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CIALIS 20 - 20mg/tab EP
Supplier:Euro-Pharmacies
Chemical Name:Tadalafil
Comes In:20mg tab
Dosage:15-30mg
Active time: aprox.20 hours
Class
hosphodiesterase inhibitor
Supplier:Euro-Pharmacies
Chemical Name:Tadalafil
Comes In:20mg tab
Dosage:15-30mg
Active time: aprox.20 hours
Class
hosphodiesterase inhibitor
Tadalafil is used to treat men who have erectile dysfunction (also called sexual impotence). Tadalafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors.
Tadalafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors.*
Erectile dysfunction is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection.
tadalafil helps to maintain an erection after by increasing blood flow to the penis.
Tadalafil is also used to treat men who have symptoms of benign prostatic hyperplasia (BPH). BPH is caused by an enlarged prostate.
Tadalafil is also used to treat the symptoms of pulmonary arterial hypertension. This is high blood pressure that occurs in the main artery that carries blood from the right side of the heart (the ventricle) to the lungs.
Tadalafil works on the PDE5 enzyme in the lungs to relax the blood vessels. This will increase the supply of blood to the lungs and reduce the workload of the heart.
Tadalafil has the slowest absorption of the available PDE5 inhibitors with a mean of 2 hours to reach its maximum concentration, compared with about 50 minutes for sildenafil and vardenafil (Briganti et al 2005). The onset of action of tadalafil may occur in as early as 15 minutes of dosing, although successful erections occur in fewer than 40% of men at this time point .
Differences in gastrointestinal absorption with fatty meals explain the varying peak plasma concentration (Tmax) among the three PDE5 inhibitors.
Its most unique characteristic is its long half-life of 17.5 hours, which lends itself to a longer therapeutic window with on-demand dosing and effective steady-state plasma concentrations*.
Dosing/ absorption
Tadalafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors.*
Erectile dysfunction is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection.
tadalafil helps to maintain an erection after by increasing blood flow to the penis.
Tadalafil is also used to treat men who have symptoms of benign prostatic hyperplasia (BPH). BPH is caused by an enlarged prostate.
Tadalafil is also used to treat the symptoms of pulmonary arterial hypertension. This is high blood pressure that occurs in the main artery that carries blood from the right side of the heart (the ventricle) to the lungs.
Tadalafil works on the PDE5 enzyme in the lungs to relax the blood vessels. This will increase the supply of blood to the lungs and reduce the workload of the heart.
Tadalafil has the slowest absorption of the available PDE5 inhibitors with a mean of 2 hours to reach its maximum concentration, compared with about 50 minutes for sildenafil and vardenafil (Briganti et al 2005). The onset of action of tadalafil may occur in as early as 15 minutes of dosing, although successful erections occur in fewer than 40% of men at this time point .
Differences in gastrointestinal absorption with fatty meals explain the varying peak plasma concentration (Tmax) among the three PDE5 inhibitors.
Its most unique characteristic is its long half-life of 17.5 hours, which lends itself to a longer therapeutic window with on-demand dosing and effective steady-state plasma concentrations*.
Dosing/ absorption
Recommended starting doses of tadalafil are 10 mg for on-demand dosing and 2.5 mg for once-daily dosing, and these doses can then be titrated up or down according to the efficacy and tolerability (ICOS 2008). It is absorbed as a low-solubility and high-permeability, or Class 2, drug within the FDA Biopharmaceuticals Classification System (Gupta et al 2005). With oral ingestion, after first-pass metabolism, tadalafil is approximately 80% bioavailable, compared to 40% and 15% with sildenafil and vardenafil, respectively.
