PM.

  2. #2
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    Complete step-by-step guide for peptide beginners

    Complete step-by-step guide for peptide beginners

    You are on this site because you have heard of and want to become more familiar with Growth Hormone Releasing Peptide (GHRP) and/or Growth Hormone Releasing Hormone (GHRH). These 2 materials administered can give you an increased quality of life in ways of anti-aging, muscular hypertrophy, fat loss, injury repair, higher bone density, and better sleep.

    GHRP can be used on its own to increase our natural Growth Hormone (GH) pulse release from the Pituitary Gland in the brain. GHRP dosed in conjunction with GHRH will amplify our growth hormone release significantly to gain maximal benefit.






    There are various types of GHRH‘s. The only GHRH to consider is tetra-substituted CJC-1295 / CJC-1295(without DAC) / mod-GRF(1-29). They are all the same thing but with a different name. They come in vials ranging in material weights measured in milligrams (mg) consisting of a solid freeze-dried (lyophilized) substance.

    There are various types of GHRP‘s. GHRP-6, GHRP-2, Hexarelin, and Ipamorelin. The differences between them are potency and side effects. GHRP-6 is very potent and makes you quite hungry. GHRP-2 is potent and can slightly affect your sleep somewhat. Hexarelin is very potent but you can desensitize from higher dosages. Ipamorelin is potent with the minimalist side effects of all 4 GHRP’s.

    Peptides are dosed via a regular 1mL needle syringe typical to what a diabetic would use. It is administered Subcutaneously (SubQ) (just under the skin into the fat tissue), most usually around the abdomen region.

    The required amount (saturation dose) is 1mcg (microgram) per Kg (Kilogram) of bodyweight. The typical usage and for ease of measuring is 100mcg of mod-GRF(1-29) and/or 100mcg of your choice of GHRP. Lower dosages will simply result in less GH release due to a slightly weaker GH pulse and reduce any side effects you may have. A higher dose will have minimal benefit and is more a waste of money than anything else. But, in saying that, the more frequently dosed in any given day would result in more frequent pulses.

    Mixing (reconstitution calculator found here) the lyophilized peptide product in their vials with Bacteriostatic Water (BW) can take some getting used to. The idea is not to add too much dilution. Typical rule of thumb is to add 0.5mL of Bacteriostatic Water to 1mg of Peptide. So a 2mg vial should reconstitute with 1mL Bacteriostatic Water. 5mg with 2.5mL, 10mg with 5mL, etc. Squirt the Bacteriostatic Water along the inside wall of the vial in a smooth controlled manner being cautious not to agitate the mixture too much. It will dissolve itself and become clear. You can roll the vial gently between your fingers or hands but don’t shake it to dissolve. The reconstitute is ok to be drawn once fully dissolved.

    On a 1mL needle, there are either 50 tick marks from 0-100, skipping every odd number OR 100 international units (IU). A 100mcg dose is half way between the 2nd and 3rd tick mark, OR 5 IU’s (if you followed the above reconstitution). There are no half tick marks. It is OK to draw mod-GRF and GHRP into the one needle for a single shot. It is NOT OK to mix peptides in the same vial or syringe for storage.

    Reconstituted peptides should be stored in the refrigerator to prevent degradation. Left at room temperature, peptide will degrade within days but kept in the fridge will last months. You can pre-load syringes and store in freezer if you want but it is more of a hassle than being worth the effort.

    Doses can be taken throughout the day but at no less than 3 hour intervals between doses. 1 dose a day is typical for light injury repair, anti-aging effects, deeper sleep, and better quality of life. The most beneficial would be to dose immediately prior to going to bed for your daily sleep period. Sleep is the time when our pituitary is most active. 2 or 3 doses per day will give the added benefit of lean tissue build, and fat loss, considering your diet consists of good quality foods.

    Doses should be taken on empty stomach to benefit the most. This is usually 3 hours or more.

    Do not consume food for between 15-30 minutes after your dosage. Best time is around 20-25 minute mark. GH pulses should peak within about 10 minutes after dosage. Fats and Carbohydrates affect the pulse dramatically. Protein has no effect on pulse and you can have a pure protein source in your stomach at anytime if you so choose to.

    Dosage timing can be beneficial to your goals. For muscle growth, the 2nd most beneficial time to dose is post workout (PWO). Best time is pre-bed because sleep is when we recover and our cells repair and grow. Within 30 minutes should be fine but sooner the better. Remember to have your meal 20-25 minutes after dose.

    For fat loss, your supplemental dose is 1 hour pre-cardio exercise after a long fasting without food. Best time is after waking up and before breakfast. During cardio exercise, maintain a moderate intensity for between 30-60 minutes. 45 minutes is a good session. You do not want to go too hard or too long. A moderate pace will utilize Free Fatty Acids (FFA) at the highest rate for energy. Refrain from eating for approximately 2 hours after your exercise because this is the time the body is still burning fat as fuel. You must eat throughout the day to reduce the chance of muscle catabolism (breakdown).

    These Bodybuilding Peptides can be used on a daily basis for the rest of your life without any harm. Enjoy!!!
    Last edited by basskiller; 05-15-2014 at 02:44 AM.

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    Reconstituting IGF-1 with 1 or 2mls with acetic acid

    1mg is equal to 1000mcgs
    1ml is 1 total syringe full of the U100 insulin syringe

    this is for 1 vial of 1mg Igf-1

    __________________________________________

    If you add 1ml of acetic acid to your 1mg vial of IGF-1r3. .

    Each hash mark is equal to 20mcgs

    so if your doing
    20mcgs ed it would be 2iu’s on the slin pin or the first hash mark (as shown on the picture)
    40mcgs ed it would be 4iu’s on the slin pin or 2nd hash mark
    60mcgs ed it would be 6iu’s on the slin pin 3rd hash mark
    80mcgs ed it would be 8iu’s on the slin pin 4th hash mark
    100mcgs ed it would be 10iu’s on the slin pin 5th and designated by the number 10 (first actual number that is printed on your insulin syringe)

    Reconstituting IGF-1 with 1 of acetic acid



    __________________________________________________

    If you add 2mls of acetic acid to your 1mg vial of IGF-1r3. .

    Each hash mark in this case is equal to 10mcgs

    so if your doing
    10mcgs ed it would be 2iu’s on the slin pin or the first hash mark (as shown on the picture)
    20mcgs ed it would be 4iu’s on the slin pin or 2nd hash mark
    30mcgs ed it would be 6iu’s on the slin pin 3rd hash mark
    40mcgs ed it would be 8iu’s on the slin pin 4th hash mark
    50mcgs ed it would be 10iu’s on the slin pin 5th and designated by the number 10 (first actual number that is printed on your insulin syringe)

    After you draw in your amount desired of reconstituted IGF-1, Take your bacteriostatic water and draw a bit of it into your syringe that contains the IGF.. It doesn’t take much and the amount is arbitrary as it will not change or effect the dose that is already in the syringe.
    shake the syringe slightly as to mix everything together and inject

    Note: using the 1ml AA method ………………………………………………………….. Note: using the 2ml AA method
    each hash mark is equal to 20mcgs…………………………………………………….. each hash mark is equal to 10mcgs


    Reconstituting IGF-1 with 2mls of acetic acid


    By basskiller

  4. #4
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    A Simple Guide to understanding peptide reconstitution

    It seems to be increasingly common that users are introducing themselves to the idea of pinning through the use of peptides (although, arguably, hcg usage is also increasing in usage for those running non-injectable cycles). While I personally find these to be a great way to get yourself comfortable with the idea of injecting, it seems many become confused nearly immediately with how to at the first step, reconstitution. So I decided to just create a quick reference for those of you out there, and show you how the simple math required is not intimidating in the least. This guide will be a bit long, as I am hoping to avoid the common questions, but I think it will be a very good guide for some, and maybe too “simple” for others.

    A short disclaimer:
    This guide is purely hypothetical, and I do not encourage the use of any PED without the close guidance of a physician. This guide takes no consideration to the laws of your country. I do not condone any illegal activity. It is merely designed to be an educational resource. This guide also does not condone the usage of Research Chemical company’s products. These products are strictly for research use only, and human usage is in violation of their terms of service.

    Alright, so this guide will follow under the assumption that you have aquired your peptide of choice (or hCG), and are ready to reconstitute it.

    You will need the following items:
    •Your Peptide Vial
    •Bacteriostatic Water
    •Alcohol Wipes (available at your local pharmacy, usually near diabetic supplies)
    •Insulin Syringe (more on this in a moment)

    A quick discussion on syringes:
    Syringe availability will vary largely depending on the laws of your state/country. In many states, such as mine, low quantity purchases of insulin syringes are available at the pharmacy without the need for a prescription. Laws such as these are in place as a counter measure to help avoid the increase of HIV transmission through unsafe needle usage, by allowing addicts to purchase clean syringes.

    Size will depend on your source. An insulin syringe will typically range from 29g to 31g. For those unaware, the smaller the gauge (the “g”), the larger the number. So a 31g will be smaller needle width than a 29g. Generally, smaller gauge needles can provide less soreness through injection, but they are also much more fragile. Having used a 31g, I do prefer them for the ease of injection (minimal “pinch” feel), but they do become increasingly fragile, so proper care is required.

    Now that you have your supplies gathered, it is time to reconstitute your peptides. Please make sure that you do this in a clean environment to reduce the risk of contamination.

    For this example, I will be using a typical 5mg product, as is typical of the GHRPs provided by many companies. Although your particular product may not contain 5mg, the same idea will hold through to other products, just with a different amount of actives. I will also be under the assumption that you will want 100mcg doses (although again, this will vary by product/your required dosing).

    Before you begin, you must do the math to understand how much bacteriostatic water you will need for your reconstitution.

    If you are looking for the said 100mcg doses, from a 5mg vial, then you will have 50 doses from this vial. 100mcg x 50 = 5,000mcg, or 5mg. You can apply this to any amount of product. For example, Ipamorelin is usually available in 2mg vials. In that case, you would have 2,000mcg of Ipamorelin, which divided by 100mcg would give you 20 doses. The amount of dosages is important here, as it will dictate how to utilize your reconstituted product.

    So back to the original 5mg product, we know we are going to have 50 doses. The idea here then, is to add enough bac water to the peptide in order to allow you to dose those individual dosage. Personally, I like to use as little Bac water as needed, but also attempt to keep it easy enough to dose. The key point here is to know that no matter how much bac water you add to your vial, 1/50 of that will always be 100mcg.

    With that said, if you add 1ml of bac water to the vial, your 100mcg dosage will be 2iu on the syringe.
    (1ml = 1cc on your syringe = 100iu, so 100iu/50 doses = 2iu).

    If you add 2ml of bac water to the vial, your 100mcg dosage will be 4iu (200iu/50 doses = 4iu).

    If you add 3ml of bac water to the vial, your 100mcg dosage will be 6iu (300iu/50 doses =6iu).

    It is up to you how much bac water you will like to use, and utilizing the option of keeping this guide non-opinionated, I won’t give a recommendation on this, however, it will be dictated by how large your vial is and how accurate your pins are (a 50iu *sold as 1/2 cc* syring will make it easier to measure smaller amounts, where a 1cc *100iu* syringe will make it more difficult to measure smaller amounts).

    Once you have an amount chosen, we can move on the the actual reconstitution. In this example, I will reconstitute with 2ml of bac water.

    1. Snap of off the plastic cover of your peptide vial and your bac water.

    2. Take an alcohol wipe, and wipe down the rubber top of both the peptide vial and your bac water, and then discard the wipe and allow vials to dry for a second or two.

    3. Take a syringe and remove the safety cap (most will have one cap over the needle, and one over the plunger). Set these caps aside, while taking precaution not to expose your needle to any other object (it is sterile!). Pull the plunger on your syringe to the maximum reading (will usually be either 1/2cc or 1cc) to allow the syringe to fill with air. (It is also common practice to draw this air from the peptide vial. You can do this by inserting the needle into the peptide vial, keeping it right side up, and drawing the air that way. Then pull the syringe from the bottle, and on to step 4).

    4. Insert the needle into the rubber portion of your bacteriostatic water. With the syringe inserted, turn the vial of bacteriostatic water upside down, and push the plunger into the syringe (this will cause the air to enter the vial). Then, slowly, draw back on the syringe back to that maximum reading, as it will allow the syringe to fill with bac water.

    Quick Note: The reason you fill your syringe with air, and then insert the air into the vial, is to keep the pressure within the vial, which will allow you to draw with much greater ease.

    5. You may now turn the vial of back water back to right side up, and remove your syringe, again taking caution to avoid the needle from coming into contact with anything else.

    6. We are now ready to insert the bac water into the peptide vial. I recommend reconstituting slowly, and avoiding adding the bac water directly onto the peptide, and rather down the sides of the vial. Take your peptide vial, and insert the syringe through the rubber stopper on an angle, enough so that once the needle penetrates the rubber, it is angled towards the side of the vial.

    7. Slowly push down on the plunger allowing the bac water to enter down the sides of the vial. Take your time doing this, as there is no rush.

    8. Once all of the bac water is into the vial, remove the syringe and gently (GENTLY!) swirl the vial allowing the peptide to dissolve into the bac water.

    9. Depending on the target amount of bac water to be added, and the size of your pin, you must now repeat steps 3-8 until you have added the correct amount of bacteriostatic water. If you are aiming for 2ml of bacteriostatic water, and are using a 1/2cc syringe, this process must be done a total of 4 times, and if using a 1cc syringe, this process must be done a total of twice.

    10. Once the proper amount is added, place the caps back on both ends of your syringe and properly discard of it. Do not reuse this syringe for injection.

    Depending on your product, refridgeration might be necessary. If so, store reconstituted product in fridge.

    That should be it. Happy research. If you have any questions, feel free to ask, but only do so after having completely read through this guide.

    If you guys like this guide, I might do some later on some common peptides, when I can get to it.

    written by h2s (Super Moderator at Swolesource)

  5. #5
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    Ipamorelin Basics

    Ipamorelin or NNC 26-0161, a polypeptide hormone, is a growth hormone secretagogue and ghrelin mimetic and analog developed by Novo Nordisk[3]. Ipamorelin belongs to the most recent generation of GHRPs from the mid 1990s and causes significant release of growth hormone by itself, due both to its suppression of somatostatin (an antagonist to GHRH) and stimulation of release of GH from the anterior pituitary, similar to GHRP-2 and GHRP-6 which are compounds from the same class (growth hormone releasing peptides).[1]
    The cells that produce and release GH are known as somatotropes.[2] Like GHRP-2, ipamorelin does not have ghrelin’s lipogenic properties. Like GHRP-2 and unlike GHRP-6 ipamorelin never induces hunger in mammals. Ipamorelin acts synergistically when applied during a native GHRH (growth-hormone releasing hormone) pulse or when coadministered with GHRH or a GHRH analog such as Sermorelin or GRF 1-29 (growth releasing factor, aminos 1-29).[1]
    The synergy comes both due to the suppression of somatostatin and the fact that ipamorelin increases GH release per-somatotrope, while GHRH increases the number of somatotropes releasing GH.[1,2] There is also a secondary effect of neuronal excitation in the hypothalamus caused by ipamorelin, which lasts for approximately 3 hours after application, similar to GHRP-2 and GHRP-6.



    Ipamorelin has a unique property among the GHRP class of peptides. That property is known as selectiveness. Raun et al demonstrated the selectiveness of ipamorelin for GH release only in a study: The development and pharmacology of a new potent growth hormone (GH) secretagogue, ipamorelin, is described.
    Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2), which displays high GH releasing potency and efficacy in vitro and in vivo. As an outcome of a major chemistry programme, ipamorelin was identified within a series of compounds lacking the central dipeptide Ala-Trp of growth hormone-releasing peptide (GHRP)-1. In vitro, ipamorelin released GH from primary rat pituitary cells with a potency and efficacy similar to GHRP-6 (ECs) = 1.3+/-0.4nmol/l and Emax = 85+/-5% vs 2.2+/-0.3nmol/l and 100%).

    A pharmacological profiling using GHRP and growth hormone-releasing hormone (GHRH) antagonists clearly demonstrated that ipamorelin, like GHRP-6, stimulates GH release via a GHRP-like receptor. In pentobarbital anaesthetised rats, ipamorelin released GH with a potency and efficacy comparable to GHRP-6 (ED50 = 80+/-42nmol/kg and Emax = 1545+/-250ng GH/ml vs 115+/-36nmol/kg and 1167+/-120ng GH/ml).
    In conscious swine, ipamorelin released GH with an ED50 = 2.3+/-0.03 nmol/kg and an Emax = 65+/-0.2 ng GH/ml plasma. Again, this was very similar to GHRP-6 (ED50 = 3.9+/-1.4 nmol/kg and Emax = 74+/-7ng GH/ml plasma). GHRP-2 displayed higher potency but lower efficacy (ED50 = 0.6 nmol/kg and Emax = 56+/-6 ng GH/ml plasma). The specificity for GH release was studied in swine.

    None of the GH secretagogues tested affected FSH, LH, PRL or TSH plasma levels. Administration of both GHRP-6 and GHRP-2 resulted in increased plasma levels of ACTH and cortisol. Very surprisingly, ipamorelin did not release ACTH or cortisol in levels significantly different from those observed following GHRH stimulation. This lack of effect on ACTH and cortisol plasma levels was evident even at doses more than 200-fold higher than the ED50 for GH release. In conclusion, ipamorelin is the first GHRP-receptor agonist with a selectivity for GH release similar to that displayed by GHRH. The specificity of ipamorelin makes this compound a very interesting candidate for future clinical development.[3]

    Whereas GHRP-6 and GHRP-2 cause a release and increase in cortisol and prolactin levels, ipamorelin only selectively releases GH at any dose. Further, a mega-dose of ipamorelin results in a concomitant mega-release of GH (up to the entire amount present in the pituitary), whereas GHRP-2 and GHRP-6 have limits of approximately 1mcg/kg in humans for their maximal GH release.[4,5]

    Cititations:
    [1] Bowers CY, Momany F, Reynolds GA. In vitro and in vivo activity of a small synthetic peptide with potent GH releasing activity. 64th Annual Meeting of the Endocrine Society, San Francisco, 1982, p. 205.
    [2]Bowers CY, Momany F, Reynolds GA, Sartor O. Multiple receptors mediate GH release. 7th International Congress of Endocrinology, Quebec, Canada, 1984, p. 464.
    [3] Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998 Nov;139(5):552-61.
    [4] Brosnan-Cook, M. et al. (1998) Iontophoretic delivery of ipamorelin, a growth hormone secretagogue. Proceedings of 80th Annual Meeting Endocrine Society, New Orleans, USA. Abstract Pp1-186.
    [5] Jogarao V S Gobburu; Henrik Agerso; William J Jusko . Pharmacokinetic-Pharmacodynamic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide in Human Volunteers. Lars Ynddal Pharmaceutical Research: Sep 1999; 16, 9; ProQuest Nursing & Allied Health Source p. 1412.

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    Insulin like growth factor-1 (IGF-1)

    Insulin like growth factor-1 (IGF-1)

    Pharmaceutical Name: Insulin-Like Growth Factor 1
    Drug Classification: Polypeptide Hormone
    Active Life: huIGF-1: approximately 10 minutes, Long R3 IGF-1: 2-5 hours






    Insulin-Like Growth Factor-1 (IGF-1) is a polypeptide protein hormone that is one of the primary substances that is responsible for tissue growth in humans, including muscle growth (1). IGF-1 is primarily secreted by the liver, with a small minority of the circulating amount of the hormone being produced and delivered by other tissues. The basic function of the hormone is to induce cellular activities. For bodybuilders and strength athletes this compound could produce good results when used due to the ability of the compound to potentially enhance muscle hyperplasia, the actual increase in number of muscle cells in the body or particular muscle.

    This effect of muscle hyperplasia that IGF-1 can help promote is the primary reason why it has become so popular among bodybuilders. It is believed that IGF-1 may be able to produce localized growth in the muscles that the IGF1 is administered into post-workout. However this effect of the hormone remains more theoretical in nature because of the lack of research available on the subject using human subjects. Despite this many users still claim that they have seen results from IGF1 when using it for this explicit purpose and it remains within the realm of possibilities. However simply because science can not discount the result as implausible does not mean that it is a given either.




    Among the other anabolic effects that IGF-1 can produce in the body are things such as increasing protein synthesis, increasing nitrogen retention, as well as inducing the growth of more muscle fibers. When an appropriate amount of amino acids (protein) is available, all of these actions within the body are able to be completed. It has been demonstrated that IGF1 can help to improve collagen production as well as the reproduction of cartilage in joints (2). The hormone has also been shown to exhibit the ability to act as a neuro-protector and promoter (3) mainly because IGF1 receptors are located in the tissue of the brain (4). It has been demonstrated that there is a potential for when supplemented with IGF1 a decrease in the progress of some brain diseases can be brought about as well as slowing the deterioration of brain function in some elderly subjects. However similar findings or any evidence of improved brain function or capacity has not been demonstrated in young, healthy individuals.

    Obviously by helping to promote these anabolic mechanisms for growth IGF-1 also acts as an anti-catabolic. This would be beneficial to those users in a calorie deficit or in other circumstances that place them at risk of losing muscle mass. IGF1 also has the ability to positively affect lipolysis in users if other necessary conditions are met, namely proper diet and training protocols. When combined with the ability to preserve muscle mass, IGF1 appears to be an attractive choice for those that are attempting to decrease their body fat while maintaining as much of their muscle mass as possible.

    IGF1 is composed of seventy amino acids, the same number as insulin. As stated earlier, it is primarily secreted by the liver. The stimulus that is responsible for this secretion is the presence of growth hormone. In fact IGF1 is primarily the causal connection between growth hormone and its anabolic and anti-catabolic capabilities. This is not to say that effects caused by growth hormone could be produced with only IGF1, but rather that the two compounds are very much related to one another and both are needed for optimal tissue growth.

    In some animal studies there have been significant findings that support the idea that IGF1 administration can help to induce large increases in both strength and muscle size. While these results have not been reproduced in humans they do suggest that the gains experienced by users are connected to the administration of IGF1 and related to the anabolic mechanisms that are caused by the hormone. However to say that the findings of some of these studies could be replicated in humans would be incorrect. For example, a twenty-seven percent increase in muscle strength was produced in mice advanced in age when administered moderate dosages of IGF1 (5). Of course it would be dubious to claim that similar gains could be made by a trained athlete that chose to use IGF1 but it does suggest that the hormone will promote at least some of the mechanisms responsible for muscle growth.

    As stated, the IGF-1 produced by the human body is seventy amino acids in length. However a different IGF1 composition is available. Called Long R3 Insulin-Like Growth Factor-1 (LR3 IGF1), it has the original seventy amino acids of regular IGF1 with a substitution of Arginine in place of Glutamic Acid at position three in the sequence. Additionally thirteen more amino acids have been added to the sequence. This extension peptide is located at the N-terminus in the sequence. These alterations were made so that the hormone would be more likely to remain active and potent when it encounters Insulin-Like Growth Factor-1 binding proteins in the body (6). All of this adds up to LR3 IGF1 being potentially three times as potent as the regular version of IGF1, or human IGF1 (huIGF1). Obviously this makes LR3 IGF1 more attractive for strength athletes and bodybuilders. For this reason it is now the most widely available version for purchase due to the compound having all of the benefits of regular IGF1, and being potentially three times as potent, while having no additional risks or side effects to that of regular IGF1.

    Use/Dosing

    Depending upon which form of IGF1 which a person is administering, the dosing will differ slightly. For huIGF1 dosing users will want to inject the drug post-workout, most likely in the muscle(s) that was worked out to help produce any potential local site growth if any is indeed possible. Due to the extremely short active life of the drug users will likely want to inject the drug several times to help and prolong the effects of the drug. Splitting the dose into two to four injections should be sufficient. When administering the compound on days where the user does not work out a similar dosing protocol could be used in any of the muscles that the user desires.

    For LR3 IGF1, because of the longer active life of the drug in comparison to huIGF1, users will not have to administer the drug as frequently. Twice daily injections should be sufficient, although a single injection daily should also be able to produce significant results for the majority of users. Again, users will want to inject the drug post-workout in the muscle(s) that were worked. However, a second injection should be done elsewhere in the day. If not, a single injection time post-workout should be used. On off days from the gym, as with huIGF1, an injection can be made and may best be administered in the morning as to best fight off muscle catabolism. Barring this, any convenient time in the day can be used. However there are those users who simply opt not to administer any IGF1 on non-training days. It is at the discretion of the user.

    Due to the possible local site growth that IGF1 may induce in users, many will split their doses and inject bilaterally. That is to say inject half of the dose into the muscle on the left side of their body and the other half of the dose in the right side of their body. Alternatively the user can simply inject the entire dose of IGF1 in one muscle on one day while making sure to inject the other muscle with the entire dose the next time that that muscle group falls in the injection rotation of the user.

    The duration that a user will want to run IGF1 for is determined by the fact that IGF1 receptors in the body become saturated as large amounts of the hormone are introduced into the body. As the use of IGF1 continues, these receptors will begin to downgrade and the effects of the hormone will begin to lessen. For this reason consistent breaks from use of IGF1 need to be taken by users. Anecdotally the majority of users report seeing their gains from IGF1 begin to diminish after using the drug for about four to six weeks. This would seemingly indicate that receptor downgrade would be happening around this mark. However there is little to no information regarding IGF1 receptor downgrade and exactly how long it takes to occur and how long it takes for these receptors to recover. We are left to decipher these personal experiences with the drug and extrapolate the most efficient way to use it. As stated, it seems that cycles of about four to six weeks are ideal for many users although longer cycles are certainly possible. When coming off of the compound an equal amount of time spent off of it as was spent using it seems to allow for the IGF1 receptors to “upgrade” and once again be able to produce the results the user experienced initially. However despite these assumptions there are countless theories and protocols that users may administer IGF1 with and if they find it beneficial then there is no reason not to use these alternative protocols. There is simply not enough research to make definitive statements about how best or how long to run this drug.

    In terms of dosing for huIGF1, users have reported seen good results when administering dosing ranging from 100 to 160 mcg per day. This total dose would be split into several injections, most of which would likely be administered post-workout. For LR3 IGF1, the generally excepted or reported range for dosing is seemingly between 40 to 120 mcg per day. Again however due to the lack of research concerning IGF1 and its use in athletes these dosages are composed of through the collection of anecdotal evidence from users and not scientific research.

    Risks/Side Effects

    Beyond the natural downgrading of the IGF1 receptors when using exogenous IGF1, there are appears to be little in the way of significant risks to the health of the user associated with its use. Caution has to be used when saying this however again due to the lack of empirical research conducted using this drug on human subjects.

    One major risk that could potentially become problematic for some users is the ability of IGF1 to promote or enhance the growth of pre-existing tumors and cancers (1). Similarly to growth hormone, IGF1 can
    accelerate the growth of tumors which is not to be unexpected due to the very nature of IGF1 as a growth factor within the body and the effect it has on cells. For this reason it is advisable that prior to undertaking use of IGF1 a user gets medically cleared by a doctor and ensures that no tumors or other diseases that could be exasperated by use of the drug are present.

    A far less potentially severe side effect of IGF1 use is the suppression of the endogenous human growth hormone production in users. Endogenous IGF1 creates a negative feedback loop for growth hormone in humans. Exogenous IGF1 will have the same effect and therefore will likely cause growth hormone production to be temporarily suppressed in users. This is another reason why users will want to cycle their use of IGF1 and not attempt to stay on the drug for extended periods of time. By limiting the use of IGF1 to only a few weeks, this should ensure the general health of the user as well as the mechanism responsible for the production of both IGF1 as well as human growth hormone.

    While not being significant, IGF1 also has the ability to lower blood glucose levels. For the most part the compound will not lower the blood glucose in users to dangerous levels unless a pre-existing condition is evident. However this lowering of blood glucose will often cause the user to feel lethargic. This sometimes lasts the duration of use of the drug but should subside once the administration of the compound ceases.

    A trait that again is shared with human growth hormone is the fact that use of IGF1 sometimes results in users having aches and pains form most notably in their wrists, fingers and hands. This is a common side effect but if it becomes unbearable a lowering of the dosage should reduce the severity of the symptoms. They will cease once administration of the drug is discontinued.

    In addition, while it is possible that IGF1 could cause abnormal organ growth and/or acromegaly it would simply take overly large doses used for long durations of time for this to occur in users. With normal use of the drug these side effects should not be a concern for the vast majority of users however.

    References

    1. Smith GD, Gunnell D, Holly J. Cancer and insulin-like growth factor-I. A potential mechanism linking the environment with cancer risk. BMJ. 2000 Oct 7;321(7265):847-8.

    2. Sienkiewicz P, Palka M, Palka J. Oxidative stress induces IGF-I receptor signaling disturbances in cultured human dermal fibroblasts. A possible mechanism for collagen biosynthesis inhibition. Cell Mol Biol Lett. 2004;9(4A):643-50.

    3. Mendez P, Azcoitia I, Garcia-Segura LM. Interdependence of oestrogen and insulin-like growth factor-I in the brain: potential for analysing neuroprotective mechanisms. J Endocrinol. 2005 Apr;185(1):11-7.

    4. Creyghton WM, van Dam PS, Koppeschaar HP. The role of the somatotropic system in cognition and other cerebral functions. Semin Vasc Med. 2004 May;4(2):167-72.

    5. Barton-Davis ER, Shoturma DI, Musaro A, Rosenthal N, Sweeney HL. Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15603-7.

    6. Walton PE, Dunshea FR, Ballard FJ. In vivo actions of IGF analogues with poor affinities for IGFBPs: metabolic and growth effects in pigs of different ages and GH responsiveness. Prog Growth Factor Res. 1995;6(2-4):385-95.

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    Peptides Explained

    A peptide is an amino chain responsible for signalling different responses in the body. These amino chains already exist in the body and that is the good thing about peptides. There are different classes of peptides according to the number sequence that I will have explained in the below article. Certain sequences are considered a PROTEIN such as HGH (Human Growth Hormone) that is 191aa.
    Insulin is actually an amino sequence considered a PROTEIN as well. Below is a statement from Wikipedia for reference. Notice below mentions a “Peptide Fragment”. This can be exampled to the product “HGH frag” that is the isolated amino chain “176-191″ that is the chain responsible for the diuretic effects of Human Growth Hormone (HGH).

    Peptides (from the Greek πεπτός, “digested” from πέσσειν “to digest”) are short polymers of amino acids linked by peptide bonds. They have the same peptide bonds as those in proteins, but are commonly shorter in length. The shortest peptides are dipeptides, consisting of two amino acids joined by a single peptide bond. There can also be tripeptides, tetrapeptides, pentapeptides, etc. Peptides have an amino end and a carboxyl end, unless they are cyclic peptides.

    A polypeptide is a single linear chain of amino acids bonded together by peptide bonds. Protein molecules consist of one or more polypeptides put together typically in a biologically functional way and sometimes have non-peptide groups attached, which can be called prosthetic groups or cofactors.

    Peptide Definitions
    One definition is that those chains that are short enough to be made synthetically from the constituent amino acids are called peptides rather than proteins. However, with the advent of better synthetic techniques, peptides as long as hundreds of amino acids can be made, including full proteins like ubiquitin. Native chemical ligation has given access to even longer proteins, so this convention seems to be outdated.
    Another definition places an informal dividing line at approximately 50 amino acids in length (some people claim shorter lengths). This definition is somewhat arbitrary. Long peptides, such as the amyloid beta peptide linked to Alzheimer’s disease, can be considered proteins; and small proteins, such as insulin, can be considered peptides.

    Peptide classes
    Here are the major classes of peptides, according to how they are produced:

    Milk peptides
    Milk peptides are formed from milk proteins by enzymatic breakdown by digestive enzymes or by the proteinases formed by lactobacilli during the fermentation of milk. Several milk peptides have been shown to have antihypertensive effects in animal and in clinical studies (see also Lactotripeptides).

    Ribosomal peptides
    Ribosomal peptides are synthesized by translation of mRNA. They are often subjected to proteolysis to generate the mature form. These function, typically in higher organisms, as hormones and signaling molecules. Some organisms produce peptides as antibiotics, such as microcins. Since they are translated, the amino acid residues involved are restricted to those utilized by the ribosome. However, these peptides frequently have posttranslational modifications, such as phosphorylation, hydroxylation, sulfonation, palmitylation, glycosylation and disulfide formation. In general, they are linear, although lariat structures have been observed. More exotic manipulations do occur, such as racemization of L-amino acids to D-amino acids in platypus venom.

    Nonribosomal peptides
    These peptides are assembled by enzymes that are specific to each peptide, rather than by the ribosome. The most common non-ribosomal peptide is glutathione, which is a component of the antioxidant defenses of most aerobic organisms. Other nonribosomal peptides are most common in unicellular organisms, plants, and fungi and are synthesized by modular enzyme complexes called nonribosomal peptide synthetases.[5] These complexes are often laid out in a similar fashion, and they can contain many different modules to perform a diverse set of chemical manipulations on the developing product.[6] These peptides are often cyclic and can have highly-complex cyclic structures, although linear nonribosomal peptides are also common. Since the system is closely related to the machinery for building fatty acids and polyketides, hybrid compounds are often found. The presence of oxazoles or thiazoles often indicates that the compound was synthesized in this fashion.

    Peptones
    Peptones are derived from animal milk or meat digested by proteolytic digestion. In addition to containing small peptides, the resulting spray-dried material includes fats, metals, salts, vitamins and many other biological compounds. Peptone is used in nutrient media for growing bacteria and fungi.

    Peptide fragments
    Peptide fragments refer to fragments of proteins that are used to identify or quantify the source protein. Often these are the products of enzymatic degradation performed in the laboratory on a controlled sample, but can also be forensic or paleontological samples that have been degraded by natural effects

    author Unknown

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    CJC-1295 Peptide Dosage

    The information below relates to using GHRH Peptides (CJC-1295 DAC and Modified GRF 1-29) as standalone products.

    Growth Hormone Releasing Hormones (GHRH):
    include Modified GRF 1-29(Cjc1295) and CJC-1295 DAC, are peptides which stimulate the pituitary gland
    to release stores of the body’s natural Growth Hormone (GH).

    Recommended Dosages
    The second most potent fat loss peptide is CJC-1295 DAC since it causes the overall GH level to rise in the body. The most potent being



    Modified GRF 1-29 Dose per injection: 100mcg Injections per vial: 20 x 100mcg dosages Amount to Inject: If you have used 1ml of water for mixing then a 100mcg dosage = 0.05ml (or 5 units on Insulin Syringe). If you have used 2ml of water for mixing then 100mcg = 0.10ml (or 10 units) and if you have used 3ml of water for mixing, then 100mcg = 0.15ml (or 15 units).

    CJC-1295 DAC Dose per injection: 2mg Injections per vial: 1 x 2mg dosages Amount to Inject: If you have used 0.5ml of water for mixing then a 2mg dosage = 0.50ml (or 50 units on Insulin Syringe). If you have used 1ml of water then a 2mg dosage = 1ml (or 100 units).

    Injection Frequency

    Modified GRF 1-29 100mcg injected 1-3 times per day, preferably together with a GHRP Peptide at 100-200mcg.

    CJC-1295 DAC 2mg injected once per week (due to its long half-life)

    Diet Restrictions

    Modified GRF 1-29 Pre-injection: The purpose of injection Modified GRF 1-29 is to have it trigger a release of GH in the body. Since fat and insulin (released after eating carbohydrates) both diminish the release of GH you should refrain from consuming any high fat or high carbohydrate meals or beverages for at least 2 hours before your injection (assuming you are injecting Modified GRF 1-29 on its own). An example of this would be eating dinner at 8pm then waiting until at least 10pm to do your injection. If you are however combining it with a GHRP peptide, studies in animals have indicated that when these peptides were taken together just 1 hour after eating their ability to release GH wasn’t diminished. Therefore if your schedule is not so flexible in regard to meal timings, you may wish to combine Modified GRF 1-29 with a GHRP peptide.

    Post-injection: 30 minutes post-injection is usually when GHRH stimulation of GH release is complete, meaning it’s safe to consume food/beverages after this time without worrying that they will cause your injection to be less effective. Consuming a high protein/carbohydrate meal at this time will create an insulin spike and therefore assist with the anabolic (muscle building) effects of GH. Those looking to burn fat should wait as long as possible before eating and when you do, only eat high protein, low fat and low carbohydrate meals to allow GH’s fat burning effects to last as long as possible.

    CJC-1295 DAC

    Due to its long half-life no dietary restrictions are required for CJC-1295 DAC to exhibit its long-term benefits on your body’s basal GH level, however, observing the same instructions as above for Modified GRF 1-29 will ensure you also take advantage of the short-term GH pulse created after a CJC-1295 DAC injection.

    Recommended Diet Cutting: High Protein with moderate fat and low carbohydrates since insulin (primarily realized in response to carbohydrates being consumed) will stop GH’s fat burning effects while it’s present.

    Bulking: High Protein, high carbohydrates, and low fat. While insulin stops GH’s fat loss properties, it is required for GH to be anabolic (muscle building), so you should always aim to spike your insulin 30 minutes post injection. (All info gathered via internet )

    Unknown

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    GH-releasing hexapeptide GHRP-6

    GH-releasing hexapeptide (GHRP-6) is a secratogue that stimulates the release of growth hormone (GH) by acting at both hypothalamic and pituitary sites which has been clinically documented in a wide variety of species in vivo and in vitro. GHRP-6 duplicates the way the growth hormone works in the body. In studies it not only has shown to enhance growth hormone levels, but also increased the pulsatile secretory bursts of GH. Another remarkable trait of GHRP-6 is its increase in normal pulsatile physiological secretion by its hypothalamic action. Initial studies with GHRP-6 suggested that this compound acted primarily on the pituitary gland and was absolutely specific for GH release. More recent studies have qualified both of these assumptions. This peptide has been clinically verified to increase GH levels, increase appetite, raise IGF-1 levels, help sleep cycles and more.

    The GHRP-6 is enclosed in an antivirus capsule, which essentially the outer capsule of a virus that contains no actual viral DNA or RNA so it is completely safe. The Antivirus used has been engineered to contain special peptides on it that actually act like an adhesive glue to certain cells in your mouth.
    These peptides are very important because by adhering to the mucosal cells in your mouth they ensure that the antivirus can inject the GHRP-6 into your cells. The antivirus signals the lipid membrane to open protein channels that actually take the peptide into the cell. Once in the cells the mucosal adhesion peptides are broken off from the peptide we added whether it be IGF, GHRP-6 or whatever. The peptide is now free to be release through the lymphatic system in its biological active form.
    This means it is carried throughout the blood stream directly from the cells in your mouth. So there is no sudden spike of GHRP-6 your own cells actually regulate its release. It never reaches any digestive enzymes or acids beyond that of the mucus in your moth which is actually at about the same pH used to store GHRP-6 in acetic acid, so claiming that it’s broken down here is ridiculous.
    The transport of the peptide to the lymphatic system is what results in a slower more controlled release of the peptide over time. A recent study has verified that a 24 hr constant iv infusion of GHRP-6 neurophysiologically (via the central nervous system) activated the GH-IGF-1 axis by activating GH secretory burst mass and amplitude by 7 -to 10-fold and increasing the basal (nonpulsitile) GH secretion by 4.5 fold.

    For example, significant increases in plasma IGF-1 concentrations were noted after 7 days of GHRP-6 infusion and have even been reported after 7 days of intranasal administration in children and in adults after 7 to 14 days of intranasal hexarelin administration. It is also of interest that long-term administration of hexarelin has been shown to significantly increase circulating GH concentrations as well. The potential clinical utility of these GH secratogues is due to the consistent clinical verification of these findings in individuals of many ages.

    Users often administer this product by placing it in a syring and squirting it into the cheeks on the side of the mouth. Users are urged not to do anything to induce excess saliva secretion because this will diminish the absorption rate of the drug by causing a larger portion of it to be flushed down the throat and dissolved by the stomach. Users are instructed not to take this product with food, because this will also greatly hinder the amount of the drug that is actually absorbed by the body. It is also important to note that users shouldn’t brush their teeth or do any kind of mouthwash 30 minutes before or after administration. The basic idea is to keep the mouth as undisturbed and as dry as possible while the hormone has time to seep into the pours on the inner lining of the mouth so that it can be properly absorbed.

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    This is awesome bass, thank you.


    Sent from my iPhone using Tapatalk
    Need Gearz? www.granabolic.me GrAnabolic@gmail.com Discount Code: h2o10%

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    The Truth about Bodybuilding Peptides

    The Truth about Bodybuilding Peptides and what you can expect

    For all the people out there that looking for instant gratification, these may not be your supplement of choice. But for the guys that are willing to go and bust our butts in the gym day in and day out and we don’t need to see an inch added our arms this week to come back and do it again next week because we know that if you keep coming back that’s where the true rewards begin.

    Don’t be fooled by other companies advertising steroid like effects from peptides like MGF or IGF or any type of GH. It’s a false claim made to make sales. And its place/people like this that are ruining the peptide business. People don’t see anything close to the results they got from their last cycle of AAS and immediately think they got screwed or scammed or that peptides are junk and a waste of money. This is the fault of the seller for not informing the client.

    When you do a cycle of AAS, what’s next?? PCT of course. All AAS users have the same fears at the end of each cycle. They don’t want to lose their hard earned gains. The gains that came so fast and so easy, but can be lost in the blink of an eye without proper PCT. And even with good PCT it’s still hard to keep everything. Then there is the other evil. ESTROGEN!!! You are popping anti-e’s and AI’s and progestin blockers that cost you a ton extra because you don’t want those bitch tits or that bloat, or the sudden fat gain. AAS = great gains, followed by anxiety. Now I’m not going to knock AAS they are a cornerstone. They give undeniable results. But at the cost of side effects, and PCT anxiety and cost. So they aren’t perfect. You spend your off time trying to maintain, let alone trying to make gains….

    Now let’s look at what happens during a cycle of peptides. Taken right with good diet and exercise just like you would for an AAS, but maybe not quite as many calories as some do on heavy cycles, you will see some small gains, some leaning out, but no where near the 20lbs of beef you put on last test/tren cycle. You might be lucky with 5lbs over the course of 6-8 weeks. But here is where it gets good. All those gains, there yours, not going anywhere, not going to suddenly start to subside, they aren’t going to result in some post cycle bloat, bitch tit formation, or fat gain. In fact your metabolism will be slightly higher from the gains. Anxiety free… no wait!!! It’s better than anxiety free; you should be just as stoked now as when you started the cycle. Because after you do a cycle of peptides like IGF or MGF especially. The gains are going to come better after the cycle then they did before. Unlike AAS where you try to gain and then maintain.

    You see steroids make the adult muscle cells (myotubules) bigger, but the bigger these cells get as we all know the harder and harder it is to make them even bigger. These myotubules are limited in size by the amount of nuclei they contain. The closer they get to being maxed the harder for them to grow and when they are maxed well that’s about it…. gains will be few and far between. Myotubules don’t divide like other cells so you pretty much have as many as you’re going to have for the most part. Hyperplasia does occur but it is a very rare process. This is where some people refer to the genetics. Because your genetics determines largely your # of myotubules you have, and the hormones that regulate them.

    This is where peptides make their mark. Growth factors in short lead to an increase in the potential of the myotubules to grow because they can influence the stem cell pools of the muscle which are their for growth and repair, to fuse with the adult myotubules and increase the # of nuclei. This means they can grow more again, and grow easier. Individual mechanisms for each peptide may very, but this is the overall effect they are all going for. So after taking some peptides you will experience better gains than before, with relatively non existent side effects, no PTC, no anxiety. These are supplements with an investment in mind, a future goal beyond the current cycle, and realistic view that real gains don’t have to come in 6-12 week segments but can come all year round.

    When you add all that up, the cost of peptides is not as far overhead as you might think. Especially when great companies provide them affordably. And they do try, I have first hand experience with some of the technology they are using, and they aren’t getting gold teeth over at the warehouse off you guys. It cost a lot of money to bring this caliber of products to the market. Peptides are complicated structures, not simple molecules like AAS. But if you in this business for the long hall, peptides have extremely good benefits to offer
    Last edited by basskiller; 09-09-2014 at 11:50 PM.

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    Bodybuilding IGF-1

    Insulin like growth factor-1 (IGF-1) is a substance which in manufactured by recombinant DNA technology. IGF-1 is the primary mediator of the growth promoting effects of human growth hormone. As such, the substance also can stimulate the growth of bone, muscle, and internal organs. Its effects on skeletal muscle are also highly hyperplasic, meaning it causes an increase in cell number. Unlike human growth hormone, however, this substance has very strong insulin like effects. It can support growth by increasing the uptake of amino acids, glucose, and fatty acids, but lowers blood sugar levels so efficiently that it can induce severe hypoglycemia if to high of a dose is taken. The increased uptake of fatty acids may also mean that the drug can increase the amount of body fat that is stored by the users. The United States FDA approved the medical use of IGF-1 in 2005. It is sold under the brand name of Increlex manufactured by the pharmaceutical company Tercica Inc. Tercica licenses this technology from Genentech, which was the first company to sell synthetic human growth hormone in the United States.

    The effect of muscle hyperplasia that IGF1 can help promote is the primary reason why it has become so popular among bodybuilders. It is believed that IGF1 may be able to produce localized growth in the muscles that the IGF1 is administered into post-workout. However this effect of the hormone remains more theoretical in nature because of the lack of research available on the subject using human subjects. Despite this many users still claim that they have seen results from IGF1 when using it for this explicit purpose and it remains within the realm of possibilities. However simply because science can not discount the result as implausible does not mean that it is a given either. Among the other anabolic effects that IGF1 can produce in the body are things such as increasing protein synthesis, increasing nitrogen retention, as well as inducing the growth of more muscle fibers. When an appropriate amount of amino acids (protein) is available, all of these actions within the body are able to be completed. It has been demonstrated that IGF1 can help to improve collagen production as well as the reproduction of cartilage in joints.

    The hormone has also been shown to exhibit the ability to act as a neuro-protector and promoter mainly because IGF1 receptors are located in the tissue of the brain. It has been demonstrated that there is a potential for when supplemented with IGF1 a decrease in the progress of some brain diseases can be brought about as well as slowing the deterioration of brain function in some elderly subjects. However similar findings or any evidence of improved brain function or capacity has not been demonstrated in young, healthy individuals. Obviously by helping to promote these anabolic mechanisms for growth IGF1 also acts as an anti-catabolic. This would be beneficial to those users in a calorie deficit or in other circumstances that place them at risk of losing muscle mass. IGF1 also has the ability to positively affect lipolysis in users if other necessary conditions are met, namely proper diet and training protocols. When combined with the ability to preserve muscle mass, IGF1 appears to be an attractive choice for those that are attempting to decrease their body fat while maintaining as much of their muscle mass as possible.

    IGF1 is composed of seventy amino acids, the same number as insulin. As stated earlier, it is primarily secreted by the liver. The stimulus that is responsible for this secretion is the presence of growth hormone. In fact IGF1 is primarily the causal connection between growth hormone and its anabolic and anti-catabolic capabilities. This is not to say that effects caused by growth hormone could be produced with only IGF1, but rather that the two compounds are very much related to one another and both are needed for optimal tissue growth.

    In terms of dosing for IGF-1, users have reported seen good results when administering dosing ranging from 100 to 160 mcg per day. This total dose would be split into several injections, most of which would likely be administered post-workout.

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    CJC-1295 unleashing The Beast by increasing GH 10 times

    So you want to look like the Hulk or maybe you just want to be lean and muscular. So what’s actually stopping you? Genetics… but what exactly is limiting your muscle growth, while at the same time limiting the burning of fat. Quite simply the answer is Myostatin. Myostatin is a direct negative regulator of the amount of skeletal muscle you have and how lean you are. Studies have proven this using mice with the myostatin knock out gene in which they don’t have myostatin to limit muscle growth. These Mighty lean ripped mice are called double muscled and they look like mice on steroids, all without working out. The prized winning Belgian Blue and Piedmontese cattle have mutations of myostatin resulting in double muscling. Mutations in humans have been shown too have the same results.

    So what is CJC-1295 and what does it have to do with myostatin you ask… CJC-1295 is a long acting synthetic version of Growth Hormone Releasing Hormone (GHRH). 30mcg/kg to 60mcg/kg doses can increase gh levels up to 10X normal for 6 days or more with plasma IGF-1 concentrations by 3X for 9-11 days. The estimated 1/2 life is 5.8-8.1 days. After multiple doses the mean IGF-1 levels remain above base level for up to 28 days. Results show that 30mcg/kg CJC-1295 is equal to 5iu’s of gh without the normal negative side effects from taking gh. In essence its much better to use CJC-1295 to make your body produce its own gh instead of taking a synthetic gh that also shuts down your normal production. So how does CJC-1295 and Myostatin relate. Growth hormone directly regulates myostatin. As growth hormone rises, myostatin lowers, which unleashes your potential for muscle growth. As myostatin lowers glucocorticoids effect on fat storage and muscle breakdown lowers. CJC-1295 dramatically raises gh levels which will dramatically lower myostatin which in turn will lower the effects of glucocorticoids fat storage and muscle breakdown. Now you know what has changed that has turned the Pro’s into Freaks.

    Steroids GH Myostatin Link

    Read this study carefully, it will show that raising testosterone to supraphysiological levels increased pulsatile gh secretion. Supraphysiological is the key word here, cause anything less has no effect. Supraphysiological Test Levels increase GH

    This study shows that androgens directly increase gh output without estrogen. Androgens directly increase GH

    Raising Testosterone levels lowers Growth Hormone Binding Protein. This protein binds up excess gh. Testosterone lowering GHBP if you read the full text you will figure out that it’s the spike in Test levels above normal from the shots that lowers GHBP proving that supraphysiological test levels raise gh and lowers GHBP

    As you can see androgens can directly and indirectly raise growth hormone levels resulting in lowering Myostatin which you already learned increases muscle mass. On a side note leptin has a huge role in fat storage and as gh raises, leptin lowers. I won’t delve into discussing leptin cause it can be complicated so do a search to learn more…

    CJC-1295
    Anti-Aging
    Lets go beyond muscle building and fat loss and discuss the well documented anti-aging benefits of growth hormone. Since this info is so plenty full online I’ll only outline the known benefits and let you fulfill you quest for Anti-Aging by doing your own research. The rate of GH secretion from the pituitary gland is at its peak around puberty, declining progressively as we age beyond that point. Around the late 30s and throughout the 40s, GH levels continue to dip considerably, causing the telltale signs of aging to appear. Fat tissue begins to collect in areas where it may have not before, the skin begins to lose thickness, bone mass becomes depleted, energy levels drop, and mental clarity may become clouded.

    For the purposes of anti-aging therapy, GH treatment functions to re-stimulate cell production to youthful levels restoring form and function to the entire body, from the inside out. Those who have undergone successful anti-aging treatment with GH or a combination of GH and other diminishing hormones such as testosterone have been reported to experience improvement in the skin’s appearance, renewed energy, mental acuity, invigorated health, enhanced sexual function, an overall sense of well being and a more youthful lean muscled look. Hundreds of studies have been done on the controlled administration of true HGH in adults. It has been shown to raise energy levels, enhance lean muscle development, decrease body fat, strengthen the heart, improve cholesterol and triglyceride levels and HDL/LDL ratios, fortify bones, smooth out skin wrinkles, sharpen memory, improve sexual function, regenerate damaged tissue, strengthen the immune system as well as improve sleep.

    Somatotropin (HGH) from the pituitary gland works by stimulating protein production and synthesis in all tissues of the body. This results in an increase in organ healing and regeneration, which is associated with increase resistance to illness and injury.

    In the skin, documentation regarding somatotropin (HGH) supplementation has shown increased collagen synthesis, which makes the skin thicker and smoother. In the bone, these studies showed increased bone density. In the internal organs and sex organs, research showed increased size and markedly improved function.
    The immune system, research also showed increased immune system regulation and activity, resulting in fewer infectious illnesses. In adults, HGH is necessary for proper repair and regeneration of injured tissues.
    One of the widely reported results of somatotropin (HGH) supplementation is the effect it has on the body’s sexual centers. Research shows heightened desire and function in both men and women.

    Beginning around the age of 20 years old, our natural production of somatotropin (HGH) begins to decline at the average rate of 14% per decade.
    By the age of 40, somatotropin (HGH) production has decreased 30% over our youthful production level, and by the age of 60, by 80% on average. The decline in somatotropin (HGH) correlates with many of the effects of aging including loss of lean body mass (muscle, bone, skin and internal organs), increase in total body fat, thinning and wrinkling of skin, decreased immune function and decreased sexual desire and function.
    As a result of the decline in somatotropin (HGH), and because it is the master hormone, other hormones also decline with age, such as Testosterone, Estrogen, Progesterone and DHEA, as well as many other important mood-elevating hormones. Examples of other hormones that also decrease are thyroid and thymus hormones, which can cause menopause in women and andropause in men.

    Growth Hormone can:

    Restore muscle loss
    Increase skin thickness
    Reduce total body fat
    Improve bone density

    People have seen specific improvements from using HGH in:

    Skin tightness and moisture
    Mental speed and clarity
    Enhanced sexual function
    Elevated mood and energy levels
    Improved aerobic capacity
    Significantly greater immune function
    Increased wound healing capacity

    So, gh therapy sounds great for anti-aging so what’s the catch… The catch is keeping your levels in a physicological level and to not exceed youthful levels. As with any hormone, raising levels above youthful normal levels can cause unwanted side effects which are easily noticed like joint problems, the development of carpel tunnel and excess water weight gain. Its simple, just lower your dose if you notice a problem. There is a huge difference between keeping levels well above normal for years for anti-aging and doing a cycle with gh/cjc-1295 that exceed normal levels. Short term higher levels have much less potitential to cause long term problems… Ok, so you are interested in anti-aging with cjc-1295, what dose should you use. When taking into consideration the studies on it’s outcome of gh production, as little as 1mg weekly is needed and no more then 2mg a week. This makes CJC-1295 extremely cost effective. Vials could be shared with fellow researchers if only 1mg is used weekly. The lab states after reconsituting cjc-1295 it can be refrozen to be used later but is best used without refreezing, so there may be a slight potiency loss by doing this.

    Dosing for Muscle Growth

    In the studies 30mcg/kg or 60mcg/kg were used resulting in 2-10 fold in gh production. A 200lb man weighs aprox 90kg… thats 200 divided by 2.2 = 90 so thats 30mcg X 90=2700mcg=2.7mg or 60mcg X 90=5400mcg=5.4mg weekly these doses showed safety… I believe a minimum 2mg a week should be used and no more then 6mg… You decided but I say start low and work your way up to the dose you are comfortable with and remember to keep this short term to reach a specific goal and then go on an anti-aging dose between cycles which would also preserve the muscle growth you build during the cycle.

    Stop Wasting Your Money On GH

    ..CJC-1295 Is More Effective
    ..costs much less
    ..less side effects because its your natural gh
    ..doesn’t shut you down
    ..Increase Natural GH 10X
    ..unleash
    ..Anti-Aging Benefits

    Storage: Refrigerate… 1yr + storage in the fridge
    Reconstituted:After reconstituting with Bacteriostatic Water use within 3-5 day

    FROM VISIONS
    get your CJC-1295 by clicking the banner link in my signature

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    Hey basskiller ur pretty in tune with peps it seems ...ok im on gh now but i wanna get the full benefit of it ...i heaf igf long lastin pep is great and what u mention seems to be amazin now is that somethin u would run with gh and aas ? I mean i hear of people usin insulin too ...i just dont want a load of chemicals too take .....u or any vet please chime in

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    Awesome info basskiller! I have been waiting for a post like this.

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    Quote Originally Posted by twistedgto View Post
    Hey basskiller ur pretty in tune with peps it seems ...ok im on gh now but i wanna get the full benefit of it ...i heaf igf long lastin pep is great and what u mention seems to be amazin now is that somethin u would run with gh and aas ? I mean i hear of people usin insulin too ...i just dont want a load of chemicals too take .....u or any vet please chime in
    There have been a lot of people that have used a combo of aas as well as insulin with GH. One of my first teachers, A man that used the handle ironmaster, years ago said there was a great synergy between GH and dbol (meaning an oral aas) Now this was probably 12 or 13 years ago and I really don't remember the aspects of it. But judging by his pics, he was doing something right. He, like I was an and older gentlemen.
    GH by itself is mainly used by older guys. While people will see some benefit from using it alone, it's really wasteful for younger guys to be taking it alone.
    In order to get the very most from it, AAs and slin have to be used. I understand where your coming from not wanting to load up with a ton of extras to make one thing work better. But knowing that, I think I would have chosen another route to take to meet my goals.. I bet it also would be much less expensive.

    I have an article written by an old friend Red Baron.. I'll post that up next.

    A warning.. Insulin is not something to take lightly. Before I ever used it.. I researched the hell out of it. Back then, You really had to search .. Now there are places that have put all this info in pretty much one place. Many sites have forums dedicated to this one drug alone.. It wasn't like that back when I started.
    I have a pretty good collection of insulin articles also.

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    HGH + IGF-1 + Insulin - A basic guide

    There are volumes of information and studies available about using HGH, IGF-1, and Insulin, but for the most part coming up with a good cycle including all of these is a tedious process and requires more reading than most people wish to do or have the time to do. The following is meant to a quick and simple reference to what a cycle including all three might look like and a brief description of the action of each component.

    THE CYCLE



    Buy one get one free on all products Weeks 1- (20-30) - HGH - On 5/ off 2
    2 - 2.5 IU's first thing in the morning
    2 - 2.5 IU's early afternoon
    injected Sub-C into abdomen, obliques, fronts of the thighs, upper triceps

    Weeks 1-5, 11-15, (21-25) - Long R3 IGF-1 - Every day
    60mcg's intramuscular post work out on workout days,
    first thing in the morning on non workout days

    Weeks 6-10, 16-20, (26-30) - Humalog - Workout days only
    8IU's immediately post workout, intramuscular
    *** alternatively, you could run the Humalog on 1-5, 11-15, (21-25) with your LR3 if you prefer, depending on your cycle goal***

    Immediately after Humalog injection - do the following
    Injection + 5 minutes - drink shake with 10g glutamine / 10g creatine / 55g dextrose
    Injection + 15 minutes - drink shake with 80g of whey protein in water
    Injection + 60 - 75 minutes - eat a protein / carb meal with 40-50g of protein, 40-50g of carbs, NO FATS
    Avoid fats for 2-3 hours for Humalog IM, 3-4 hours for Humalog sub-q, 4-5 hours for Humulin-R.
    **keep some glucose tablets or other simple carbs on hand for the active window of your insulin. Hypo symptoms can and will hit hard and fast and you will have little time to react. This is the main danger of insulin use. Be ready.***

    OPTIONAL
    T3 - 12.5mcg per day (or 12.5mcgs ->100-150mcgs ->12.5mcgs if used for fat loss instead of protein synthesis assist)

    HGH



    HGH should ideally be used for 20-30 week cycles (or longer). The dosage should be between 2-3IU per day if you are using GH primarily for fat loss, 4-5 IU's a day for both fat loss and muscle growth, and approximately 1.0 - 2.0 IU's a day for females. It is best to split your injections 1/2 first thing in the morning, 1/2 early afternoon if your dose is above 2.0IU's per day. Your pituitary will naturally produce about 10 pulses of GH per day. Each injection you take will create a negative feedback loop that will suppress these pulses for about 4 hours. By taking your injections first thing in the morning and early afternoon you will still allow your body to release its biggest pulse, which normally occurs shortly after going to sleep at night.

    When starting out with your HGH cycle, for most people it is wise to begin you dose at 1.5 - 2.0IU per day for the first couple of weeks, and then begin increasing your dose by 0.5 to 1.0 units every week or two until you reach your desired level. While it isn't an absolute necessity to do this, if you are sensitive to the type of sides HGH present you will often times avoid these sides of joint pain/swelling, and bloating/water retention by slowly acclimating to your ultimate 4-5 IU's /day goal.

    You should use an U100 insulin syringe for injecting HGH, and inject it Sub-C into your abdomen, obliques, top of thighs, triceps. Rotate injection sites. HGH can have a small localized fat loss benefit, so keep this in mind when choosing your injection sites.

    IGF-1
    When HGH makes it pass through the liver, a release of IGF-1 is a result. IGF-1 appears to be the key player in muscle growth. It stimulates both the differentiation and proliferation of myoblast. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. While HGH will cause an increase in your IGF-1 level over the course of a few months, HGH has a cumulative effect, so the addition of IGF-1 will greatly speed up the time to results.

    There are two types of IGF-1 that will typically be used by bodybuilders. One is bio-identical HuIGF-1, a 70 amino acid string. The other is Long R3 IGF-1, which is an 83 amino acid analog of human IGF-I comprising the complete human IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus (hence the long). Which of these you use depends on your goal.

    HuIGF-1 is very short lived in the body (half life of probably around 10 minutes). This type of IGF-1 is very useful if you are seeking local site growth. Since it is so short lived, little of the IGF-1 makes it to other tissues and IGF-1 receptors in the body. The way to inject this is immediately post work out into the muscle that you wish to have local site growth. Use a U100 insulin syringe, and inject 80mcg's bilaterally into the desired muscle immediately post workout. For this type of IGF-1, I would use it workout days only or if desired you could inject on non-workout days first thing in the morning into a muscle group worked the previous day.

    For Long R3 IGF-1, it isn't as critical that you inject into a local site as long R3 has a active window of many hours, and is designed specifically to resist being bound. Since it is common to reconstitute this type of IGF-1 with Benzyl Alcohol, Acetic Acid, or Hydrochloric Acid I would still recommend that you inject intra-muscular. It can and probably will leave a nice red irritated spot if you inject Sub-C. I still inject into a muscle just worked to take advantage of increased IGF-1 receptors, but because of the long activity window of this type of IGF-1 any muscle will work well and give you good results,. I would suggest that you inject between 40-80mcg's per day everyday immediately post workout on workout days, and first thing in the morning on non-workout days.

    Use a U-100 insulin syringe with 1/2" needle to inject IGF-1 intramuscular (bilaterally for HuIGF-1, bilaterally optional for Long R3)


    Insulin
    Working out causes us to end up in a catabolic state. It is important to back in a positive nitrogen balance as soon as possible. When not using insulin, we drink some dextrose with our protein to cause an insulin spike immediately post workout to help shuttle the protein and sugars to the muscles.

    Insulin is very good at shuttling nutrients to the muscles, and works in a very complimentary manner with GH in the types of things that they shuttle. Also, HGH can cause an amount of insulin resistance, so adding some insulin to your cycle will offset any potential resistance that might occur during your HGH cycle.

    For the purposes that we are using insulin, a dosage of 4-10IU's is adequate and should be used immediately post workout. I personally prefer using Humalog intramuscular as it will cause a rapid spike and clear out of your system quickly. You can use it sub-q or use Humulin-R instead, but each of these will result in a longer active window, thus a longer time to avoid eating any fats and watching your carb intake. Any fats or over abundance of carbs will end up being stored as fat during insulin's active window. The approximate windows are:
    Humalog
    Intramuscular ---- 2-3 hours
    subcutaneous --- 3-4 hours
    Humulin R
    Intramuscular ---- 3-4 hours
    subcutaneous --- 4-5 hours

    Use a U-100 insulin syringe with 1/2" needle to inject IM immediately post workout. Alternatively, you can inject Sub-C if desired or if you wish a longer active window for some reason. Begin with a dose of 2IU's or so, and increase the dose each workout day until you reach your 8IU's.

    If for some reason you wish to avoid insulin, I would still suggest that immediately post workout you spike you own endogenous insulin by drinking 80 grams of dextrose / 40 grams of whey isolate protein. While this certainly won't do the work of 8-10 IU's of Humalog, it will most certainly assist getting your muscle back in a nitrogen positive environment in a short amount of time.
    T3
    HGH can have a slight inhibitory effect on your thyroid. For most people this is minimal and does not require any additional thyroid be taken, but if you wish to augment protein synthesis as well as give yourself a slight boost in thyroid without shutting down your own production, you can add 12.5mcg of T3 daily to your HGH, IGF-1, Insulin cycle. This will aid both in bulking and cutting.

    If you add this, you should also consider taking some thyroid support supplements such as t-100x, bladderwrack, coleus forskolin. You should check and make sure your intake of trace minerals (selenium, zinc, copper) is sufficient to aid in the conversion of T4 to T3.

    If you are going to take more than 12.5 mcg of T3, you will need to cycle the dose both up and down to avoid a rebound effect when going off cycle, but for our use with an HGH cycle and use in assisting with protein synthesis, 12.5mcg will be sufficient. If you wish to use T3 in conjunction with the above for heavy cutting, begin with 12.5mcgs, ramp up to 100-150mcgs, then slowly back down tapering back to 12.5 mcgs for a time before discontinuing use. This will minimize the chance for rebound while your own thyroid gets back in gear.

    Well, I think that about covers it. add a cycle or two of your favorite testosterone and you have a great combination for bulking or cutting.
    By RED BARON

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    Melanotan II

    Melanotan II was developed originally as potential preventative treatments for various forms of skin cancer. It was thought that by artificially stimulating the internal tanning process among members of the population that were at high risk to develop skin cancer due to sun exposure that one may be able to lower the chances of these individuals from developing the disease later in life. While these findings have been relatively inconclusive in terms of the original intent of the product a few secondary uses for the drug have been found and are now utilized by many.


    The IGF-1's are excluded from this sale

    The main purpose that both Melanotan and Melanotan II are now administered for is their ability to act as a tanning agent. Both are synthetic hormones that once introduced into the body are able to cause a reaction within it that is similar to the natural tanning process that one goes through without the risks or need for sunlight to be present, while remembering that some of the benefits of exposure to the sun will also not be present. Along with the benefits of providing a tan without the need for extensive exposure to sunlight as well as improved sexual performance and/or desire, Melanotan II also may help to decrease the appetite via targeting an appetite-suppression receptor in the brain. This effect is not an overwhelming one but is noticeable for the majority of users and desirable for many. The duration of the tanning effect of the drug once a user ceases administering it will once again depend on several factors. The majority of users however will notice that the tan achieved with the drug will fade and become unnoticeable within four to eight weeks after ceasing the administration of the drug.

    The libido enhancement and sexual performance benefits will fade much quicker along with the appetite suppressing effect. The tan that is created is considered a “natural” one in both the reaction that causes it in the body as well as the outward appearance of the skin once the drug has taken full effect. It should be noted however that to achieve the full effect of the hormones one will still have to expose themselves to sunlight and/or artificial tanning beds, etc. Unlike Melanotan however, Melanotan II has libido and sexual performance enhancing capabilities. This is due to Melanotan II having the metabolite Bremelanotide. Bremelanotide is currently under research as a possible treatment for various forms of sexual dysfunction, including both sexual arousal disorders as well as erectile dysfunction. Since however Bremelanotide has not been made available for use by the general public, for those wanting to reap its benefits in terms of its sexual performance improvements, Melanotan II is the only option at this point. It is believed that the source of this improvement in both sexual performance and arousal is the action of the hormone on the hypothalamus of the user. This, however, is still a theory in need of further investigation.

    For most individuals, during the loading phase with the hormone, a range of between 0.015 to 0.02 milligrams per kilogram of body weight per injection should be sufficient. These injections would take place anywhere from twice daily to as infrequently as once every other day or longer. For the maintenance phase many individuals will find that a dose of approximately 0.01 milligrams per kilogram of body weight administered once every few days should be sufficient to maintain the effects of the hormone. As stated however, the reactions to Melanotan II are highly individualized so experimentation when first using this hormone will be necessitated. As always, lower doses should be utilized to begin with and increased as needed and as one is able to gage their tolerance for the drug.
    Last edited by basskiller; 07-12-2014 at 09:49 AM.

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    Anti-aging Growth Hormone Peptide

    Human Growth Hormone (HGH) Dosage:

    Month 1: HGH 2 IU one injection every other day
    Months 2-4: HGH 3 IU one injection five days a week
    Months 5-6: HGH 4 IU one injection five days a week
    4-6 month cycles are optimal, year round if you are over age 35.
    muscle building growth hormone

    Human Growth Hormone (rHGH, HGH, or GH) is a protein molecule consisting of 191 amino acids. Genetically engineered human growth hormone is completely identical to the growth hormone made by the pituitary gland. Researchers have proven growth hormone therapy can reverse the biological effects of aging. HGH is widely appreciated for aesthetics and body recomposition, not necessarily as a performance enhancer.

    HGH is released in pulses that take place during the day. Growth hormone is rapidly converted in the liver to its powerful growth promoting metabolite, Insulin like Growth Factor. IGF-1 is measured in the blood to determine the level of growth hormone secretion. Most of the beneficial effects of human growth hormone are directly attributable to IGF-1. Growth hormone replacement/stimulation is the most effective therapy to reverse the effects of aging.

    At age 30 people have people have spent most of their lives with relatively high levels of HGH. HGH is responsible for growth during childhood as well as for repair and regeneration of tissue. By the time we are 30 our bodies no longer naturally produce enough GH to handle the damage that is taking place. As this continues, we age. Increasing HGH in our bodies, we can slow, or even reverse many of the manifestations of aging.






    What HGH can do:
    •Reduce excess body fat, especially abdominal fat. (The reduction of abdominal fat is the single most profound effect of HGH replacement in many people)
    •Decrease in the waist to hip ratio. (Meaning fat is removed primarily from around the waist where it is associated with a high risk of coronary disease)
    •Increase muscle mass and bone density. (and physical strength if combined with moderate exercise)
    •Reduce wrinkling of the skin and some other effects of skin aging.
    •Strengthen the immune system & enhance feeling of well being.

    Human Growth Hormone takes several weeks to months of use benefit from its effects. There are a number of substances that increase the natural secretion of HGH. Some of them are amino acids. The relationship of certain amino acids to growth hormone is complex and varies greatly among different individuals and among individuals of different ages.

    HGH is a Bodybuilding Research Peptide that comes in the form of lyophilized powder. Any other form that you see advertised or run across is likely NOT the real deal. The only way to administer true HGH is by sub-q or intramuscular injection. Be aware that HGH is not anabolic by itself. Careful measures need to be in place during reconstitution.

    Reconstituting HGH, one vial contains powdered freeze-dried HGH and the other vial contains sterile water with a bacteriostatic preservative. When the user is ready to begin, a certain amount of the sterile water is drawn out of the second vial (with a needle and syringe) and injected into the first vial to dissolve the powdered HGH. The solution is then ready for injection. The unused portion is to be kept refrigerated. Use reconstituted HGH within 3 or 4 weeks.

    The best way to begin HGH is to start with a low dose and ease your way into higher doses. This will allow you to avoid (or at least minimize) many of the more common sides of HGH such as lethargy, bloating and joint pain. Most can tolerate 1-2 IU per day with few sides. HGH administration should be done on an empty stomach as fats and carbohydrates blunt release. Natural production of GH is 1 IU, give or take a half.

    Half life of HGH is 2 hours when injected sub-q with a four hour period which there is a suppression of naturally produced GH. Intramuscular injections shorten the half life. Subcutaneous injections over the long term can lead to spot reduction. Whether or not HGH has any localized benefit from IM injection is unknown, but speculated.

    For bodybuilders growth hormone is best taken in conjunction with insulin, anabolics/androgens, and thyroid hormone. Insulin is extremely effective with HGH as the injections cause a down regulation of insulin sensitivity in the body. HGH is tightly regulated by the FDA, but HGH is not a controlled substance on the federal level in the United States.

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    HGH fragment 176-191

    * Reduces the most stubborn abdominal fat.
    * Increases muscle mass.
    * Increases IGF-1 levels, in an effective manner, thus making this a peptide that burns fat and exhibits anabolic function.
    * Increases energy expenditure.
    * Improves lipid profiles and lipolytic activity.
    * Does not negatively impact blood glucose level, nor does cell proliferation occur, like Human Growth Hormone.
    * Extremely potent and effective fat burner.




    The (HGH fragment 176-191) is a stabilized analogue of the growth hormone-releasing factor (GRF) that induces growth hormone (GH) in a specific and physiological manner. To date studies suggest that (HGH fragment 176-191) has several beneficial features: it reduces abdominal fat (in particular visceral fat), without compromising glycemic control (blood glucose), it increases muscle mass and improves the lipid profile. These characteristics make it an ideal candidate for the treatment of excess abdominal fat, an important aspect of HIV-associated lipodystrophy.

    At a dosage of 500mcg the (HGH fragment 176-191) was shown to increase lipolytic activity in adipose tissue. In other words this fragment potently burns body fat, especially stubborn adipose body fat, and it does so potently! Of significance, is that the fragment has no negative impact on insulin sensitivity, a stark contrast from its Human Growth Hormone counterpart.(Ng FM, Sun J,Sharma L, Libinaka R, Jiang WJ, and Gianello R 2000).

    Not only does the (HGH fragment 176-191) not interfere with the body~~~8217;s natural insulin regulation as Human Growth Hormone can, the (HGH fragment 176-191) does not result in cellular proliferation as Human Growth Hormone does. The fragment is similar to Human Growth Hormone, hence the shared amino acid sequence, however, the (HGH fragment 176-191) does not induce hyperglycaemia or reduce insulin secretion. The (HGH fragment 176-191) does not compete for the hGH receptor and nor does it induce cell proliferation, unlike Human Growth Hormone. (Wu Z, Ng FM. 1993). Thusly, this is a very beneficial peptide in terms of burning fat, without unwanted and undesirable side effects. Of particular note is the fragments ability to increase IGF-1 levels which translate into the fragments ability to give collateral anti-aging and anabolic effects along with its ability to induce lipplytic (fat burning) activity.

    In yet another study, the (HGH fragment 176-191) exhibits the ability to burn through adipose tissue by increasing lipolytic activity (the breakdown of fat) , in the most stubborn body fat (adipose tissue) while increasing energy expenditure and glucose and fat oxidation in ob/ob mice treated with (HGH fragment 176-191). In addition, (HGH fragment 176-191) increased in vitro lipolytic activity and decreased lipogenic activity in isolated adipose tissue from obese rodents and humans.(Heffernan MA, Jiang WJ, Thorburn AW, Ng FM. 2000).

    Thusly, the (HGH fragment 176-191) exhibits the ability to burn through stubborn adipose tissue, while increasing energy expenditure, muscle mass, and fat oxidation. All studies have pointed to the fact that the fragment is an effective treatment for obesity and fat loss, and much safer than its Human Growth Hormone counterpart.

    Includes Sodium Chloride for Dilution, all vials are dosed at 2mg (2000mcg).



    -The mean Relative Insulin Resistance (RIR) increased in all groups with no statistically significant differences among groups (Figure 2).
    -There were no statistically significant treatment differences in the changes from the baseline in fasting insulin levels and OGTT insulin (data not shown).


    -At week 12, a statistically significant treatment difference (p=0.04, ANOVA) in mean total cholesterol was observed.
    -Values increased by 5% and 3% in the placebo and 1 mg groups, respectively and decreased by 6% in the 2mg group (Figure 5).
    -Changes were significantly different in the 2mg group when compared to the placebo and 1mg groups (p<0.05), and were mainly explained by comparable changes in the mean non-HDL cholesterol values (Figure 5.).
    -HDL cholesterol and triglycerides levels remained unchanged (data not shown).

    -Mean IGF-1 levels increased in a dose dependant manner over the study period (Figure 6).
    -IGF-1 increases were associated with no clear dose-related pattern of adverse events suspected to be related to the study drug.
    .

    RESEARCH DOSAGE: frag 176-191


    500mcg-2mg every day
    STORAGE:
    REFRGIRATE UPON RECEIPT.
    KEEP REFRIGERATED AFTER RECONSTITUTION ALLOW 24 HOURS FOR THE PEPTIDE TO SETTLE BEFORE BEGINNING YOUR RESEARCH.
    NCLUDES SODIUM CHLORIDE FOR DILUTION Academic References & Further Information
    Heffernan MA, Jiang WJ, Thorburn AW, Ng FM. (2000). Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism. Am J Physiol Endocrinol Metab. 2000 Sep;279(3):E501-7.
    Ng FM, Sun J,Sharma L, Libinaka R, Jiang WJ, and Gianello R (2000). Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000;53(6):274-8.
    Wu Z, Ng FM (1993). Antilipogenic action of synthetic C-terminal sequence 177-191 of human growth hormone. Biochem Mol Biol Int. 1993 May;30(1):187-96.

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